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narjournal.bsky.social
Nucleic Acids Research
@narjournal.bsky.social
1.4K followers 17 following 80 posts
Nucleic Acids Research (NAR), from Oxford University Press, publishes the results of leading-edge research into physical, chemical, biochemical and biological aspects of nucleic acids and proteins involved in nucleic acid metabolism and/or interactions
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narjournal.bsky.social
Nucleic Acids Research @narjournal.bsky.social · Jan 31
Hello Everyone! 👋 Nucleic Acids Research is excited to be on Bluesky! Please follow us for the latest #Research, #Breakthrough articles, journal issues and more. Also, please consider adding us to your starter packs!
narjournal.bsky.social
📣 Authors wanted! Submit to NARMME's Special Collection on Repeat Expansion Diseases by Jan 2026🧬

🔍Find out more: academic.oup.com/narmolmed/pa...

👉Submit: mc.manuscriptcentral.com/narmme

#CallForPapers #Genomics #RareDiseases #NARMME
October 30, 2025 at 10:28 AM
narjournal.bsky.social
🧬 New in NARGAB: A fast, scalable CHT method identifies genomic regions with shared effects across traits. Applied to psychiatric pleiotropy and cucumber virus resistance.

Read: doi.org/10.1093/narg...

#CHT #MultiTraitAnalysis #PsychiatricGenetics #PlantGenomics
October 16, 2025 at 3:45 PM
narjournal.bsky.social
🧬 New in NARMME: RNA splicing tweaks rescue tau toxicity in C. elegans. Modifying tri-snRNP proteins rescues tau-induced deficits in transgenic C. elegans, restoring behaviour, neurodegeneration and extending lifespan.
Read: doi.org/10.1093/narm...
#Alzheimers #RNAsplicing #Neurodegeneration
October 16, 2025 at 3:41 PM
narjournal.bsky.social
⭐ NAR Breakthrough! ⭐
🔬 How do #kinetochores rebuild each #cellcycle?
A new study reveals the order of assembly, hidden interdependencies, and a new regulatory mechanism.
🧬 Read more: academic.oup.com/nar/article/... @suebiggins.bsky.social @fredhutch.org

#NARbreakthrough #ChromosomeSegregation
October 15, 2025 at 1:49 PM
narjournal.bsky.social
Five years ago, Dr. Doudna @jenniferdoudna.bsky.social and Dr. Charpentier won the #NobelPrize for #CRISPR/Cas9, revolutionizing gene editing and science as we know it. 🎉🎉Celebrate this milestone with our #specialcollections academic.oup.com/nar/pages/cr... and academic.oup.com/nar/pages/cr...
October 7, 2025 at 5:48 AM
narjournal.bsky.social
⭐ NAR Breakthrough! ⭐
New research highlights CHD1L in the chromosome 1q21.1 region—linked to #autism, head size & growth.
🧠 It controls #DNApackaging & genes for #braindevelopment, #cellfate & #connectivity.
Read more: doi.org/10.1093/nar/...
#NARBreakthrough #Neuroscience @igbmc.bsky.social
Disrupted transcriptional networks regulated by CHD1L during neurodevelopment underlie the mirrored neuroanatomical and growth phenotypes of the 1q21.1 copy number variant
Abstract. Distal 1q21.1 deletions and duplications are associated with variable phenotypes including autism, head circumference and height defects. To eluc
doi.org
September 24, 2025 at 5:34 PM
narjournal.bsky.social
🧬 New in NARGAB: authors compared human exome sequencing kits, showing how design differences impact capture efficiency and downstream analysis. Useful insights for choosing the right kit!

📖 Read: doi.org/10.1093/narg...

#ExomeSequencing #Genomics #Bioinformatics #NARGAB
September 22, 2025 at 2:19 PM
narjournal.bsky.social
🧬New in NARGAB: a composite hypothesis testing (CHT) method to find genetic regions affecting multiple traits is described which is efficient, scalable and applied to psychiatric disorders and viral resistance in cucumber.

Read here: doi.org/10.1093/narg...

