#FunctionalGenomics
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plosbiology.org
#Candida albicans is a leading opportunistic fungal #pathogen of humans. Ci Fu, Leah Cowen &co expand the GRACE #Calbicans #FunctionalGenomics resource, identifying genes important for temperature-dependent fitness & highlighting its power to reveal vulnerabilities @plosbiology.org 🧪 plos.io/3Wft0Xg
Screening of expanded GRACE mutant collection at six temperatures reveals distinct functional enrichment in genes clustered by fitness profile. Top left: Schematic of GRACE mutant construction. Bottom left: Summary of GRACE mutant collection expansion based on manual curation of biological process gene ontology annotation on Candida Genome Database (CGD). Pie chart with four concentric rings visualizes the relative proportion of genes from various versions of the GRACE collection with biological process descriptions completely unannotated or annotated based on: experimentally characterization, S. cerevisiae ortholog, S. pombe ortholog, orthologs in other fungal species, conserved protein domains, or unannotated; see Materials and methods for full details. Right: Heatmap of genes ordered by hierarchical clustering of essentiality scores across screening temperatures. A score of 4 (red) represents no growth and 0 (yellow) represents growth comparable to wild type.
October 20, 2025 at 5:11 PM
plosbiology.org
#Candida albicans is a leading opportunistic fungal #pathogen of humans. Ci Fu, Leah Cowen &co expand the GRACE #Calbicans #FunctionalGenomics resource, identifying genes important for temperature-dependent fitness & highlighting its power to reveal vulnerabilities @plosbiology.org 🧪 plos.io/3Wft0Xg
Screening of expanded GRACE mutant collection at six temperatures reveals distinct functional enrichment in genes clustered by fitness profile. Top left: Schematic of GRACE mutant construction. Bottom left: Summary of GRACE mutant collection expansion based on manual curation of biological process gene ontology annotation on Candida Genome Database (CGD). Pie chart with four concentric rings visualizes the relative proportion of genes from various versions of the GRACE collection with biological process descriptions completely unannotated or annotated based on: experimentally characterization, S. cerevisiae ortholog, S. pombe ortholog, orthologs in other fungal species, conserved protein domains, or unannotated; see Materials and methods for full details. Right: Heatmap of genes ordered by hierarchical clustering of essentiality scores across screening temperatures. A score of 4 (red) represents no growth and 0 (yellow) represents growth comparable to wild type.
October 20, 2025 at 12:55 PM
plosbiology.org
#Candida albicans is a leading opportunistic fungal #pathogen of humans. Ci Fu, Leah Cowen &co expand the GRACE #Calbicans #FunctionalGenomics resource, identifying genes important for temperature-dependent fitness & highlighting its power to reveal vulnerabilities @plosbiology.org 🧪 plos.io/3Wft0Xg
Screening of expanded GRACE mutant collection at six temperatures reveals distinct functional enrichment in genes clustered by fitness profile. Top left: Schematic of GRACE mutant construction. Bottom left: Summary of GRACE mutant collection expansion based on manual curation of biological process gene ontology annotation on Candida Genome Database (CGD). Pie chart with four concentric rings visualizes the relative proportion of genes from various versions of the GRACE collection with biological process descriptions completely unannotated or annotated based on: experimentally characterization, S. cerevisiae ortholog, S. pombe ortholog, orthologs in other fungal species, conserved protein domains, or unannotated; see Materials and methods for full details. Right: Heatmap of genes ordered by hierarchical clustering of essentiality scores across screening temperatures. A score of 4 (red) represents no growth and 0 (yellow) represents growth comparable to wild type.
October 20, 2025 at 7:46 AM
varianteffect.bsky.social
📣Call for Abstracts
for the Mutational Scanning Symposium! #VariantEffect26
🗓️ March 25-27, 2026
📍 Melbourne, Australia (and online!)
📝 Submit your abstract (deadline is Nov 2nd, 2025!)
➡️ Registration is also now open!!
ℹ️ www.mss2026.org

#FunctionalGenomics #Symposium #Australia #CallForAbstracts
September 26, 2025 at 1:52 PM
zornitza.bsky.social
Emma Palmer @AusGenomics #functionalgenomics: the ups and downs of clinical #genomics, we must put the needs of patients and families first
December 20, 2024 at 9:45 PM
varianteffect.bsky.social
📌🗓️ April 1st 2025
ℹ️ www.varianteffect.org/seminar-series #FunctionalGenomics #Seminar
with Joyce Kang and Yiyun Rao
The image is a promotional poster for the "Variant Effects Seminar Series" taking place on April 1st, 2025. The top section has a blue pixelated background with white text stating the seminar details, including differing time zones. Below this, on a light background, two speaker portraits are prominently displayed in circular frames. Each portrait is accompanied by the speaker’s name in bold, dark blue text and their presentation title. On the left, an abstract DNA helix graphic in black adds a scientific element. The bottom section contains a Zoom link, additional information, and a QR code for direct access. A butterfly icon and a social media handle are included for contact.
March 13, 2025 at 7:41 PM
bicurean.bsky.social
Genetics set the stage, but genomics reveal how our bodies respond & heal. Knowing your weak spots means better prevention & recovery.

