Matthias Trost
@mtrost.bsky.social
Professor of Proteomics. Currently at Newcastle University UK. he/him
Here in personal capacity.
Here in personal capacity.
I have a PhD position available with start date September 2026 at the University of Manchester.
Proteomics analysis of flow cytometry-based isolated pathogen-containing phagosomes
Due to funding requirements, this position is for UK home students only.
www.findaphd.com/phds/project...
Proteomics analysis of flow cytometry-based isolated pathogen-containing phagosomes
Due to funding requirements, this position is for UK home students only.
www.findaphd.com/phds/project...
Proteomics analysis of flow cytometry-based isolated pathogen-containing phagosomes at The University of Manchester on FindAPhD.com
PhD Project - Proteomics analysis of flow cytometry-based isolated pathogen-containing phagosomes at The University of Manchester, listed on FindAPhD.com
www.findaphd.com
December 15, 2025 at 12:15 PM
I have a PhD position available with start date September 2026 at the University of Manchester.
Proteomics analysis of flow cytometry-based isolated pathogen-containing phagosomes
Due to funding requirements, this position is for UK home students only.
www.findaphd.com/phds/project...
Proteomics analysis of flow cytometry-based isolated pathogen-containing phagosomes
Due to funding requirements, this position is for UK home students only.
www.findaphd.com/phds/project...
Reposted by Matthias Trost
Nice preprint from @derm-scientist.bsky.social! Ubiquitin system is key for tissue architecture in CYLD cutaneous syndrome (CCS) skin tumours.
"Comparative ubiquitinomics of human skin reveals insulin receptor ubiquitination as a regulator of collagen secretion."
www.biorxiv.org/content/10.6...
"Comparative ubiquitinomics of human skin reveals insulin receptor ubiquitination as a regulator of collagen secretion."
www.biorxiv.org/content/10.6...
December 8, 2025 at 5:49 PM
Nice preprint from @derm-scientist.bsky.social! Ubiquitin system is key for tissue architecture in CYLD cutaneous syndrome (CCS) skin tumours.
"Comparative ubiquitinomics of human skin reveals insulin receptor ubiquitination as a regulator of collagen secretion."
www.biorxiv.org/content/10.6...
"Comparative ubiquitinomics of human skin reveals insulin receptor ubiquitination as a regulator of collagen secretion."
www.biorxiv.org/content/10.6...
Reposting this.
If you are interested in applying for this fellowship in a research area of our lab's interest, let me know.
If you are interested in applying for this fellowship in a research area of our lab's interest, let me know.
Three Bicentenary research fellowships on offer at @officialuom.bsky.social @fbmh-uom.bsky.social for exceptional ECRs with <3y postdoc experience
3yrs salary + £30k pa research expenses
Do you have a great idea & want to join @mermanchester.bsky.social?
www.bmh.manchester.ac.uk/research/sup...
3yrs salary + £30k pa research expenses
Do you have a great idea & want to join @mermanchester.bsky.social?
www.bmh.manchester.ac.uk/research/sup...
Bicentenary Early Career Research Fellowships | Biology, Medicine and Health | University of Manchester
Find out about and apply for a Bicentenary Early Career Research Fellowship.
www.bmh.manchester.ac.uk
October 10, 2025 at 8:36 AM
Reposting this.
If you are interested in applying for this fellowship in a research area of our lab's interest, let me know.
If you are interested in applying for this fellowship in a research area of our lab's interest, let me know.
Some news!
We will move to the University of Manchester @manchester.ac.uk in January!
We will keep some association with. Newcastle University for a while.
Very excited!
We will move to the University of Manchester @manchester.ac.uk in January!
We will keep some association with. Newcastle University for a while.
Very excited!
October 6, 2025 at 8:06 AM
Some news!
We will move to the University of Manchester @manchester.ac.uk in January!
We will keep some association with. Newcastle University for a while.
Very excited!
We will move to the University of Manchester @manchester.ac.uk in January!
We will keep some association with. Newcastle University for a while.
Very excited!
Are you using DIA mass spectrometry in proteomics?
We have just put this paper online: www.biorxiv.org/content/10.1...
Here, we came up with some Recommendations for Quantitative Data-Independent Acquisition (DIA) Proteomics using Controlled Quantitative Experiments (CQEs)
1/4
We have just put this paper online: www.biorxiv.org/content/10.1...
Here, we came up with some Recommendations for Quantitative Data-Independent Acquisition (DIA) Proteomics using Controlled Quantitative Experiments (CQEs)
1/4
Recommendations for Quantitative Data-Independent Acquisition (DIA) Proteomics using Controlled Quantitative Experiments (CQEs)
Advances in mass spectrometry and associated computational tools have resulted in the wide-spread adoption of Data-Independent Acquisition (DIA) for proteomics. Experiments using state-of-the-art inst...
eur03.safelinks.protection.outlook.com
September 23, 2025 at 9:44 AM
Are you using DIA mass spectrometry in proteomics?
We have just put this paper online: www.biorxiv.org/content/10.1...
