Tyler Weaver
@tmweaver.bsky.social
Assistant Professor, Biochemistry and Molecular Genetics, UVA School of Medicine. Studying mechanisms of chromatin-based DNA repair.
Check out the perspective my lab wrote with @freudlab.bsky.social. We provide our perspective on recent work describing the structural basis of chromatin-based base excision repair!
🎉 Joint paper from the Freudenthal and @tmweaver.bsky.social Labs!
Abbey Vito’s first publication discusses a tug-of-war between BER enzymes and chromatin for access to damaged DNA, a battle central to genome stability.
Built on Tyler's foundational work! tinyurl.com/ywkt2bt5
Abbey Vito’s first publication discusses a tug-of-war between BER enzymes and chromatin for access to damaged DNA, a battle central to genome stability.
Built on Tyler's foundational work! tinyurl.com/ywkt2bt5
Base excision repair in chromatin: A tug-of-war for DNA damage
Base excision repair (BER) is a genome surveillance pathway responsible for repairing DNA base lesions distributed throughout the chromatinized eukary…
tinyurl.com
November 4, 2025 at 11:10 AM
Check out the perspective my lab wrote with @freudlab.bsky.social. We provide our perspective on recent work describing the structural basis of chromatin-based base excision repair!
Reposted by Tyler Weaver
See our paper “Mechanism of trinucleotide repeat expansion by MutSβ-MutLγ and contraction by FAN1”. Using biochemistry, we show how DNA incisions by the MutLγ nuclease can lead to expansions, and how expansion is prevented by FAN1. Well done Issam and Valentina!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
October 27, 2025 at 1:12 PM
See our paper “Mechanism of trinucleotide repeat expansion by MutSβ-MutLγ and contraction by FAN1”. Using biochemistry, we show how DNA incisions by the MutLγ nuclease can lead to expansions, and how expansion is prevented by FAN1. Well done Issam and Valentina!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
The final piece of my postdoctoral work in the @freudlab.bsky.social was recently published!
Quite amazing what this small little repair polymerase can do to fill 1-nt gaps in chromatin.
www.nature.com/articles/s41...
Quite amazing what this small little repair polymerase can do to fill 1-nt gaps in chromatin.
www.nature.com/articles/s41...
March 24, 2025 at 12:33 PM
The final piece of my postdoctoral work in the @freudlab.bsky.social was recently published!
Quite amazing what this small little repair polymerase can do to fill 1-nt gaps in chromatin.
www.nature.com/articles/s41...
Quite amazing what this small little repair polymerase can do to fill 1-nt gaps in chromatin.
www.nature.com/articles/s41...
Reposted by Tyler Weaver
🔊There's still time to register for the #EMGS webinar: An Applied Genetic Toxicology Career in the Pharmaceutical Industry with Zhanna Sobol on April 8, 2025 at 12:00 PM EST!
Register Now: emgs-us.org/event/AGTCPI...
Register Now: emgs-us.org/event/AGTCPI...
March 12, 2025 at 6:36 PM
🔊There's still time to register for the #EMGS webinar: An Applied Genetic Toxicology Career in the Pharmaceutical Industry with Zhanna Sobol on April 8, 2025 at 12:00 PM EST!
Register Now: emgs-us.org/event/AGTCPI...
Register Now: emgs-us.org/event/AGTCPI...
Reposted by Tyler Weaver
I am extremely proud to see our work about Hepatitis B now published in @cellpress.bsky.social
From basic research to identifying the key step of infection & a potential first drug for curing this devastating disease. This has been an incredible journey.🧵
www.cell.com/cell/fulltex...
From basic research to identifying the key step of infection & a potential first drug for curing this devastating disease. This has been an incredible journey.🧵
www.cell.com/cell/fulltex...
A nucleosome switch primes hepatitis B virus infection
A reconstituted cccDNA platform facilitated the discovery of an early chromatinization
event that promotes transcription of the hepatitis B virus (HBV) regulatory X gene.
