Christine Cucinotta
@chrstne.bsky.social
Assistant prof at OSU|epigenomics of cellular reawakening in yeast & neural stem cells|views mine!|she/her
Diversity, Equity, & Inclusion are values essential to an ethical and modern society|Black lives matter|Trans rights are human rights
Diversity, Equity, & Inclusion are values essential to an ethical and modern society|Black lives matter|Trans rights are human rights
this is awesome - really nice work and congrats!!!
February 10, 2026 at 9:17 PM
this is awesome - really nice work and congrats!!!
Reposted by Christine Cucinotta
๐ LEE LAB PAPER ANNOUNCEMENT for this month's issue of #GENETICS! We're celebrating from both coasts, bc after defending her MS in 2024, Deepshi's now a biotech researcher in the Bay Area.
tl;dr: nucleosome remodeling is necessary to repair germline DNA damage ๐งฌ
academic.oup.com/genetics/art...
tl;dr: nucleosome remodeling is necessary to repair germline DNA damage ๐งฌ
academic.oup.com/genetics/art...
February 9, 2026 at 6:26 PM
๐ LEE LAB PAPER ANNOUNCEMENT for this month's issue of #GENETICS! We're celebrating from both coasts, bc after defending her MS in 2024, Deepshi's now a biotech researcher in the Bay Area.
tl;dr: nucleosome remodeling is necessary to repair germline DNA damage ๐งฌ
academic.oup.com/genetics/art...
tl;dr: nucleosome remodeling is necessary to repair germline DNA damage ๐งฌ
academic.oup.com/genetics/art...
Reposted by Christine Cucinotta
I think that, like with art, papers offer an opportunity for you to tell the story your own way. Could another person research the same question? Yes. However, each person has the opportunity to do it and communicate it in their own way, and we must protect that ๐งช
February 10, 2026 at 3:13 PM
I think that, like with art, papers offer an opportunity for you to tell the story your own way. Could another person research the same question? Yes. However, each person has the opportunity to do it and communicate it in their own way, and we must protect that ๐งช
Reposted by Christine Cucinotta
Letโs make it viral folks. Thank you @histoftech.bsky.social.
No joke: I got angry hate mail today for writing an obituary of a Black woman scientistโbecause the person felt she did didnโt deserve the recognition.
Which just makes me want to share it again: www.nature.com/articles/d41...
Which just makes me want to share it again: www.nature.com/articles/d41...
Gladys Mae West obituary: mathematician who pioneered GPS technology
She made key contributions to US cold-war science despite facing huge barriers as a Black woman.
www.nature.com
February 6, 2026 at 2:27 PM
Letโs make it viral folks. Thank you @histoftech.bsky.social.
Reposted by Christine Cucinotta
๐งฌ๐ฌ๐ฅ @science.org Live-cell single-molecule dynamics of eukaryotic RNA polymerase machineries | Science www.science.org/doi/10.1126/...
Live-cell single-molecule dynamics of eukaryotic RNA polymerase machineries
Eukaryotic gene expression is orchestrated by RNA polymerases (RNAPI, II, and III) and associated factors, yet their real-time dynamics remain obscure. Using single-molecule tracking in living yeast, ...
www.science.org
February 6, 2026 at 12:14 AM
๐งฌ๐ฌ๐ฅ @science.org Live-cell single-molecule dynamics of eukaryotic RNA polymerase machineries | Science www.science.org/doi/10.1126/...
Reposted by Christine Cucinotta
So the question here is mis-specified. There is no "alternative" research funding in any way that would make American biomedical research whole for researchers to seek out. 1/ www.statnews.com/2026/02/03/p... via @statnews.com
We asked whether principal investigators have plans in place for how research can continue without them
Researchers must be mindful of unexpected events that may leave them incapacitated or unable to lead their research projects or labs.
www.statnews.com
February 4, 2026 at 10:35 AM
So the question here is mis-specified. There is no "alternative" research funding in any way that would make American biomedical research whole for researchers to seek out. 1/ www.statnews.com/2026/02/03/p... via @statnews.com
Reposted by Christine Cucinotta
More attention here, please.
