Nucleic Acids Research
@narjournal.bsky.social
Nucleic Acids Research (NAR), from Oxford University Press, publishes the results of leading-edge research into physical, chemical, biochemical and biological aspects of nucleic acids and proteins involved in nucleic acid metabolism and/or interactions
📣 Authors wanted! Submit to NARMME's Special Collection on Repeat Expansion Diseases by Jan 2026🧬
🔍Find out more: academic.oup.com/narmolmed/pa...
👉Submit: mc.manuscriptcentral.com/narmme
#CallForPapers #Genomics #RareDiseases #NARMME
🔍Find out more: academic.oup.com/narmolmed/pa...
👉Submit: mc.manuscriptcentral.com/narmme
#CallForPapers #Genomics #RareDiseases #NARMME
October 30, 2025 at 10:28 AM
📣 Authors wanted! Submit to NARMME's Special Collection on Repeat Expansion Diseases by Jan 2026🧬
🔍Find out more: academic.oup.com/narmolmed/pa...
👉Submit: mc.manuscriptcentral.com/narmme
#CallForPapers #Genomics #RareDiseases #NARMME
🔍Find out more: academic.oup.com/narmolmed/pa...
👉Submit: mc.manuscriptcentral.com/narmme
#CallForPapers #Genomics #RareDiseases #NARMME
🧬 New in NARGAB: A fast, scalable CHT method identifies genomic regions with shared effects across traits. Applied to psychiatric pleiotropy and cucumber virus resistance.
Read: doi.org/10.1093/narg...
#CHT #MultiTraitAnalysis #PsychiatricGenetics #PlantGenomics
Read: doi.org/10.1093/narg...
#CHT #MultiTraitAnalysis #PsychiatricGenetics #PlantGenomics
October 16, 2025 at 3:45 PM
🧬 New in NARGAB: A fast, scalable CHT method identifies genomic regions with shared effects across traits. Applied to psychiatric pleiotropy and cucumber virus resistance.
Read: doi.org/10.1093/narg...
#CHT #MultiTraitAnalysis #PsychiatricGenetics #PlantGenomics
Read: doi.org/10.1093/narg...
#CHT #MultiTraitAnalysis #PsychiatricGenetics #PlantGenomics
🧬 New in NARMME: RNA splicing tweaks rescue tau toxicity in C. elegans. Modifying tri-snRNP proteins rescues tau-induced deficits in transgenic C. elegans, restoring behaviour, neurodegeneration and extending lifespan.
Read: doi.org/10.1093/narm...
#Alzheimers #RNAsplicing #Neurodegeneration
Read: doi.org/10.1093/narm...
#Alzheimers #RNAsplicing #Neurodegeneration
October 16, 2025 at 3:41 PM
🧬 New in NARMME: RNA splicing tweaks rescue tau toxicity in C. elegans. Modifying tri-snRNP proteins rescues tau-induced deficits in transgenic C. elegans, restoring behaviour, neurodegeneration and extending lifespan.
Read: doi.org/10.1093/narm...
#Alzheimers #RNAsplicing #Neurodegeneration
Read: doi.org/10.1093/narm...
#Alzheimers #RNAsplicing #Neurodegeneration
⭐ NAR Breakthrough! ⭐
🔬 How do #kinetochores rebuild each #cellcycle?
A new study reveals the order of assembly, hidden interdependencies, and a new regulatory mechanism.
🧬 Read more: academic.oup.com/nar/article/... @suebiggins.bsky.social @fredhutch.org
#NARbreakthrough #ChromosomeSegregation
🔬 How do #kinetochores rebuild each #cellcycle?
A new study reveals the order of assembly, hidden interdependencies, and a new regulatory mechanism.
🧬 Read more: academic.oup.com/nar/article/... @suebiggins.bsky.social @fredhutch.org
#NARbreakthrough #ChromosomeSegregation
October 15, 2025 at 1:49 PM
⭐ NAR Breakthrough! ⭐
🔬 How do #kinetochores rebuild each #cellcycle?
A new study reveals the order of assembly, hidden interdependencies, and a new regulatory mechanism.
🧬 Read more: academic.oup.com/nar/article/... @suebiggins.bsky.social @fredhutch.org
#NARbreakthrough #ChromosomeSegregation
🔬 How do #kinetochores rebuild each #cellcycle?
