Golob
@golob.bsky.social
Physician scientist, microbiome expert, and coder. Empty EPIC inbox and busy GitHub
Reposted by Golob
Yikes!!!
Get your Zoster vaccine! @naturemedicine.bsky.social
A consistent relationship of VZV reactivation with dementia in 100M US adults after controlling for nearly 400 measured characteristics, with zoster vaccines reducing risk of dementia in dose-dependent manner
www.nature.com/articles/s41...
A consistent relationship of VZV reactivation with dementia in 100M US adults after controlling for nearly 400 measured characteristics, with zoster vaccines reducing risk of dementia in dose-dependent manner
www.nature.com/articles/s41...
October 6, 2025 at 8:28 PM
Yikes!!!
Reposted by Golob
Ancient viral DNA in the human genome shapes early development
Stem-cell models provide evidence that viral DNA sequences that entered the human genome in the past were repurposed to aid early stages of embryonic development.
www.nature.com/artic...
1/2
Stem-cell models provide evidence that viral DNA sequences that entered the human genome in the past were repurposed to aid early stages of embryonic development.
www.nature.com/artic...
1/2
Ancient viral DNA in the human genome shapes early development
Nature - Stem-cell models provide evidence that viral DNA sequences that entered the human genome in the past were repurposed to aid early stages of embryonic development.
www.nature.com
October 6, 2025 at 9:15 PM
Ancient viral DNA in the human genome shapes early development
Stem-cell models provide evidence that viral DNA sequences that entered the human genome in the past were repurposed to aid early stages of embryonic development.
www.nature.com/artic...
1/2
Stem-cell models provide evidence that viral DNA sequences that entered the human genome in the past were repurposed to aid early stages of embryonic development.
www.nature.com/artic...
1/2
Reposted by Golob
Bluetorial:
The announcement to move scientific review out of the institutes and centers into the Center for Scientific Review (CSR) and its potential consequences
The announcement to move scientific review out of the institutes and centers into the Center for Scientific Review (CSR) and its potential consequences
a cartoon of homer simpson holding a card
ALT: a cartoon of homer simpson holding a card
media.tenor.com
March 7, 2025 at 3:32 AM
Bluetorial:
The announcement to move scientific review out of the institutes and centers into the Center for Scientific Review (CSR) and its potential consequences
The announcement to move scientific review out of the institutes and centers into the Center for Scientific Review (CSR) and its potential consequences
What would you do with $120bn? I would hire Tony Gilroy to write proper Star Trek episodes provide them and then take the remaining $115bn and make as many infectious diseases extinct as possible. www.forbes.com/sites/dereks...
Elon Musk Is Officially $121 Billion Poorer Than His Peak—As Tesla Stock Erases Most All Of Its Election Rally
One of the biggest victims of the tariff selloff, Tesla stock's post-election rally now stands at less than 5% after once enjoying a 90% gain.
www.forbes.com
March 7, 2025 at 4:20 AM
What would you do with $120bn? I would hire Tony Gilroy to write proper Star Trek episodes provide them and then take the remaining $115bn and make as many infectious diseases extinct as possible. www.forbes.com/sites/dereks...
Reposted by Golob
SCOOP: On his second day as HHS secretary, RFK Jr., the onetime environmentalist, killed climate change programs at NIH that research and prepare for the health effects of extreme weather and a warming planet. This is not going to make Americans healthy.
www.motherjones.com/politics/202...
www.motherjones.com/politics/202...
RFK Jr., one-time environmentalist, kills NIH climate change programs
He pulled HHS support from projects that aim to protect Americans' health.
www.motherjones.com
February 19, 2025 at 10:49 PM
SCOOP: On his second day as HHS secretary, RFK Jr., the onetime environmentalist, killed climate change programs at NIH that research and prepare for the health effects of extreme weather and a warming planet. This is not going to make Americans healthy.
www.motherjones.com/politics/202...
www.motherjones.com/politics/202...
Reposted by Golob
Science loss continuing to mount
Biomedical graduate admissions paused or cut back as some universities respond to Trump orders on research - STAT
apple.news/APlQhGHRrSfy...
apple.news/APlQhGHRrSfy...
