Christine Cucinotta
@chrstne.bsky.social
Assistant prof at OSU|epigenomics of cellular reawakening in yeast & neural stem cells|views mine!|she/her
Diversity, Equity, & Inclusion are values essential to an ethical and modern society|Black lives matter|Trans rights are human rights
Diversity, Equity, & Inclusion are values essential to an ethical and modern society|Black lives matter|Trans rights are human rights
Reposted by Christine Cucinotta
🎉 LEE LAB PAPER ANNOUNCEMENT for this month's issue of #GENETICS! We're celebrating from both coasts, bc after defending her MS in 2024, Deepshi's now a biotech researcher in the Bay Area.
tl;dr: nucleosome remodeling is necessary to repair germline DNA damage 🧬
academic.oup.com/genetics/art...
tl;dr: nucleosome remodeling is necessary to repair germline DNA damage 🧬
academic.oup.com/genetics/art...
February 9, 2026 at 6:26 PM
🎉 LEE LAB PAPER ANNOUNCEMENT for this month's issue of #GENETICS! We're celebrating from both coasts, bc after defending her MS in 2024, Deepshi's now a biotech researcher in the Bay Area.
tl;dr: nucleosome remodeling is necessary to repair germline DNA damage 🧬
academic.oup.com/genetics/art...
tl;dr: nucleosome remodeling is necessary to repair germline DNA damage 🧬
academic.oup.com/genetics/art...
Reposted by Christine Cucinotta
I think that, like with art, papers offer an opportunity for you to tell the story your own way. Could another person research the same question? Yes. However, each person has the opportunity to do it and communicate it in their own way, and we must protect that 🧪
February 10, 2026 at 3:13 PM
I think that, like with art, papers offer an opportunity for you to tell the story your own way. Could another person research the same question? Yes. However, each person has the opportunity to do it and communicate it in their own way, and we must protect that 🧪
Reposted by Christine Cucinotta
Let’s make it viral folks. Thank you @histoftech.bsky.social.
No joke: I got angry hate mail today for writing an obituary of a Black woman scientist—because the person felt she did didn’t deserve the recognition.
Which just makes me want to share it again: www.nature.com/articles/d41...
Which just makes me want to share it again: www.nature.com/articles/d41...
Gladys Mae West obituary: mathematician who pioneered GPS technology
She made key contributions to US cold-war science despite facing huge barriers as a Black woman.
www.nature.com
February 6, 2026 at 2:27 PM
Let’s make it viral folks. Thank you @histoftech.bsky.social.
Reposted by Christine Cucinotta
🧬🔬🎥 @science.org Live-cell single-molecule dynamics of eukaryotic RNA polymerase machineries | Science www.science.org/doi/10.1126/...
Live-cell single-molecule dynamics of eukaryotic RNA polymerase machineries
Eukaryotic gene expression is orchestrated by RNA polymerases (RNAPI, II, and III) and associated factors, yet their real-time dynamics remain obscure. Using single-molecule tracking in living yeast, ...
www.science.org
February 6, 2026 at 12:14 AM
🧬🔬🎥 @science.org Live-cell single-molecule dynamics of eukaryotic RNA polymerase machineries | Science www.science.org/doi/10.1126/...
Reposted by Christine Cucinotta
So the question here is mis-specified. There is no "alternative" research funding in any way that would make American biomedical research whole for researchers to seek out. 1/ www.statnews.com/2026/02/03/p... via @statnews.com
We asked whether principal investigators have plans in place for how research can continue without them
Researchers must be mindful of unexpected events that may leave them incapacitated or unable to lead their research projects or labs.
www.statnews.com
February 4, 2026 at 10:35 AM
So the question here is mis-specified. There is no "alternative" research funding in any way that would make American biomedical research whole for researchers to seek out. 1/ www.statnews.com/2026/02/03/p... via @statnews.com
Reposted by Christine Cucinotta
More attention here, please.
Floored by this story. A man wrote a pollite email to a federal prosecutor objecting to the deportation of an Afghan seeking asylum. DHS responded with an administrative warrant to get the man's info from Google, then visited his home to intimidate him.
DHS Hunts Down 67-Year-Old U.S. Citizen Who Criticized Them in Email
The Department of Homeland Security is using a little-known tool to go after its critics.
newrepublic.com
February 4, 2026 at 12:10 AM
More attention here, please.
Reposted by Christine Cucinotta
Terrific paper on a new chromosomal
compartment where extensive loop
extrusion isolates domains from
other such domains
compartment where extensive loop
extrusion isolates domains from
other such domains
How do compartmentalization & loop extrusion organize eukaryotic genomes beyond classical model organisms?
