Ferroptosis1
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ferroptosis.bsky.social
Ferroptosis1
@ferroptosis.bsky.social
48 followers 59 following 12 posts
A community for people interested in #ferroptosis and related #iron, #lipid, #selenium and #mitochondrial biology. Posts by @masaldan.bsky.social
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ferroptosis.bsky.social
academic.oup.com/brain/advanc...
Iron on trial: recasting the role of iron in neurodegeneration
Iron is essential for brain health but can become harmful when dysregulated. Ayton et al. summarise recent clinical trial results showing negative effects
academic.oup.com
October 30, 2025 at 10:49 AM
Reposted by Ferroptosis1
angelifriedmann.bsky.social
(1) New preprint from our lab!
HMOX1 controls a heme/ferritin switch that protects cells from ferroptosis.
Loss of HMOX1 stabilizes heme, boosts ferritin, and suppresses ferroptotic death.
👉 doi.org/10.1101/2025...
#ferroptosis #heme #ironmetabolism #preprint
HMOX1 controls a heme/ferritin switch that protects cells from ferroptosis
Modulating the intracellular labile iron pool (LIP) has emerged as a promising strategy to induce ferroptosis in cancer cells, offering a way to overcome resistance to apoptosis-based therapies. One o...
doi.org
October 16, 2025 at 3:20 AM
ferroptosis.bsky.social
www.nature.com/articles/s43...
Heme and iron toxicity in the aged spleen impairs T cell immunity through iron deprivation - Nature Aging
In their study, Ezuz et al. show that the aged spleen contributes to T cell aging through hemolytic stress and an increasingly heme- and iron-rich microenvironment. T cells adapt by limiting their iro...
www.nature.com
October 22, 2025 at 8:32 AM
Reposted by Ferroptosis1
scienceofpd.bsky.social
New research presents a data common named the "Neurolipid Atlas" - a useful resource prepopulated with isogenic iPS cell-derived lipidomics data for different brain conditions ( #Alzheimers, #Parkinsons, #ALS, #FTD)
www.nature.com/articles/s42...
September 22, 2025 at 10:51 AM
Reposted by Ferroptosis1
auscelldeathsoc.bsky.social
🔬 Exciting news for the ferroptosis community!
FerrOZtosis 2.0 symposium is happening this 19th September 2025 at The Florey, Melbourne.
📅 Abstract deadline: August 15
📍 Details & registration: lnkd.in/dn7imCzd
We are excited to announce FerrOZtosis 2.0! | Scott Ayton
We are excited to announce FerrOZtosis 2.0! Come join us on the 19th of September at the Florey for a day full of ferroptosis. Our international guest speaker is the co-discoverer of ferroptosis, Pro...
www.linkedin.com
August 11, 2025 at 6:08 AM
Reposted by Ferroptosis1
prepub-neurodegen.bsky.social
Lithium Chloride Inhibits Iron Dysregulation and Ferroptosis in Induced Pluripotent Stem Cells with ApoE4/E4 from a sporadic Alzheimer's disease patient #NeuroDegeneration 🧪🧠
https://www.biorxiv.org/content/10.1101/2025.08.28.672956v1
September 2, 2025 at 4:02 PM
Reposted by Ferroptosis1
frezzalab.bsky.social
www.nature.com/articles/s41...

Coenzyme Q headgroup intermediates can ameliorate a mitochondrial encephalopathy
Coenzyme Q headgroup intermediates can ameliorate a mitochondrial encephalopathy - Nature
Decreased brain coenzyme Q10 levels cause encephalopathy and are associated with neurodegeneration; supplementation with 4-HMA or 4-HB restores coenzyme Q10 synthesis in mice and humans with HPDL vari...
www.nature.com
July 9, 2025 at 4:04 PM
ferroptosis.bsky.social
Wow
June 4, 2025 at 10:51 PM
Reposted by Ferroptosis1
olzmannlab.bsky.social
FYI - We've extended abstract submission deadline to June 8. Submit soon to be considered for a short talk. Come join us at the first FASEB #Ferroptosis meeting! It's going to be awwwwesome! 🤩
events.faseb.org/event/11797f...
Home - Ferroptosis, Oxidative Stress, and Lipid Metabolism
events.faseb.org
June 3, 2025 at 4:24 PM
Reposted by Ferroptosis1
olzmannlab.bsky.social
Thrilled this paper is out! We solved the first cocrystal structure of FSP1 with an inhibitor (FSEN1), providing mechanistic insight & a foundation for medchem. Led by Amalia Megarioti & Sitao Zhang. A terrific collaboration with Da Jia.