Floored by this story. A man wrote a pollite email to a federal prosecutor objecting to the deportation of an Afghan seeking asylum. DHS responded with an administrative warrant to get the man's info from Google, then visited his home to intimidate him.
DHS Hunts Down 67-Year-Old U.S. Citizen Who Criticized Them in Email
The Department of Homeland Security is using a little-known tool to go after its critics.
newrepublic.com
February 4, 2026 at 12:10 AM
More attention here, please.
Reposted by Christine Cucinotta
Terrific paper on a new chromosomal
compartment where extensive loop
extrusion isolates domains from
other such domains
compartment where extensive loop
extrusion isolates domains from
other such domains
How do compartmentalization & loop extrusion organize eukaryotic genomes beyond classical model organisms?
Hi-C analysis of silkworm chromosomes by Drinnenberg, Muller, Mirny et al reveals new combination of these mechanisms, and a new, secluded โSโ compartment
link.springer.com/article/10.1...
Hi-C analysis of silkworm chromosomes by Drinnenberg, Muller, Mirny et al reveals new combination of these mechanisms, and a new, secluded โSโ compartment
link.springer.com/article/10.1...
Unique territorial and compartmental organization of chromosomes in the holocentric silkworm - The EMBO Journal
Hallmarks of multicellular eukaryotic genome organization are chromosome territories, compartments, and loop-extrusion-mediated structures, including TADs. However, these have mainly been observed in ...
link.springer.com
February 3, 2026 at 9:55 PM
Terrific paper on a new chromosomal
compartment where extensive loop
extrusion isolates domains from
other such domains
compartment where extensive loop
extrusion isolates domains from
other such domains
Congrats!!! ๐คฉ
February 2, 2026 at 11:42 PM
Congrats!!! ๐คฉ
Reposted by Christine Cucinotta
Unquestionably the result of combined effort from all current and former lab members, support from colleagues @CSU and @CU, and support from @hhmi-science.bsky.social and NIH over decades. A heartfelt ๐ to my nominators and of course @vilcekfoundation.bsky.social.
vilcek.org/prizes/prize...
vilcek.org/prizes/prize...
Karolin Luger - Vilcek Foundation
Karolin Luger's research led to the capture of a high resolution image of chromatin, resulting in the development of innovative drug treatments for diseases like cancer.
vilcek.org
February 2, 2026 at 11:37 PM
Unquestionably the result of combined effort from all current and former lab members, support from colleagues @CSU and @CU, and support from @hhmi-science.bsky.social and NIH over decades. A heartfelt ๐ to my nominators and of course @vilcekfoundation.bsky.social.
vilcek.org/prizes/prize...
vilcek.org/prizes/prize...
Reposted by Christine Cucinotta
excellent thread
I had intended to post something about this new Google DeepMind paper that appeared yesterday in Nature, but the press coverage has added to what there is to say. So this is a long ๐งต
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Advancing regulatory variant effect prediction with AlphaGenome - Nature
AlphaGenome, a deep learning model that inputs 1-Mb DNA sequence to predict functional genomic tracks at single-base resolution across diverse modalities, outperforms existing models in variant effect...
www.nature.com
January 30, 2026 at 1:01 PM
excellent thread
Reposted by Christine Cucinotta
Everyone who tut-tuts co-workers concerned about their job and health insurance should probably include some info on their own household finances, retirement situation and health conditions, current and anticipated.
Powerful piece in STAT this morning from some NIH staff members who have resigned
www.statnews.com/2026/01/10/n...
1/3
www.statnews.com/2026/01/10/n...
1/3
The NIH has lost its scientific integrity. So we left
โWe can no longer lend our credibility to an organization that has lost its integrity,โ write four scientists and administrators who recently resigned from the NIH.
www.statnews.com
January 10, 2026 at 4:04 PM
Everyone who tut-tuts co-workers concerned about their job and health insurance should probably include some info on their own household finances, retirement situation and health conditions, current and anticipated.
