@sebastianparis.bsky.social
Our work from 2023 on copper regulating inflammation and sepsis. Promising new avenue to tackle septic shock. www.nature.com/articles/s41...
A druggable copper-signalling pathway that drives inflammation - Nature
Cellular uptake of copper(ii) by CD44 has a key role in regulating cellular plasticity via copper(ii)-dependent downstream signalling events.
www.nature.com
May 8, 2025 at 6:30 AM
Our work from 2023 on copper regulating inflammation and sepsis. Promising new avenue to tackle septic shock. www.nature.com/articles/s41...
Reposted
Salt Lake City, Utah, and Boise, Idaho, adopted official Pride flags on Tuesday in response to state laws barring the display of any nonofficial flags at schools and government buildings.
Salt Lake City and Boise Adopt Official Pride Flags in Response to State Laws
www.nytimes.com
May 7, 2025 at 3:32 PM
Salt Lake City, Utah, and Boise, Idaho, adopted official Pride flags on Tuesday in response to state laws barring the display of any nonofficial flags at schools and government buildings.
Reposted
I’m thankful that the MN State Legislature expanded access to MinnesotaCare in 2023.
My dad has been able to receive cancer treatment and healthcare as a result of this. It’s been a blessing.
Unfortunately, there’s a real threat that this will be gutted during the last few days of session. 1/
My dad has been able to receive cancer treatment and healthcare as a result of this. It’s been a blessing.
Unfortunately, there’s a real threat that this will be gutted during the last few days of session. 1/
May 7, 2025 at 1:34 PM
I’m thankful that the MN State Legislature expanded access to MinnesotaCare in 2023.
My dad has been able to receive cancer treatment and healthcare as a result of this. It’s been a blessing.
Unfortunately, there’s a real threat that this will be gutted during the last few days of session. 1/
My dad has been able to receive cancer treatment and healthcare as a result of this. It’s been a blessing.
Unfortunately, there’s a real threat that this will be gutted during the last few days of session. 1/
Our new exciting work on ferroptosis initiation in lysosomes. New molecule killing persister cancer cells. www.nature.com/articles/s41... #ferroptosis #cancer #metastasis
Activation of lysosomal iron triggers ferroptosis in cancer - Nature
Some cancer cells exhibit high loads of reactive iron in lysosomes, and this feature is exploited by using fentomycin-1, a newly developed small molecule, to induce ferroptosis.
www.nature.com
May 8, 2025 at 4:25 AM
Our new exciting work on ferroptosis initiation in lysosomes. New molecule killing persister cancer cells. www.nature.com/articles/s41... #ferroptosis #cancer #metastasis
Reposted
And the fantastic News & Views summary from @mikelangelipid.bsky.social and
@olzmannlab.bsky.social: www.nature.com/articles/d41...
@olzmannlab.bsky.social: www.nature.com/articles/d41...
Lipid-degrading small molecule kills cancer cells by ferroptosis
A molecule designed to activate iron locked up in organelles called lysosomes and thereby induce cell death might offer a way to tackle treatment-resistant cancer.
www.nature.com
May 7, 2025 at 4:01 PM
And the fantastic News & Views summary from @mikelangelipid.bsky.social and
@olzmannlab.bsky.social: www.nature.com/articles/d41...
@olzmannlab.bsky.social: www.nature.com/articles/d41...
Reposted
Our team (hsph.harvard.edu/research/ube...) is excited to have contributed to the intranodal in vivo testing of the remarkable new compound, Fentomycin-1. Congrats to team Rodriguez et al. for the implications of this work in targeting ferroptosis in cancer. Check it out here!
new out in Nature, very cool story www.nature.com/articles/s41...
Activation of lysosomal iron triggers ferroptosis in cancer - Nature
Some cancer cells exhibit high loads of reactive iron in lysosomes, and this feature is exploited by using fentomycin-1, a newly developed small molecule, to induce ferroptosis.
www.nature.com
May 7, 2025 at 3:57 PM
Our team (hsph.harvard.edu/research/ube...) is excited to have contributed to the intranodal in vivo testing of the remarkable new compound, Fentomycin-1. Congrats to team Rodriguez et al. for the implications of this work in targeting ferroptosis in cancer. Check it out here!
Reposted
Excited to see our N&V w/ @mikelangelipid.bsky.social published in Nature, highlighting new work from Raphael Rodriguez and team. A heterofunctional molecule that activates lysosomal iron triggers lipid peroxidation and ferroptosis in therapy-resistant cancer cells. www.nature.com/articles/d41...
Lipid-degrading small molecule kills cancer cells by ferroptosis
A molecule designed to activate iron locked up in organelles called lysosomes and thereby induce cell death might offer a way to tackle treatment-resistant cancer.
www.nature.com
May 7, 2025 at 10:17 PM
Excited to see our N&V w/ @mikelangelipid.bsky.social published in Nature, highlighting new work from Raphael Rodriguez and team. A heterofunctional molecule that activates lysosomal iron triggers lipid peroxidation and ferroptosis in therapy-resistant cancer cells. www.nature.com/articles/d41...
Reposted
My painting BLUEBONNETS
May 7, 2025 at 9:46 PM
My painting BLUEBONNETS