The Science of Parkinson's
@scienceofpd.bsky.social
Personal account of the Director of Research at Cure Parkinson's - All views my own - Kiwi - Kia kaha - 侘寂 - https://scienceofparkinsons.com/
Hey early-career researchers!
@cureparkinsons.org.uk is taking applications for our annual Research Committee Internship programme. Open to PhD students & post-docs doing #Parkinsons research in the UK or Europe (Oooh, Europe as well this year!!!)
cureparkinsons.org.uk/2025/10/cure...
@cureparkinsons.org.uk is taking applications for our annual Research Committee Internship programme. Open to PhD students & post-docs doing #Parkinsons research in the UK or Europe (Oooh, Europe as well this year!!!)
cureparkinsons.org.uk/2025/10/cure...
Cure Parkinson’s invite applications for interns to join their research committee - Cure Parkinson's
Cure Parkinson’s are inviting applications for early-career researchers (ECRs) to join their research grant evaluation committee. The aim of the
cureparkinsons.org.uk
November 11, 2025 at 9:48 AM
Hey early-career researchers!
@cureparkinsons.org.uk is taking applications for our annual Research Committee Internship programme. Open to PhD students & post-docs doing #Parkinsons research in the UK or Europe (Oooh, Europe as well this year!!!)
cureparkinsons.org.uk/2025/10/cure...
@cureparkinsons.org.uk is taking applications for our annual Research Committee Internship programme. Open to PhD students & post-docs doing #Parkinsons research in the UK or Europe (Oooh, Europe as well this year!!!)
cureparkinsons.org.uk/2025/10/cure...
The launch of our updated Research Strategy at @cureparkinsons.org.uk
4 central pillars:
👉Grow our treatment selection process
👉Accelerate the clinical testing of new agents
👉Combination therapies
👉Make disease modification more personalised
Read more:
cureparkinsons.org.uk/2025/11/an-u...
4 central pillars:
👉Grow our treatment selection process
👉Accelerate the clinical testing of new agents
👉Combination therapies
👉Make disease modification more personalised
Read more:
cureparkinsons.org.uk/2025/11/an-u...
An update to our research strategy - Cure Parkinson's
Every few years, we set out to review and refresh our research strategy. This document underpins everything we do at Cure Parkinson’s and provides the
cureparkinsons.org.uk
November 11, 2025 at 7:53 AM
The launch of our updated Research Strategy at @cureparkinsons.org.uk
4 central pillars:
👉Grow our treatment selection process
👉Accelerate the clinical testing of new agents
👉Combination therapies
👉Make disease modification more personalised
Read more:
cureparkinsons.org.uk/2025/11/an-u...
4 central pillars:
👉Grow our treatment selection process
👉Accelerate the clinical testing of new agents
👉Combination therapies
👉Make disease modification more personalised
Read more:
cureparkinsons.org.uk/2025/11/an-u...
Interesting - new data "provides a detailed evaluation of the relationship between human leukocyte antigen alleles & Lewy body disease pathology" highlighting the importance of immune-related genetic factors in etiology
onlinelibrary.wiley.com/doi/10.1002/...
onlinelibrary.wiley.com/doi/10.1002/...
November 7, 2025 at 7:55 PM
Interesting - new data "provides a detailed evaluation of the relationship between human leukocyte antigen alleles & Lewy body disease pathology" highlighting the importance of immune-related genetic factors in etiology
onlinelibrary.wiley.com/doi/10.1002/...
onlinelibrary.wiley.com/doi/10.1002/...
More real world data (214K matched individuals with a multinational representation) finds people living with T2 diabetes who initiate GLP-1 R agonists (vs DPP4i or basal insulin) have a lower risk of new-onset neurodegeneration ( #Parkinsons data is muddy)
cardiab.biomedcentral.com/articles/10....
cardiab.biomedcentral.com/articles/10....