Brief Skytorial!
1/9
Cocrystal structure reveals the mechanism of FSP1 inhibition by FSEN1 | PNAS
FSP1 is an FAD-dependent oxidoreductase that uses NAD(P)H to regenerate the reduced forms of lipophilic quinone antioxidants, such as coenzyme Q10 ...
www.pnas.org
May 29, 2025 at 6:02 PM
Reposted by Ferroptosis1
micharapelab.bsky.social
Congratulations James! From basic discovery to drugging it in such a short time! Amazing work out of #MolecularTherapeutics @mti-ucb.bsky.social @ucberkeleyofficial.bsky.social!!!
olzmannlab.bsky.social James Olzmann @olzmannlab.bsky.social · May 29
Thrilled this paper is out! We solved the first cocrystal structure of FSP1 with an inhibitor (FSEN1), providing mechanistic insight & a foundation for medchem. Led by Amalia Megarioti & Sitao Zhang. A terrific collaboration with Da Jia.
Brief Skytorial!
1/9
Cocrystal structure reveals the mechanism of FSP1 inhibition by FSEN1 | PNAS
FSP1 is an FAD-dependent oxidoreductase that uses NAD(P)H to regenerate the reduced forms of lipophilic quinone antioxidants, such as coenzyme Q10 ...
www.pnas.org
May 29, 2025 at 8:56 PM
ferroptosis.bsky.social
rdcu.be/emFqP Excellent review of our current understanding of ferroptosis in the brain and some of the challenges of studying it
Neuroferroptosis in health and diseases
Nature Reviews Neuroscience - The brain’s high lipid content, iron levels and oxygen metabolism uniquely predispose it to ferroptosis, an iron-dependent form of regulated cell death. In this...
rdcu.be
May 22, 2025 at 10:20 PM
Reposted by Ferroptosis1
scienceofpd.bsky.social
"Despite 80% sequence identity with cytosolic human H-chain ferritin, ferrous ion oxidation at the catalytic diiron ferroxidase center of mitochondrial ferritin proceeds via a distinct mechanism"
www.nature.com/articles/s41...
Human mitochondrial ferritin exhibits highly unusual iron-O2 chemistry distinct from that of cytosolic ferritins - Nature Communications
Human mitochondrial ferritin protects against oxidative stress by detoxifying iron. Here, highly unusual iron-oxygen chemistry, involving formation of a mixed valent diiron site and a tyrosine radical...
www.nature.com
May 21, 2025 at 6:00 AM
Reposted by Ferroptosis1
olzmannlab.bsky.social
Excited to see our N&V w/ @mikelangelipid.bsky.social published in Nature, highlighting new work from Raphael Rodriguez and team. A heterofunctional molecule that activates lysosomal iron triggers lipid peroxidation and ferroptosis in therapy-resistant cancer cells. www.nature.com/articles/d41...
Lipid-degrading small molecule kills cancer cells by ferroptosis
A molecule designed to activate iron locked up in organelles called lysosomes and thereby induce cell death might offer a way to tackle treatment-resistant cancer.
www.nature.com
May 7, 2025 at 10:17 PM
Reposted by Ferroptosis1
sebastianparis.bsky.social
Our new exciting work on ferroptosis initiation in lysosomes. New molecule killing persister cancer cells. www.nature.com/articles/s41... #ferroptosis #cancer #metastasis
Activation of lysosomal iron triggers ferroptosis in cancer - Nature
Some cancer cells exhibit high loads of reactive iron in lysosomes, and this feature is exploited by using fentomycin-1, a newly developed small molecule, to induce ferroptosis.
www.nature.com
May 8, 2025 at 4:25 AM
Reposted by Ferroptosis1
brentstockwell.bsky.social
Here is our latest paper in @ACSBiol on compounds that restore activity to the R152H GPX4 variant, found in patients with SSMD. Congrats to Hengrui, Farhad and Russ on a great collaboration! @columbia #ferroptosis pubs.acs.org/doi/full/10....