The use of a small-molecule c...
www.cell.com
February 21, 2025 at 5:31 PM
I am extremely proud to see our work about Hepatitis B now published in @cellpress.bsky.social
From basic research to identifying the key step of infection & a potential first drug for curing this devastating disease. This has been an incredible journey.🧵
www.cell.com/cell/fulltex...
From basic research to identifying the key step of infection & a potential first drug for curing this devastating disease. This has been an incredible journey.🧵
www.cell.com/cell/fulltex...
We are still accepting application for the Postdoc position in my lab! We have some exciting projects at the interface of DNA repair and chromatin biology. If interested, please get in touch or apply for the position through the link below!
jobs.virginia.edu/us/en/job/R0...
jobs.virginia.edu/us/en/job/R0...
jobs.virginia.edu
February 10, 2025 at 2:24 PM
We are still accepting application for the Postdoc position in my lab! We have some exciting projects at the interface of DNA repair and chromatin biology. If interested, please get in touch or apply for the position through the link below!
jobs.virginia.edu/us/en/job/R0...
jobs.virginia.edu/us/en/job/R0...
Reposted by Tyler Weaver
Come be our colleague! @cu-bmg.bsky.social is running an open rank search for a structural biologist specializing in cryo-EM/ET. This is a great opportunity in a highly collegial and collaborative department.
Apply here: cu.taleo.net/careersectio...
Apply here: cu.taleo.net/careersectio...
January 27, 2025 at 4:36 PM
Come be our colleague! @cu-bmg.bsky.social is running an open rank search for a structural biologist specializing in cryo-EM/ET. This is a great opportunity in a highly collegial and collaborative department.
Apply here: cu.taleo.net/careersectio...
Apply here: cu.taleo.net/careersectio...
My lab at UVA is looking to hire a Lab Technician to join our team! This position is ideal for someone interested in obtaining research experience prior to graduate and/or medical school.
jobs.virginia.edu/us/en/job/UO...
jobs.virginia.edu/us/en/job/UO...
Lab Technician 1 or 2 in Biochemistry & Molecular Genetics in Charlottesville, Virginia, United States of America | Research at University of Virginia
Apply for Lab Technician 1 or 2 in Biochemistry & Molecular Genetics job with University of Virginia in Charlottesville, Virginia, United States of America. Research at University of Virginia
jobs.virginia.edu
January 27, 2025 at 4:06 PM
My lab at UVA is looking to hire a Lab Technician to join our team! This position is ideal for someone interested in obtaining research experience prior to graduate and/or medical school.
jobs.virginia.edu/us/en/job/UO...
jobs.virginia.edu/us/en/job/UO...
Reposted by Tyler Weaver
It is still possible to apply to this postdoc position in my group if you are motivated by using your QM/MM and MD skills to study the fascinating histone post-translational modifications! 🥳
Deadline is the 1st of March #job #compchem #histones #DNA
Apply on the CNRS website : lnkd.in/eNxR-TPH
Deadline is the 1st of March #job #compchem #histones #DNA
Apply on the CNRS website : lnkd.in/eNxR-TPH
First post here, how exciting!! 🥳
📣💻[JOB OFFER] I am looking for a postdoc with experience in QM/MM, MD and biosystems, and who would be motivated to study the formation mechanisms of oxydative histone modifications. Please share! #compchem #histones #PTM #redox
www.linkedin.com/posts/activi...
📣💻[JOB OFFER] I am looking for a postdoc with experience in QM/MM, MD and biosystems, and who would be motivated to study the formation mechanisms of oxydative histone modifications. Please share! #compchem #histones #PTM #redox
www.linkedin.com/posts/activi...
Emmanuelle Bignon on LinkedIn: Job offer - pdoc CHROM
📢🧬I have a postdoc position open for people with experience using QM/MM on biosystems! Do not hesitate to apply if you're interested in investigating the…
www.linkedin.com
January 21, 2025 at 11:07 AM
It is still possible to apply to this postdoc position in my group if you are motivated by using your QM/MM and MD skills to study the fascinating histone post-translational modifications! 🥳
Deadline is the 1st of March #job #compchem #histones #DNA
Apply on the CNRS website : lnkd.in/eNxR-TPH
Deadline is the 1st of March #job #compchem #histones #DNA
Apply on the CNRS website : lnkd.in/eNxR-TPH
Reposted by Tyler Weaver
The #EMGS is now seeking a new Editor-in-Chief for
@EMMjournal! In this pivotal role, the new EIC will influence EMM’s direction and uphold its high scientific standards as the official journal of the EMGS!