Reposted by Christine Cucinotta
Join our virtual seminar!
@sedonamurphy.bsky.social presents cutting-edge research on 3D genome organisation & epigenetic memory in development, moderated by @stefanschoenfelder.bsky.social
๐ Jan 8, 4pm UK
๐ป Zoom
Register: us02web.zoom.us/webinar/regi...
#3DGenome #Epigenetics #ChromatinBiology
@sedonamurphy.bsky.social presents cutting-edge research on 3D genome organisation & epigenetic memory in development, moderated by @stefanschoenfelder.bsky.social
๐ Jan 8, 4pm UK
๐ป Zoom
Register: us02web.zoom.us/webinar/regi...
#3DGenome #Epigenetics #ChromatinBiology
January 6, 2026 at 2:04 PM
Join our virtual seminar!
@sedonamurphy.bsky.social presents cutting-edge research on 3D genome organisation & epigenetic memory in development, moderated by @stefanschoenfelder.bsky.social
๐ Jan 8, 4pm UK
๐ป Zoom
Register: us02web.zoom.us/webinar/regi...
#3DGenome #Epigenetics #ChromatinBiology
@sedonamurphy.bsky.social presents cutting-edge research on 3D genome organisation & epigenetic memory in development, moderated by @stefanschoenfelder.bsky.social
๐ Jan 8, 4pm UK
๐ป Zoom
Register: us02web.zoom.us/webinar/regi...
#3DGenome #Epigenetics #ChromatinBiology
Reposted by Christine Cucinotta
Can someone please respond to Stephen Miller with this message from Frank Sinatra?
December 26, 2025 at 8:04 PM
Can someone please respond to Stephen Miller with this message from Frank Sinatra?
Reposted by Christine Cucinotta
Please folks. Learn the history.
December 26, 2025 at 9:01 PM
Please folks. Learn the history.
Reposted by Christine Cucinotta
My lab is hiring a postdoc (ERC funded)! If you're interested, get in touch!
December 18, 2025 at 8:36 AM
My lab is hiring a postdoc (ERC funded)! If you're interested, get in touch!
Reposted by Christine Cucinotta
A major output of the 4D Nucleome project appeared today. This is the joint effort of many scientists working together and (publicly) sharing data and results for several years. We hope this is of interest to many genome biologists!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
An integrated view of the structure and function of the human 4D nucleome - Nature
The 4D Nucleome Project demonstrates the use of genomic assays and computational methods to measure genome folding and then predict genomic structure from DNA sequence, facilitatin...
www.nature.com
December 17, 2025 at 8:59 PM
A major output of the 4D Nucleome project appeared today. This is the joint effort of many scientists working together and (publicly) sharing data and results for several years. We hope this is of interest to many genome biologists!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
im maxed out on my ssri after only half a semester ๐
December 17, 2025 at 3:23 AM
im maxed out on my ssri after only half a semester ๐
Reposted by Christine Cucinotta
@pravrutharaman.bsky.social got super intrigued about EZHIP/CATACOMB, previously identified as a histone H3K27M mimic of PRC2. You can read about her efforts here: www.biorxiv.org/content/10.6... We hope these analyses will help spur more analyses in this very cool gene! 1/
Dynamic evolution of EZHIP, an inhibitor of the Polycomb Repressive Complex 2 in mammals
The Polycomb Repressive Complex 2 (PRC2) is an ancient, conserved chromatin-interacting complex that controls gene expression, facilitating differentiation and cellular identity during development. It...
www.biorxiv.org
December 13, 2025 at 10:08 PM
@pravrutharaman.bsky.social got super intrigued about EZHIP/CATACOMB, previously identified as a histone H3K27M mimic of PRC2. You can read about her efforts here: www.biorxiv.org/content/10.6... We hope these analyses will help spur more analyses in this very cool gene! 1/
Reposted by Christine Cucinotta
Confused by all the histones that are cropping up in organisms that are decidedly NOT eukaryotes? check out our review - fantastic work by team NucEvo in the #Lugerlab
The Expanding Histone Universe: Histone-Based DNA Organization in Noneukaryotic Organisms - www.annualreviews.org/content/jour...
