Mark Hedglin
@hedglinlab.bsky.social
The Hedglin lab in the department of Chemistry at the Pennsylvania State University utilizes chemical, biochemical, and biophysical approaches to study the mechanisms of human genome integrity maintenance.
Pinned
Mark Hedglin
@hedglinlab.bsky.social
· Sep 17
Postdoctoral Scholar (Chemistry Department)
APPLICATION INSTRUCTIONS: CURRENT PENN STATE EMPLOYEE (faculty, staff, technical service, or student), please login to Workday to complete the internal application process. Please do not apply here, a...
psu.wd1.myworkdayjobs.com
We ARE…HIRING POSTDOCS!!
The Hedglin Lab at PSU is looking for PhD graduates interested in biophysical & kinetic investigations of human DNA replication pathways. Further details of the position are below. Please spread the word & DM with any questions.
psu.wd1.myworkdayjobs.com/PSU_Academic...
The Hedglin Lab at PSU is looking for PhD graduates interested in biophysical & kinetic investigations of human DNA replication pathways. Further details of the position are below. Please spread the word & DM with any questions.
psu.wd1.myworkdayjobs.com/PSU_Academic...
Reposted by Mark Hedglin
Great to see our latest study out in NAR Cancer: Replication-associated base excision repair/single-strand break repair regulates PARG inhibitor response via the PRMT1/PRMT5/ATR axis url: academic.oup.com/narcancer/ar... @weldeiry.bsky.social @emgsus.bsky.social
Replication-associated base excision repair/single-strand break repair regulates PARG inhibitor response via the PRMT1/PRMT5/ATR axis
Abstract. Poly(ADP-ribose) polymerases 1 and 2 (PARP1/PARP2), and poly(ADP-ribose) glycohydrolase (PARG), modulate the level of poly(ADP-ribose) (PAR), a p
academic.oup.com
December 31, 2025 at 5:16 PM
Great to see our latest study out in NAR Cancer: Replication-associated base excision repair/single-strand break repair regulates PARG inhibitor response via the PRMT1/PRMT5/ATR axis url: academic.oup.com/narcancer/ar... @weldeiry.bsky.social @emgsus.bsky.social
Great start to 2026! Another successful collaboration with @professorantony.bsky.social lab & final to piece to Dr. Jessica L. Norris's Chemistry PhD thesis with new additions by current Chemistry PhD graduate student Grace Young. Thanks to NIGMS for funding our groups.
doi.org/10.1093/nar/gkaf1478
doi.org/10.1093/nar/gkaf1478
Validate User
academic.oup.com
January 7, 2026 at 1:32 PM
Great start to 2026! Another successful collaboration with @professorantony.bsky.social lab & final to piece to Dr. Jessica L. Norris's Chemistry PhD thesis with new additions by current Chemistry PhD graduate student Grace Young. Thanks to NIGMS for funding our groups.
doi.org/10.1093/nar/gkaf1478
doi.org/10.1093/nar/gkaf1478
Reposted by Mark Hedglin
What does phosphorylation do to RPA?
This has been a long-standing question in the field of genome integrity.
In our newest publication in Nature Communications rdcu.be/eT4z3 with @proforiganti.bsky.social , we reveal the answer.
Thanks to funding from NIGMS to our groups.
This has been a long-standing question in the field of genome integrity.
In our newest publication in Nature Communications rdcu.be/eT4z3 with @proforiganti.bsky.social , we reveal the answer.
Thanks to funding from NIGMS to our groups.
December 10, 2025 at 3:49 PM
What does phosphorylation do to RPA?
This has been a long-standing question in the field of genome integrity.
In our newest publication in Nature Communications rdcu.be/eT4z3 with @proforiganti.bsky.social , we reveal the answer.
Thanks to funding from NIGMS to our groups.
This has been a long-standing question in the field of genome integrity.
In our newest publication in Nature Communications rdcu.be/eT4z3 with @proforiganti.bsky.social , we reveal the answer.
Thanks to funding from NIGMS to our groups.
