Fritz Roth
@fritzroth.bsky.social
Opinions here are my own.
Day job: Professor and Chair,
Computational & Systems Biology,
University of Pittsburgh School of Medicine
https://rothlab.csb.pitt.edu/
Systematically testing impacts of genetic change & mapping protein interaction dynamics
Day job: Professor and Chair,
Computational & Systems Biology,
University of Pittsburgh School of Medicine
https://rothlab.csb.pitt.edu/
Systematically testing impacts of genetic change & mapping protein interaction dynamics
Reposted by Fritz Roth
It is a great honour to be part of this study! Congratulations to Daniel Tabet, @fritzroth.bsky.social and the entire team!! This is a huge step forward regarding functional studies of LDLR!
www.science.org/doi/10.1126/...
@helsinki.fi @eassociety.bsky.social
www.science.org/doi/10.1126/...
@helsinki.fi @eassociety.bsky.social
The functional landscape of coding variation in the familial hypercholesterolemia gene LDLR
Variants in the familial hypercholesterolemia gene LDLR—the most important genetic driver of cardiovascular disease—can raise circulating low-density lipoprotein (LDL) cholesterol concentrations and i...
www.science.org
October 31, 2025 at 9:27 AM
It is a great honour to be part of this study! Congratulations to Daniel Tabet, @fritzroth.bsky.social and the entire team!! This is a huge step forward regarding functional studies of LDLR!
www.science.org/doi/10.1126/...
@helsinki.fi @eassociety.bsky.social
www.science.org/doi/10.1126/...
@helsinki.fi @eassociety.bsky.social
About yesterday's NIH notice...
grants.nih.gov/grants/guide...
Does anyone know whether those who submitted a new R01 app BEFORE the shutdown, and all those who submitted apps via the NIH system that was OPEN during the shutdown will need to resubmit??
grants.nih.gov/grants/guide...
Does anyone know whether those who submitted a new R01 app BEFORE the shutdown, and all those who submitted apps via the NIH system that was OPEN during the shutdown will need to resubmit??
NOT-OD-26-005: Interim Guidance on Reopening of NIH Extramural Activities
NIH Funding Opportunities and Notices in the NIH Guide for Grants and Contracts: Interim Guidance on Reopening of NIH Extramural Activities NOT-OD-26-005. NIH
grants.nih.gov
November 15, 2025 at 12:41 PM
About yesterday's NIH notice...
grants.nih.gov/grants/guide...
Does anyone know whether those who submitted a new R01 app BEFORE the shutdown, and all those who submitted apps via the NIH system that was OPEN during the shutdown will need to resubmit??
grants.nih.gov/grants/guide...
Does anyone know whether those who submitted a new R01 app BEFORE the shutdown, and all those who submitted apps via the NIH system that was OPEN during the shutdown will need to resubmit??
Reposted by Fritz Roth
Deepest coverage of the administrative leave for @jenna-m-norton.bsky.social from @aniloza.bsky.social at STAT
www.statnews.com/2025/11/14/n...
1/4
www.statnews.com/2025/11/14/n...
1/4
NIH abruptly places outspoken critic of Trump administration on leave
Jenna Norton, a vocal critic of Trump administration actions at the NIH, was abruptly placed on administrative leave this week.
www.statnews.com
November 15, 2025 at 12:07 PM
Deepest coverage of the administrative leave for @jenna-m-norton.bsky.social from @aniloza.bsky.social at STAT
www.statnews.com/2025/11/14/n...
1/4
www.statnews.com/2025/11/14/n...
1/4
Reposted by Fritz Roth
Reposted by Fritz Roth
110 million years ago, a spinosaur's dinner got the best of it. Turns out the dino's fossilized vomit contained a new species of filter-feeding pterosaur!
I came across this paper a few days ago on social media and had a blast covering it for @science.org: www.science.org/content/arti...
I came across this paper a few days ago on social media and had a blast covering it for @science.org: www.science.org/content/arti...
Fossil vomit contains new species of pterosaur from Brazil
Filter-feeding flying reptile was likely devoured by a dinosaur during the early Cretaceous
www.science.org
November 13, 2025 at 5:33 PM
110 million years ago, a spinosaur's dinner got the best of it. Turns out the dino's fossilized vomit contained a new species of filter-feeding pterosaur!