#Genomics #CHT #Bioinformatics #NARGAB
September 22, 2025 at 2:16 PM
narjournal.bsky.social
🤰 New research in NARMME reveals that uterine glands, not just eggs, are sensitive to maternal aging. 🧬 FOXC1 marks early dysfunction, reshaping how we understand fertility decline.

📖 Read more: lnkd.in/eahrVbMt

#FertilityResearch #FOXC1 #ReproductiveScience #NARMME #OpenAccessPublication
September 19, 2025 at 5:04 PM
narjournal.bsky.social
💡 New in NARMME: TRL1 enzyme from Candida glabrata changes shape to control RNA repair, vital for fungal survival. Its absence in humans makes it a promising antifungal drug target.

📖 Read more: doi.org/10.1093/narm...

#TRL1 #RNARepair #AntifungalResearch #DrugDiscovery #NARMME #OpenAccess
September 18, 2025 at 4:56 PM
narjournal.bsky.social
🔬 New study in NARMME explores how azvudine (FNC) targets HIV-1 RT & SARS-CoV-2 RdRp🧬

📖 doi.org/10.1093/narm...

#Azvudine #AntiviralAgents #HIVResearch #SARSCoV2 #NARMolecularMedicine #OpenAccessPublication
September 18, 2025 at 4:47 PM
narjournal.bsky.social
💡A new RNAi strategy described in NARMME embeds miR-based shRNAs into a gamma-retroviral intron, enabling gene knockdown and protein coexpression with high viral titers.

📖 doi.org/10.1093/narm...

#RNAi #GeneTherapy #RetroviralVectors #MolecularBiology #NARMME #OpenAccessPublication
September 15, 2025 at 1:33 PM
narjournal.bsky.social
🧬 A new review in NARMME explores how chromatin preserves cell identity and how its breakdown may drive diseases like neurodegeneration and cancer.

📖 doi.org/10.1093/narm...

#Epigenetics #Chromatin #CellBiology #Genomics #Neuroscience #MolecularBiology #OpenAccess #NARMolecularMedicine
September 15, 2025 at 1:11 PM
narjournal.bsky.social
🐟 New in NARMME: malat1 in zebrafish triggers signaling for retinal repair guided by Notch, Wnt & TGF-β pathways. In mammals, TGF-β blocks regeneration revealing a key difference in healing potential.

🔗 doi.org/10.1093/narm...

#Zebrafish #RetinaRepair #Malat1 #MolecularBiology #NARMME #OpenAccess
September 12, 2025 at 11:31 AM
narjournal.bsky.social
🦟 New in NARMME: for the first time, microRNA in tsetse fly saliva carrying Trypanosoma brucei were profiled. Infected flies carry less diverse microRNAs, hinting roles in how the disease spreads.

🔗 doi.org/10.1093/narm...

#SleepingSickness #TsetseFly #MicroRNA #Trypanosomes #NARMME #OpenAccess
September 12, 2025 at 11:26 AM
narjournal.bsky.social
⭐ #NARBreakthrough in #RNAengineering!⭐
University of Utah @utah.edu chemists show that a single dye can emit two colors with engineered #Broccoli #aptamers (Golden = yellow, Red = red).
They built the first ratiometric biosensor to track #glycine dynamics!
Read more 👉 doi.org/10.1093/nar/...
September 11, 2025 at 2:42 PM
narjournal.bsky.social
🌟 Discover NARGAB Editor's Choice articles, hand-picked by our Editor-in-Chief for their quality and impact.

👉 All articles are free to read and download, explore the full collection now!

🔗 academic.oup.com/nargab/pages...

#NARGenomicsandBioinformatics #EditorsChoice #OpenAccess
September 9, 2025 at 1:57 PM
Reposted by Nucleic Acids Research
oxfordacademic.bsky.social
@narjournal.bsky.social invites you to join the 2026 Early Career Investigator Advisory Board cohort!