A new study reveals the order of assembly, hidden interdependencies, and a new regulatory mechanism.
🧬 Read more: academic.oup.com/nar/article/... @suebiggins.bsky.social @fredhutch.org
#NARbreakthrough #ChromosomeSegregation
Five years ago, Dr. Doudna @jenniferdoudna.bsky.social and Dr. Charpentier won the #NobelPrize for #CRISPR/Cas9, revolutionizing gene editing and science as we know it. 🎉🎉Celebrate this milestone with our #specialcollections academic.oup.com/nar/pages/cr... and academic.oup.com/nar/pages/cr...
October 7, 2025 at 5:48 AM
Five years ago, Dr. Doudna @jenniferdoudna.bsky.social and Dr. Charpentier won the #NobelPrize for #CRISPR/Cas9, revolutionizing gene editing and science as we know it. 🎉🎉Celebrate this milestone with our #specialcollections academic.oup.com/nar/pages/cr... and academic.oup.com/nar/pages/cr...
🧬 New in NARGAB: authors compared human exome sequencing kits, showing how design differences impact capture efficiency and downstream analysis. Useful insights for choosing the right kit!
📖 Read: doi.org/10.1093/narg...
#ExomeSequencing #Genomics #Bioinformatics #NARGAB
📖 Read: doi.org/10.1093/narg...
#ExomeSequencing #Genomics #Bioinformatics #NARGAB
September 22, 2025 at 2:19 PM
🧬 New in NARGAB: authors compared human exome sequencing kits, showing how design differences impact capture efficiency and downstream analysis. Useful insights for choosing the right kit!
📖 Read: doi.org/10.1093/narg...
#ExomeSequencing #Genomics #Bioinformatics #NARGAB
📖 Read: doi.org/10.1093/narg...
#ExomeSequencing #Genomics #Bioinformatics #NARGAB
🧬New in NARGAB: a composite hypothesis testing (CHT) method to find genetic regions affecting multiple traits is described which is efficient, scalable and applied to psychiatric disorders and viral resistance in cucumber.
Read here: doi.org/10.1093/narg...
#Genomics #CHT #Bioinformatics #NARGAB
Read here: doi.org/10.1093/narg...
#Genomics #CHT #Bioinformatics #NARGAB
September 22, 2025 at 2:16 PM
🧬New in NARGAB: a composite hypothesis testing (CHT) method to find genetic regions affecting multiple traits is described which is efficient, scalable and applied to psychiatric disorders and viral resistance in cucumber.
Read here: doi.org/10.1093/narg...
#Genomics #CHT #Bioinformatics #NARGAB
Read here: doi.org/10.1093/narg...
#Genomics #CHT #Bioinformatics #NARGAB
🤰 New research in NARMME reveals that uterine glands, not just eggs, are sensitive to maternal aging. 🧬 FOXC1 marks early dysfunction, reshaping how we understand fertility decline.
📖 Read more: lnkd.in/eahrVbMt
#FertilityResearch #FOXC1 #ReproductiveScience #NARMME #OpenAccessPublication
📖 Read more: lnkd.in/eahrVbMt
#FertilityResearch #FOXC1 #ReproductiveScience #NARMME #OpenAccessPublication
September 19, 2025 at 5:04 PM
🤰 New research in NARMME reveals that uterine glands, not just eggs, are sensitive to maternal aging. 🧬 FOXC1 marks early dysfunction, reshaping how we understand fertility decline.
📖 Read more: lnkd.in/eahrVbMt
#FertilityResearch #FOXC1 #ReproductiveScience #NARMME #OpenAccessPublication
📖 Read more: lnkd.in/eahrVbMt
#FertilityResearch #FOXC1 #ReproductiveScience #NARMME #OpenAccessPublication
💡 New in NARMME: TRL1 enzyme from Candida glabrata changes shape to control RNA repair, vital for fungal survival. Its absence in humans makes it a promising antifungal drug target.
📖 Read more: doi.org/10.1093/narm...
#TRL1 #RNARepair #AntifungalResearch #DrugDiscovery #NARMME #OpenAccess
📖 Read more: doi.org/10.1093/narm...