#FunctionalGenomics #Biohacking #Healing #madetobewhole
September 21, 2025 at 9:51 PM
ergabiodiv.bsky.social
Missed last year’s #ERGA BioGenome #Analysis and #Applications seminars? Catch up on all 10 sessions on our channel! 📺 Topics include #Phylogenomics, #FunctionalGenomics, #PopulationGenomics, and #ComparativeGenomics.

Watch now: youtube.com/playlist?lis...

Subscribe and stay updated! 🧬
ERGA BioGenome Analysis & Applications Seminars - YouTube
https://www.erga-biodiversity.eu/post/erga-biogenome-analysis-and-applications-seminars
youtube.com
January 10, 2025 at 8:50 AM
varianteffect.bsky.social
🧬 Interested in variant interpretation?
#FunctionalGenomics #Pharmacogenetics #MutationalScanning #VariantEffectPredictor #RareDisease #Collaboration #PrecisionMedicine
Check out our list of publications!
📖 www.varianteffect.org/publications/
July 23, 2025 at 1:04 PM
varianteffect.bsky.social
Welcome to the first Variant Effects Seminar Series of 2025! Kicking off on Jan 7 with two amazing speakers: Ujjwal Rathore and Matthew Howard. Don’t miss it! varianteffect.org/seminar-series
#FunctionalGenomics #Seminar
The image is a promotional poster for the "Variant Effects Seminar Series" taking place on January 7th, 2025. The design features a dark blue header with white text displaying the event title and date. Below, the timings are listed for different time zones. In the center, two portrait photographs of speakers, Ujjwal Rathore on the left and Matthew Howard on the right, are displayed. Ujjwal Rathore is wearing a dark blazer and white shirt, while Matthew Howard is in a light green shirt with a casual background featuring a palm tree. Below each image are their names in bold, followed by a brief description of their respective topics. On the left side, there is a stylized DNA strand illustration which is the AVE logo. At the bottom, there is information about a Zoom link, a website for more information, a small butterfly icon for Bluesky, and a QR code labeled "Zoom QR."
January 4, 2025 at 2:36 PM
juanifernandino.bsky.social
This international collaboration involves researchers from the INTECH Instituto Tecnológico de Chascomús (CONICET–UNSAM), the Escuela de Bio y Nanotecnologías (UNSAM), and Universidad Nacional del Santa (Peru).

#CRISPR #FunctionalGenomics #Aquaculture #FishBiotech #GeneEditing #Sustainable
April 17, 2025 at 2:53 AM
elembio.bsky.social
🧬 What if #CRISPRscreening could be faster, richer, and easier? DISS on #AVITI24 integrates guide RNA sequencing, protein, and cell morphology in one workflow—no library prep, results in days. Download our infographic to see how: bit.ly/4oCzxIt

#FunctionalGenomics
August 18, 2025 at 5:47 PM
ravnskjaer-lab.bsky.social
Thrilled to share our new manuscript on a novel signaling module in hepatic stellate cells by Sofie👩‍🔬, Peter👨‍💻, Daniel👨‍🔬 & Kamilla👩‍🔬 and our many amazing collaborators 🙏, now online at JHEP:#MASH #liver #gpcr #fibrosis #functionalgenomics #singlecell

sciencedirect.com/science/articl…
March 2, 2025 at 6:50 AM
bia-uk.bsky.social
🔬 #FunctionalGenomics is reshaping how we understand disease, design therapies, and improve patient outcomes.➡️ shorturl.at/hAOw1

Organisations like Johnson & Johnson are helping lead the charge, combining large-scale UK datasets (like UK Biobank and Our Future Health UK)
June 16, 2025 at 9:42 AM
puckerlabpapers.bsky.social
NAVIP: Unraveling the Influence of Neighboring Small Sequence Variants on Functional Impact Prediction
doi.org/10.1371/jour...

#Bioinformatics #VariantCalling #VariantAnnotation #FunctionalGenomics #Genomics #PlantSci #DataScience #OpenData #OpenAccess #BigData #Python #100DaysOfCode
NAVIP: Unraveling the influence of neighboring small sequence variants on functional impact prediction
Once a suitable reference sequence has been generated, intra-species variation is often assessed by re-sequencing. Variant calling processes can reveal all differences between strains, accessions, gen...
doi.org
July 26, 2025 at 10:08 PM
elembio.bsky.social
Curious about Direct In Sample Sequencing (DISS)? 🧬 Visit poster 4008T today at #ASHG2025 to see how Daniel applies DISS to optical pooled screens and spatial transcriptomics. 📅 Oct 16 | 2:30–4:30 PM 📍 Poster Hall
Download the poster here: https://bit.ly/3Wa5MSd.