Graduate student admissions paused and cut back as universities react to Trump orders on research — STAT
Acceptances for biomedical graduate students and postdoctoral scholars are being cut back at some universities and medical centers across the country as many grapple with the potential impact of the T...
apple.news
February 20, 2025 at 4:18 AM
Science loss continuing to mount
Reposted by Golob
Scheduled COVID and shingles shots for tomorrow morning. Looking forward to an incredibly achy Valentine's Day!
February 13, 2025 at 11:34 PM
Scheduled COVID and shingles shots for tomorrow morning. Looking forward to an incredibly achy Valentine's Day!
Reposted by Golob
Trying to clear up some of the chaos: #NIH's acting director attempts to clarify for anxious staff what they can and cannot do during the new administration's "communications pause," @owermohle.bsky.social reports. www.statnews.com/2025/01/27/n...
NIH clarifies restrictions on staff after Trump's broad freeze sparked chaos
Ongoing clinical trials can continue, and scientists can keep publishing their findings, a memo shows.
www.statnews.com
January 27, 2025 at 8:58 PM
Trying to clear up some of the chaos: #NIH's acting director attempts to clarify for anxious staff what they can and cannot do during the new administration's "communications pause," @owermohle.bsky.social reports. www.statnews.com/2025/01/27/n...
Reposted by Golob
"She takes 5 million grams of diazepam as needed"
#DictationError
#DictationError
January 27, 2025 at 7:04 PM
"She takes 5 million grams of diazepam as needed"
#DictationError
#DictationError
Reposted by Golob
Amen, Jeremy! Amen!
Started off this morning emailing my Senators and Congressman about the NIH and the potential damage being done by unnecessary disruptions.
They need to hear from us loud and clear. Constituents matter to them as one of the primary purposes of a politician is to get re-elected (and its their job).
They need to hear from us loud and clear. Constituents matter to them as one of the primary purposes of a politician is to get re-elected (and its their job).
January 23, 2025 at 1:52 PM
Amen, Jeremy! Amen!
Reposted by Golob
Clear, straightforward explanation of the review/approval process for vaccines here from @drjoshs.bsky.social
Important counter to the anti-vaccine mythology out there www.youtube.com/live/0gwDLB6...
Important counter to the anti-vaccine mythology out there www.youtube.com/live/0gwDLB6...
LIVE: Roundtable on Vaccines and Public Health
YouTube video by Senator Bernie Sanders
www.youtube.com
January 23, 2025 at 1:57 PM
Clear, straightforward explanation of the review/approval process for vaccines here from @drjoshs.bsky.social
Important counter to the anti-vaccine mythology out there www.youtube.com/live/0gwDLB6...
Important counter to the anti-vaccine mythology out there www.youtube.com/live/0gwDLB6...
Reposted by Golob
Scientific advancements aside, this is economically irresponsible
Every $1 spent by NIH generates $2.46
For example, in 2023, $47B in NIH spending generated ~$93B
Halting NIH spending will LOSE the US a lot of money (and talent)
Every $1 spent by NIH generates $2.46
For example, in 2023, $47B in NIH spending generated ~$93B
Halting NIH spending will LOSE the US a lot of money (and talent)
January 22, 2025 at 11:04 PM
Scientific advancements aside, this is economically irresponsible
Every $1 spent by NIH generates $2.46
For example, in 2023, $47B in NIH spending generated ~$93B
Halting NIH spending will LOSE the US a lot of money (and talent)
Every $1 spent by NIH generates $2.46
For example, in 2023, $47B in NIH spending generated ~$93B
Halting NIH spending will LOSE the US a lot of money (and talent)
Reposted by Golob
“The impact of the collective executive orders and directives appears devastating.” scim.ag/40ureTO
Trump hits NIH with ‘devastating’ freezes on meetings, travel, communications, and hiring
Researchers facing
scim.ag
January 22, 2025 at 11:28 PM
“The impact of the collective executive orders and directives appears devastating.” scim.ag/40ureTO
Reposted by Golob
Predictors of Cryptococcus gattii clinical presentation and outcome: An international study
doi.org/10.1093/cid/...
doi.org/10.1093/cid/...
