Depends on timescale and applications I guess. MS3 is currently limited to the tribrid line, where there have been big improvements recently with parallel ion accumulation for MS3, and the new Stellar quad-ion trap where it can run 40Hz MS3.

assets.thermofisher.cn/TFS-Assets/C...

Mass spectrometers appearing in the news, in this case the work of the Murdoch Children's Research Institute.

www.foxnews.com/health/inter...

Really nice results from the Olsen group, evaluating the pre-accumulation method, which multiplies Orbitrap duty cycle at short transients and allows >70 Hz repetition rates.

They then combined it with PhiSDM spectral processing, mitigating the resolution sacrifice.
www.biorxiv.org/content/10.1...

We could go so much further...

Yeah about that...

Enlightening and accessible work from Josh Coon's group. It's good to see comparisons coming up.

Wonder how many more Olink proteins would be shared with the deeper multi-fraction Seer/Astral analysis with 6k IDs.