Christl Gaubitz
@christlgaubitz.bsky.social
Postdoc in Tom Miller’s group @UCPH 😃🧬🔬 studying DNA replication, interested in microbiology and molecular mechanisms
Reposted by Christl Gaubitz
We are hiring a postdoc! 🧪
▶️ Project: nucleotide metabolism (genomics & biochemistry)
▶️ Start date: spring 2026 (flexible)
▶️ More info and application: tinyurl.com/3kjrbb2x
Please share 🌏
@fbm-unil.bsky.social @dib-unil.bsky.social @unil.bsky.social @snsf.ch
▶️ Project: nucleotide metabolism (genomics & biochemistry)
▶️ Start date: spring 2026 (flexible)
▶️ More info and application: tinyurl.com/3kjrbb2x
Please share 🌏
@fbm-unil.bsky.social @dib-unil.bsky.social @unil.bsky.social @snsf.ch
Career Opportunities: Postdoctoral position in cellular metabolism (22584)
tinyurl.com
November 20, 2025 at 6:26 AM
We are hiring a postdoc! 🧪
▶️ Project: nucleotide metabolism (genomics & biochemistry)
▶️ Start date: spring 2026 (flexible)
▶️ More info and application: tinyurl.com/3kjrbb2x
Please share 🌏
@fbm-unil.bsky.social @dib-unil.bsky.social @unil.bsky.social @snsf.ch
▶️ Project: nucleotide metabolism (genomics & biochemistry)
▶️ Start date: spring 2026 (flexible)
▶️ More info and application: tinyurl.com/3kjrbb2x
Please share 🌏
@fbm-unil.bsky.social @dib-unil.bsky.social @unil.bsky.social @snsf.ch
Reposted by Christl Gaubitz
𝗖𝗮𝗻 𝗰𝗲𝗹𝗹𝘀 𝗲𝘃𝗲𝗿 𝘁𝗿𝘂𝗹𝘆 𝗿𝗲𝗰𝗼𝘃𝗲𝗿 𝗳𝗿𝗼𝗺 𝗗𝗡𝗔 𝗱𝗮𝗺𝗮𝗴𝗲?Excited to share our new study “Repair of DNA double-strand breaks leaves heritable impairment to genome function”, revealing DNA repair’s hidden cost, out now @science.org tinyurl.com/5n6zw3ye. Led by @sbantele.bsky.social and Jiri Lukas.🧵👇1/n
Repair of DNA double-strand breaks leaves heritable impairment to genome function
Upon DNA breakage, a genomic locus undergoes alterations in three-dimensional chromatin architecture to facilitate signaling and repair. Although cells possess mechanisms to repair damaged DNA, it is ...
tinyurl.com
November 6, 2025 at 11:05 PM
𝗖𝗮𝗻 𝗰𝗲𝗹𝗹𝘀 𝗲𝘃𝗲𝗿 𝘁𝗿𝘂𝗹𝘆 𝗿𝗲𝗰𝗼𝘃𝗲𝗿 𝗳𝗿𝗼𝗺 𝗗𝗡𝗔 𝗱𝗮𝗺𝗮𝗴𝗲?Excited to share our new study “Repair of DNA double-strand breaks leaves heritable impairment to genome function”, revealing DNA repair’s hidden cost, out now @science.org tinyurl.com/5n6zw3ye. Led by @sbantele.bsky.social and Jiri Lukas.🧵👇1/n
Reposted by Christl Gaubitz
Check out some of my illustrations featuring DNA that is, actually, structurally accurate.
Whilst color is absent at the nanoscale, I choose it to highlight the form and function.
These illustrations are grounded in structural data.
#blender3d #sciart #DNA #scicomm
Whilst color is absent at the nanoscale, I choose it to highlight the form and function.
These illustrations are grounded in structural data.
#blender3d #sciart #DNA #scicomm
October 27, 2025 at 8:02 PM
Check out some of my illustrations featuring DNA that is, actually, structurally accurate.
