The Science of Parkinson's
@scienceofpd.bsky.social
Personal account of the Director of Research at Cure Parkinson's - All views my own - Kiwi - Kia kaha - 侘寂 - https://scienceofparkinsons.com/
Ever wondered about the role of USP10 in neurodegenerative conditions?
Yeah, me too
A new review provides a useful overview, with a good section on #Parkinsons
nyaspubs.onlinelibrary.wiley.com/doi/10.1111/...
Yeah, me too
A new review provides a useful overview, with a good section on #Parkinsons
nyaspubs.onlinelibrary.wiley.com/doi/10.1111/...
November 25, 2025 at 11:05 AM
Ever wondered about the role of USP10 in neurodegenerative conditions?
Yeah, me too
A new review provides a useful overview, with a good section on #Parkinsons
nyaspubs.onlinelibrary.wiley.com/doi/10.1111/...
Yeah, me too
A new review provides a useful overview, with a good section on #Parkinsons
nyaspubs.onlinelibrary.wiley.com/doi/10.1111/...
Combinations - all the cool kids are doing them!
New research presents patient-derived iPSC models of #ALS that identified baricitinib + memantine + riluzole as a promising potential therapeutic combination
www.nature.com/articles/s41...
New research presents patient-derived iPSC models of #ALS that identified baricitinib + memantine + riluzole as a promising potential therapeutic combination
www.nature.com/articles/s41...
November 25, 2025 at 10:50 AM
Combinations - all the cool kids are doing them!
New research presents patient-derived iPSC models of #ALS that identified baricitinib + memantine + riluzole as a promising potential therapeutic combination
www.nature.com/articles/s41...
New research presents patient-derived iPSC models of #ALS that identified baricitinib + memantine + riluzole as a promising potential therapeutic combination
www.nature.com/articles/s41...
Researchers analyzed structural & task-free functional MRI scans from patients across the #Alzheimers -frontotemporal dementia (FTD) spectrum to identify relationships between gray matter atrophy & functional connectivity
www.nature.com/articles/s41...
www.nature.com/articles/s41...
November 23, 2025 at 12:03 PM
Researchers analyzed structural & task-free functional MRI scans from patients across the #Alzheimers -frontotemporal dementia (FTD) spectrum to identify relationships between gray matter atrophy & functional connectivity
www.nature.com/articles/s41...
www.nature.com/articles/s41...
"Acting as a molecular glue, spermine orchestrates in vivo condensation of α-synuclein, influences condensate mobility, & promotes degradation via autophagy, specifically through autophagosome expansion"; Spermine improves #Parkinsons C.elegans model
www.nature.com/articles/s41...
www.nature.com/articles/s41...
November 23, 2025 at 11:57 AM
"Acting as a molecular glue, spermine orchestrates in vivo condensation of α-synuclein, influences condensate mobility, & promotes degradation via autophagy, specifically through autophagosome expansion"; Spermine improves #Parkinsons C.elegans model
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Intermittent hypercapnia (low levels of CO2 in ON-OFF cycles, 3x 10-minute sessions = ~30 min),⬆️the total α-syn, neurofilament light, GFAP, amyloid β1-42, amyloid β1-40, & phosphorylated tau 217 in the plasma of both controls & people with #Parkinsons
www.nature.com/articles/s41...
www.nature.com/articles/s41...
November 23, 2025 at 11:53 AM
Intermittent hypercapnia (low levels of CO2 in ON-OFF cycles, 3x 10-minute sessions = ~30 min),⬆️the total α-syn, neurofilament light, GFAP, amyloid β1-42, amyloid β1-40, & phosphorylated tau 217 in the plasma of both controls & people with #Parkinsons
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Researchers reveal a distinct role for #Parkinsons associated protein DJ-1 in regulating intercellular communication under oxidative stress, highlighting a novel extracellular vesicles-mediated function of DJ-1 that may contribute to PD pathogenesis
www.nature.com/articles/s41...
www.nature.com/articles/s41...
November 23, 2025 at 11:47 AM
Researchers reveal a distinct role for #Parkinsons associated protein DJ-1 in regulating intercellular communication under oxidative stress, highlighting a novel extracellular vesicles-mediated function of DJ-1 that may contribute to PD pathogenesis
www.nature.com/articles/s41...
www.nature.com/articles/s41...