January 7, 2025 at 10:15 PM
Predictors of Cryptococcus gattii clinical presentation and outcome: An international study
doi.org/10.1093/cid/...
doi.org/10.1093/cid/...
IF I was in California and at risk of severe influenza (older, immunocompromised, asthma, etc.) I would consider masking indoors in crowds.
www.cdc.gov/nwss/rv/wwd-...
Please be safe and take care of each other.
www.cdc.gov/nwss/rv/wwd-...
Please be safe and take care of each other.
December 21, 2024 at 3:49 AM
IF I was in California and at risk of severe influenza (older, immunocompromised, asthma, etc.) I would consider masking indoors in crowds.
www.cdc.gov/nwss/rv/wwd-...
Please be safe and take care of each other.
www.cdc.gov/nwss/rv/wwd-...
Please be safe and take care of each other.
Reposted by Golob
#MedSky🧪 #IDSky #pedsky #publichealth
🧵 by @richardhirschs1
🧪 CDC has confirmed California toddler had H5N1 (2.3.4.4b).
🧪They DONT say if it was an Avian (D1.1) or Bovine (B3.13) 🦠 .This is CRITICALLY important.
The only other 🇺🇸 case with H5N1 & NO animal contact had the Bovine virus (Missouri).
🧵 by @richardhirschs1
🧪 CDC has confirmed California toddler had H5N1 (2.3.4.4b).
🧪They DONT say if it was an Avian (D1.1) or Bovine (B3.13) 🦠 .This is CRITICALLY important.
The only other 🇺🇸 case with H5N1 & NO animal contact had the Bovine virus (Missouri).
From bad to worse: How avian flu must change to trigger a human pandemic
Scientists identify three key changes needed to adapt the virus to mammals
www.science.org
December 5, 2024 at 1:35 PM
#MedSky🧪 #IDSky #pedsky #publichealth
🧵 by @richardhirschs1
🧪 CDC has confirmed California toddler had H5N1 (2.3.4.4b).
🧪They DONT say if it was an Avian (D1.1) or Bovine (B3.13) 🦠 .This is CRITICALLY important.
The only other 🇺🇸 case with H5N1 & NO animal contact had the Bovine virus (Missouri).
🧵 by @richardhirschs1
🧪 CDC has confirmed California toddler had H5N1 (2.3.4.4b).
🧪They DONT say if it was an Avian (D1.1) or Bovine (B3.13) 🦠 .This is CRITICALLY important.
The only other 🇺🇸 case with H5N1 & NO animal contact had the Bovine virus (Missouri).
Reposted by Golob
A single mutation in bovine influenza H5N1 hemagglutinin switches specificity to human receptors
www.science.org/doi/10.1126/...
@science.org
www.science.org/doi/10.1126/...
@science.org
December 6, 2024 at 4:12 AM
A single mutation in bovine influenza H5N1 hemagglutinin switches specificity to human receptors
www.science.org/doi/10.1126/...
@science.org
www.science.org/doi/10.1126/...
@science.org
Reposted by Golob
Emergence of Escherichia coli ST131 carrying carbapenemase genes, European Union/European Economic Area, August 2012 to May 2024
www.eurosurveillance.org/content/10.2...
#RIVM #ECDC #NVMM #surveillance #AMR #WAAW #EAAD
www.eurosurveillance.org/content/10.2...
#RIVM #ECDC #NVMM #surveillance #AMR #WAAW #EAAD
Emergence of Escherichia coli ST131 carrying carbapenemase genes, European Union/European Economic Area, August 2012 to May 2024
Analysis of 594 isolates of Escherichia coli sequence type (ST)131 and its single locus variants carrying carbapenemase genes from 17 European Union/European Economic Area countries revealed acquisiti...
www.eurosurveillance.org
November 21, 2024 at 5:46 PM
Emergence of Escherichia coli ST131 carrying carbapenemase genes, European Union/European Economic Area, August 2012 to May 2024
www.eurosurveillance.org/content/10.2...
#RIVM #ECDC #NVMM #surveillance #AMR #WAAW #EAAD
www.eurosurveillance.org/content/10.2...