Learn More: emgs-us.org/news/687716/...
@EMMjournal! In this pivotal role, the new EIC will influence EMM’s direction and uphold its high scientific standards as the official journal of the EMGS!
Learn More: emgs-us.org/news/687716/...
December 16, 2024 at 5:24 PM
The #EMGS is now seeking a new Editor-in-Chief for
@EMMjournal! In this pivotal role, the new EIC will influence EMM’s direction and uphold its high scientific standards as the official journal of the EMGS!
Learn More: emgs-us.org/news/687716/...
@EMMjournal! In this pivotal role, the new EIC will influence EMM’s direction and uphold its high scientific standards as the official journal of the EMGS!
Learn More: emgs-us.org/news/687716/...
My lab is looking to hire a Postdoc to study mechanisms of DNA repair in chromatin using biochemical, biophysical, and structural biology approaches! Feel free to share with anyone you think may be interested.
jobs.virginia.edu/us/en/job/R0...
jobs.virginia.edu/us/en/job/R0...
Postdoctoral Research Associate in Biochemistry and Molecular Genetics – Weaver Lab in Charlottesville, Virginia, United States of America | Research at University of Virginia
Apply for Postdoctoral Research Associate in Biochemistry and Molecular Genetics – Weaver Lab job with University of Virginia in Charlottesville, Virginia, United States of America. Research at Univer...
jobs.virginia.edu
January 16, 2025 at 8:35 PM
My lab is looking to hire a Postdoc to study mechanisms of DNA repair in chromatin using biochemical, biophysical, and structural biology approaches! Feel free to share with anyone you think may be interested.
jobs.virginia.edu/us/en/job/R0...
jobs.virginia.edu/us/en/job/R0...
Reposted by Tyler Weaver
Our Pathway to Independence programme aims to support postdocs going on the job market in 2025 with training, mentorship, profile-raising and networking opportunities.
Apply by 31 Jan 2025: https://buff.ly/3VJGgDC
#DevBio #StemCells🧪
Apply by 31 Jan 2025: https://buff.ly/3VJGgDC
#DevBio #StemCells🧪
January 14, 2025 at 4:15 PM
Our Pathway to Independence programme aims to support postdocs going on the job market in 2025 with training, mentorship, profile-raising and networking opportunities.
Apply by 31 Jan 2025: https://buff.ly/3VJGgDC
#DevBio #StemCells🧪
Apply by 31 Jan 2025: https://buff.ly/3VJGgDC
#DevBio #StemCells🧪
The Weaver Lab is officially open today…Let’s see if we can fill up this empty lab space!
January 2, 2025 at 5:55 PM
The Weaver Lab is officially open today…Let’s see if we can fill up this empty lab space!
Reposted by Tyler Weaver
Is chromatin ordered or disordered? It all depends on the linker DNA length.
Check our latest work with Mike Rosen and Sy Redding. We explore how changes in linker DNA length (as small as 1 bp) fine-tune chromatin structure, between order and disorder, and the properties of chromatin droplets
Check our latest work with Mike Rosen and Sy Redding. We explore how changes in linker DNA length (as small as 1 bp) fine-tune chromatin structure, between order and disorder, and the properties of chromatin droplets
December 24, 2024 at 9:48 AM
Is chromatin ordered or disordered? It all depends on the linker DNA length.
Check our latest work with Mike Rosen and Sy Redding. We explore how changes in linker DNA length (as small as 1 bp) fine-tune chromatin structure, between order and disorder, and the properties of chromatin droplets
Check our latest work with Mike Rosen and Sy Redding. We explore how changes in linker DNA length (as small as 1 bp) fine-tune chromatin structure, between order and disorder, and the properties of chromatin droplets
Our preprint from earlier this year on the oxidation-induced mutational landscape in human cells was just published! www.nature.com/articles/s41...