Reposted by Mark Hedglin
POSTDOCTORAL POSITION IN STRUCTURAL BIOLOGY
We need a structural biologist to work on several CryoEM datasets. For more information, please visit: www.antonylab.org
Expertise in structure refinement and model-building are required.
Please share.
We need a structural biologist to work on several CryoEM datasets. For more information, please visit: www.antonylab.org
Expertise in structure refinement and model-building are required.
Please share.
ANTONY LAB SAINT LOUIS UNIVERSITY SCHOOL OF MEDICINE
Edwin Antony Lab Website
www.antonylab.org
November 18, 2025 at 7:05 PM
POSTDOCTORAL POSITION IN STRUCTURAL BIOLOGY
We need a structural biologist to work on several CryoEM datasets. For more information, please visit: www.antonylab.org
Expertise in structure refinement and model-building are required.
Please share.
We need a structural biologist to work on several CryoEM datasets. For more information, please visit: www.antonylab.org
Expertise in structure refinement and model-building are required.
Please share.
Members of @acsbiol.bsky.social, the Fall 2025 Election is occurring now & will run until 11/28. To ensure you receive your ballot, be sure that your ACS membership is up to date & your email filters are set to receive from elections@vote-now.com.
October 31, 2025 at 8:20 PM
Members of @acsbiol.bsky.social, the Fall 2025 Election is occurring now & will run until 11/28. To ensure you receive your ballot, be sure that your ACS membership is up to date & your email filters are set to receive from elections@vote-now.com.
Had such an exceptional seminar visit to the Dept. of Biochemistry & Molecular Genetics @ the University of Virginia School of Medicine. Beautiful campus & outstanding scientific community. Thank you @tmweaver.bsky.social for the invitation & all staff, students & faculty for the hospitality.
September 19, 2025 at 6:01 PM
Had such an exceptional seminar visit to the Dept. of Biochemistry & Molecular Genetics @ the University of Virginia School of Medicine. Beautiful campus & outstanding scientific community. Thank you @tmweaver.bsky.social for the invitation & all staff, students & faculty for the hospitality.
We ARE…HIRING POSTDOCS!!
The Hedglin Lab at PSU is looking for PhD graduates interested in biophysical & kinetic investigations of human DNA replication pathways. Further details of the position are below. Please spread the word & DM with any questions.
psu.wd1.myworkdayjobs.com/PSU_Academic...
The Hedglin Lab at PSU is looking for PhD graduates interested in biophysical & kinetic investigations of human DNA replication pathways. Further details of the position are below. Please spread the word & DM with any questions.
psu.wd1.myworkdayjobs.com/PSU_Academic...
Postdoctoral Scholar (Chemistry Department)
APPLICATION INSTRUCTIONS: CURRENT PENN STATE EMPLOYEE (faculty, staff, technical service, or student), please login to Workday to complete the internal application process. Please do not apply here, a...
psu.wd1.myworkdayjobs.com
September 17, 2025 at 4:16 AM
We ARE…HIRING POSTDOCS!!
The Hedglin Lab at PSU is looking for PhD graduates interested in biophysical & kinetic investigations of human DNA replication pathways. Further details of the position are below. Please spread the word & DM with any questions.
psu.wd1.myworkdayjobs.com/PSU_Academic...
The Hedglin Lab at PSU is looking for PhD graduates interested in biophysical & kinetic investigations of human DNA replication pathways. Further details of the position are below. Please spread the word & DM with any questions.
psu.wd1.myworkdayjobs.com/PSU_Academic...
Reposted by Mark Hedglin
Co-organizing a one day FREE conference on Genome Instability- Discovery to Personalized Medicine 11/1/25. Please join us! Short talks available. https//noncredit.t...
September 3, 2025 at 3:36 PM
Co-organizing a one day FREE conference on Genome Instability- Discovery to Personalized Medicine 11/1/25. Please join us! Short talks available. https//noncredit.t...
Reposted by Mark Hedglin
It is not always safe to repair DNA Damage. Sometimes, cells "just bypass it".
During DNA replication, repair of lesions on DNA can be dangerous. Cells instead "tolerate" DNA damage and focus on finishing replication.
Read our review and find out why and how: doi.org/10.1016/j.ti...