Hi-C analysis of silkworm chromosomes by Drinnenberg, Muller, Mirny et al reveals new combination of these mechanisms, and a new, secluded “S” compartment
link.springer.com/article/10.1...
Hi-C analysis of silkworm chromosomes by Drinnenberg, Muller, Mirny et al reveals new combination of these mechanisms, and a new, secluded “S” compartment
link.springer.com/article/10.1...
Unique territorial and compartmental organization of chromosomes in the holocentric silkworm - The EMBO Journal
Hallmarks of multicellular eukaryotic genome organization are chromosome territories, compartments, and loop-extrusion-mediated structures, including TADs. However, these have mainly been observed in ...
link.springer.com
February 3, 2026 at 9:55 PM
Terrific paper on a new chromosomal
compartment where extensive loop
extrusion isolates domains from
other such domains
compartment where extensive loop
extrusion isolates domains from
other such domains
Reposted by Christine Cucinotta
Unquestionably the result of combined effort from all current and former lab members, support from colleagues @CSU and @CU, and support from @hhmi-science.bsky.social and NIH over decades. A heartfelt 🙏 to my nominators and of course @vilcekfoundation.bsky.social.
vilcek.org/prizes/prize...
vilcek.org/prizes/prize...
Karolin Luger - Vilcek Foundation
Karolin Luger's research led to the capture of a high resolution image of chromatin, resulting in the development of innovative drug treatments for diseases like cancer.
vilcek.org
February 2, 2026 at 11:37 PM
Unquestionably the result of combined effort from all current and former lab members, support from colleagues @CSU and @CU, and support from @hhmi-science.bsky.social and NIH over decades. A heartfelt 🙏 to my nominators and of course @vilcekfoundation.bsky.social.
vilcek.org/prizes/prize...
vilcek.org/prizes/prize...
Reposted by Christine Cucinotta
excellent thread
I had intended to post something about this new Google DeepMind paper that appeared yesterday in Nature, but the press coverage has added to what there is to say. So this is a long 🧵
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Advancing regulatory variant effect prediction with AlphaGenome - Nature
AlphaGenome, a deep learning model that inputs 1-Mb DNA sequence to predict functional genomic tracks at single-base resolution across diverse modalities, outperforms existing models in variant effect...
www.nature.com
January 30, 2026 at 1:01 PM
excellent thread
Reposted by Christine Cucinotta
Everyone who tut-tuts co-workers concerned about their job and health insurance should probably include some info on their own household finances, retirement situation and health conditions, current and anticipated.
Powerful piece in STAT this morning from some NIH staff members who have resigned
www.statnews.com/2026/01/10/n...
1/3
www.statnews.com/2026/01/10/n...
1/3
The NIH has lost its scientific integrity. So we left
“We can no longer lend our credibility to an organization that has lost its integrity,” write four scientists and administrators who recently resigned from the NIH.
www.statnews.com
January 10, 2026 at 4:04 PM
Everyone who tut-tuts co-workers concerned about their job and health insurance should probably include some info on their own household finances, retirement situation and health conditions, current and anticipated.
Reposted by Christine Cucinotta
Join our virtual seminar!
@sedonamurphy.bsky.social presents cutting-edge research on 3D genome organisation & epigenetic memory in development, moderated by @stefanschoenfelder.bsky.social
📅 Jan 8, 4pm UK
💻 Zoom
Register: us02web.zoom.us/webinar/regi...
#3DGenome #Epigenetics #ChromatinBiology
@sedonamurphy.bsky.social presents cutting-edge research on 3D genome organisation & epigenetic memory in development, moderated by @stefanschoenfelder.bsky.social
📅 Jan 8, 4pm UK
💻 Zoom
Register: us02web.zoom.us/webinar/regi...
#3DGenome #Epigenetics #ChromatinBiology
January 6, 2026 at 2:04 PM
Join our virtual seminar!
@sedonamurphy.bsky.social presents cutting-edge research on 3D genome organisation & epigenetic memory in development, moderated by @stefanschoenfelder.bsky.social
📅 Jan 8, 4pm UK
💻 Zoom
Register: us02web.zoom.us/webinar/regi...
#3DGenome #Epigenetics #ChromatinBiology
@sedonamurphy.bsky.social presents cutting-edge research on 3D genome organisation & epigenetic memory in development, moderated by @stefanschoenfelder.bsky.social
📅 Jan 8, 4pm UK
💻 Zoom
Register: us02web.zoom.us/webinar/regi...
#3DGenome #Epigenetics #ChromatinBiology
Reposted by Christine Cucinotta
Can someone please respond to Stephen Miller with this message from Frank Sinatra?
