The Science of Parkinson's
@scienceofpd.bsky.social
Personal account of the Director of Research at Cure Parkinson's - All views my own - Kiwi - Kia kaha - 侘寂 - https://scienceofparkinsons.com/
"Positive skin biopsy for p-α-syn occurs across the spectrum of cognitive presentations of LBD including prodromal DLB, albeit at a lower freq. in this retrospective review of atypical cases compared with typical clinical presentations"
movementdisorders.onlinelibrary.wiley.com/doi/10.1002/...
movementdisorders.onlinelibrary.wiley.com/doi/10.1002/...
movementdisorders.onlinelibrary.wiley.com
December 30, 2025 at 6:34 PM
"Positive skin biopsy for p-α-syn occurs across the spectrum of cognitive presentations of LBD including prodromal DLB, albeit at a lower freq. in this retrospective review of atypical cases compared with typical clinical presentations"
movementdisorders.onlinelibrary.wiley.com/doi/10.1002/...
movementdisorders.onlinelibrary.wiley.com/doi/10.1002/...
Useful review of the small-molecule therapies field for GBA1-associated #Parkinsons; "Clinical trials of GBA1-modulating therapeutics will be challenging with regard to the optimal timing of the intervention & appropriate outcome parameters"
movementdisorders.onlinelibrary.wiley.com/doi/10.1002/...
movementdisorders.onlinelibrary.wiley.com/doi/10.1002/...
December 30, 2025 at 6:18 PM
Useful review of the small-molecule therapies field for GBA1-associated #Parkinsons; "Clinical trials of GBA1-modulating therapeutics will be challenging with regard to the optimal timing of the intervention & appropriate outcome parameters"
movementdisorders.onlinelibrary.wiley.com/doi/10.1002/...
movementdisorders.onlinelibrary.wiley.com/doi/10.1002/...
Disturbing reading: "Using mainly public funds, the scientific community paid the 5 large publishers $1.06 billion in 4 years. And according to this estimate, the sum covers only the fees to publish open access studies"
english.elpais.com/science-tech...
english.elpais.com/science-tech...
Scientists paid large publishers over $1 billion in four years to have their studies published with open access
A study reveals that academic megajournals ‘Scientific Reports’ and ‘Nature Communications’ have cornered the market
english.elpais.com
December 30, 2025 at 5:17 PM
Disturbing reading: "Using mainly public funds, the scientific community paid the 5 large publishers $1.06 billion in 4 years. And according to this estimate, the sum covers only the fees to publish open access studies"
english.elpais.com/science-tech...
english.elpais.com/science-tech...
New clinical trial registered: PREVENTION-IN-PD - The development of a multidomain lifestyle intervention study for 99 people with prodromal & clinical #Parkinsons in Germany; Support in 4 areas: exercise, Mediterranean diet, sleep, & cognitive training
clinicaltrials.gov/study/NCT072...
clinicaltrials.gov/study/NCT072...
ClinicalTrials.gov
clinicaltrials.gov
December 28, 2025 at 9:19 PM
New clinical trial registered: PREVENTION-IN-PD - The development of a multidomain lifestyle intervention study for 99 people with prodromal & clinical #Parkinsons in Germany; Support in 4 areas: exercise, Mediterranean diet, sleep, & cognitive training
clinicaltrials.gov/study/NCT072...
clinicaltrials.gov/study/NCT072...
New clinical trial registered: Annovis Bio initiate an open-label Phase 2/3,36 month clinical trial investigating the long-term safety of Buntanetap in treating 500 participants with #Parkinsons
clinicaltrials.gov/study/NCT072...
clinicaltrials.gov/study/NCT072...
ClinicalTrials.gov
clinicaltrials.gov
December 28, 2025 at 9:15 PM
New clinical trial registered: Annovis Bio initiate an open-label Phase 2/3,36 month clinical trial investigating the long-term safety of Buntanetap in treating 500 participants with #Parkinsons
clinicaltrials.gov/study/NCT072...
clinicaltrials.gov/study/NCT072...