During DNA replication, repair of lesions on DNA can be dangerous. Cells instead "tolerate" DNA damage and focus on finishing replication.
Read our review and find out why and how: doi.org/10.1016/j.ti...
August 22, 2025 at 11:48 AM
It is not always safe to repair DNA Damage. Sometimes, cells "just bypass it".
During DNA replication, repair of lesions on DNA can be dangerous. Cells instead "tolerate" DNA damage and focus on finishing replication.
Read our review and find out why and how: doi.org/10.1016/j.ti...
During DNA replication, repair of lesions on DNA can be dangerous. Cells instead "tolerate" DNA damage and focus on finishing replication.
Read our review and find out why and how: doi.org/10.1016/j.ti...
Reposted by Mark Hedglin
We have openings for a postdoctoral training program on DNA Damage and Oncogenic Signaling. Our past trainees have been very successful. Apply by Aug 31 for full consideration. See link for details. www.imgs-coh.edu/postdoctoral...
Postdoctoral Training Programs
Funded by the National Cancer Institute (T32CA186895), the program at City of Hope provides exceptionally motivated, recent (2 years or less) postdoctoral fellows with scientific knowledge, researc
www.imgs-coh.edu
August 19, 2025 at 6:32 PM
We have openings for a postdoctoral training program on DNA Damage and Oncogenic Signaling. Our past trainees have been very successful. Apply by Aug 31 for full consideration. See link for details. www.imgs-coh.edu/postdoctoral...
So happy & excited to see this out. An honest & sincere thank you to the editor & reviewers for their constructive criticism & feedback that helped bring the best version of this story to life!
doi.org/10.1093/nar/...
doi.org/10.1093/nar/...
A human high-fidelity DNA polymerase holoenzyme has a wide range of lesion bypass activities
Abstract. During replication, lagging strand lesions are initially encountered by high-fidelity DNA polymerase (pol) holoenzymes comprised of pol δ and the
doi.org
July 17, 2025 at 8:25 PM
So happy & excited to see this out. An honest & sincere thank you to the editor & reviewers for their constructive criticism & feedback that helped bring the best version of this story to life!
doi.org/10.1093/nar/...
doi.org/10.1093/nar/...
Reposted by Mark Hedglin
Our new review on how the initiation of DNA replication is coordinated with transcription is now online! Congratulations to @syedshahidmusvi.bsky.social!
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
From cooperation to conflicts – a complicated relationship between transcription and replication.
A tight coordination between transcription and DNA replication is essential to maintain genome stability. Both excessive transcription and upregulated…
www.sciencedirect.com
July 17, 2025 at 2:59 PM
Our new review on how the initiation of DNA replication is coordinated with transcription is now online! Congratulations to @syedshahidmusvi.bsky.social!
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
#3 Chemistry PhD defense from the lab was a success. Congratulations Dr. Rachel Dannenberg, PhD!! We are so very proud of you & excited for your future. Thank you for your unwavering dedication, determination, grit & everlasting footprint on the lab.
June 11, 2025 at 7:30 PM
#3 Chemistry PhD defense from the lab was a success. Congratulations Dr. Rachel Dannenberg, PhD!! We are so very proud of you & excited for your future. Thank you for your unwavering dedication, determination, grit & everlasting footprint on the lab.
Reposted by Mark Hedglin
Join us NEXT WEEK for the #EMGS webinar "Oxidative DNA Damage and Repair: Impacts and Methods of Detection," featuring a workshop lead by Drs. Laurie Sanders and Tobias Dansen, a keynote talk by Dr. Karlene Cimprich, and more!
Register Today: emgs-us.org/event/OxiDNA...
Register Today: emgs-us.org/event/OxiDNA...
June 3, 2025 at 7:20 PM
Join us NEXT WEEK for the #EMGS webinar "Oxidative DNA Damage and Repair: Impacts and Methods of Detection," featuring a workshop lead by Drs. Laurie Sanders and Tobias Dansen, a keynote talk by Dr. Karlene Cimprich, and more!
Register Today: emgs-us.org/event/OxiDNA...
Register Today: emgs-us.org/event/OxiDNA...