A 12-month, multicenter, randomized, open-label phase 2 trial in sub-Saharan Africa investigated Mucuna pruriens monotherapy in 32 untreated #Parkinsons patients. Results show improved quality of life, motor & non-motor symptoms. A cost effective answer?
journals.sagepub.com/doi/10.1177/...
journals.sagepub.com/doi/10.1177/...
November 22, 2025 at 11:08 PM
A 12-month, multicenter, randomized, open-label phase 2 trial in sub-Saharan Africa investigated Mucuna pruriens monotherapy in 32 untreated #Parkinsons patients. Results show improved quality of life, motor & non-motor symptoms. A cost effective answer?
journals.sagepub.com/doi/10.1177/...
journals.sagepub.com/doi/10.1177/...
I love the name of this study: BUTTER
This was an open-label target engagement study of dietary tributyrin (500 mg taken orally 3x daily) in 14 people with #Parkinsons for 30 days; Interesting results, novel [11C]butyrate PET ligand used
www.neurotherapeuticsjournal.org/article/S187...
This was an open-label target engagement study of dietary tributyrin (500 mg taken orally 3x daily) in 14 people with #Parkinsons for 30 days; Interesting results, novel [11C]butyrate PET ligand used
www.neurotherapeuticsjournal.org/article/S187...
November 22, 2025 at 11:02 PM
I love the name of this study: BUTTER
This was an open-label target engagement study of dietary tributyrin (500 mg taken orally 3x daily) in 14 people with #Parkinsons for 30 days; Interesting results, novel [11C]butyrate PET ligand used
www.neurotherapeuticsjournal.org/article/S187...
This was an open-label target engagement study of dietary tributyrin (500 mg taken orally 3x daily) in 14 people with #Parkinsons for 30 days; Interesting results, novel [11C]butyrate PET ligand used
www.neurotherapeuticsjournal.org/article/S187...
Downregulation of Macrophage migration inhibitory factor (MIF) attenuates neuroinflammation - via TLR4/MyD88/TRAF6/NF-κB pathway - resulting in neuroprotection of dopaminergic neurons in a model of #Parkinsons (MPTP mouse)
www.nature.com/articles/s42...
www.nature.com/articles/s42...
November 21, 2025 at 10:09 AM
Downregulation of Macrophage migration inhibitory factor (MIF) attenuates neuroinflammation - via TLR4/MyD88/TRAF6/NF-κB pathway - resulting in neuroprotection of dopaminergic neurons in a model of #Parkinsons (MPTP mouse)
www.nature.com/articles/s42...
www.nature.com/articles/s42...
Researchers conduct a brain imaging-based metabolic time series comparison, & reveal hypometabolism in bilateral clusters in the substantia nigra in #Parkinsons patients (vs controls)
www.nature.com/articles/s41...
www.nature.com/articles/s41...
November 21, 2025 at 10:03 AM
Researchers conduct a brain imaging-based metabolic time series comparison, & reveal hypometabolism in bilateral clusters in the substantia nigra in #Parkinsons patients (vs controls)
www.nature.com/articles/s41...
www.nature.com/articles/s41...
A new multi-ethnic Asian #Parkinsons cohort study provides epidemiology & clinical insights, particularly around the distribution of LRRK2 Asian variants - suggesting they influence onset age, familial occurrence, non-motor features, & disease course
www.nature.com/articles/s41...
www.nature.com/articles/s41...
November 21, 2025 at 9:56 AM
A new multi-ethnic Asian #Parkinsons cohort study provides epidemiology & clinical insights, particularly around the distribution of LRRK2 Asian variants - suggesting they influence onset age, familial occurrence, non-motor features, & disease course
www.nature.com/articles/s41...
www.nature.com/articles/s41...
New paper from @malutansey.bsky.social et al reports that #Parkinsons -linked LRRK2 & GBA1 variants converge on peripheral blood immune cell dysregulation; LRRK2 inhibitors & GCase activators modulate ex vivo response to bacterial exposure
movementdisorders.onlinelibrary.wiley.com/doi/10.1002/...
movementdisorders.onlinelibrary.wiley.com/doi/10.1002/...