New clinical trial registered: @narayananlab.bsky.social & collaborators initiate the Terazosin And Metabolic Engagement in Parkinson's Disease (or TAME-PD) study - a Phase 1/2 study assessing 26 weeks of terazosin in 100 people with early #Parkinsons
clinicaltrials.gov/study/NCT072...
clinicaltrials.gov/study/NCT072...
ClinicalTrials.gov
clinicaltrials.gov
December 28, 2025 at 9:11 PM
New clinical trial registered: @narayananlab.bsky.social & collaborators initiate the Terazosin And Metabolic Engagement in Parkinson's Disease (or TAME-PD) study - a Phase 1/2 study assessing 26 weeks of terazosin in 100 people with early #Parkinsons
clinicaltrials.gov/study/NCT072...
clinicaltrials.gov/study/NCT072...
New review highlights new research on alpha synuclein–lipid interactions across different experimental models & proposes that early disruptions in neuronal lipid metabolism may lead to altered membrane composition & aggregation of aSyn
movementdisorders.onlinelibrary.wiley.com/doi/10.1002/...
movementdisorders.onlinelibrary.wiley.com/doi/10.1002/...
December 28, 2025 at 9:04 PM
New review highlights new research on alpha synuclein–lipid interactions across different experimental models & proposes that early disruptions in neuronal lipid metabolism may lead to altered membrane composition & aggregation of aSyn
movementdisorders.onlinelibrary.wiley.com/doi/10.1002/...
movementdisorders.onlinelibrary.wiley.com/doi/10.1002/...
New research reports that distinct digital mobility outcomes patterns across #Parkinsons severity & between PD & controls support their utility as sensitive, scalable outcome measures for future clinical trials
journals.sagepub.com/doi/10.1177/...
journals.sagepub.com/doi/10.1177/...
December 28, 2025 at 8:57 PM
New research reports that distinct digital mobility outcomes patterns across #Parkinsons severity & between PD & controls support their utility as sensitive, scalable outcome measures for future clinical trials
journals.sagepub.com/doi/10.1177/...
journals.sagepub.com/doi/10.1177/...
Researchers present a novel cell-penetrating PEP-1-Phosphoglycerate mutase 5 (PGAM5) fusion protein that rescues models of #Parkinsons
onlinelibrary.wiley.com/doi/10.1111/...
onlinelibrary.wiley.com/doi/10.1111/...
December 28, 2025 at 8:49 PM
Researchers present a novel cell-penetrating PEP-1-Phosphoglycerate mutase 5 (PGAM5) fusion protein that rescues models of #Parkinsons
onlinelibrary.wiley.com/doi/10.1111/...
onlinelibrary.wiley.com/doi/10.1111/...
A prospective, blinded study evaluating phosphorylated alpha-synuclein detection from skin biopsies finds 96.0% (48/50) positive results in dementia with Lewy bodies cases, 31% (8/26) of controls with⬇️MoCA, & 3.3% (4/120) of controls with normal MoCA.
onlinelibrary.wiley.com/doi/10.1002/...
onlinelibrary.wiley.com/doi/10.1002/...
December 28, 2025 at 8:44 PM
A prospective, blinded study evaluating phosphorylated alpha-synuclein detection from skin biopsies finds 96.0% (48/50) positive results in dementia with Lewy bodies cases, 31% (8/26) of controls with⬇️MoCA, & 3.3% (4/120) of controls with normal MoCA.
onlinelibrary.wiley.com/doi/10.1002/...
onlinelibrary.wiley.com/doi/10.1002/...
Walter Koroshetz, director of the National Institute of Neurological Disorders & Stroke, emailed NINDS staff late Friday night explaining that a request to reappoint him was denied, adding that his current temporary extension ends Sunday
www.statnews.com/2025/12/27/n...
www.statnews.com/2025/12/27/n...