#RIVM #ECDC #NVMM #surveillance #AMR #WAAW #EAAD
Reposted by Golob
🚨 Delighted to share our paper defining a new role for IL-6 in TB. 🚨
We used genetic variation to show *reduced* IL-6 signalling is causally associated with *lower* risk of TB.
Lead author @gushamilton.bsky.social
#TBSky #IDSky #ImmunoSky www.thelancet.com/journals/lan...
Thread 👇 (1/8)
We used genetic variation to show *reduced* IL-6 signalling is causally associated with *lower* risk of TB.
Lead author @gushamilton.bsky.social
#TBSky #IDSky #ImmunoSky www.thelancet.com/journals/lan...
Thread 👇 (1/8)
Altered IL-6 signalling and risk of tuberculosis: a multi-ancestry mendelian randomisation study
Our findings propose a causal relationship between reduced IL-6 signalling and lower
risk of tuberculosis, akin to the effect seen in other IL-6 mediated diseases. This
study suggests that IL-6 antago...
www.thelancet.com
November 21, 2024 at 10:30 AM
🚨 Delighted to share our paper defining a new role for IL-6 in TB. 🚨
We used genetic variation to show *reduced* IL-6 signalling is causally associated with *lower* risk of TB.
Lead author @gushamilton.bsky.social
#TBSky #IDSky #ImmunoSky www.thelancet.com/journals/lan...
Thread 👇 (1/8)
We used genetic variation to show *reduced* IL-6 signalling is causally associated with *lower* risk of TB.
Lead author @gushamilton.bsky.social
#TBSky #IDSky #ImmunoSky www.thelancet.com/journals/lan...
Thread 👇 (1/8)
Reposted by Golob
Just going to bring across my prior tweets on this topic.
From a great mate on the dark App.
The kids aren't OKAY🔥🔥🔥🤬
@buonsenso.bsky.social 😔💔
www.nature.com/articles/s41...
The kids aren't OKAY🔥🔥🔥🤬
@buonsenso.bsky.social 😔💔
www.nature.com/articles/s41...
Long COVID syndrome in children: neutrophilic granulocyte dysfunction and its correlation with disease severity - Pediatric Research
Pediatric Research - Long COVID syndrome in children: neutrophilic granulocyte dysfunction and its correlation with disease severity
www.nature.com
November 28, 2024 at 12:43 PM
Just going to bring across my prior tweets on this topic.
Reposted by Golob
#vaccineswork example 4578
Cervical cancer mortality in US women younger than 25 years significantly declined between 2016 and 2021, likely due to the widespread adoption of HPV vaccination.
ja.ma/4i9ghPC
ja.ma/4i9ghPC
November 28, 2024 at 12:41 AM
#vaccineswork example 4578
Reposted by Golob
1/23 Big news for the #ObenaufLab! So excited to finally share our new study providing another puzzle piece, why immunotherapy fails in many tumors, now out in @Nature 🧵👇 www.nature.com/articles/s41...
November 27, 2024 at 5:58 PM
1/23 Big news for the #ObenaufLab! So excited to finally share our new study providing another puzzle piece, why immunotherapy fails in many tumors, now out in @Nature 🧵👇 www.nature.com/articles/s41...
Reposted by Golob
Reposted by Golob
📢 Brand new ID faculty position just posted @fredhutch.bsky.social in Seattle. Join our ID group that studies infections in immunocompromised hosts. The Emerald city has great academics, phenomenal facilities, outstanding collaborators - all in amazing surroundings.
apply.interfolio.com/159913
apply.interfolio.com/159913
November 26, 2024 at 6:18 PM
📢 Brand new ID faculty position just posted @fredhutch.bsky.social in Seattle. Join our ID group that studies infections in immunocompromised hosts. The Emerald city has great academics, phenomenal facilities, outstanding collaborators - all in amazing surroundings.
apply.interfolio.com/159913
apply.interfolio.com/159913
Reposted by Golob
As an "AI" researcher, I also hate "AI".
November 23, 2024 at 8:22 PM
As an "AI" researcher, I also hate "AI".