November 21, 2025 at 9:42 AM
New paper from @malutansey.bsky.social et al reports that #Parkinsons -linked LRRK2 & GBA1 variants converge on peripheral blood immune cell dysregulation; LRRK2 inhibitors & GCase activators modulate ex vivo response to bacterial exposure
movementdisorders.onlinelibrary.wiley.com/doi/10.1002/...
movementdisorders.onlinelibrary.wiley.com/doi/10.1002/...
New paper presents previously uncharacterized genomic dynamics in 18 cells from three human brains utilizing single cell long-read whole genome sequencing, highlighting CNS specific activity of transposable elements
www.nature.com/articles/s42...
www.nature.com/articles/s42...
November 21, 2025 at 9:31 AM
New paper presents previously uncharacterized genomic dynamics in 18 cells from three human brains utilizing single cell long-read whole genome sequencing, highlighting CNS specific activity of transposable elements
www.nature.com/articles/s42...
www.nature.com/articles/s42...
New research points to a convergent mechanism of PINK1–Parkin activation by mitochondrial damage: Loss of mitochondrial membrane potential stalls PINK1 import during its transfer from translocase of the outer membrane (TOM) to the inner membrane (TIM23)
www.embopress.org/doi/full/10....
www.embopress.org/doi/full/10....
November 21, 2025 at 9:23 AM
New research points to a convergent mechanism of PINK1–Parkin activation by mitochondrial damage: Loss of mitochondrial membrane potential stalls PINK1 import during its transfer from translocase of the outer membrane (TOM) to the inner membrane (TIM23)
www.embopress.org/doi/full/10....
www.embopress.org/doi/full/10....
Researchers report low dose GLP-1R agonist treatment for 30 weeks in♂️mice at 11 months of age (mid-life) results in body-wide multi-omic age-counteracting effects & improved certain physical functions; Effects were specific to aged mice, not young adults
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
November 21, 2025 at 9:13 AM
Researchers report low dose GLP-1R agonist treatment for 30 weeks in♂️mice at 11 months of age (mid-life) results in body-wide multi-omic age-counteracting effects & improved certain physical functions; Effects were specific to aged mice, not young adults
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
A new review "places α-synuclein at the nexus of mechanistic synergy between #Parkinsons & depression, & incorporates secondary analyses of genomic & transcriptomic datasets to identify convergent genes & pathways"; Potential biomarker?
www.nature.com/articles/s41...
www.nature.com/articles/s41...
November 20, 2025 at 11:51 PM
A new review "places α-synuclein at the nexus of mechanistic synergy between #Parkinsons & depression, & incorporates secondary analyses of genomic & transcriptomic datasets to identify convergent genes & pathways"; Potential biomarker?
www.nature.com/articles/s41...
www.nature.com/articles/s41...
New research reports that synphilin-1 modulates alpha synuclein assembly, release & uptake - highlighting the importance of Sph1 & other aSyn-interacting proteins in synucleinopathies
www.nature.com/articles/s41...
www.nature.com/articles/s41...
November 20, 2025 at 11:48 PM
New research reports that synphilin-1 modulates alpha synuclein assembly, release & uptake - highlighting the importance of Sph1 & other aSyn-interacting proteins in synucleinopathies
www.nature.com/articles/s41...
www.nature.com/articles/s41...
New preclinical data provides support for chimeric antigen receptor (CAR)-engineered astrocytes in the context of #Parkinsons; Therapeutic potential demonstrated in A53T PD transgenic mice
translationalneurodegeneration.biomedcentral.com/articles/10....
translationalneurodegeneration.biomedcentral.com/articles/10....
November 20, 2025 at 11:43 PM
New preclinical data provides support for chimeric antigen receptor (CAR)-engineered astrocytes in the context of #Parkinsons; Therapeutic potential demonstrated in A53T PD transgenic mice
translationalneurodegeneration.biomedcentral.com/articles/10....
translationalneurodegeneration.biomedcentral.com/articles/10....