December 26, 2025 at 8:04 PM
Can someone please respond to Stephen Miller with this message from Frank Sinatra?
Reposted by Christine Cucinotta
Please folks. Learn the history.
December 26, 2025 at 9:01 PM
Please folks. Learn the history.
Reposted by Christine Cucinotta
My lab is hiring a postdoc (ERC funded)! If you're interested, get in touch!
December 18, 2025 at 8:36 AM
My lab is hiring a postdoc (ERC funded)! If you're interested, get in touch!
Reposted by Christine Cucinotta
A major output of the 4D Nucleome project appeared today. This is the joint effort of many scientists working together and (publicly) sharing data and results for several years. We hope this is of interest to many genome biologists!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
An integrated view of the structure and function of the human 4D nucleome - Nature
The 4D Nucleome Project demonstrates the use of genomic assays and computational methods to measure genome folding and then predict genomic structure from DNA sequence, facilitatin...
www.nature.com
December 17, 2025 at 8:59 PM
A major output of the 4D Nucleome project appeared today. This is the joint effort of many scientists working together and (publicly) sharing data and results for several years. We hope this is of interest to many genome biologists!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Christine Cucinotta
@pravrutharaman.bsky.social got super intrigued about EZHIP/CATACOMB, previously identified as a histone H3K27M mimic of PRC2. You can read about her efforts here: www.biorxiv.org/content/10.6... We hope these analyses will help spur more analyses in this very cool gene! 1/
Dynamic evolution of EZHIP, an inhibitor of the Polycomb Repressive Complex 2 in mammals
The Polycomb Repressive Complex 2 (PRC2) is an ancient, conserved chromatin-interacting complex that controls gene expression, facilitating differentiation and cellular identity during development. It...
www.biorxiv.org
December 13, 2025 at 10:08 PM
@pravrutharaman.bsky.social got super intrigued about EZHIP/CATACOMB, previously identified as a histone H3K27M mimic of PRC2. You can read about her efforts here: www.biorxiv.org/content/10.6... We hope these analyses will help spur more analyses in this very cool gene! 1/
Reposted by Christine Cucinotta
Confused by all the histones that are cropping up in organisms that are decidedly NOT eukaryotes? check out our review - fantastic work by team NucEvo in the #Lugerlab
The Expanding Histone Universe: Histone-Based DNA Organization in Noneukaryotic Organisms - www.annualreviews.org/content/jour...
The Expanding Histone Universe: Histone-Based DNA Organization in Noneukaryotic Organisms - www.annualreviews.org/content/jour...
December 9, 2025 at 3:14 PM
Confused by all the histones that are cropping up in organisms that are decidedly NOT eukaryotes? check out our review - fantastic work by team NucEvo in the #Lugerlab
The Expanding Histone Universe: Histone-Based DNA Organization in Noneukaryotic Organisms - www.annualreviews.org/content/jour...
The Expanding Histone Universe: Histone-Based DNA Organization in Noneukaryotic Organisms - www.annualreviews.org/content/jour...
coming up for air after long periods of major depression feels like whiplash. late to the horrible news of our loss of Zara Weinberg.
at a loss for words but she was one of the most amazing people i’ve known. brilliant. empathetic. making a huge difference in the world. i will miss her terribly.
at a loss for words but she was one of the most amazing people i’ve known. brilliant. empathetic. making a huge difference in the world. i will miss her terribly.
December 2, 2025 at 7:32 PM
coming up for air after long periods of major depression feels like whiplash. late to the horrible news of our loss of Zara Weinberg.
at a loss for words but she was one of the most amazing people i’ve known. brilliant. empathetic. making a huge difference in the world. i will miss her terribly.
at a loss for words but she was one of the most amazing people i’ve known. brilliant. empathetic. making a huge difference in the world. i will miss her terribly.
Reposted by Christine Cucinotta
Get bedder v0.1.8 and r𝗲𝗮𝗱 𝘁𝗵𝗲 𝗱𝗼𝗰𝘂𝗺𝗲𝗻𝘁𝗮𝘁𝗶𝗼𝗻 here: github.com/quinlan-lab/...
We are looking for researchers to kick the tires, integrate bedder into their pipelines, and provide feedback on the Python functions, performance, and overall user experience! Please share and give us your feedback.
We are looking for researchers to kick the tires, integrate bedder into their pipelines, and provide feedback on the Python functions, performance, and overall user experience! Please share and give us your feedback.