Director of NIH neurological disorders institute is ousted, adding to leadership churn
Walter Koroshetz, director of the National Institute of Neurological Disorders and Stroke, will soon be leaving his role, STAT has learned. His departure
www.statnews.com
December 28, 2025 at 8:36 PM
Walter Koroshetz, director of the National Institute of Neurological Disorders & Stroke, emailed NINDS staff late Friday night explaining that a request to reappoint him was denied, adding that his current temporary extension ends Sunday
www.statnews.com/2025/12/27/n...
www.statnews.com/2025/12/27/n...
Researchers report that "dopamine caused α-synuclein oligomerization via oxidation of methionine residues" can be inhibited by Pyridoxamine (a form of vitamin B6) in a dose-dependent manner, through stable adduct formation (scavenging dopamine o-quinone)
www.nature.com/articles/s41...
www.nature.com/articles/s41...
December 28, 2025 at 8:17 PM
Researchers report that "dopamine caused α-synuclein oligomerization via oxidation of methionine residues" can be inhibited by Pyridoxamine (a form of vitamin B6) in a dose-dependent manner, through stable adduct formation (scavenging dopamine o-quinone)
www.nature.com/articles/s41...
www.nature.com/articles/s41...
New research finds that #Parkinsons -associated alpha-synuclein amyloids can degrade adenosine triphosphate (ATP) in a catalytic fashion (producing adenosine diphosphate & adenosine monophosphate); Upon prolonged incubation, all ATP is irreversibly consumed
www.nature.com/articles/s41...
www.nature.com/articles/s41...
December 28, 2025 at 8:11 PM
New research finds that #Parkinsons -associated alpha-synuclein amyloids can degrade adenosine triphosphate (ATP) in a catalytic fashion (producing adenosine diphosphate & adenosine monophosphate); Upon prolonged incubation, all ATP is irreversibly consumed
www.nature.com/articles/s41...
www.nature.com/articles/s41...
New review explores the historical developments & key milestones in ubiquitination research, with a focus on its roles in both health & disease ( #Parkinsons gets a mention); Fascinating evolution of potential therapeutic approaches
www.nature.com/articles/s41...
www.nature.com/articles/s41...
December 25, 2025 at 6:39 PM
New review explores the historical developments & key milestones in ubiquitination research, with a focus on its roles in both health & disease ( #Parkinsons gets a mention); Fascinating evolution of potential therapeutic approaches
www.nature.com/articles/s41...
www.nature.com/articles/s41...
By analysing the membrane proteome for α-syn fibril binding, researchers propose that a cell surface mGluR4–NPDC1 complex participates in the neurodegeneration induced by #Parkinsons -associated alpha synuclein; Transgenic KO mice = protection
www.nature.com/articles/s41...
www.nature.com/articles/s41...
December 25, 2025 at 6:32 PM
By analysing the membrane proteome for α-syn fibril binding, researchers propose that a cell surface mGluR4–NPDC1 complex participates in the neurodegeneration induced by #Parkinsons -associated alpha synuclein; Transgenic KO mice = protection
www.nature.com/articles/s41...
www.nature.com/articles/s41...
#Parkinsons -associated alpha-synuclein co-pathology drives tau accumulation in #Alzheimers patients & iPSCs-derived models
alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
Alpha‐Synuclein co‐pathology drives tau accumulation in Alzheimer's disease patients and iPSCs‐derived models
Background The molecular basis for accelerated cognitive decline seen in Alzheimer's Disease (AD) cases presenting with cortical alpha-Synuclein co-pathology is not well understood. Mouse experiment...
alz-journals.onlinelibrary.wiley.com
December 25, 2025 at 6:25 PM
#Parkinsons -associated alpha-synuclein co-pathology drives tau accumulation in #Alzheimers patients & iPSCs-derived models
alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
Researchers analyzed GRN variants in >18K PD patients and compared sociodemographic, genetic, & clinical data between individuals with & without GRN variants; 24 (0.13%) PD cases harbored 16 unique pathogenic or likely pathogenic GRN variants
movementdisorders.onlinelibrary.wiley.com/doi/10.1002/...
movementdisorders.onlinelibrary.wiley.com/doi/10.1002/...