#TRL1 #RNARepair #AntifungalResearch #DrugDiscovery #NARMME #OpenAccess
September 18, 2025 at 4:56 PM
💡 New in NARMME: TRL1 enzyme from Candida glabrata changes shape to control RNA repair, vital for fungal survival. Its absence in humans makes it a promising antifungal drug target.
📖 Read more: doi.org/10.1093/narm...
#TRL1 #RNARepair #AntifungalResearch #DrugDiscovery #NARMME #OpenAccess
📖 Read more: doi.org/10.1093/narm...
#TRL1 #RNARepair #AntifungalResearch #DrugDiscovery #NARMME #OpenAccess
🔬 New study in NARMME explores how azvudine (FNC) targets HIV-1 RT & SARS-CoV-2 RdRp🧬
📖 doi.org/10.1093/narm...
#Azvudine #AntiviralAgents #HIVResearch #SARSCoV2 #NARMolecularMedicine #OpenAccessPublication
📖 doi.org/10.1093/narm...
#Azvudine #AntiviralAgents #HIVResearch #SARSCoV2 #NARMolecularMedicine #OpenAccessPublication
September 18, 2025 at 4:47 PM
🔬 New study in NARMME explores how azvudine (FNC) targets HIV-1 RT & SARS-CoV-2 RdRp🧬
📖 doi.org/10.1093/narm...
#Azvudine #AntiviralAgents #HIVResearch #SARSCoV2 #NARMolecularMedicine #OpenAccessPublication
📖 doi.org/10.1093/narm...
#Azvudine #AntiviralAgents #HIVResearch #SARSCoV2 #NARMolecularMedicine #OpenAccessPublication
💡A new RNAi strategy described in NARMME embeds miR-based shRNAs into a gamma-retroviral intron, enabling gene knockdown and protein coexpression with high viral titers.
📖 doi.org/10.1093/narm...
#RNAi #GeneTherapy #RetroviralVectors #MolecularBiology #NARMME #OpenAccessPublication
📖 doi.org/10.1093/narm...
#RNAi #GeneTherapy #RetroviralVectors #MolecularBiology #NARMME #OpenAccessPublication
September 15, 2025 at 1:33 PM
💡A new RNAi strategy described in NARMME embeds miR-based shRNAs into a gamma-retroviral intron, enabling gene knockdown and protein coexpression with high viral titers.
📖 doi.org/10.1093/narm...
#RNAi #GeneTherapy #RetroviralVectors #MolecularBiology #NARMME #OpenAccessPublication
📖 doi.org/10.1093/narm...
#RNAi #GeneTherapy #RetroviralVectors #MolecularBiology #NARMME #OpenAccessPublication
🧬 A new review in NARMME explores how chromatin preserves cell identity and how its breakdown may drive diseases like neurodegeneration and cancer.
📖 doi.org/10.1093/narm...
#Epigenetics #Chromatin #CellBiology #Genomics #Neuroscience #MolecularBiology #OpenAccess #NARMolecularMedicine
📖 doi.org/10.1093/narm...
#Epigenetics #Chromatin #CellBiology #Genomics #Neuroscience #MolecularBiology #OpenAccess #NARMolecularMedicine
September 15, 2025 at 1:11 PM
🧬 A new review in NARMME explores how chromatin preserves cell identity and how its breakdown may drive diseases like neurodegeneration and cancer.
📖 doi.org/10.1093/narm...
#Epigenetics #Chromatin #CellBiology #Genomics #Neuroscience #MolecularBiology #OpenAccess #NARMolecularMedicine
📖 doi.org/10.1093/narm...
#Epigenetics #Chromatin #CellBiology #Genomics #Neuroscience #MolecularBiology #OpenAccess #NARMolecularMedicine
🐟 New in NARMME: malat1 in zebrafish triggers signaling for retinal repair guided by Notch, Wnt & TGF-β pathways. In mammals, TGF-β blocks regeneration revealing a key difference in healing potential.
🔗 doi.org/10.1093/narm...
#Zebrafish #RetinaRepair #Malat1 #MolecularBiology #NARMME #OpenAccess
🔗 doi.org/10.1093/narm...
#Zebrafish #RetinaRepair #Malat1 #MolecularBiology #NARMME #OpenAccess
September 12, 2025 at 11:31 AM
🐟 New in NARMME: malat1 in zebrafish triggers signaling for retinal repair guided by Notch, Wnt & TGF-β pathways. In mammals, TGF-β blocks regeneration revealing a key difference in healing potential.
