The multi-ion isolation is the tricky part. That really requires a different cell design and power supply scheme - but since the IRM potentials are derived from the C-Trap's, it cannot simply be exchanged. Also no free space.

Small downside of a highly integrated design like the Exploris module.

You aren't alone in this, it just represents a shockingly large project. The platform lacks a convenient spot to incorporate an analytical trap or isolation cell.

It's every day now.

RF heating under space charge we've seen before with stacked ring devices. Wonder if it can be exploited for say desolvation?

🧵(4/7)

🔬 We have put together a fascinating #Keynote #Speakers team:
• Prof. Albert Heck - @hecklab.bsky.social
• Dr. Hamish Stewart - @hamishs.bsky.social
• Prof. Olga Vitek - @olgavitek.bsky.social l
• Prof. Ron M.A. Heeren

Congratulations!

That's wild.

Is a lager shandy on the list.

The biggest use case for MS3 has been TMT, so presumably the Gygi groups papers on the Ascend, Eclipse and previous instruments are most relevant.

pubs.acs.org/doi/10.1021/...

Depends on timescale and applications I guess. MS3 is currently limited to the tribrid line, where there have been big improvements recently with parallel ion accumulation for MS3, and the new Stellar quad-ion trap where it can run 40Hz MS3.

assets.thermofisher.cn/TFS-Assets/C...

We had to rewrite AGC control completely and lost some of the legacy functionality.

The eDR/multiplexed SIM implementation, while ultimately relatively simple, took quite a lot of effort to implement.

One learns something every day

That's interesting, I would've assumed all Exploris instruments (aside MX) would have the same rules for multiplexed SIM.

Actually surprising older "helpful" restrictions didn't stick across generations.

Ah! This one's definitely aimed at Orbitrap.

For Astral analyser itself there's some debate whether multiplexing will be useful. Maybe multiple scans with different mass ranges, but usually scan averaging alone should be preferable.

Perhaps ideally the combination of Astral and OT full MS scans...

I'm sorry, I don't follow. Which patent do you mean here?

This paper would have been largely complete by the time the MAP-MS preprint came out, barely two months ago. A very easy oversight.

I think I'm the only one with input into both projects, and this didn't even occur to me on my reviewed.

The common root of the Boxcar method is cited however.