It's official: Promoted to Associate Professor of Chemistry with Tenure. Beyond proud & excited for the lab to continue our journey in the genome stability field & charter new territories from within such an amazing community.
Penn State announces tenure-line faculty promotions, effective July 1, 2025 | Penn State University
The following is a list of academic promotions for tenured and tenure-line faculty members at Penn State, effective July 1, 2025.
www.psu.edu
May 29, 2025 at 1:04 PM
It's official: Promoted to Associate Professor of Chemistry with Tenure. Beyond proud & excited for the lab to continue our journey in the genome stability field & charter new territories from within such an amazing community.
Reposted by Mark Hedglin
Don't miss the next #EMGS webinar "Oxidative DNA Damage and Repair: Impacts and Methods of Detection," presented by the EMGS DNA Repair SIG. 🧬
Register Today: emgs-us.org/event/OxiDNAWEB
Register Today: emgs-us.org/event/OxiDNAWEB
May 6, 2025 at 6:07 PM
Don't miss the next #EMGS webinar "Oxidative DNA Damage and Repair: Impacts and Methods of Detection," presented by the EMGS DNA Repair SIG. 🧬
Register Today: emgs-us.org/event/OxiDNAWEB
Register Today: emgs-us.org/event/OxiDNAWEB
Reposted by Mark Hedglin
Our story detailing how asymmetry in nitrogenase-like proteins regulate electron transfer reactions is finally out! rdcu.be/ejaeK Congratulations to postdoc @rajnandani.bsky.social and fantastic collaborators. Thanks to funding from the Department of Energy and the NIH.
Cryo-EM captures the coordination of asymmetric electron transfer through a di-copper site in DPOR
Nature Communications - CryoEM snapshots of the nitrogenase-like DPOR protein complex captured during turnover reveal that asymmetric conformational changes, substrate recognition, and an interplay...
rdcu.be
April 24, 2025 at 2:11 PM
Our story detailing how asymmetry in nitrogenase-like proteins regulate electron transfer reactions is finally out! rdcu.be/ejaeK Congratulations to postdoc @rajnandani.bsky.social and fantastic collaborators. Thanks to funding from the Department of Energy and the NIH.
Reposted by Mark Hedglin
🧬 Don't miss the fourth and final session of NAR Cancer's 5th Anniversary Virtual Symposium!
🕛 Thursday 17 April at 12pm US Eastern time
👥 Speakers include Dr Elise Fouquerel and Dr Robert W. Sobol
Register here: lnkd.in/eRxxSxeu
#NARCancer #PARPInhibitors #DNARepair #GenomicStability
🕛 Thursday 17 April at 12pm US Eastern time
👥 Speakers include Dr Elise Fouquerel and Dr Robert W. Sobol
Register here: lnkd.in/eRxxSxeu
#NARCancer #PARPInhibitors #DNARepair #GenomicStability
April 15, 2025 at 3:23 PM
🧬 Don't miss the fourth and final session of NAR Cancer's 5th Anniversary Virtual Symposium!
🕛 Thursday 17 April at 12pm US Eastern time
👥 Speakers include Dr Elise Fouquerel and Dr Robert W. Sobol
Register here: lnkd.in/eRxxSxeu
#NARCancer #PARPInhibitors #DNARepair #GenomicStability
🕛 Thursday 17 April at 12pm US Eastern time
👥 Speakers include Dr Elise Fouquerel and Dr Robert W. Sobol
Register here: lnkd.in/eRxxSxeu
#NARCancer #PARPInhibitors #DNARepair #GenomicStability
Excited to share our new pre-print. Direct, ensemble FRET assays developed by our lab reveal that assembly of Rad51 filaments at stalled replication sites via RPA/Rad51 exchange causes complete & irreversible PCNA unloading. Big implications for interplay between human DNA damage tolerance pathways
www.biorxiv.org
April 1, 2025 at 5:58 PM
Excited to share our new pre-print. Direct, ensemble FRET assays developed by our lab reveal that assembly of Rad51 filaments at stalled replication sites via RPA/Rad51 exchange causes complete & irreversible PCNA unloading. Big implications for interplay between human DNA damage tolerance pathways
Reposted by Mark Hedglin
The final piece of my postdoctoral work in the @freudlab.bsky.social was recently published!
