Fritz Roth
@fritzroth.bsky.social
Opinions here are my own.
Day job: Professor and Chair,
Computational & Systems Biology,
University of Pittsburgh School of Medicine
https://rothlab.csb.pitt.edu/
Systematically testing impacts of genetic change & mapping protein interaction dynamics
Day job: Professor and Chair,
Computational & Systems Biology,
University of Pittsburgh School of Medicine
https://rothlab.csb.pitt.edu/
Systematically testing impacts of genetic change & mapping protein interaction dynamics
Congrats Yun will be excited to read! Did you assess performance after removing common benign variants? Perhaps the main application of variant effect predictors is classifying rare variants, but as the REVEL paper showed, common benign variants are not representative of rare benign variants.
September 23, 2025 at 2:02 PM
Congrats Yun will be excited to read! Did you assess performance after removing common benign variants? Perhaps the main application of variant effect predictors is classifying rare variants, but as the REVEL paper showed, common benign variants are not representative of rare benign variants.