🔗 doi.org/10.1093/narm...
#Zebrafish #RetinaRepair #Malat1 #MolecularBiology #NARMME #OpenAccess
🔗 doi.org/10.1093/narm...
#Zebrafish #RetinaRepair #Malat1 #MolecularBiology #NARMME #OpenAccess
🦟 New in NARMME: for the first time, microRNA in tsetse fly saliva carrying Trypanosoma brucei were profiled. Infected flies carry less diverse microRNAs, hinting roles in how the disease spreads.
🔗 doi.org/10.1093/narm...
#SleepingSickness #TsetseFly #MicroRNA #Trypanosomes #NARMME #OpenAccess
🔗 doi.org/10.1093/narm...
#SleepingSickness #TsetseFly #MicroRNA #Trypanosomes #NARMME #OpenAccess
September 12, 2025 at 11:26 AM
🦟 New in NARMME: for the first time, microRNA in tsetse fly saliva carrying Trypanosoma brucei were profiled. Infected flies carry less diverse microRNAs, hinting roles in how the disease spreads.
🔗 doi.org/10.1093/narm...
#SleepingSickness #TsetseFly #MicroRNA #Trypanosomes #NARMME #OpenAccess
🔗 doi.org/10.1093/narm...
#SleepingSickness #TsetseFly #MicroRNA #Trypanosomes #NARMME #OpenAccess
⭐ #NARBreakthrough in #RNAengineering!⭐
University of Utah @utah.edu chemists show that a single dye can emit two colors with engineered #Broccoli #aptamers (Golden = yellow, Red = red).
They built the first ratiometric biosensor to track #glycine dynamics!
Read more 👉 doi.org/10.1093/nar/...
University of Utah @utah.edu chemists show that a single dye can emit two colors with engineered #Broccoli #aptamers (Golden = yellow, Red = red).
They built the first ratiometric biosensor to track #glycine dynamics!
Read more 👉 doi.org/10.1093/nar/...
September 11, 2025 at 2:42 PM
⭐ #NARBreakthrough in #RNAengineering!⭐
University of Utah @utah.edu chemists show that a single dye can emit two colors with engineered #Broccoli #aptamers (Golden = yellow, Red = red).
They built the first ratiometric biosensor to track #glycine dynamics!
Read more 👉 doi.org/10.1093/nar/...
University of Utah @utah.edu chemists show that a single dye can emit two colors with engineered #Broccoli #aptamers (Golden = yellow, Red = red).
They built the first ratiometric biosensor to track #glycine dynamics!
Read more 👉 doi.org/10.1093/nar/...
🌟 Discover NARGAB Editor's Choice articles, hand-picked by our Editor-in-Chief for their quality and impact.
👉 All articles are free to read and download, explore the full collection now!
🔗 academic.oup.com/nargab/pages...
#NARGenomicsandBioinformatics #EditorsChoice #OpenAccess
👉 All articles are free to read and download, explore the full collection now!
🔗 academic.oup.com/nargab/pages...
#NARGenomicsandBioinformatics #EditorsChoice #OpenAccess
September 9, 2025 at 1:57 PM
🌟 Discover NARGAB Editor's Choice articles, hand-picked by our Editor-in-Chief for their quality and impact.
👉 All articles are free to read and download, explore the full collection now!
🔗 academic.oup.com/nargab/pages...
#NARGenomicsandBioinformatics #EditorsChoice #OpenAccess
👉 All articles are free to read and download, explore the full collection now!
🔗 academic.oup.com/nargab/pages...
#NARGenomicsandBioinformatics #EditorsChoice #OpenAccess
⭐NAR Breakthrough!⭐
🧬 New study shows Prp22 has a dual role in #splicing—an ATP-independent function that promotes #exonligation by stabilizing Slu7, and an ATP-dependent role that drives Slu7 dissociation + #mRNArelease.
📖 ttps://doi.org/10.1093/nar/gkaf823
#NARBreakthrough #RNA #RNAHelicase
🧬 New study shows Prp22 has a dual role in #splicing—an ATP-independent function that promotes #exonligation by stabilizing Slu7, and an ATP-dependent role that drives Slu7 dissociation + #mRNArelease.