The Expanding Histone Universe: Histone-Based DNA Organization in Noneukaryotic Organisms - www.annualreviews.org/content/jour...
December 9, 2025 at 3:14 PM
Confused by all the histones that are cropping up in organisms that are decidedly NOT eukaryotes? check out our review - fantastic work by team NucEvo in the #Lugerlab
The Expanding Histone Universe: Histone-Based DNA Organization in Noneukaryotic Organisms - www.annualreviews.org/content/jour...
The Expanding Histone Universe: Histone-Based DNA Organization in Noneukaryotic Organisms - www.annualreviews.org/content/jour...
we need to make science culture better. for Zara. we should keep her legacy going forever
December 2, 2025 at 8:11 PM
we need to make science culture better. for Zara. we should keep her legacy going forever
first met Zara at an Opeth show when we were both phd students. she had the best taste in music. I'll think of her every time i listen to Opeth for nostalgia, Sleater-Kinney (ofc), and basically any good music. time to go back thru her 5x5s
December 2, 2025 at 8:06 PM
first met Zara at an Opeth show when we were both phd students. she had the best taste in music. I'll think of her every time i listen to Opeth for nostalgia, Sleater-Kinney (ofc), and basically any good music. time to go back thru her 5x5s
i knew she was sick and still it is a shock. i miss her so much
December 2, 2025 at 7:43 PM
i knew she was sick and still it is a shock. i miss her so much
coming up for air after long periods of major depression feels like whiplash. late to the horrible news of our loss of Zara Weinberg.
at a loss for words but she was one of the most amazing people iโve known. brilliant. empathetic. making a huge difference in the world. i will miss her terribly.
at a loss for words but she was one of the most amazing people iโve known. brilliant. empathetic. making a huge difference in the world. i will miss her terribly.
December 2, 2025 at 7:32 PM
coming up for air after long periods of major depression feels like whiplash. late to the horrible news of our loss of Zara Weinberg.
at a loss for words but she was one of the most amazing people iโve known. brilliant. empathetic. making a huge difference in the world. i will miss her terribly.
at a loss for words but she was one of the most amazing people iโve known. brilliant. empathetic. making a huge difference in the world. i will miss her terribly.
Reposted by Christine Cucinotta
Get bedder v0.1.8 and r๐ฒ๐ฎ๐ฑ ๐๐ต๐ฒ ๐ฑ๐ผ๐ฐ๐๐บ๐ฒ๐ป๐๐ฎ๐๐ถ๐ผ๐ป here: github.com/quinlan-lab/...
We are looking for researchers to kick the tires, integrate bedder into their pipelines, and provide feedback on the Python functions, performance, and overall user experience! Please share and give us your feedback.
We are looking for researchers to kick the tires, integrate bedder into their pipelines, and provide feedback on the Python functions, performance, and overall user experience! Please share and give us your feedback.
Release Release v0.1.8 ยท quinlan-lab/bedder-rs
Changes in v0.1.8
Downloads
bedder-static-linux-x86_64: Static binary for Linux x86_64 (no dependencies required)
bedder-static-macos-x86_64-python3.13: macOS x86_64 binary built with Python 3.13
...
github.com
December 2, 2025 at 2:28 AM
Get bedder v0.1.8 and r๐ฒ๐ฎ๐ฑ ๐๐ต๐ฒ ๐ฑ๐ผ๐ฐ๐๐บ๐ฒ๐ป๐๐ฎ๐๐ถ๐ผ๐ป here: github.com/quinlan-lab/...
We are looking for researchers to kick the tires, integrate bedder into their pipelines, and provide feedback on the Python functions, performance, and overall user experience! Please share and give us your feedback.
We are looking for researchers to kick the tires, integrate bedder into their pipelines, and provide feedback on the Python functions, performance, and overall user experience! Please share and give us your feedback.