November 7, 2025 at 7:48 PM
More real world data (214K matched individuals with a multinational representation) finds people living with T2 diabetes who initiate GLP-1 R agonists (vs DPP4i or basal insulin) have a lower risk of new-onset neurodegeneration ( #Parkinsons data is muddy)
cardiab.biomedcentral.com/articles/10....
cardiab.biomedcentral.com/articles/10....
New research from BioArctic shows that their monoclonal antibody Exidavnemab binds to aggregated α-synuclein in human brains affected by α-synucleinopathies (including #Parkinsons)
www.neurotherapeuticsjournal.org/article/S187...
www.neurotherapeuticsjournal.org/article/S187...
November 7, 2025 at 7:38 PM
New research from BioArctic shows that their monoclonal antibody Exidavnemab binds to aggregated α-synuclein in human brains affected by α-synucleinopathies (including #Parkinsons)
www.neurotherapeuticsjournal.org/article/S187...
www.neurotherapeuticsjournal.org/article/S187...
A systematic review & meta-analysis of table tennis finds it to be "a safe, feasible, & effective non-pharmacological intervention for enhancing cognitive & motor outcomes in individuals" with #Alzheimers & #Parkinsons
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
November 7, 2025 at 7:34 PM
A systematic review & meta-analysis of table tennis finds it to be "a safe, feasible, & effective non-pharmacological intervention for enhancing cognitive & motor outcomes in individuals" with #Alzheimers & #Parkinsons
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Researchers profile extracellular vesicles (EV) proteomes & lipidomes from plasma across life, & identify both age-independent & age-dependent EV-based biomarkers predictive of prodromal #Parkinsons - also distinguishing PD from multiple system atrophy
www.cell.com/cell-reports...
www.cell.com/cell-reports...
November 7, 2025 at 7:25 PM
Researchers profile extracellular vesicles (EV) proteomes & lipidomes from plasma across life, & identify both age-independent & age-dependent EV-based biomarkers predictive of prodromal #Parkinsons - also distinguishing PD from multiple system atrophy
www.cell.com/cell-reports...
www.cell.com/cell-reports...
Gain Therapeutics publish their glucocerebrosidase target engagement & therapeutic plasma & cerebrospinal fluid levels data from their Phase 1 clinical testing of GT-02287 (their allosteric GCase enzyme modulator) in 73 healthy volunteers
movementdisorders.onlinelibrary.wiley.com/doi/10.1002/...
movementdisorders.onlinelibrary.wiley.com/doi/10.1002/...
Glucocerebrosidase Target Engagement and Therapeutic Plasma and Cerebrospinal Fluid Levels After GT‐02287 Administration in Healthy Volunteers
Background
Variants in the GBA1 gene can increase the risk of Parkinson's disease (PD) by reducing glucocerebrosidase (GCase) activity, disrupting lysosomal and mitochondrial function, and increasin.....
movementdisorders.onlinelibrary.wiley.com
November 6, 2025 at 7:50 PM
Gain Therapeutics publish their glucocerebrosidase target engagement & therapeutic plasma & cerebrospinal fluid levels data from their Phase 1 clinical testing of GT-02287 (their allosteric GCase enzyme modulator) in 73 healthy volunteers
movementdisorders.onlinelibrary.wiley.com/doi/10.1002/...
movementdisorders.onlinelibrary.wiley.com/doi/10.1002/...
Really looking forward to presenting at the @neurologyacademy.bsky.social Cutting Edge Science for #Parkinsons clinicians event in Sheffield on the 26th Nov - Lots of really impressive speakers!
Can we cure #Parkinsons?
That’s the question Dr Simon Stott @scienceofpd.bsky.social will explore at this year's Cutting Edge Science for Parkinson's Clinicians conference. #PDCES
📅 Wed 26th Nov 2025
📍 Join us in Sheffield or attend virtually
Register now: neurologyacademy.org/events/meeti...
That’s the question Dr Simon Stott @scienceofpd.bsky.social will explore at this year's Cutting Edge Science for Parkinson's Clinicians conference. #PDCES
📅 Wed 26th Nov 2025
📍 Join us in Sheffield or attend virtually
Register now: neurologyacademy.org/events/meeti...