📖 ttps://doi.org/10.1093/nar/gkaf823
#NARBreakthrough #RNA #RNAHelicase
August 29, 2025 at 3:09 PM
⭐NAR Breakthrough!⭐
🧬 New study shows Prp22 has a dual role in #splicing—an ATP-independent function that promotes #exonligation by stabilizing Slu7, and an ATP-dependent role that drives Slu7 dissociation + #mRNArelease.
📖 ttps://doi.org/10.1093/nar/gkaf823
#NARBreakthrough #RNA #RNAHelicase
🧬 New study shows Prp22 has a dual role in #splicing—an ATP-independent function that promotes #exonligation by stabilizing Slu7, and an ATP-dependent role that drives Slu7 dissociation + #mRNArelease.
📖 ttps://doi.org/10.1093/nar/gkaf823
#NARBreakthrough #RNA #RNAHelicase
🧬 IQ2 could be a new approach to treating visceral leishmaniasis (VL) via c-MYC gene silencing and immune cell reactivation!🥊
📖 Read in NARMME: doi.org/10.1093/narm...
#VisceralLeishmaniasis #KalaAzar #Parasitology #MolecularBiology #OAPublication
📖 Read in NARMME: doi.org/10.1093/narm...
#VisceralLeishmaniasis #KalaAzar #Parasitology #MolecularBiology #OAPublication
August 19, 2025 at 11:36 AM
🧬 IQ2 could be a new approach to treating visceral leishmaniasis (VL) via c-MYC gene silencing and immune cell reactivation!🥊
📖 Read in NARMME: doi.org/10.1093/narm...
#VisceralLeishmaniasis #KalaAzar #Parasitology #MolecularBiology #OAPublication
📖 Read in NARMME: doi.org/10.1093/narm...
#VisceralLeishmaniasis #KalaAzar #Parasitology #MolecularBiology #OAPublication
🧬 DM1 is a complex genetic disease affecting multiple body systems. A fast, reliable method to measure DMPK & MBNL1 proteins across diverse cell models is described in NARMME: doi.org/10.1093/narm...
@varechavala.bsky.social
#DM1Research #MyotonicDystrophy #MolecularBiology #OAPublication
@varechavala.bsky.social
#DM1Research #MyotonicDystrophy #MolecularBiology #OAPublication
August 19, 2025 at 11:07 AM
🧬 DM1 is a complex genetic disease affecting multiple body systems. A fast, reliable method to measure DMPK & MBNL1 proteins across diverse cell models is described in NARMME: doi.org/10.1093/narm...
@varechavala.bsky.social
#DM1Research #MyotonicDystrophy #MolecularBiology #OAPublication
@varechavala.bsky.social
#DM1Research #MyotonicDystrophy #MolecularBiology #OAPublication
Dr. Yoshikazu Hattori generated the mutants and performed NMR analysis, while Prof. Yoshiyuki Tanaka directed and conceptualized the entire project.
August 4, 2025 at 9:09 AM
Dr. Yoshikazu Hattori generated the mutants and performed NMR analysis, while Prof. Yoshiyuki Tanaka directed and conceptualized the entire project.
Prof. Masaki Unno led the crystallographic analysis, while Dr. Masayuki Morikawa contributed kinetics and mass spectrometry to uncover the mechanism.
August 4, 2025 at 9:09 AM
Prof. Masaki Unno led the crystallographic analysis, while Dr. Masayuki Morikawa contributed kinetics and mass spectrometry to uncover the mechanism.
⭐NAR Breakthrough!⭐
AlphaFold2 predicted LSI–RDF interactions and experimentally validated several new functional pairs.
@phoeberice.bsky.social @femijohn.bsky.social
doi.org/10.1093/nar/...
#NARBreakthrough #SyntheticBiology #AlphaFold2 #GenomeEditing #ComputationalBiology
AlphaFold2 predicted LSI–RDF interactions and experimentally validated several new functional pairs.
@phoeberice.bsky.social @femijohn.bsky.social
doi.org/10.1093/nar/...
#NARBreakthrough #SyntheticBiology #AlphaFold2 #GenomeEditing #ComputationalBiology
July 24, 2025 at 9:38 AM
⭐NAR Breakthrough!⭐
AlphaFold2 predicted LSI–RDF interactions and experimentally validated several new functional pairs.