Pathogenic or Likely Pathogenic GRN Variants Are Found in 0.1% of Parkinson's Disease Patients
Background Parkinsonism may be observed in multiple neurodegenerative diseases, including GRN-associated frontotemporal dementia (FTD-GRN), complicating the differential diagnosis of Parkinson's dis...
movementdisorders.onlinelibrary.wiley.com
December 25, 2025 at 6:24 PM
Researchers analyzed GRN variants in >18K PD patients and compared sociodemographic, genetic, & clinical data between individuals with & without GRN variants; 24 (0.13%) PD cases harbored 16 unique pathogenic or likely pathogenic GRN variants
movementdisorders.onlinelibrary.wiley.com/doi/10.1002/...
movementdisorders.onlinelibrary.wiley.com/doi/10.1002/...
The results of first-in-human, single ascending dose & food-effect study in healthy volunteers of SUL-238, an inhibitor of mitochondrial reverse electron flux & ROS, have been presented; Safe & well-tolerated
alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
First‐In‐Human, Single Ascending Dose and Food‐Effect Study in Healthy Volunteers of SUL‐238, a Novel Orally Administered Mitochondria‐Directed Drug Candidate
Background There is compelling evidence that mitochondrial dysfunction may be crucial in the pathophysiology of Alzheimer’s disease (AD) and Parkinson’s disease (PD). SUL-238 is a novel, investigati...
alz-journals.onlinelibrary.wiley.com
December 25, 2025 at 6:12 PM
The results of first-in-human, single ascending dose & food-effect study in healthy volunteers of SUL-238, an inhibitor of mitochondrial reverse electron flux & ROS, have been presented; Safe & well-tolerated
alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
Bulk RNA sequencing was performed on frozen human amygdala of 20 #Parkinsons & 20 controls w/o dementia or any other neurodegen disorder; Results suggest cellular alterations related to mitochondrial dysfunc., oxygen homeostasis, & inflammation
alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
Amygdala gene alterations in Parkinson's disease
Background The amygdala is closely connected to the olfactory bulb and involved in olfactory processing as well. It is a particularly susceptible region that accumulates a-synuclein pathology in Par...
alz-journals.onlinelibrary.wiley.com
December 25, 2025 at 6:07 PM
Bulk RNA sequencing was performed on frozen human amygdala of 20 #Parkinsons & 20 controls w/o dementia or any other neurodegen disorder; Results suggest cellular alterations related to mitochondrial dysfunc., oxygen homeostasis, & inflammation
alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
New review explores insights into PINK1/Parkin function & dysfunction from Drosophila models; How good is this as a model of #Parkinsons? Very thorough overview - my weekend reading
portlandpress.com/biochemj/art...
portlandpress.com/biochemj/art...
December 25, 2025 at 6:04 PM
New review explores insights into PINK1/Parkin function & dysfunction from Drosophila models; How good is this as a model of #Parkinsons? Very thorough overview - my weekend reading
portlandpress.com/biochemj/art...
portlandpress.com/biochemj/art...
Hope Biosciences Research Foundation reports encouraging data from their randomized, double-blind, single center Phase 2 trial of allogeneic adipose‑derived mesenchymal stem cell therapy in 60 people with #Parkinsons (NCT04995081 - 17 primary outcomes?)
www.businesswire.com/news/home/20...
www.businesswire.com/news/home/20...
www.businesswire.com
December 23, 2025 at 6:46 PM
Hope Biosciences Research Foundation reports encouraging data from their randomized, double-blind, single center Phase 2 trial of allogeneic adipose‑derived mesenchymal stem cell therapy in 60 people with #Parkinsons (NCT04995081 - 17 primary outcomes?)
www.businesswire.com/news/home/20...
www.businesswire.com/news/home/20...
Webinar to look out for in the new year:
The first @cureparkinsons.org.uk #Parkinsons webinar for 2026 will focus on young onset PD - about 5-10% of people with PD are diagnosed before the age of 50, tune in to learn more:
cureparkinsons.org.uk/2025/12/webi...