May 8, 2025 at 12:28 PM
Reposted by Ferroptosis1
ubellackerlab.bsky.social
Our team (hsph.harvard.edu/research/ube...) is excited to have contributed to the intranodal in vivo testing of the remarkable new compound, Fentomycin-1. Congrats to team Rodriguez et al. for the implications of this work in targeting ferroptosis in cancer. Check it out here!
May 7, 2025 at 3:57 PM
Reposted by Ferroptosis1
mikelangelipid.bsky.social
Fantastic new study from Raphael Rodriguez' lab shows that induced proximity concepts can be used to induce Ferroptosis! Inducing proximity of lysosomal iron and lipids induces lipid peroxidation! What a cool concept! Have a look at our News/Views with @olzmannlab.bsky.social shorturl.at/cbc8D
Lipid-degrading small molecule kills cancer cells by ferroptosis
A molecule designed to activate iron locked up in organelles called lysosomes and thereby induce cell death might offer a way to tackle treatment-resistant cancer.
shorturl.at
May 8, 2025 at 1:17 AM
Reposted by Ferroptosis1
olzmannlab.bsky.social
Reminder: The 1st FASEB #Ferroptosis Meeting is this summer! Spectacular speaker lineup + short talks selected from submitted abstracts. It is going to be awesome! Trainees, newcomers & all interested are welcome!
📅 Abstract deadline: June 1, 2025.
shorturl.at/QA6T1
May 3, 2025 at 5:09 PM
Reposted by Ferroptosis1
mikelangelipid.bsky.social
Join for the first FASEB Ferroptosis conference in the US this July! This stellar speaker line up brings together almost all leaders in the field!
olzmannlab.bsky.social James Olzmann @olzmannlab.bsky.social · May 3
Reminder: The 1st FASEB #Ferroptosis Meeting is this summer! Spectacular speaker lineup + short talks selected from submitted abstracts. It is going to be awesome! Trainees, newcomers & all interested are welcome!
📅 Abstract deadline: June 1, 2025.
shorturl.at/QA6T1
May 4, 2025 at 1:44 AM
Reposted by Ferroptosis1
micharapelab.bsky.social
Thank you to @brentstockwell.bsky.social of @columbiauniversity.bsky.social for visiting #MolecularTherapeutics at @mti-ucb.bsky.social @ucberkeleyofficial.bsky.social and presenting a tour-de-force through the ferroptosis field!
May 2, 2025 at 4:58 PM
Reposted by Ferroptosis1
bigearthdata.bsky.social
Palmitoylation regulates ferroptosis and anti-tumor immunity
->Nature | More info from EcoSearch
Palmitoylation regulates ferroptosis and anti-tumor immunity
Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In...
www.nature.com
May 3, 2025 at 5:27 AM
ferroptosis.bsky.social
Interesting study that attempts to explain how NAC rescues from direct GPX4 covalent binding inhibitors. Was always a bit of a mystery and it looks to me like there might be more to it. www.cell.com/cell-chemica...
N-acetyl-l-cysteine averts ferroptosis by fostering glutathione peroxidase 4
Zheng and Zhang et al. identify N-acetyl-l-cysteine (NAC) and its enantiomer N-acetyl-d-cysteine (d-NAC) as direct reducing substrates of glutathione peroxidase 4 (GPX4). They further reveal a broad r...
www.cell.com
May 3, 2025 at 10:13 AM
Reposted by Ferroptosis1
vonkarstedtlab.bsky.social
What do cells undergoing #ferroptosis #celldeath release? Read all about it in our atlas on ferroptosis #secretomes out now in Cell Death and Differentiation #CDDpress
Great collaboration with @cecad.bsky.social @frezzalab.bsky.social @kreuzaler.bsky.social @almutschulze.bsky.social

rdcu.be/ejp9C
An atlas of ferroptosis-induced secretomes
Cell Death & Differentiation - An atlas of ferroptosis-induced secretomes
rdcu.be
April 26, 2025 at 9:42 AM
Reposted by Ferroptosis1
mpibp.bsky.social
Have you heard of ferroptosis? 💥 This is the iron-driven, propagating form of cell death! Our Membrane Dynamics Department (@office-garcia.bsky.social) has developed an optical tool to trigger and control it.

🔗Find out more: www.biophys.mpg.de/2857694/shining-a-new-light-on-ferroptosis?c=2011019
Abstract representation of a cell undergoing ferroptosis with a central blue shape, encircled by green dots, and outer red membrane resembling petals. This image was generated using AI.
April 24, 2025 at 12:56 PM