#FunctionalGenomics
October 16, 2025 at 8:37 PM
jenniejlin.bsky.social
So cool to see friend from post-doc days, @hanrui_zhang of @Columbia, at NU giving fascinating seminar on #functionalgenomics of macrophage biology in cardiometabolic disease!
November 22, 2024 at 2:46 PM
varianteffect.bsky.social
🗓️Save the date: Feb 4, 2025! Toni Beltran @crg.eu dives into the Human Domainome with deep mutational scans, and Alexandra Bendel (EPFL) explores the Genetic Architecture of Protein Function. Join us!
ℹ️ www.varianteffect.org/seminar-series #FunctionalGenomics #Seminar
The image is a promotional poster for the "Variant Effects Seminar Series" scheduled for February 4th, 2025. At the top, the title appears against a blue, patterned background. The time is specified across various time zones below the date. Two speaker sections are featured: the top section has a photo of a person with a beard and a light shirt outdoors. To the right is the name "Toni Beltran" followed by the talk title "Mutating the human domainome." Below, a section features a photo of a person with long hair against a plain backdrop. To the left is the name "Alexandra Bendel" and talk title, "The genetic architecture of protein function." On the left, there is a large DNA double helix graphic. At the bottom, a line separates the main content from webinar-related details, including a Zoom link, more information, and social media handles. A QR code is on the right.
January 27, 2025 at 1:35 PM
winhide.bsky.social
Finally: Pathprinting: An integrative approach to understand the functional basis of disease#functionalgenomics #OA

bit.ly/14g1Efo
December 10, 2024 at 6:51 PM
elembio.bsky.social
#CRISPRscreening without the wait. ⏱️ #AVITI24 with Direct In Sample Sequencing delivers guide RNA, protein & morphology readouts together so you can get results in days, not weeks. Download the infographic: https://bit.ly/4oCzxIt

#FunctionalGenomics #Multiomics
September 3, 2025 at 4:08 PM
julianamiranda.bsky.social
🚀Unlocking Large-Scale Genomic Public #Databases! 🧬Co-organized by myself, Profs. Karoline Kuchenbaecker & Inga Prokopenko, this first-time course will explore e.g. #GWAS #PGS Catalogs & #functionalgenomics tools. Open to all, especially trainees @eshg_young. Welcome to join us! #genomics #genetics
eshg.bsky.social European Society of Human Genetics @eshg.bsky.social · Feb 20
Pre-Conference Course Registration is Now Open!

✅ Clinical NGS Data Interpretation
✅ Professional Development: Interactive Approaches to Genetic Teaching
✅ Unleashing the Power of Large-Scale Genomic Public Databases

🔗 Secure your spot now! 👉 buff.ly/4k0YXx0

#eshg #Genetics #NGS #Genomics
February 23, 2025 at 1:03 PM
varianteffect.bsky.social
📽️ The January recordings are now online! #FunctionalGenomics #Seminar Huge thanks to our amazing speakers: @matthewkhoward.bsky.social and Ujjwal Rathore. Check out their talks below! ⬇️ 🧵1/2
January 27, 2025 at 2:01 PM
mlopes0811.bsky.social
Our new paper has been published: "Global Functional Genomics Reveals GRK5 as a Cystic Fibrosis Therapeutic Target Synergistic with Current Modulators" in @cp-iscience.bsky.social 👨‍🔬🧬🔬🧫 💊
#cysticfibrosis #CFTR #FunctionalGenomics #noveltherapeutics #precisionmedicine www.cell.com/iscience/ful...
Global Functional Genomics Reveals GRK5 as a Cystic Fibrosis Therapeutic Target Synergistic with Current Modulators
Cystic Fibrosis (CF) is a life-shortening disease affecting >160,000 individuals worldwide predominantly with respiratory symptoms. About 80% of individuals with CF have the p.Phe508del variant that c...
www.cell.com
February 5, 2025 at 2:47 PM
jenniejlin.bsky.social
Gene nodes, networks, and bones, oh my! @cr_farber of @UVA gave an exciting and elegant @NU_Nephrology Grand Rounds seminar on the genetic determinants of BMD. Be on the look out for some exciting developments in the #functionalgenomics of bone disease! #NURGR #nukidney
November 22, 2024 at 12:19 PM
zornitza.bsky.social
@AusGenomics #functionalgenomics Steve Brown @The_MRC: IMPC is a fantastic open source project, go and look for your ‘new’ #gene, mouse model may already be there!
December 20, 2024 at 9:55 PM