Whilst color is absent at the nanoscale, I choose it to highlight the form and function.
These illustrations are grounded in structural data.
#blender3d #sciart #DNA #scicomm
Whilst color is absent at the nanoscale, I choose it to highlight the form and function.
These illustrations are grounded in structural data.
#blender3d #sciart #DNA #scicomm
Reposted by Christl Gaubitz
See our paper “Mechanism of trinucleotide repeat expansion by MutSβ-MutLγ and contraction by FAN1”. Using biochemistry, we show how DNA incisions by the MutLγ nuclease can lead to expansions, and how expansion is prevented by FAN1. Well done Issam and Valentina!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
October 27, 2025 at 1:12 PM
See our paper “Mechanism of trinucleotide repeat expansion by MutSβ-MutLγ and contraction by FAN1”. Using biochemistry, we show how DNA incisions by the MutLγ nuclease can lead to expansions, and how expansion is prevented by FAN1. Well done Issam and Valentina!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Christl Gaubitz
Bringing invisible ideas to life.
#sciart #blender3D #illustration
*illustrations created for Mary Munson’s Lab website at UMass Chan Medical School*
#sciart #blender3D #illustration
*illustrations created for Mary Munson’s Lab website at UMass Chan Medical School*
October 1, 2025 at 8:32 AM
Bringing invisible ideas to life.
#sciart #blender3D #illustration
*illustrations created for Mary Munson’s Lab website at UMass Chan Medical School*
#sciart #blender3D #illustration
*illustrations created for Mary Munson’s Lab website at UMass Chan Medical School*
Reposted by Christl Gaubitz
October 7, 2025 at 8:00 AM
Reposted by Christl Gaubitz
Excited to share our lab’s latest preprint! We identify DDIAS as a novel single-stranded DNA-binding component of the TOPBP1–CIP2A complex, which acts in a mitotic DNA damage response pathway to protect chromosome integrity. Short summary below, and read it here: www.biorxiv.org/content/10.1...
DDIAS is a single-stranded DNA-binding effector of the TOPBP1-CIP2A complex in mitosis
DNA double-strand breaks and unresolved DNA replication intermediates are particularly dangerous during mitosis. Paradoxically, cells inactivate canonical DNA repair mechanisms during chromosome segre...
www.biorxiv.org
September 10, 2025 at 3:18 PM
Excited to share our lab’s latest preprint! We identify DDIAS as a novel single-stranded DNA-binding component of the TOPBP1–CIP2A complex, which acts in a mitotic DNA damage response pathway to protect chromosome integrity. Short summary below, and read it here: www.biorxiv.org/content/10.1...
Reposted by Christl Gaubitz
Yadav, Jadhav, @hanasedlackova.bsky.social et al present a novel cell-permeable biotin-HaloTag ligand. The reported ligand expands the HaloTag toolbox by enabling in vivo labeling & providing capabilities for efficient affinity capture of protein variants from live cells rupress.org/jcb/article/...
July 16, 2025 at 4:15 PM
Yadav, Jadhav, @hanasedlackova.bsky.social et al present a novel cell-permeable biotin-HaloTag ligand. The reported ligand expands the HaloTag toolbox by enabling in vivo labeling & providing capabilities for efficient affinity capture of protein variants from live cells rupress.org/jcb/article/...
Reposted by Christl Gaubitz
Proud to share our first lab pre-print: “SND3 is the membrane insertase within a fungal multipass translocon” where @tzujingyang.bsky.social solved the structure of a ribosome-associated SND3-translocon complex involved in ER membrane protein insertion ➡️ doi.org/10.1101/2025...
July 12, 2025 at 12:49 AM
Proud to share our first lab pre-print: “SND3 is the membrane insertase within a fungal multipass translocon” where @tzujingyang.bsky.social solved the structure of a ribosome-associated SND3-translocon complex involved in ER membrane protein insertion ➡️ doi.org/10.1101/2025...