I’m still amazed how much chromatin structure impacts oxidation-induced mutagenesis. Our cryo-EM contribution in this work provides a glimpse into why!
I’m still amazed how much chromatin structure impacts oxidation-induced mutagenesis. Our cryo-EM contribution in this work provides a glimpse into why!
December 23, 2024 at 10:58 PM
Our preprint from earlier this year on the oxidation-induced mutational landscape in human cells was just published! www.nature.com/articles/s41...
I’m still amazed how much chromatin structure impacts oxidation-induced mutagenesis. Our cryo-EM contribution in this work provides a glimpse into why!
I’m still amazed how much chromatin structure impacts oxidation-induced mutagenesis. Our cryo-EM contribution in this work provides a glimpse into why!
Reposted by Tyler Weaver
a short and sweet paper in which we use 3D STED and Micro-C analysis to show dramatic changes in large 3D chromatin structures in quiescence. www.biorxiv.org/content/10.1...
Sir2 is required for the quiescence-specific condensed three-dimensional chromatin structure of rDNA
Quiescence in Saccharomyces cerevisiae is a reversible G0 crucial for long-term survival under nutrient-deprived conditions. During quiescence, the genome is hypoacetylated and chromatin undergoes sig...
www.biorxiv.org
December 13, 2024 at 2:59 PM
a short and sweet paper in which we use 3D STED and Micro-C analysis to show dramatic changes in large 3D chromatin structures in quiescence. www.biorxiv.org/content/10.1...
Reposted by Tyler Weaver
www.biorxiv.org/content/10.1... incredible study from Huabin Zhou and the Villa & Rosen labs -- a blueprint for mapping human chromatin with cryo-ET. The future of chromatin structural analysis in situ has arrived.
Quantitative Spatial Analysis of Chromatin Biomolecular Condensates using Cryo-Electron Tomography
Phase separation is an important mechanism to generate certain biomolecular condensates and organize the cell interior. Condensate formation and function remain incompletely understood due to difficul...
www.biorxiv.org
December 6, 2024 at 2:32 PM
www.biorxiv.org/content/10.1... incredible study from Huabin Zhou and the Villa & Rosen labs -- a blueprint for mapping human chromatin with cryo-ET. The future of chromatin structural analysis in situ has arrived.
Reposted by Tyler Weaver
Today was the last day in lab for @tmweaver.bsky.social. We enjoyed lunch and gave him a 3D print of his first cryo-EM structure.
Tyler's era was marked by incredible science, friendship, fun, collabs, and cats! He will do amazing at UVA running his own lab. We will miss you buddy #gogetem 🥹
Tyler's era was marked by incredible science, friendship, fun, collabs, and cats! He will do amazing at UVA running his own lab. We will miss you buddy #gogetem 🥹
December 2, 2024 at 10:54 PM
Today was the last day in lab for @tmweaver.bsky.social. We enjoyed lunch and gave him a 3D print of his first cryo-EM structure.
Tyler's era was marked by incredible science, friendship, fun, collabs, and cats! He will do amazing at UVA running his own lab. We will miss you buddy #gogetem 🥹
Tyler's era was marked by incredible science, friendship, fun, collabs, and cats! He will do amazing at UVA running his own lab. We will miss you buddy #gogetem 🥹
Reposted by Tyler Weaver
Super excited to share our latest paper led by graduate student Mariia Mikhova! She used single molecule live cell imaging to dissect the kinetics of DNA break repair by non homologous end joining. We estimate the NHEJ pathway can repair up to 1000 breaks per minute!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Single-molecule imaging reveals the kinetics of non-homologous end-joining in living cells - Nature Communications
Non-homologous end joining repairs most double stranded DNA breaks in human cells. Here, the authors apply a single-molecule imaging approach visualizing the recruitment of DNA repair proteins to DNA ...
www.nature.com
November 23, 2024 at 1:14 AM
Super excited to share our latest paper led by graduate student Mariia Mikhova! She used single molecule live cell imaging to dissect the kinetics of DNA break repair by non homologous end joining. We estimate the NHEJ pathway can repair up to 1000 breaks per minute!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Tyler Weaver
Happy to celebrate Brittiani Schnable's PhD work on thymine DNA glycosylase! www.nature.com/articles/s41...