I came across this paper a few days ago on social media and had a blast covering it for @science.org: www.science.org/content/arti...
I came across this paper a few days ago on social media and had a blast covering it for @science.org: www.science.org/content/arti...
Reposted by Fritz Roth
So excited about this new work from our CardioVar consortium out this week in Science led by the amazing Daniel Tabet and @fritzroth.bsky.social.
www.science.org/doi/10.1126/
www.science.org/doi/10.1126/
November 1, 2025 at 8:33 PM
So excited about this new work from our CardioVar consortium out this week in Science led by the amazing Daniel Tabet and @fritzroth.bsky.social.
www.science.org/doi/10.1126/
www.science.org/doi/10.1126/
Reposted by Fritz Roth
Check out this cool new paper from my Toronto colleagues Kieran Campbell and Anne-Claude Gingras.
How can we scale subcellular spatial proteomics across many experiments and conditions?
Our new paper presents a genetic algorithm and evaluation framework that optimizes bait subsets for proximity proteomics platforms like BioID enabling context-specific proteome mapping.
Our new paper presents a genetic algorithm and evaluation framework that optimizes bait subsets for proximity proteomics platforms like BioID enabling context-specific proteome mapping.
October 23, 2025 at 1:45 PM
Check out this cool new paper from my Toronto colleagues Kieran Campbell and Anne-Claude Gingras.
Reposted by Fritz Roth
Happy Mole Day for all who celebrate
October 23, 2025 at 12:09 PM
Happy Mole Day for all who celebrate
Reposted by Fritz Roth
"Stay true to the mission of your college or university…the government doesn’t get to dictate how we teach and who we teach." —Wesleyan University President @msroth.bsky.social joined MSNBC to discuss the threat of the Trump administration's compact for #HigherEd #AcademicSky
October 21, 2025 at 5:42 PM
"Stay true to the mission of your college or university…the government doesn’t get to dictate how we teach and who we teach." —Wesleyan University President @msroth.bsky.social joined MSNBC to discuss the threat of the Trump administration's compact for #HigherEd #AcademicSky
Reposted by Fritz Roth
🎉 New in #GENETICS: Functional Genomics & Systems Biology section! Highlighting cutting-edge studies on molecular networks, systems-level insights, and innovative methods.
Read more: buff.ly/wWVZdrS%F0%9...
Read more: buff.ly/wWVZdrS%F0%9...
Announcing the new “Functional Genomics and Systems Biology” section in GENETICS
The GSA Journals are introducing Functional Genomics and Systems Biology, a new section led by Brenda Andrews and Marian Walhout that highlights systems-level studies of genetic networks and pathways.
buff.ly
October 21, 2025 at 4:06 PM
🎉 New in #GENETICS: Functional Genomics & Systems Biology section! Highlighting cutting-edge studies on molecular networks, systems-level insights, and innovative methods.
Read more: buff.ly/wWVZdrS%F0%9...
Read more: buff.ly/wWVZdrS%F0%9...
Reposted by Fritz Roth
Evidence that even when LLMs produce similar results to humans, they “rely on lexical associations and statistical priors rather than contextual reasoning or normative criteria. We term this divergence epistemia: the illusion of knowledge emerging when surface plausibility replaces verification”
PNAS
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...
www.pnas.org
October 17, 2025 at 7:40 AM
Evidence that even when LLMs produce similar results to humans, they “rely on lexical associations and statistical priors rather than contextual reasoning or normative criteria. We term this divergence epistemia: the illusion of knowledge emerging when surface plausibility replaces verification”
Reposted by Fritz Roth
This is a powerful account from a PhD student whose fellowship was terminated by NIH because it was part of a "diversity" program without any other considerations or understanding of what the program or the students were actually doing.
undark.org/2025/10/09/o...
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undark.org/2025/10/09/o...
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NIH Student Grant Cancellation Will Weaken Scientific Innovation
The termination of federal F31 diversity fellowships puts many graduate students in a bind — and U.S. science at risk.
undark.org
October 13, 2025 at 2:41 PM
This is a powerful account from a PhD student whose fellowship was terminated by NIH because it was part of a "diversity" program without any other considerations or understanding of what the program or the students were actually doing.
undark.org/2025/10/09/o...
1/2
undark.org/2025/10/09/o...