Reposted by Christl Gaubitz
Check out the paper led by Dr. Helen Findlay @plymouthmarine.bsky.social 🧪🌊🦑
#OceanAcidification : Another Planetary Boundary Crossed
doi.org/10.1111/gcb....
#OceanAcidification : Another Planetary Boundary Crossed
doi.org/10.1111/gcb....
June 9, 2025 at 5:19 PM
Check out the paper led by Dr. Helen Findlay @plymouthmarine.bsky.social 🧪🌊🦑
#OceanAcidification : Another Planetary Boundary Crossed
doi.org/10.1111/gcb....
#OceanAcidification : Another Planetary Boundary Crossed
doi.org/10.1111/gcb....
Reposted by Christl Gaubitz
hey, that's me!
The structure of a thermostable phage's Portal Vertex and Neck Complex illuminates its maturation process www.biorxiv.org/content/10.1101/2025.04.14.648768v1 #cryoem
April 16, 2025 at 5:35 PM
hey, that's me!
Reposted by Christl Gaubitz
Excited to share our new pre-print. Direct, ensemble FRET assays developed by our lab reveal that assembly of Rad51 filaments at stalled replication sites via RPA/Rad51 exchange causes complete & irreversible PCNA unloading. Big implications for interplay between human DNA damage tolerance pathways
www.biorxiv.org
April 1, 2025 at 5:58 PM
Excited to share our new pre-print. Direct, ensemble FRET assays developed by our lab reveal that assembly of Rad51 filaments at stalled replication sites via RPA/Rad51 exchange causes complete & irreversible PCNA unloading. Big implications for interplay between human DNA damage tolerance pathways
Reposted by Christl Gaubitz
Hey #Geneva, stand up for science today at noon!
Join me & Vice Rector Sébastian Castelltort (University of Geneva) for a walk-out at the CMU (or go to Campus Biotech at 11:30, they're having one too)!
#unige
#standupforscience
#MedSky #IDSky #academicsky
standupforscience2025.org/local-event-...
Join me & Vice Rector Sébastian Castelltort (University of Geneva) for a walk-out at the CMU (or go to Campus Biotech at 11:30, they're having one too)!
#unige
#standupforscience
#MedSky #IDSky #academicsky
standupforscience2025.org/local-event-...
Local SUFS Events
Stand Up for Science is officially supporting rallies in Washington DC and 31 other cities around the country. This means that a confirmed site leader—backed by our core team—is actively organizing…
standupforscience2025.org
March 7, 2025 at 7:00 AM
Hey #Geneva, stand up for science today at noon!
Join me & Vice Rector Sébastian Castelltort (University of Geneva) for a walk-out at the CMU (or go to Campus Biotech at 11:30, they're having one too)!
#unige
#standupforscience
#MedSky #IDSky #academicsky
standupforscience2025.org/local-event-...
Join me & Vice Rector Sébastian Castelltort (University of Geneva) for a walk-out at the CMU (or go to Campus Biotech at 11:30, they're having one too)!
#unige
#standupforscience
#MedSky #IDSky #academicsky
standupforscience2025.org/local-event-...
Reposted by Christl Gaubitz
ChimeraX can run Foldseek to find similar structures, such as distantly related homologs, and analyze the results, for example, mapping all ligands onto your query structure. Here are ligands mapped onto Nipah virus G protein. www.rbvi.ucsf.edu/chimerax/dat...
March 6, 2025 at 11:06 PM
ChimeraX can run Foldseek to find similar structures, such as distantly related homologs, and analyze the results, for example, mapping all ligands onto your query structure. Here are ligands mapped onto Nipah virus G protein. www.rbvi.ucsf.edu/chimerax/dat...
Reposted by Christl Gaubitz
Very excited to share that my thesis work is out in Molecular Cell! We trained a Structure and Omics informed Classifier (SPOC) to score binary AlphaFold multimer (AF-M) predictions by structural quality and consistency with experimental omics datasets. www.cell.com/molecular-ce...
