Christine Cucinotta
@chrstne.bsky.social
Assistant prof at OSU|epigenomics of cellular reawakening in yeast & neural stem cells|views mine!|she/her
Diversity, Equity, & Inclusion are values essential to an ethical and modern society|Black lives matter|Trans rights are human rights
Diversity, Equity, & Inclusion are values essential to an ethical and modern society|Black lives matter|Trans rights are human rights
Reposted by Christine Cucinotta
The lab published a nice paper, so we celebrated at our Friday lab meeting 🎉
#Publication #Science #GraduateSchool #BiomedicalSciences #Timeless #Cancer #Research #Senescence
#Publication #Science #GraduateSchool #BiomedicalSciences #Timeless #Cancer #Research #Senescence
November 14, 2025 at 7:34 PM
The lab published a nice paper, so we celebrated at our Friday lab meeting 🎉
#Publication #Science #GraduateSchool #BiomedicalSciences #Timeless #Cancer #Research #Senescence
#Publication #Science #GraduateSchool #BiomedicalSciences #Timeless #Cancer #Research #Senescence
i hate it here.
this is awful in so many ways i dont even have the words
this is awful in so many ways i dont even have the words
“The prohibited activities would include joint research, co-authorship on papers, and advising a foreign graduate student or postdoctoral fellow. The language is retroactive, meaning any interactions during the previous 5 years could make a scientist ineligible for future federal funding.”
U.S. Congress considers sweeping ban on Chinese collaborations
Researchers speak out against proposal that would bar funding for U.S. scientists working with Chinese partners or training Chinese students
www.science.org
November 14, 2025 at 12:28 PM
i hate it here.
this is awful in so many ways i dont even have the words
this is awful in so many ways i dont even have the words
Reposted by Christine Cucinotta
Congrats again, everyone
November 13, 2025 at 2:27 PM
Congrats again, everyone
wow this is incredibly tragic. tms has been huge in helping me get better. but depression is the worst -- and the stigma surrounding it is still pervasive. im so sad to hear this.
November 12, 2025 at 6:46 PM
wow this is incredibly tragic. tms has been huge in helping me get better. but depression is the worst -- and the stigma surrounding it is still pervasive. im so sad to hear this.
Reposted by Christine Cucinotta
Had an amazing time at the CSHL Genome Informatics 2025 conference!
Presented my poster: “Investigating quiescence-specific roles of FUN30 in chromatin compaction” 🧬
@chrstne.bsky.social
#GI2025 #Chromatin #Genomics #Quiescence
Presented my poster: “Investigating quiescence-specific roles of FUN30 in chromatin compaction” 🧬
@chrstne.bsky.social
#GI2025 #Chromatin #Genomics #Quiescence
November 12, 2025 at 6:32 PM
Had an amazing time at the CSHL Genome Informatics 2025 conference!
Presented my poster: “Investigating quiescence-specific roles of FUN30 in chromatin compaction” 🧬
@chrstne.bsky.social
#GI2025 #Chromatin #Genomics #Quiescence
Presented my poster: “Investigating quiescence-specific roles of FUN30 in chromatin compaction” 🧬
@chrstne.bsky.social
#GI2025 #Chromatin #Genomics #Quiescence
Reposted by Christine Cucinotta
This October I’m drawing 1 molecule a day inspired by proteins in pdb @rcsbpdb.bsky.social
Day 13
Prompt DRINK
Pdb: 7BTW
A pair of mitochondrial outer membrane β-barrel SAM complexes from Saccharomyces cerevisiae, the yeast used to make beer.
Cheers!
Next: TRUNK
Suggestions?
Day 13
Prompt DRINK
Pdb: 7BTW
A pair of mitochondrial outer membrane β-barrel SAM complexes from Saccharomyces cerevisiae, the yeast used to make beer.
Cheers!
Next: TRUNK
Suggestions?
October 14, 2025 at 5:57 AM
This October I’m drawing 1 molecule a day inspired by proteins in pdb @rcsbpdb.bsky.social
Day 13
Prompt DRINK
Pdb: 7BTW
A pair of mitochondrial outer membrane β-barrel SAM complexes from Saccharomyces cerevisiae, the yeast used to make beer.
Cheers!
Next: TRUNK
Suggestions?
Day 13
Prompt DRINK
Pdb: 7BTW
A pair of mitochondrial outer membrane β-barrel SAM complexes from Saccharomyces cerevisiae, the yeast used to make beer.