Thymine DNA glycosylase combines sliding, hopping, and nucleosome interactions to efficiently search for 5-formylcytosine - Nature Communications
Thymine DNA glycosylase is an essential DNA repair enzyme involved in oxidative demethylation of 5- methylC. In this study the authors have tracked specific and non-specific DNA binding of TDG at the ...
www.nature.com
November 20, 2024 at 10:06 PM
Happy to celebrate Brittiani Schnable's PhD work on thymine DNA glycosylase! www.nature.com/articles/s41...
Reposted by Tyler Weaver
Our paper on the strange ATP-dependent chromatin remodeler Smarcad1 paper is out and freely accessible. Differential regulation of its many activities by phosphorylation. Congrats to Briana and @nhoitsma.bsky.social 🧪https://www.sciencedirect.com/science/article/pii/S0021925824023950?via%3Dihub
Phosphorylation regulates the chromatin remodeler SMARCAD1 in nucleosome binding, ATP hydrolysis, and histone exchange
Maintaining the dynamic structure of chromatin is critical for regulating the cellular processes that require access to the DNA template, such as DNA …
www.sciencedirect.com
November 18, 2024 at 8:48 PM
Our paper on the strange ATP-dependent chromatin remodeler Smarcad1 paper is out and freely accessible. Differential regulation of its many activities by phosphorylation. Congrats to Briana and @nhoitsma.bsky.social 🧪https://www.sciencedirect.com/science/article/pii/S0021925824023950?via%3Dihub
Time to introduce myself! Incoming Assistant Professor at UVA-SOM. Interested in chromatin structure and DNA repair.
Here is some of my final work in the @freudlab.bsky.social, where we determine how 1-nt gaps in the nucleosome are filled during DNA repair.
www.biorxiv.org/content/10.1...
Here is some of my final work in the @freudlab.bsky.social, where we determine how 1-nt gaps in the nucleosome are filled during DNA repair.
www.biorxiv.org/content/10.1...
November 15, 2024 at 2:19 PM
Time to introduce myself! Incoming Assistant Professor at UVA-SOM. Interested in chromatin structure and DNA repair.
Here is some of my final work in the @freudlab.bsky.social, where we determine how 1-nt gaps in the nucleosome are filled during DNA repair.
www.biorxiv.org/content/10.1...
Here is some of my final work in the @freudlab.bsky.social, where we determine how 1-nt gaps in the nucleosome are filled during DNA repair.
www.biorxiv.org/content/10.1...
Reposted by Tyler Weaver
New DNA repair/genome stability work by our
@icrlondon.bsky.social colleagues, led by Peter Martin in Wojciech Niedzwiedz’ lab. Check it out!
@icrlondon.bsky.social colleagues, led by Peter Martin in Wojciech Niedzwiedz’ lab. Check it out!
The mitotic CIP2A-TOPBP1 axis facilitates mitotic pathway choice between MiDAS and MMEJ https://www.biorxiv.org/content/10.1101/2024.11.12.621593v1
The mitotic CIP2A-TOPBP1 axis facilitates mitotic pathway choice between MiDAS and MMEJ https://www.biorxiv.org/content/10.1101/2024.11.12.621593v1
Mitotic DNA double-strand breaks (DSBs) accumulate in response to replication stress or BRCA1/2 defi
www.biorxiv.org
November 14, 2024 at 7:02 AM
New DNA repair/genome stability work by our
@icrlondon.bsky.social colleagues, led by Peter Martin in Wojciech Niedzwiedz’ lab. Check it out!
@icrlondon.bsky.social colleagues, led by Peter Martin in Wojciech Niedzwiedz’ lab. Check it out!