Here, we came up with some Recommendations for Quantitative Data-Independent Acquisition (DIA) Proteomics using Controlled Quantitative Experiments (CQEs)
1/4
We have just put this paper online: www.biorxiv.org/content/10.1...
Here, we came up with some Recommendations for Quantitative Data-Independent Acquisition (DIA) Proteomics using Controlled Quantitative Experiments (CQEs)
1/4
Very happy that we have been awarded a £800k grant from the MRC for a novel mass spectrometer for the @newcastleuni.bsky.social NUPPA facility.
Thanks to everyone involved!
Thanks to everyone involved!
July 26, 2025 at 10:37 AM
Very happy that we have been awarded a £800k grant from the MRC for a novel mass spectrometer for the @newcastleuni.bsky.social NUPPA facility.
Thanks to everyone involved!
Thanks to everyone involved!
Amazing podcast on the mitochondrial donation babies. Great work by wonderful colleagues@mitonewcastle.bsky.social at @newcastleuni.bsky.social and the @lilyfoundation.bsky.social
www.theguardian.com/science/audi...
www.theguardian.com/science/audi...
The babies born with DNA from three parents – podcast
Doctors in the UK have announced the birth of eight healthy babies after performing a groundbreaking procedure that creates IVF embryos with DNA from three people. Ian Sample tells Madeleine Finlay ab...
www.theguardian.com
July 22, 2025 at 4:23 PM
Amazing podcast on the mitochondrial donation babies. Great work by wonderful colleagues@mitonewcastle.bsky.social at @newcastleuni.bsky.social and the @lilyfoundation.bsky.social
www.theguardian.com/science/audi...
www.theguardian.com/science/audi...
In life sciences there are two types of people in my experience: those that embrace and exploit omics and other large scale data technologies and those who work on one problem at the time. I had many collaborators from either side.
1/2
1/2
June 27, 2025 at 10:04 AM
In life sciences there are two types of people in my experience: those that embrace and exploit omics and other large scale data technologies and those who work on one problem at the time. I had many collaborators from either side.
1/2
1/2
The financial crisis of the HE sector in the UK now leads to increased numbers of grant and fellowship applications, pushing down the success rates. Since also overheads increased, in some cases we will see success rates halved.
There is a BBSRC fellowship which will have a success rate of 5%.
There is a BBSRC fellowship which will have a success rate of 5%.
June 20, 2025 at 9:08 AM
The financial crisis of the HE sector in the UK now leads to increased numbers of grant and fellowship applications, pushing down the success rates. Since also overheads increased, in some cases we will see success rates halved.
There is a BBSRC fellowship which will have a success rate of 5%.
There is a BBSRC fellowship which will have a success rate of 5%.
@drandyfrey.bsky.social having quite some interest at his poster at #EUPA2025
We have performed a controlled quantitative experiment with a three proteome mix and come up with recommendations using DIA.
Biorxiv paper out soon (hopefully!)
We have performed a controlled quantitative experiment with a three proteome mix and come up with recommendations using DIA.
Biorxiv paper out soon (hopefully!)
June 19, 2025 at 2:18 PM
@drandyfrey.bsky.social having quite some interest at his poster at #EUPA2025
We have performed a controlled quantitative experiment with a three proteome mix and come up with recommendations using DIA.
Biorxiv paper out soon (hopefully!)
We have performed a controlled quantitative experiment with a three proteome mix and come up with recommendations using DIA.
Biorxiv paper out soon (hopefully!)
The location and food will make it impossible for anyone else to ever make a better EUPA conference. Thank you for organising such an excellent event! #EUPA2025
June 19, 2025 at 11:24 AM
The location and food will make it impossible for anyone else to ever make a better EUPA conference. Thank you for organising such an excellent event! #EUPA2025
Some of y'all can't handle 2 high agency males going at it and it really shows.
June 6, 2025 at 1:39 PM
Some of y'all can't handle 2 high agency males going at it and it really shows.
Does anyone have an update on the number of ASMS attendees?
Does anyone know how many delegates are at #ASMS2025 ?
I would assume that immigration policy and the blocking of grants will affect the numbers...
I would assume that immigration policy and the blocking of grants will affect the numbers...
June 6, 2025 at 11:55 AM
Does anyone have an update on the number of ASMS attendees?
Reposted by Matthias Trost
Wow, yes. An amazing glimpse of the LLM Lie Machine at work. Anyone whose students are bring tempted by LLMs, sharing this could be very helpful showing how it lies, and how it fails.
This is a hell of a thing to read.
Diabolus Ex Machina
This Is Not An Essay
open.substack.com
June 3, 2025 at 4:00 PM
Wow, yes. An amazing glimpse of the LLM Lie Machine at work. Anyone whose students are bring tempted by LLMs, sharing this could be very helpful showing how it lies, and how it fails.
Does anyone know how many delegates are at #ASMS2025 ?
I would assume that immigration policy and the blocking of grants will affect the numbers...
I would assume that immigration policy and the blocking of grants will affect the numbers...
June 2, 2025 at 9:08 AM
Does anyone know how many delegates are at #ASMS2025 ?
I would assume that immigration policy and the blocking of grants will affect the numbers...
I would assume that immigration policy and the blocking of grants will affect the numbers...