Predictomes, a classifier-curated database of AlphaFold-modeled protein-protein interactions
Schmid and Walter train a classifier that discerns functionally relevant structure
predictions in proteome-wide protein-protein interaction (PPI) screens using AlphaFold-Multimer,
and they use this co...
www.cell.com
February 26, 2025 at 6:14 PM
Very excited to share that my thesis work is out in Molecular Cell! We trained a Structure and Omics informed Classifier (SPOC) to score binary AlphaFold multimer (AF-M) predictions by structural quality and consistency with experimental omics datasets. www.cell.com/molecular-ce...
Reposted by Christl Gaubitz
Sign the Petition
Petition to Reverse the NIH Indirect Cost Cap (NOT-OD-25-068)
www.change.org
March 6, 2025 at 7:00 AM
Reposted by Christl Gaubitz
I will close the letter for signatures at 17:00 today (UK time). Last chance to voice your support before this evening's meeting of the Royal Society.
There are now over 3000 signatories to my letter asking the Royal Society to explain why it has taken no action and said nothing about evident contraventions of its code of conduct by Elon Musk FRS.
forms.gle/dBGaHk7SYUNA...
forms.gle/dBGaHk7SYUNA...
Open letter to the President of the Royal Society – time to stand up for your values
If you wish to show your support for the letter below regarding apparent inaction by the Royal Society in the face of breaches of its code of conduct by Elon Musk FRS, please sign below. I invite anyo...
forms.gle
March 3, 2025 at 12:24 PM
I will close the letter for signatures at 17:00 today (UK time). Last chance to voice your support before this evening's meeting of the Royal Society.
Reposted by Christl Gaubitz
Can AlphaFold refine structures for X-ray & Cryo-EM/ET data? Now it can! Great collab with @moalquraishi.bsky.social and @randyjread.bsky.social led by @alisiafadini.bsky.social and @minhuanli.bsky.social. 🧵below. Code to follow...
Structural biology is in an era of dynamics & assemblies but turning raw experimental data into atomic models at scale remains challenging. @minhuanli.bsky.social and I present ROCKET🚀: an AlphaFold augmentation that integrates crystallographic and cryoEM/ET data with room for more! 1/14.
February 24, 2025 at 1:18 PM
Can AlphaFold refine structures for X-ray & Cryo-EM/ET data? Now it can! Great collab with @moalquraishi.bsky.social and @randyjread.bsky.social led by @alisiafadini.bsky.social and @minhuanli.bsky.social. 🧵below. Code to follow...
Reposted by Christl Gaubitz
CT friends! We are standing up for Science on March 7th in Hartford!
Stay tuned for details —
@centromellone.bsky.social
@davidbreslowlab.bsky.social
@gregggonsalves.bsky.social @luskinglab.bsky.social
Stay tuned for details —
@centromellone.bsky.social
@davidbreslowlab.bsky.social
@gregggonsalves.bsky.social @luskinglab.bsky.social
February 23, 2025 at 2:58 AM
CT friends! We are standing up for Science on March 7th in Hartford!
Stay tuned for details —
@centromellone.bsky.social
@davidbreslowlab.bsky.social
@gregggonsalves.bsky.social @luskinglab.bsky.social
Stay tuned for details —
@centromellone.bsky.social
@davidbreslowlab.bsky.social
@gregggonsalves.bsky.social @luskinglab.bsky.social
Reposted by Christl Gaubitz
Tomorrow is the last day to submit your application for the INTERACT PhD Programme!
Apply now: https://buff.ly/4hj1bGh
Apply now: https://buff.ly/4hj1bGh
February 19, 2025 at 8:00 AM
Tomorrow is the last day to submit your application for the INTERACT PhD Programme!
Apply now: https://buff.ly/4hj1bGh
Apply now: https://buff.ly/4hj1bGh
Reposted by Christl Gaubitz
Science needs more bridges to the global south 🌍! Do share this great opportunity we are offering @mpifkf.bsky.social! Last year was a great success: www.fkf.mpg.de/8350642/2024...