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Reposted by Fritz Roth
The Virginia Senate just told UVA it’s not getting state funding if it accepts the compact since UVA exists to serve Virginia, its residents, & their interests—not be a tool of the federal govt. Scoop from our student newspaper, who’ve been doing vital reporting www.cavalierdaily.com/article/2025...
October 10, 2025 at 9:45 PM
The Virginia Senate just told UVA it’s not getting state funding if it accepts the compact since UVA exists to serve Virginia, its residents, & their interests—not be a tool of the federal govt. Scoop from our student newspaper, who’ve been doing vital reporting www.cavalierdaily.com/article/2025...
Reposted by Fritz Roth
Reposted by Fritz Roth
Thank you, Sam. It is from the heart.
I am really glad that @jeremymberg.bsky.social wrote this. Everybody who cares about science, and about knowledge generation and civil society generally, should read and share with their favorite administrator.
Deafening Quiet from the Scientific Establishment
open.substack.com/pub/donmoyni...
Deafening Quiet from the Scientific Establishment
open.substack.com/pub/donmoyni...
Deafening Quiet from the Scientific Establishment
Leaders are underestimating the risks of not fighting back
open.substack.com
October 9, 2025 at 2:35 PM
Thank you, Sam. It is from the heart.
Reposted by Fritz Roth
We're now recruiting early career group leaders at the Crick to lead ambitious research programmes and explore bold scientific questions.
Hear our Director, Edith Heard, explain why the Crick is a unique place for curiosity-driven research.
Apply now ➡️ www.crick.ac.uk/careers-stud...
Hear our Director, Edith Heard, explain why the Crick is a unique place for curiosity-driven research.
Apply now ➡️ www.crick.ac.uk/careers-stud...
October 9, 2025 at 2:06 PM
We're now recruiting early career group leaders at the Crick to lead ambitious research programmes and explore bold scientific questions.
Hear our Director, Edith Heard, explain why the Crick is a unique place for curiosity-driven research.
Apply now ➡️ www.crick.ac.uk/careers-stud...
Hear our Director, Edith Heard, explain why the Crick is a unique place for curiosity-driven research.
Apply now ➡️ www.crick.ac.uk/careers-stud...
Reposted by Fritz Roth
📣Call for Abstracts
for the Mutational Scanning Symposium! #VariantEffect26
🗓️ March 25-27, 2026
📍 Melbourne, Australia (and online!)
📝 Submit your abstract (deadline is Nov 2nd, 2025!)
➡️ Registration is also now open!!
ℹ️ www.mss2026.org
#FunctionalGenomics #Symposium #Australia #CallForAbstracts
for the Mutational Scanning Symposium! #VariantEffect26
🗓️ March 25-27, 2026
📍 Melbourne, Australia (and online!)
📝 Submit your abstract (deadline is Nov 2nd, 2025!)
➡️ Registration is also now open!!
ℹ️ www.mss2026.org
#FunctionalGenomics #Symposium #Australia #CallForAbstracts
September 26, 2025 at 1:52 PM
📣Call for Abstracts
for the Mutational Scanning Symposium! #VariantEffect26
🗓️ March 25-27, 2026
📍 Melbourne, Australia (and online!)
📝 Submit your abstract (deadline is Nov 2nd, 2025!)
➡️ Registration is also now open!!
ℹ️ www.mss2026.org
#FunctionalGenomics #Symposium #Australia #CallForAbstracts
for the Mutational Scanning Symposium! #VariantEffect26
🗓️ March 25-27, 2026
📍 Melbourne, Australia (and online!)
📝 Submit your abstract (deadline is Nov 2nd, 2025!)
➡️ Registration is also now open!!
ℹ️ www.mss2026.org
#FunctionalGenomics #Symposium #Australia #CallForAbstracts
Reposted by Fritz Roth
We are #Hiring!
Communications role for our Global Alliance! 🌍🧬
Please share this post with your network, or apply if you are interested!
📍 Location: Hinxton, England
🕒 Part-time role
ℹ️ sanger.wd103.myworkdayjobs.com/en-US/Wellco...
#ScienceJobs #Communications #Genomics
#PartTimeRole #UKJobs
Communications role for our Global Alliance! 🌍🧬
Please share this post with your network, or apply if you are interested!
📍 Location: Hinxton, England
🕒 Part-time role
ℹ️ sanger.wd103.myworkdayjobs.com/en-US/Wellco...