Reposted by Matthias Trost
Two days left for abstract submission and early bird registration for BSPR2025!
Less than one week to go until the deadline for abstract submission and early bird registration for the British Society for Proteome Research @ukbspr.bsky.social annual conference 2025 in Liverpool! Deadline is Friday May 16! For more details see here: www.bspr.org/annual-meeti...
Annual Meetings | BSPR
www.bspr.org
May 14, 2025 at 7:44 PM
Two days left for abstract submission and early bird registration for BSPR2025!
Reposted by Matthias Trost
Less than one week to go until the deadline for abstract submission and early bird registration for the British Society for Proteome Research @ukbspr.bsky.social annual conference 2025 in Liverpool! Deadline is Friday May 16! For more details see here: www.bspr.org/annual-meeti...
Annual Meetings | BSPR
www.bspr.org
May 11, 2025 at 1:43 PM
Less than one week to go until the deadline for abstract submission and early bird registration for the British Society for Proteome Research @ukbspr.bsky.social annual conference 2025 in Liverpool! Deadline is Friday May 16! For more details see here: www.bspr.org/annual-meeti...
Who would have thought that hard right nationalist governments do ethnic cleansing and start wars?
May 7, 2025 at 8:54 AM
Who would have thought that hard right nationalist governments do ethnic cleansing and start wars?
Labour dropping Net Zero will lead to Reform voters still voting Reform and Labour voters voting for the Greens.
God, show some spine and do what is right.
God, show some spine and do what is right.
Labour MPs are starting to get nervous about net zero, after a disappointing set of election results
A minister cast doubt over Ed Miliband's political future
An MP said net zero could "play out the same way as Brexit"
Story by me & @matildamartin.bsky.social 👇
A minister cast doubt over Ed Miliband's political future
An MP said net zero could "play out the same way as Brexit"
Story by me & @matildamartin.bsky.social 👇
Labour Figures Starting To Get Nervous About Net Zero Following Local Election Results
Labour MPs are growing increasingly nervous about the government’s approach to net zero following Reform’s sweeping success in the local and mayora...
www.politicshome.com
May 2, 2025 at 8:26 PM
Labour dropping Net Zero will lead to Reform voters still voting Reform and Labour voters voting for the Greens.
God, show some spine and do what is right.
God, show some spine and do what is right.
Sigh. Want to go to two conferences in France and ideally take the train to reduce my CO2 output.
To get to Paris I can either spend £500 to take the train or fly for £88.
This is so fucked up.
To get to Paris I can either spend £500 to take the train or fly for £88.
This is so fucked up.
May 1, 2025 at 11:23 AM
Sigh. Want to go to two conferences in France and ideally take the train to reduce my CO2 output.
To get to Paris I can either spend £500 to take the train or fly for £88.
This is so fucked up.
To get to Paris I can either spend £500 to take the train or fly for £88.
This is so fucked up.
I would like to share our latest work: After years of optimisation, we have developed a flow cytometry-based method to isolate pathogen-containing phagosomes. Paired with sensitive proteomics, this provides exciting new insights into host-pathogen interactions!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Flow cytometry-based isolation combined with ultra-sensitive proteomics of Salmonella-containing phagosomes reveals novel insights into host-pathogen interactions
Macrophages engulf pathogens into dynamic phagosomes, which many bacteria manipulate for survival. However, isolating pure pathogen-containing phagosomes remains challenging. Here, we developed a nove...
www.biorxiv.org
April 29, 2025 at 12:54 PM
I would like to share our latest work: After years of optimisation, we have developed a flow cytometry-based method to isolate pathogen-containing phagosomes. Paired with sensitive proteomics, this provides exciting new insights into host-pathogen interactions!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Matthias Trost
🆕 “Science and medicine in the USA are being violently dismembered while the world watches [...] bullies are only emboldened by acquiescence or indifference.”
The Lancet’s latest Editorial: Supporting medical science in the USA www.thelancet.com/journals/lan...
The Lancet’s latest Editorial: Supporting medical science in the USA www.thelancet.com/journals/lan...
April 25, 2025 at 12:28 PM
🆕 “Science and medicine in the USA are being violently dismembered while the world watches [...] bullies are only emboldened by acquiescence or indifference.”
The Lancet’s latest Editorial: Supporting medical science in the USA www.thelancet.com/journals/lan...
The Lancet’s latest Editorial: Supporting medical science in the USA www.thelancet.com/journals/lan...
Communication with an autistic teenage boy via text is 99% getting answers like "yes", "no" and "ok".
But even that you never get without a prompt.
But even that you never get without a prompt.
April 25, 2025 at 10:16 AM
Communication with an autistic teenage boy via text is 99% getting answers like "yes", "no" and "ok".
But even that you never get without a prompt.
But even that you never get without a prompt.
Reposted by Matthias Trost
Journal editors are now receiving such letters from the US government. The entire scientific community must unite to support our journals in flatly resisting such illegal interventions.
April 17, 2025 at 9:28 PM
Journal editors are now receiving such letters from the US government. The entire scientific community must unite to support our journals in flatly resisting such illegal interventions.