Cheers!
Next: TRUNK
Suggestions?
Reposted by Christine Cucinotta
Roughly 900 PIs who will not be getting their award in FY2025. But also they will not have that money for FY2026, FY2027, FY2028 or FY2029. and *next* year, we will be adding some more applicants to this list even if by some miracle the NIH budget is the same.
November 5, 2025 at 5:42 PM
Roughly 900 PIs who will not be getting their award in FY2025. But also they will not have that money for FY2026, FY2027, FY2028 or FY2029. and *next* year, we will be adding some more applicants to this list even if by some miracle the NIH budget is the same.
Reposted by Christine Cucinotta
and there it is. the absolutely massive change in R01s funded multi-year. our perceptions that the new mandate, sorry strong suggestion, has had a dramatic effect on forward funding and therefore success rates is validated.
2025
Here the largest fraction is for R01 awards, followed by RF1s, and R21s.
In most cases, these were R01s that had not particularly reason to be forward funded except that NIH had put itself in a situation when large amounts of funding needed to be committed by the end of the fiscal year
21/25
Here the largest fraction is for R01 awards, followed by RF1s, and R21s.
In most cases, these were R01s that had not particularly reason to be forward funded except that NIH had put itself in a situation when large amounts of funding needed to be committed by the end of the fiscal year
21/25
November 5, 2025 at 4:45 PM
and there it is. the absolutely massive change in R01s funded multi-year. our perceptions that the new mandate, sorry strong suggestion, has had a dramatic effect on forward funding and therefore success rates is validated.
Reposted by Christine Cucinotta
And importantly, while a few years to settle out might seem no biggie, it sure as heck is a big deal to those PIs who have been on the job for just a few years and are looking at the tenure decision looming ahead.
November 5, 2025 at 5:46 PM
And importantly, while a few years to settle out might seem no biggie, it sure as heck is a big deal to those PIs who have been on the job for just a few years and are looking at the tenure decision looming ahead.
Reposted by Christine Cucinotta
We built a targeted protein degradation–based system to mimic reproductive age-related aneuploidy in young eggs - revealing how chromosome errors associated with female infertility arise with age. 🧬✨
With @jiyeonleem.bsky.social and our team at Yale MCDB.
Read: www.nature.com/articles/s43...
With @jiyeonleem.bsky.social and our team at Yale MCDB.
Read: www.nature.com/articles/s43...
A versatile cohesion manipulation system probes female reproductive age-related egg aneuploidy - Nature Aging
To study pathways that lead to aneuploidy during aging, the authors provide a system that enables cohesion protein depletion in mouse oocytes, mimicking effects that occur during aging. They uncover a...
www.nature.com
November 4, 2025 at 1:17 PM
We built a targeted protein degradation–based system to mimic reproductive age-related aneuploidy in young eggs - revealing how chromosome errors associated with female infertility arise with age. 🧬✨
With @jiyeonleem.bsky.social and our team at Yale MCDB.
Read: www.nature.com/articles/s43...
With @jiyeonleem.bsky.social and our team at Yale MCDB.
Read: www.nature.com/articles/s43...
Reposted by Christine Cucinotta
Our paper in Science is out! @souravagrawal.bsky.social, @rlynn.bsky.social, @susvirkar.bsky.social, and the rest of the team show human RPA is a telomerase processivity factor essential for telomere maintenance. This reshapes our thinking about telomerase regulation. www.science.org/doi/10.1126/...
Human RPA is an essential telomerase processivity factor for maintaining telomeres
Telomerase counteracts telomere shortening by repeatedly adding DNA repeats to chromosome ends. We identified the replication protein A (RPA) heterotrimer as a telomerase processivity factor critical ...
www.science.org
October 30, 2025 at 10:07 PM
Our paper in Science is out! @souravagrawal.bsky.social, @rlynn.bsky.social, @susvirkar.bsky.social, and the rest of the team show human RPA is a telomerase processivity factor essential for telomere maintenance. This reshapes our thinking about telomerase regulation. www.science.org/doi/10.1126/...
Reposted by Christine Cucinotta
Really positive sign that open source projects are standing up to do the right thing. Kudos to the Python folks: www.theregister.com/2025/10/27/p...