November 6, 2025 at 5:22 PM
Really looking forward to presenting at the @neurologyacademy.bsky.social Cutting Edge Science for #Parkinsons clinicians event in Sheffield on the 26th Nov - Lots of really impressive speakers!
Synthetic α-synuclein fibrils replicate in mice causing Multiple-system atrophy-like path.
Researchers report hi-res. structural analyses of synthetic α-synuclein fibrils (1B fibrils) that developed glial cytoplasmic inclusions in vivo
www.nature.com/articles/s41...
Researchers report hi-res. structural analyses of synthetic α-synuclein fibrils (1B fibrils) that developed glial cytoplasmic inclusions in vivo
www.nature.com/articles/s41...
November 6, 2025 at 5:20 PM
Synthetic α-synuclein fibrils replicate in mice causing Multiple-system atrophy-like path.
Researchers report hi-res. structural analyses of synthetic α-synuclein fibrils (1B fibrils) that developed glial cytoplasmic inclusions in vivo
www.nature.com/articles/s41...
Researchers report hi-res. structural analyses of synthetic α-synuclein fibrils (1B fibrils) that developed glial cytoplasmic inclusions in vivo
www.nature.com/articles/s41...
A really nice piece from @aucklanduni.bsky.social on Prof Sir Richard Faull - I worked in his labs a lifetime ago, and much of his positivity that comes through this story still resonates with me. Shame to see him stepping away, but what an amazing legacy!
stories.auckland.ac.nz/sir-richard-...
stories.auckland.ac.nz/sir-richard-...
November 4, 2025 at 4:18 PM
A really nice piece from @aucklanduni.bsky.social on Prof Sir Richard Faull - I worked in his labs a lifetime ago, and much of his positivity that comes through this story still resonates with me. Shame to see him stepping away, but what an amazing legacy!
stories.auckland.ac.nz/sir-richard-...
stories.auckland.ac.nz/sir-richard-...
People of the United Kingdom!
Support the Movers & Shakers with their parliamentary debate!
Write to your local MP using the template that the team have provided you, & get them focused on #Parkinsons matters!
www.moversandshakerspodcast.com/post/write-t...
Support the Movers & Shakers with their parliamentary debate!
Write to your local MP using the template that the team have provided you, & get them focused on #Parkinsons matters!
www.moversandshakerspodcast.com/post/write-t...
Write to your MP
Help us ensure the Parky Charter has all the support it can in time for its upcoming Parliament debate
www.moversandshakerspodcast.com
November 3, 2025 at 9:25 PM
People of the United Kingdom!
Support the Movers & Shakers with their parliamentary debate!
Write to your local MP using the template that the team have provided you, & get them focused on #Parkinsons matters!
www.moversandshakerspodcast.com/post/write-t...
Support the Movers & Shakers with their parliamentary debate!
Write to your local MP using the template that the team have provided you, & get them focused on #Parkinsons matters!
www.moversandshakerspodcast.com/post/write-t...
New review evaluated the role of digital health technologies as outcome tools in pharmacological trials for #Parkinsons; 42 studies were included, covering 26 distinct DHTs (11 wearable sensors & 15 nonwearable systems); Only Opal=Level 1a
movementdisorders.onlinelibrary.wiley.com/doi/10.1002/...
movementdisorders.onlinelibrary.wiley.com/doi/10.1002/...
Assessing Digital Health Technologies for Outcome Measurement in Parkinson's Disease Drug Trials: A Systematic Review
Traditional clinical assessments in Parkinson's disease (PD) trials are limited by subjectivity and inter-rater variability. Digital health technologies (DHT) offer an objective continuous assessment...
movementdisorders.onlinelibrary.wiley.com
November 2, 2025 at 1:23 PM
New review evaluated the role of digital health technologies as outcome tools in pharmacological trials for #Parkinsons; 42 studies were included, covering 26 distinct DHTs (11 wearable sensors & 15 nonwearable systems); Only Opal=Level 1a
movementdisorders.onlinelibrary.wiley.com/doi/10.1002/...
movementdisorders.onlinelibrary.wiley.com/doi/10.1002/...