Release Release v0.1.8 · quinlan-lab/bedder-rs
Changes in v0.1.8
Downloads
bedder-static-linux-x86_64: Static binary for Linux x86_64 (no dependencies required)
bedder-static-macos-x86_64-python3.13: macOS x86_64 binary built with Python 3.13
...
github.com
December 2, 2025 at 2:28 AM
Get bedder v0.1.8 and r𝗲𝗮𝗱 𝘁𝗵𝗲 𝗱𝗼𝗰𝘂𝗺𝗲𝗻𝘁𝗮𝘁𝗶𝗼𝗻 here: github.com/quinlan-lab/...
We are looking for researchers to kick the tires, integrate bedder into their pipelines, and provide feedback on the Python functions, performance, and overall user experience! Please share and give us your feedback.
We are looking for researchers to kick the tires, integrate bedder into their pipelines, and provide feedback on the Python functions, performance, and overall user experience! Please share and give us your feedback.
Reposted by Christine Cucinotta
We are thrilled to announce the first official release (v0.1.8) of #𝗯𝗲𝗱𝗱𝗲𝗿, the successor to one of our flagship tool, #𝗯𝗲𝗱𝘁𝗼𝗼𝗹𝘀! Based on ideas we conceived of long ago (!), this was achieved thanks to the dedication of Brent Pedersen.
1/n
1/n
Intro to Bedder – The Quinlan Lab
quinlanlab.org
December 2, 2025 at 2:28 AM
Reposted by Christine Cucinotta
Truly enjoyed writing this piece about recent discoveries by @bloodgenes.bsky.social and colleagues about how we can improve HSC expansion & gene editing by blocking ferroptosis!
Our @natcellbio.nature.com N&V: rdcu.be/eR25t
Associated article: tinyurl.com/msf9x8fn
Our @natcellbio.nature.com N&V: rdcu.be/eR25t
Associated article: tinyurl.com/msf9x8fn
Blocking ferroptosis to expand human HSCs
Nature Cell Biology - Haematopoietic stem cells (HSCs) are used in a variety of cellular therapies, but our ability to support these cells ex vivo remains technically challenging. A new study...
rdcu.be
December 1, 2025 at 4:57 PM
Truly enjoyed writing this piece about recent discoveries by @bloodgenes.bsky.social and colleagues about how we can improve HSC expansion & gene editing by blocking ferroptosis!
Our @natcellbio.nature.com N&V: rdcu.be/eR25t
Associated article: tinyurl.com/msf9x8fn
Our @natcellbio.nature.com N&V: rdcu.be/eR25t
Associated article: tinyurl.com/msf9x8fn
Reposted by Christine Cucinotta
AI is good at needling people, had me in stitches following this thread!
say what now?
AI has been infiltrating knitting and crochet spaces, filling them with useless patterns. Here's why that's happening and what can be done about it.
www.plagiarismtoday.com/2025/11/24/t...
#AI #Knitting #Crochet #FiberArt #Copyright
www.plagiarismtoday.com/2025/11/24/t...
#AI #Knitting #Crochet #FiberArt #Copyright
November 24, 2025 at 9:48 PM
AI is good at needling people, had me in stitches following this thread!
the best thing ever is when the person you are writing a letter for makes calendar invites for you for the deadlines
November 17, 2025 at 4:24 PM
the best thing ever is when the person you are writing a letter for makes calendar invites for you for the deadlines
Reposted by Christine Cucinotta
The lab published a nice paper, so we celebrated at our Friday lab meeting 🎉
#Publication #Science #GraduateSchool #BiomedicalSciences #Timeless #Cancer #Research #Senescence
#Publication #Science #GraduateSchool #BiomedicalSciences #Timeless #Cancer #Research #Senescence
November 14, 2025 at 7:34 PM
The lab published a nice paper, so we celebrated at our Friday lab meeting 🎉
#Publication #Science #GraduateSchool #BiomedicalSciences #Timeless #Cancer #Research #Senescence
#Publication #Science #GraduateSchool #BiomedicalSciences #Timeless #Cancer #Research #Senescence
i hate it here.
this is awful in so many ways i dont even have the words
this is awful in so many ways i dont even have the words
“The prohibited activities would include joint research, co-authorship on papers, and advising a foreign graduate student or postdoctoral fellow. The language is retroactive, meaning any interactions during the previous 5 years could make a scientist ineligible for future federal funding.”
U.S. Congress considers sweeping ban on Chinese collaborations
Researchers speak out against proposal that would bar funding for U.S. scientists working with Chinese partners or training Chinese students
www.science.org
November 14, 2025 at 12:28 PM
i hate it here.
this is awful in so many ways i dont even have the words
this is awful in so many ways i dont even have the words