Python Foundation rejects $1.5M grant with no-DEI strings
: Foundation says it won't compromise policy of inclusivity even if that cash would've really helped
www.theregister.com
October 28, 2025 at 3:17 PM
Really positive sign that open source projects are standing up to do the right thing. Kudos to the Python folks: www.theregister.com/2025/10/27/p...
Reposted by Christine Cucinotta
👀Next Wednesday, Oct 22nd, at #FragileNucleosome seminar, we are excited to host @alicelaigle.bsky.social and @seungsookim.bsky.social to tell us about amazing work they are doing!
🗓️Register here for upcoming session and the entire series:
us06web.zoom.us/webinar/regi...
🗓️Register here for upcoming session and the entire series:
us06web.zoom.us/webinar/regi...
October 14, 2025 at 6:34 AM
👀Next Wednesday, Oct 22nd, at #FragileNucleosome seminar, we are excited to host @alicelaigle.bsky.social and @seungsookim.bsky.social to tell us about amazing work they are doing!
🗓️Register here for upcoming session and the entire series:
us06web.zoom.us/webinar/regi...
🗓️Register here for upcoming session and the entire series:
us06web.zoom.us/webinar/regi...
Reposted by Christine Cucinotta
I am seeing a lot of people reposting Lakota Man today bc it's Indigenous Peoples Day. A reminder that he is not well liked amongst many (most?) Natives on social media. Many of us blocked him a long time ago. Some of the reasons why are in this article.
www.dailydot.com/irl/lakotama...
www.dailydot.com/irl/lakotama...
Who is LakotaMan, the user behind one of the most popular Native American accounts on X?
John Martin is adored by white X users—but infamous among Native and Indigenous communities.
www.dailydot.com
October 13, 2025 at 2:06 PM
I am seeing a lot of people reposting Lakota Man today bc it's Indigenous Peoples Day. A reminder that he is not well liked amongst many (most?) Natives on social media. Many of us blocked him a long time ago. Some of the reasons why are in this article.
www.dailydot.com/irl/lakotama...
www.dailydot.com/irl/lakotama...
Reposted by Christine Cucinotta
Beautiful, layered argument for the use of model organisms, especially small ones, in research. A must read!
October 10, 2025 at 10:15 PM
Beautiful, layered argument for the use of model organisms, especially small ones, in research. A must read!
Reposted by Christine Cucinotta
15 years in the making, we confirmed that mitochondria - the powerhouse of the cell - have an unusual localization in patients who experience psychosis (including schizophrenia and bipolar disorders). You’ll never guess what kind of patient cells we used to make this discovery… 🧵
October 10, 2025 at 4:47 PM
15 years in the making, we confirmed that mitochondria - the powerhouse of the cell - have an unusual localization in patients who experience psychosis (including schizophrenia and bipolar disorders). You’ll never guess what kind of patient cells we used to make this discovery… 🧵
Reposted by Christine Cucinotta
Nobel Peace Prize 2025: "The committee commended Machado as a “brave and committed champion of peace” who had kept “the flame of democracy burning during a growing darkness”. 🔥
www.theguardian.com/world/2025/o...
www.theguardian.com/world/2025/o...
Venezuelan politician María Corina Machado wins Nobel peace prize
Leader of country’s opposition receives award after scrutiny surrounding committee and comments by Donald Trump
www.theguardian.com
October 10, 2025 at 12:03 PM
Nobel Peace Prize 2025: "The committee commended Machado as a “brave and committed champion of peace” who had kept “the flame of democracy burning during a growing darkness”. 🔥
www.theguardian.com/world/2025/o...
www.theguardian.com/world/2025/o...
Reposted by Christine Cucinotta
This is nothing more than a continuation of the president’s desperate weaponization of our justice system.
I am not fearful — I am fearless.
We will fight these baseless charges aggressively, and my office will continue to fiercely protect New Yorkers and their rights..
I am not fearful — I am fearless.
We will fight these baseless charges aggressively, and my office will continue to fiercely protect New Yorkers and their rights..
October 9, 2025 at 9:36 PM
This is nothing more than a continuation of the president’s desperate weaponization of our justice system.
I am not fearful — I am fearless.
We will fight these baseless charges aggressively, and my office will continue to fiercely protect New Yorkers and their rights..
I am not fearful — I am fearless.
We will fight these baseless charges aggressively, and my office will continue to fiercely protect New Yorkers and their rights..