Researchers analyse adverse events (AE) reported for Catechol-O-MethylTransferase (COMT) inhibitors used in #Parkinsons treatment using data from the FDA Adverse Event Reporting System (FAERS - 2018 to 2023); Entacapone appears to be the safest
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Safety of COMT-inhibitors in parkinson’s disease: a phase-IV comparative study on adverse events of Tolcapone, Entacapone and Opicapone - Journal of Neural Transmission
Catechol-O-methyltransferase (COMT) inhibitors—Tolcapone, Entacapone, and Opicapone—are adjunct therapies for advanced Parkinson’s disease (PD), improving motor control. Their distinct safety profiles...
link.springer.com
November 2, 2025 at 1:18 PM
Researchers analyse adverse events (AE) reported for Catechol-O-MethylTransferase (COMT) inhibitors used in #Parkinsons treatment using data from the FDA Adverse Event Reporting System (FAERS - 2018 to 2023); Entacapone appears to be the safest
link.springer.com/article/10.1...
link.springer.com/article/10.1...
A useful review of the wonderful world of induced proximity-based therapeutic modalities (Arvinas' LRRK2-targeting PROTAC ARV-102 - which is being developed for #Parkinsons - gets a mention)
www.nature.com/articles/s41...
www.nature.com/articles/s41...
November 1, 2025 at 4:34 PM
A useful review of the wonderful world of induced proximity-based therapeutic modalities (Arvinas' LRRK2-targeting PROTAC ARV-102 - which is being developed for #Parkinsons - gets a mention)
www.nature.com/articles/s41...
www.nature.com/articles/s41...
New research reports that mitochondrial localization in the developing proximal tubule depends on the activity of #Parkinsons-associated LRRK2
www.nature.com/articles/s41...
www.nature.com/articles/s41...
November 1, 2025 at 4:30 PM
New research reports that mitochondrial localization in the developing proximal tubule depends on the activity of #Parkinsons-associated LRRK2
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Could soft magnetoelastic balls represent a quantitative diagnostic tool for #Parkinsons? The ball "converts movements into magnetic fields, & magnetic induction, which transforms the magnetic fields into measurable electrical signals"
www.cell.com/cell-biomate...
www.cell.com/cell-biomate...
November 1, 2025 at 4:23 PM
Could soft magnetoelastic balls represent a quantitative diagnostic tool for #Parkinsons? The ball "converts movements into magnetic fields, & magnetic induction, which transforms the magnetic fields into measurable electrical signals"
www.cell.com/cell-biomate...
www.cell.com/cell-biomate...
Continuous delivery: Oral administration (with benserazide) of bioengineered gut bacterium producing L-DOPA maintains therapeutic plasma L-DOPA concentrations &⬆️CNS dopamine levels while transiently residing in the gut; Improves mouse model of #Parkinsons
www.cell.com/cell-host-mi...
www.cell.com/cell-host-mi...
November 1, 2025 at 2:09 PM
Continuous delivery: Oral administration (with benserazide) of bioengineered gut bacterium producing L-DOPA maintains therapeutic plasma L-DOPA concentrations &⬆️CNS dopamine levels while transiently residing in the gut; Improves mouse model of #Parkinsons
www.cell.com/cell-host-mi...
www.cell.com/cell-host-mi...
Investigating localization of αSyn proteoforms, researchers report lysosomal αSyn was detected solely by targeting the N-terminus or the NAC domain, & not with antibodies targeting Serine 129-PαSyn or other epitopes at the C-terminus
molecularneurodegeneration.biomedcentral.com/articles/10....
molecularneurodegeneration.biomedcentral.com/articles/10....