Quite amazing what this small little repair polymerase can do to fill 1-nt gaps in chromatin.
www.nature.com/articles/s41...
Quite amazing what this small little repair polymerase can do to fill 1-nt gaps in chromatin.
www.nature.com/articles/s41...
March 24, 2025 at 12:33 PM
The final piece of my postdoctoral work in the @freudlab.bsky.social was recently published!
Quite amazing what this small little repair polymerase can do to fill 1-nt gaps in chromatin.
www.nature.com/articles/s41...
Quite amazing what this small little repair polymerase can do to fill 1-nt gaps in chromatin.
www.nature.com/articles/s41...
Reposted by Mark Hedglin
Why does yeast replication require two alternative clamp loaders?
Joe Yeeles and coworkers show that RFC can only load PCNA on lagging strands, while leading strand polymerases necessitate the involvement of CMG-interaction Ctf18-RFC
www.embopress.org/doi/full/10....
Joe Yeeles and coworkers show that RFC can only load PCNA on lagging strands, while leading strand polymerases necessitate the involvement of CMG-interaction Ctf18-RFC
www.embopress.org/doi/full/10....
March 3, 2025 at 5:28 PM
Why does yeast replication require two alternative clamp loaders?
Joe Yeeles and coworkers show that RFC can only load PCNA on lagging strands, while leading strand polymerases necessitate the involvement of CMG-interaction Ctf18-RFC
www.embopress.org/doi/full/10....
Joe Yeeles and coworkers show that RFC can only load PCNA on lagging strands, while leading strand polymerases necessitate the involvement of CMG-interaction Ctf18-RFC
www.embopress.org/doi/full/10....
Reposted by Mark Hedglin
Exciting new preprint led by @glowingtelomeres.bsky.social reveals how 6-thio-dG (THIO drug) targets telomeres in cancers. This drug “traps” telomerase in a non-productive state to prevent telomere lengthening and cancer cell growth. www.biorxiv.org/content/10.1...
Chemotherapeutic 6-thio-2’-deoxyguanosine selectively targets and inhibits telomerase by inducing a non-productive telomere-bound telomerase complex
Most cancers upregulate the telomere lengthening enzyme telomerase to achieve unlimited cell division. How chemotherapeutic nucleoside 6-thio-2’-deoxyguanosine (6-thio-dG) targets telomerase to inhibi...
www.biorxiv.org
March 3, 2025 at 6:34 PM
Exciting new preprint led by @glowingtelomeres.bsky.social reveals how 6-thio-dG (THIO drug) targets telomeres in cancers. This drug “traps” telomerase in a non-productive state to prevent telomere lengthening and cancer cell growth. www.biorxiv.org/content/10.1...
Reposted by Mark Hedglin
NAR Cancer 5th anniversary symposium on manipulating DNA repair and the DDR - Session 2 this Thursday, Feb 13, noon US Eastern time. Kara Bernstein and Joanna Loizou speaking. In collaboration with Social DNAing. Information and free registration link at academic.oup.com/narcancer/pa...
February 11, 2025 at 3:56 PM
NAR Cancer 5th anniversary symposium on manipulating DNA repair and the DDR - Session 2 this Thursday, Feb 13, noon US Eastern time. Kara Bernstein and Joanna Loizou speaking. In collaboration with Social DNAing. Information and free registration link at academic.oup.com/narcancer/pa...
Reposted by Mark Hedglin
We are still accepting application for the Postdoc position in my lab! We have some exciting projects at the interface of DNA repair and chromatin biology. If interested, please get in touch or apply for the position through the link below!
jobs.virginia.edu/us/en/job/R0...
jobs.virginia.edu/us/en/job/R0...
jobs.virginia.edu
February 10, 2025 at 2:24 PM
We are still accepting application for the Postdoc position in my lab! We have some exciting projects at the interface of DNA repair and chromatin biology. If interested, please get in touch or apply for the position through the link below!
jobs.virginia.edu/us/en/job/R0...
jobs.virginia.edu/us/en/job/R0...