#ScienceJobs #Communications #Genomics
#PartTimeRole #UKJobs
October 1, 2025 at 1:52 PM
We are #Hiring!
Communications role for our Global Alliance! 🌍🧬
Please share this post with your network, or apply if you are interested!
📍 Location: Hinxton, England
🕒 Part-time role
ℹ️ sanger.wd103.myworkdayjobs.com/en-US/Wellco...
#ScienceJobs #Communications #Genomics
#PartTimeRole #UKJobs
Communications role for our Global Alliance! 🌍🧬
Please share this post with your network, or apply if you are interested!
📍 Location: Hinxton, England
🕒 Part-time role
ℹ️ sanger.wd103.myworkdayjobs.com/en-US/Wellco...
#ScienceJobs #Communications #Genomics
#PartTimeRole #UKJobs
Reposted by Fritz Roth
Reposted by Fritz Roth
Very pleased to share this long term (nearly 20 years) study of yeasts isolated from vineyards and forests, now up on biorxiv:
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
September 24, 2025 at 8:24 PM
Very pleased to share this long term (nearly 20 years) study of yeasts isolated from vineyards and forests, now up on biorxiv:
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Fritz Roth
A statue of President Trump and Jeffrey Epstein holding hands has been removed from the National Mall a day after it was placed there. The statue had a permit to remain in front of the Capitol until Sunday night.
Statue of Trump and Epstein holding hands removed from National Mall
The statue, the latest installation by an anonymous group of artists critical of the president, was supposed to be on display until 8 p.m. Sunday.
www.washingtonpost.com
September 24, 2025 at 4:45 PM
A statue of President Trump and Jeffrey Epstein holding hands has been removed from the National Mall a day after it was placed there. The statue had a permit to remain in front of the Capitol until Sunday night.
Reposted by Fritz Roth
Reposted by Fritz Roth
Let's be clear: no one should be taking medical advice from the man who told Americans to inject bleach.
To moms worried about the Tylenol they took while pregnant: you deserve better than being RFK Jr's scapegoat.
And to the autism community: you are loved exactly as you are.
To moms worried about the Tylenol they took while pregnant: you deserve better than being RFK Jr's scapegoat.
And to the autism community: you are loved exactly as you are.
September 23, 2025 at 7:20 PM
Let's be clear: no one should be taking medical advice from the man who told Americans to inject bleach.
To moms worried about the Tylenol they took while pregnant: you deserve better than being RFK Jr's scapegoat.
And to the autism community: you are loved exactly as you are.
To moms worried about the Tylenol they took while pregnant: you deserve better than being RFK Jr's scapegoat.
And to the autism community: you are loved exactly as you are.
Reposted by Fritz Roth
🚨 Microbiologists! We are recruiting Assistant / Associate Professors in 3 collaborative areas of our U. Pittsburgh School of Medicine.
1) MMG (my dept): fundamental research in med micro
2) Peds ID / I4Kids institute
3) Center for Vaccine Research
🔗 to all 3 w/info: www.linkedin.com/posts/vaughn...
1) MMG (my dept): fundamental research in med micro
2) Peds ID / I4Kids institute
3) Center for Vaccine Research
🔗 to all 3 w/info: www.linkedin.com/posts/vaughn...
Faculty Professor Associate - Full-Time | Vaughn Cooper
We are recruiting Faculty microbiologists in three (3) different, complementary, and collaborative areas at the University of Pittsburgh associated with the School of Medicine.
1) Fundamental researc...
www.linkedin.com
September 23, 2025 at 10:31 PM
🚨 Microbiologists! We are recruiting Assistant / Associate Professors in 3 collaborative areas of our U. Pittsburgh School of Medicine.
1) MMG (my dept): fundamental research in med micro
2) Peds ID / I4Kids institute
3) Center for Vaccine Research
🔗 to all 3 w/info: www.linkedin.com/posts/vaughn...
1) MMG (my dept): fundamental research in med micro
2) Peds ID / I4Kids institute
3) Center for Vaccine Research
🔗 to all 3 w/info: www.linkedin.com/posts/vaughn...
Reposted by Fritz Roth
3 cheers for NIH grant staff! Regardless of everything else, they are heros!
September 22, 2025 at 5:24 PM
3 cheers for NIH grant staff! Regardless of everything else, they are heros!