November 1, 2025 at 2:03 PM
Investigating localization of αSyn proteoforms, researchers report lysosomal αSyn was detected solely by targeting the N-terminus or the NAC domain, & not with antibodies targeting Serine 129-PαSyn or other epitopes at the C-terminus
molecularneurodegeneration.biomedcentral.com/articles/10....
molecularneurodegeneration.biomedcentral.com/articles/10....
New clinical trial registered: Medtronic have initiated the Adaptive DBS Algorithm for Personalized therapy in #Parkinsons (ADAPT-PD) China study; They will be recruiting 62 participants
clinicaltrials.gov/study/NCT072...
clinicaltrials.gov/study/NCT072...
ClinicalTrials.gov
clinicaltrials.gov
November 1, 2025 at 1:03 PM
New clinical trial registered: Medtronic have initiated the Adaptive DBS Algorithm for Personalized therapy in #Parkinsons (ADAPT-PD) China study; They will be recruiting 62 participants
clinicaltrials.gov/study/NCT072...
clinicaltrials.gov/study/NCT072...
New clinical trial registered: The study will investigate the use of ultra-low, anti-inflammatory doses of radiation therapy for the treatment of #Parkinsons; N=20 by invitation
clinicaltrials.gov/study/NCT072...
clinicaltrials.gov/study/NCT072...
ClinicalTrials.gov
clinicaltrials.gov
November 1, 2025 at 1:01 PM
New clinical trial registered: The study will investigate the use of ultra-low, anti-inflammatory doses of radiation therapy for the treatment of #Parkinsons; N=20 by invitation
clinicaltrials.gov/study/NCT072...
clinicaltrials.gov/study/NCT072...
A study investigating the role of irisin in an MPTP-induced mouse model of #Parkinsons finds it inhibits dopaminergic neuron lactate metabolism & repairs mitochondrial function by activating SIRT1 signaling pathway
www.nature.com/articles/s42...
www.nature.com/articles/s42...
November 1, 2025 at 1:00 PM
A study investigating the role of irisin in an MPTP-induced mouse model of #Parkinsons finds it inhibits dopaminergic neuron lactate metabolism & repairs mitochondrial function by activating SIRT1 signaling pathway
www.nature.com/articles/s42...
www.nature.com/articles/s42...
New paper presents "BrainSTEM" (Brain Single-cell Two tiEr Mapping): A single-cell multiresolution fetal brain atlas reveals transcriptomic fidelity of human midbrain cultures
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
November 1, 2025 at 12:57 PM
New paper presents "BrainSTEM" (Brain Single-cell Two tiEr Mapping): A single-cell multiresolution fetal brain atlas reveals transcriptomic fidelity of human midbrain cultures
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Using cryo-ET, researchers show that both normal human LRRK2 & #Parkinsons -associated LRRK2 mutants can oligomerize on microtubules in their autoinhibited states; The new interface involves N-terminal repeats that were disordered in the active-LRRK2
elifesciences.org/articles/100...
elifesciences.org/articles/100...
November 1, 2025 at 12:51 PM
Using cryo-ET, researchers show that both normal human LRRK2 & #Parkinsons -associated LRRK2 mutants can oligomerize on microtubules in their autoinhibited states; The new interface involves N-terminal repeats that were disordered in the active-LRRK2
elifesciences.org/articles/100...
elifesciences.org/articles/100...
New research indicates that high household exposure to herbicides & other pesticides may increase the risk of developing #Parkinsons & lead to an earlier onset of the disease
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Household herbicide use is associated with the risk of Parkinson’s disease and a younger age at onset in PPMI and Fox Insight cohorts - Journal of Neural Transmission
The association of household pesticide exposure with Parkinson’s disease has been less explored than occupational exposure. Using data from the Parkinson's Progression Markers Initiative and the Fox I...
link.springer.com
November 1, 2025 at 12:36 PM
New research indicates that high household exposure to herbicides & other pesticides may increase the risk of developing #Parkinsons & lead to an earlier onset of the disease
link.springer.com/article/10.1...
link.springer.com/article/10.1...