@phoeberice.bsky.social @femijohn.bsky.social
doi.org/10.1093/nar/...
#NARBreakthrough #SyntheticBiology #AlphaFold2 #GenomeEditing #ComputationalBiology
AlphaFold2 predicted LSI–RDF interactions and experimentally validated several new functional pairs.
@phoeberice.bsky.social @femijohn.bsky.social
doi.org/10.1093/nar/...
#NARBreakthrough #SyntheticBiology #AlphaFold2 #GenomeEditing #ComputationalBiology
⭐NAR Breakthrough!⭐
🧬Mutation rates at the 3' end of DNA primer strands vary with run length. 4 TIM pathways in yeast DNA replication may be universal and linked to human disease.
📖 doi.org/10.1093/nar/...
#YeastGenetics #Genomics #DNAReplication #MolecularBiology
🧬Mutation rates at the 3' end of DNA primer strands vary with run length. 4 TIM pathways in yeast DNA replication may be universal and linked to human disease.
📖 doi.org/10.1093/nar/...
#YeastGenetics #Genomics #DNAReplication #MolecularBiology
July 23, 2025 at 9:33 AM
⭐NAR Breakthrough!⭐
🧬Mutation rates at the 3' end of DNA primer strands vary with run length. 4 TIM pathways in yeast DNA replication may be universal and linked to human disease.
📖 doi.org/10.1093/nar/...
#YeastGenetics #Genomics #DNAReplication #MolecularBiology
🧬Mutation rates at the 3' end of DNA primer strands vary with run length. 4 TIM pathways in yeast DNA replication may be universal and linked to human disease.
📖 doi.org/10.1093/nar/...
#YeastGenetics #Genomics #DNAReplication #MolecularBiology
📢 The 23rd annual NAR Web Server Issue is live!
🧬 Featuring 72 new web servers across scientific & medical fields.
👏 Huge thanks to all authors, editors and reviewers!
🔗 Issue: lnkd.in/dVyUdAVN
📝 Editorial: lnkd.in/d9qh3QEh
#NARWebServer #GeneticSoftware #MolecularBiology #OpenAccessIssue
🧬 Featuring 72 new web servers across scientific & medical fields.
👏 Huge thanks to all authors, editors and reviewers!
🔗 Issue: lnkd.in/dVyUdAVN
📝 Editorial: lnkd.in/d9qh3QEh
#NARWebServer #GeneticSoftware #MolecularBiology #OpenAccessIssue
July 17, 2025 at 3:08 PM
📢 The 23rd annual NAR Web Server Issue is live!
🧬 Featuring 72 new web servers across scientific & medical fields.
👏 Huge thanks to all authors, editors and reviewers!
🔗 Issue: lnkd.in/dVyUdAVN
📝 Editorial: lnkd.in/d9qh3QEh
#NARWebServer #GeneticSoftware #MolecularBiology #OpenAccessIssue
🧬 Featuring 72 new web servers across scientific & medical fields.
👏 Huge thanks to all authors, editors and reviewers!
🔗 Issue: lnkd.in/dVyUdAVN
📝 Editorial: lnkd.in/d9qh3QEh
#NARWebServer #GeneticSoftware #MolecularBiology #OpenAccessIssue
🔬 A new study in NAR Genomics and Bioinformatics compares short-read and long-read sequencing, aligning results at the cDNA level using UMIs 🧬
📖 Dive into the full article: doi.org/10.1093/narg...
#Sequencing #Bioinformatics #GeneExpression #Genomics #UniqueMolecularIdentifier #NARGAB
📖 Dive into the full article: doi.org/10.1093/narg...
#Sequencing #Bioinformatics #GeneExpression #Genomics #UniqueMolecularIdentifier #NARGAB
July 16, 2025 at 1:44 PM
🔬 A new study in NAR Genomics and Bioinformatics compares short-read and long-read sequencing, aligning results at the cDNA level using UMIs 🧬
📖 Dive into the full article: doi.org/10.1093/narg...
#Sequencing #Bioinformatics #GeneExpression #Genomics #UniqueMolecularIdentifier #NARGAB
📖 Dive into the full article: doi.org/10.1093/narg...
#Sequencing #Bioinformatics #GeneExpression #Genomics #UniqueMolecularIdentifier #NARGAB