Reposted by Christine Cucinotta
Friendly reminder: 🎉 Pre-register today & get ready to join our FREE online celebration. Everyone is welcome. To keep #BlackInMicro alive Donate: tinyurl.com/GiveBiM and Register to attend: linktr.ee/BlackInMicro (see links in bio) #BiMWeek2025
October 9, 2025 at 5:54 PM
Friendly reminder: 🎉 Pre-register today & get ready to join our FREE online celebration. Everyone is welcome. To keep #BlackInMicro alive Donate: tinyurl.com/GiveBiM and Register to attend: linktr.ee/BlackInMicro (see links in bio) #BiMWeek2025
Reposted by Christine Cucinotta
A lot of good answers in the comments section. It’s more important now to teach understanding (rather than just syntax). If the experimental design was inadequate, it doesn’t matter if the coding was perfect. If the interpretation was wrong, it doesn’t matter if the statistics were done right.
Y'all. I just got ChatGPT to do everything in R for this manuscript. I mean EVERYTHING. And it's all legit and reproducible. I'm shook.
How are we mentoring our trainees in statistics now? Who needs to learn coding in R line by line, and who doesn't?
scienceforeveryone.science/statistics-i...
How are we mentoring our trainees in statistics now? Who needs to learn coding in R line by line, and who doesn't?
scienceforeveryone.science/statistics-i...
Statistics in the era of AI
How do we mentor, teach, and do stats when AI can do so much of the work?
scienceforeveryone.science
October 9, 2025 at 12:27 PM
A lot of good answers in the comments section. It’s more important now to teach understanding (rather than just syntax). If the experimental design was inadequate, it doesn’t matter if the coding was perfect. If the interpretation was wrong, it doesn’t matter if the statistics were done right.
Reposted by Christine Cucinotta
Republican Senators, with an assist from Sen. John Fetterman, voted down an attempt to block the Trump administration’s missile strikes on alleged Venezuelan drug boats. interc.pt/4o9CBur
October 9, 2025 at 11:46 AM
Republican Senators, with an assist from Sen. John Fetterman, voted down an attempt to block the Trump administration’s missile strikes on alleged Venezuelan drug boats. interc.pt/4o9CBur
Reposted by Christine Cucinotta
"rather than articulating and defending these goals and processes, many parts of the scientific establishment seemed to be rushing to violate one of the first tenets of historian Timothy Snyder’s important book On Tyranny: Do not obey in advance." 🧪
I have been trying to get this published as an op-ed, but I am going to post it here since I think it is timely in light of the "consent" extortion events.
Deafening Quiet from the Scientific Establishment
jeremymberg.github.io/jeremyberg.g...
1/14
Deafening Quiet from the Scientific Establishment
jeremymberg.github.io/jeremyberg.g...
1/14
jeremymberg.github.io
October 6, 2025 at 11:36 PM
"rather than articulating and defending these goals and processes, many parts of the scientific establishment seemed to be rushing to violate one of the first tenets of historian Timothy Snyder’s important book On Tyranny: Do not obey in advance." 🧪
Reposted by Christine Cucinotta
Reposted by Christine Cucinotta
I have been trying to get this published as an op-ed, but I am going to post it here since I think it is timely in light of the "consent" extortion events.
Deafening Quiet from the Scientific Establishment
jeremymberg.github.io/jeremyberg.g...
1/14
Deafening Quiet from the Scientific Establishment
jeremymberg.github.io/jeremyberg.g...
1/14
jeremymberg.github.io
October 6, 2025 at 11:28 PM
I have been trying to get this published as an op-ed, but I am going to post it here since I think it is timely in light of the "consent" extortion events.
Deafening Quiet from the Scientific Establishment
jeremymberg.github.io/jeremyberg.g...
1/14
Deafening Quiet from the Scientific Establishment
jeremymberg.github.io/jeremyberg.g...
1/14
Reposted by Christine Cucinotta
5. I don't know that US will ever be a stable place for science again. I know that sounds nihilistic but the 50% of the country that voted for Trump is not going anywhere and they appear to be ok with blowing up the entire research infrastructure for shits and giggles.
October 3, 2025 at 2:57 PM
5. I don't know that US will ever be a stable place for science again. I know that sounds nihilistic but the 50% of the country that voted for Trump is not going anywhere and they appear to be ok with blowing up the entire research infrastructure for shits and giggles.