The first @cureparkinsons.org.uk #Parkinsons webinar for 2026 will focus on young onset PD - about 5-10% of people with PD are diagnosed before the age of 50, tune in to learn more:
cureparkinsons.org.uk/2025/12/webi...
December 23, 2025 at 5:52 PM
Webinar to look out for in the new year:
The first @cureparkinsons.org.uk #Parkinsons webinar for 2026 will focus on young onset PD - about 5-10% of people with PD are diagnosed before the age of 50, tune in to learn more:
cureparkinsons.org.uk/2025/12/webi...
The first @cureparkinsons.org.uk #Parkinsons webinar for 2026 will focus on young onset PD - about 5-10% of people with PD are diagnosed before the age of 50, tune in to learn more:
cureparkinsons.org.uk/2025/12/webi...
I'm 4 episodes in.
And it is soooo good!
@cureparkinsons.org.uk has released the audiobook of Tom Isaacs' "Shake well before use" for FREE!
If nothing else, just listen to the first 5 mins of episode 2 where Tom describes his #Parkinsons diagnosis experience
cureparkinsons.org.uk/2025/12/shak...
And it is soooo good!
@cureparkinsons.org.uk has released the audiobook of Tom Isaacs' "Shake well before use" for FREE!
If nothing else, just listen to the first 5 mins of episode 2 where Tom describes his #Parkinsons diagnosis experience
cureparkinsons.org.uk/2025/12/shak...
Shake Well Before Use: From Coastin' To Cure Parkinson's - Cure Parkinson's
As a thank you to all of our incredible supporters at the end of our 20th anniversary year, we're bringing you an audiobook journey like no other. Listen
cureparkinsons.org.uk
December 23, 2025 at 2:16 PM
I'm 4 episodes in.
And it is soooo good!
@cureparkinsons.org.uk has released the audiobook of Tom Isaacs' "Shake well before use" for FREE!
If nothing else, just listen to the first 5 mins of episode 2 where Tom describes his #Parkinsons diagnosis experience
cureparkinsons.org.uk/2025/12/shak...
And it is soooo good!
@cureparkinsons.org.uk has released the audiobook of Tom Isaacs' "Shake well before use" for FREE!
If nothing else, just listen to the first 5 mins of episode 2 where Tom describes his #Parkinsons diagnosis experience
cureparkinsons.org.uk/2025/12/shak...
Jean-Martin Charcot at 200 years
Who is Jean-Martin Charcot?
Shame on you for asking!
"The founder of modern neurology" who took a particular interest in #Parkinsons
Understand that everyone in the field of neurology passed through his classes!
www.thieme-connect.de/products/ejo...
Who is Jean-Martin Charcot?
Shame on you for asking!
"The founder of modern neurology" who took a particular interest in #Parkinsons
Understand that everyone in the field of neurology passed through his classes!
www.thieme-connect.de/products/ejo...
December 23, 2025 at 2:08 PM
Jean-Martin Charcot at 200 years
Who is Jean-Martin Charcot?
Shame on you for asking!
"The founder of modern neurology" who took a particular interest in #Parkinsons
Understand that everyone in the field of neurology passed through his classes!
www.thieme-connect.de/products/ejo...
Who is Jean-Martin Charcot?
Shame on you for asking!
"The founder of modern neurology" who took a particular interest in #Parkinsons
Understand that everyone in the field of neurology passed through his classes!
www.thieme-connect.de/products/ejo...
New research reports the results of an epigenome-wide association study of enriched neurons from postmortem #Parkinsons brains; Highlights epigenetic regulation of genes related to LRRK2 & endolysosomal sorting, as well as neuroinflammation genes
www.nature.com/articles/s41...
www.nature.com/articles/s41...
December 23, 2025 at 2:04 PM
New research reports the results of an epigenome-wide association study of enriched neurons from postmortem #Parkinsons brains; Highlights epigenetic regulation of genes related to LRRK2 & endolysosomal sorting, as well as neuroinflammation genes
www.nature.com/articles/s41...
www.nature.com/articles/s41...