New research suggest that the nucleus basalis of Meynert white matter pathways could serve as non-invasive biomarkers indicating risk for clinical conversion & cortical pathology in iRBD & #Parkinsons, both baseline & longitudinal cognitive function
academic.oup.com/braincomms/a...
academic.oup.com/braincomms/a...
November 20, 2025 at 11:36 PM
New research suggest that the nucleus basalis of Meynert white matter pathways could serve as non-invasive biomarkers indicating risk for clinical conversion & cortical pathology in iRBD & #Parkinsons, both baseline & longitudinal cognitive function
academic.oup.com/braincomms/a...
academic.oup.com/braincomms/a...
Vincere Biosciences has been awarded $5M from the Michael J Fox Foundation to advance their USP30 inhibitors & accompanying biomarkers for #Parkinsons through IND-enabling studies that will pave the way towards Phase 1 clinical trials
vincerebio.com/wp-content/u...
vincerebio.com/wp-content/u...
November 20, 2025 at 11:14 PM
Vincere Biosciences has been awarded $5M from the Michael J Fox Foundation to advance their USP30 inhibitors & accompanying biomarkers for #Parkinsons through IND-enabling studies that will pave the way towards Phase 1 clinical trials
vincerebio.com/wp-content/u...
vincerebio.com/wp-content/u...
Aspen Neuroscience announces $115M in series C financing to accelerate their autologous cell therapy candidate ANPD001 for #Parkinsons
aspenneuroscience.com/aspen-neuros...
aspenneuroscience.com/aspen-neuros...
November 20, 2025 at 11:07 PM
Aspen Neuroscience announces $115M in series C financing to accelerate their autologous cell therapy candidate ANPD001 for #Parkinsons
aspenneuroscience.com/aspen-neuros...
aspenneuroscience.com/aspen-neuros...
Are you looking for experience in the grant evaluation process?
Here's the deal:
We have 4x meetings of our Research Committee each year (3x virtual & 1x in person, with a nice dinner afterwards!). First meeting, you will just observe, second meeting, you are allowed to speak!
Here's the deal:
We have 4x meetings of our Research Committee each year (3x virtual & 1x in person, with a nice dinner afterwards!). First meeting, you will just observe, second meeting, you are allowed to speak!
November 19, 2025 at 10:50 PM
Are you looking for experience in the grant evaluation process?
Here's the deal:
We have 4x meetings of our Research Committee each year (3x virtual & 1x in person, with a nice dinner afterwards!). First meeting, you will just observe, second meeting, you are allowed to speak!
Here's the deal:
We have 4x meetings of our Research Committee each year (3x virtual & 1x in person, with a nice dinner afterwards!). First meeting, you will just observe, second meeting, you are allowed to speak!
New research presents the development of convolutional neural networks for high-throughput, unbiased, automated brain-wide histopathological analysis in mouse models of synucleinopathies
www.nature.com/articles/s41...
www.nature.com/articles/s41...
November 19, 2025 at 10:46 PM
New research presents the development of convolutional neural networks for high-throughput, unbiased, automated brain-wide histopathological analysis in mouse models of synucleinopathies
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Researchers characterize an Atp13a2 KO rat model & observe alterations in locomotor & fine motor skills, neuroinflam., zinc dyshomeostasis, electrophysiological disturbances, & autophagy-lysosomal pathway dysfunctions without overt nigrostriatal degen.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
November 19, 2025 at 10:41 PM
Researchers characterize an Atp13a2 KO rat model & observe alterations in locomotor & fine motor skills, neuroinflam., zinc dyshomeostasis, electrophysiological disturbances, & autophagy-lysosomal pathway dysfunctions without overt nigrostriatal degen.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
SPARK-NS have opened applications for a free course & introduction to a unique funding opportunity for principal investigators in Europe & the UK who are interested in or currently developing a therapeutic for #autism or #Parkinsons; Madrid: 25-27th March
sparkns.org/short-course...
sparkns.org/short-course...
November 19, 2025 at 11:21 AM
SPARK-NS have opened applications for a free course & introduction to a unique funding opportunity for principal investigators in Europe & the UK who are interested in or currently developing a therapeutic for #autism or #Parkinsons; Madrid: 25-27th March
sparkns.org/short-course...
sparkns.org/short-course...