We are so excited to be able to offer it again
Science benefits from diversity!
#STEM #Chemsky #SciSky #PhySky
We are so excited to be able to offer it again
Science benefits from diversity!
#STEM #Chemsky #SciSky #PhySky
February 3, 2025 at 8:32 AM
Science needs more bridges to the global south 🌍! Do share this great opportunity we are offering @mpifkf.bsky.social! Last year was a great success: www.fkf.mpg.de/8350642/2024...
We are so excited to be able to offer it again
Science benefits from diversity!
#STEM #Chemsky #SciSky #PhySky
We are so excited to be able to offer it again
Science benefits from diversity!
#STEM #Chemsky #SciSky #PhySky
Reposted by Christl Gaubitz
From a journalist friend: Just spreading the word. The CDC is purging data, so people should archive their favorite CDC datasets today, namely ones around race/ethnic diversity, LGBTQ, and reproductive health. Also health data involving climate. The youth risk behavior survey has already gone down.
January 31, 2025 at 3:43 PM
From a journalist friend: Just spreading the word. The CDC is purging data, so people should archive their favorite CDC datasets today, namely ones around race/ethnic diversity, LGBTQ, and reproductive health. Also health data involving climate. The youth risk behavior survey has already gone down.
Reposted by Christl Gaubitz
This is legit - the organizers (including unions) are organizing. When I ask those in the know what we can do that will actually matter, the answer includes collective action of this type.
I'm joining @nancykanwisher.bsky.social and all the others for this Thurs 3p ET effort. I hope you do too!
I'm joining @nancykanwisher.bsky.social and all the others for this Thurs 3p ET effort. I hope you do too!
Academic workers across the country are organizing to call on our congressional representatives on Thursday, 1/30, at 3pm ET / 12pm PT to demand these restrictions be lifted immediately.
There will be a training over zoom at the beginning of the event.
Join us!
form.jotform.com/250226137228...
There will be a training over zoom at the beginning of the event.
Join us!
form.jotform.com/250226137228...
Join researchers across the country in fighting restrictions on the NIH
Please click the link to complete this form.
form.jotform.com
January 28, 2025 at 11:15 AM
This is legit - the organizers (including unions) are organizing. When I ask those in the know what we can do that will actually matter, the answer includes collective action of this type.
I'm joining @nancykanwisher.bsky.social and all the others for this Thurs 3p ET effort. I hope you do too!
I'm joining @nancykanwisher.bsky.social and all the others for this Thurs 3p ET effort. I hope you do too!
Reposted by Christl Gaubitz
we are recruiting a postdoc to work on a collaborative project with the lab of Nynke Dekker in Oxford @nynkedekkerlab.bsky.social. Please RT www.hubrecht.eu/job/postdoc-...
Postdoc - 38 hours p/w - Hubrecht Institute
Description of the project: During every cell cycle, our cells need to accurately copy their DNA and chromatin organization. This process is essential for life, and when faulty, it leads to diseases, ...
www.hubrecht.eu
January 24, 2025 at 12:59 PM
we are recruiting a postdoc to work on a collaborative project with the lab of Nynke Dekker in Oxford @nynkedekkerlab.bsky.social. Please RT www.hubrecht.eu/job/postdoc-...
Reposted by Christl Gaubitz
@professorantony.bsky.social and our teams are excited to share new preprint on RPA phosphocode and G2-M transition. Thanks to the efforts of lead authors -Poonam Roshan and Vikas Kaushik!
Mechanism of RPA phosphocode priming and tuning by Cdk1/Wee1 signaling circuit https://www.biorxiv.org/content/10.1101/2025.01.16.633180v1
January 17, 2025 at 11:58 AM
@professorantony.bsky.social and our teams are excited to share new preprint on RPA phosphocode and G2-M transition. Thanks to the efforts of lead authors -Poonam Roshan and Vikas Kaushik!