You can collaborate with Executive Editors, influence the future of science, and elevate your career. Apply now or tag a colleague who might be interested: oxford.ly/47js8Ye
Join Early Career Investigator Advisory Board
Nucleic Acids Research (NAR) warmly welcomes you to join us in shaping the future of our research community. We recognize the vital role that NAR can play in nu
oxford.ly
August 29, 2025 at 12:30 PM
narjournal.bsky.social
⭐NAR Breakthrough!⭐

🧬 New study shows Prp22 has a dual role in #splicing—an ATP-independent function that promotes #exonligation by stabilizing Slu7, and an ATP-dependent role that drives Slu7 dissociation + #mRNArelease.
📖 ttps://doi.org/10.1093/nar/gkaf823

#NARBreakthrough #RNA #RNAHelicase
August 29, 2025 at 3:09 PM
narjournal.bsky.social
⭐NAR Breakthrough!⭐
🧬 New study shows that small activating RNAs can boost MBNL1 expression in #myotonicdystrophy cells, restoring splicing balance. This highlights #RNAactivation (RNAa) as a promising #therapeutic strategy for this #raredisease.
📖 doi.org/10.1093/nar/...
#NARBreakthrough
Promoter-targeted small RNA duplexes increase MBNL1 transcription and mitigate myotonic dystrophy-associated spliceopathy
Abstract. Functional depletion of Muscleblind-like (MBNL) proteins is a key trigger of myotonic dystrophy (DM)-associated alternative splicing (AltS) defec
doi.org
August 20, 2025 at 3:18 PM
narjournal.bsky.social
🧬 IQ2 could be a new approach to treating visceral leishmaniasis (VL) via c-MYC gene silencing and immune cell reactivation!🥊

📖 Read in NARMME: doi.org/10.1093/narm...

#VisceralLeishmaniasis #KalaAzar #Parasitology #MolecularBiology #OAPublication
August 19, 2025 at 11:36 AM
narjournal.bsky.social
🧬 DM1 is a complex genetic disease affecting multiple body systems. A fast, reliable method to measure DMPK & MBNL1 proteins across diverse cell models is described in NARMME: doi.org/10.1093/narm...
@varechavala.bsky.social
#DM1Research #MyotonicDystrophy #MolecularBiology #OAPublication
August 19, 2025 at 11:07 AM
Reposted by Nucleic Acids Research
nar-cancer-editor.bsky.social
N6-methyladenosine in R-loop homeostasis. Short review in NAR Cancer from Chun-Long Chen and coworkers. Effects on transcription, repair, centromere and telomere stability, and R-loop dynamics. Targeting as a cancer therapeutic strategy. academic.oup.com/narcancer/ar...
m6A modification in R-loop homeostasis: a potential target for cancer therapeutics
Abstract. R-loops or DNA–RNA hybrids are prominent nucleic acid structures that commonly arise during transcription. These structures play important biolog
academic.oup.com
August 15, 2025 at 4:14 PM
Reposted by Nucleic Acids Research
nar-cancer-editor.bsky.social
New insights into gene regulation in melanoma, the deadliest skin cancer: SETD6-catalyzed methylation of BRD4 and chromatin-localized interaction with MITF. From Tzofit Elbaz Biton, Dan Levy, and coworkers, published in NAR Cancer. academic.oup.com/narcancer/ar...
SETD6 mediates selective interaction and genomic occupancy of BRD4 and MITF in melanoma cells
Abstract. Aberrant transcriptional programs mediate malignant transformation of melanoma, the most aggressive form of skin cancer. The lysine methyltransfe
academic.oup.com
August 10, 2025 at 7:29 PM
Reposted by Nucleic Acids Research
nar-cancer-editor.bsky.social
Beyond BRCA status: machine-learning assisted multichannel imaging platform for cell-by-cell analysis of HR competency, enabling patient stratification. “Editor’s Choice” in NAR Cancer. academic.oup.com/narcancer/ar...
Automated machine learning profiling with MAP-HR for quantifying homologous recombination foci in patient samples
Abstract. Accurate visualization and quantification of homologous recombination (HR)-associated foci in readily available patient samples are critical for
academic.oup.com
August 14, 2025 at 5:34 PM