Introducing The Structural History of Eukarya (SHE): The first proteome-scale phylogeny constructed entirely from 3D structure.
We computed 300 trillion alignments across 1,542 species to map the tree of life. 🧵👇 (1/5)

New Title Alert: meteor- a tool for computing crystallographic difference maps that specializes in robust identification of weak signals from minor populations such as bound ligands or time-resolved experimental changes.

Learn more here: buff.ly/bgJYF9N

#SBGrid #SBGridSoftware #StructuralBiology

Check our new preprint smoothing rugged Cryo-EM landscapes: shorturl.at/gYs9U

We tackle practical hurdles of Optimal Transport (OT) loss—differentiability, cost & noise sensitivity—make it a feasible inference workhorse.
W/ G. Woollard, D. Herreros, @pilarcossio.bsky.social, K. Dao Duc 🧵👇 (1/9)

The Inaugural Flatiron Institute Cryo-EM Conformational Heterogeneity Challenge pubmed.ncbi.nlm.nih.gov/41280101/ #cryoem

Frontier structural biology chases low occupancies: weak binders in drug discovery & fleeting intermediates in time-resolved studies. When squeezing SNR, confirmation bias looms – you can see what you hope to see in the noise! Enter METEOR ☄️, our denoising+phasing framework! 1/8

Excited to share our latest @nature.com: How does naloxone (Narcan) stop an opioid overdose? We determined the first GDP-bound μ-opioid receptor–G protein structures and found naloxone traps a novel "latent” state, preventing GDP release and G protein activation.💊🧪 🧵👇 www.nature.com/articles/s41...

If you missed the live presentation with
@alisiafadini.bsky.social and @minhuanli.bsky.social introducing ROCKET, you can watch the video on SBGrid's YouTube channel.

More here: buff.ly/nsA12eg

#SBGrid #Webinars

OpenFold3-preview (OF3p) is out: a sneak peek of our AF3-based structure prediction model. Our aim for OF3 is full AF3-parity for every modality. We now believe we have a clear path towards this goal and are releasing OF3p to enable building in the OF3 ecosystem. More👇

ROCKET's webinar on cryo-EM+crystal data-guided protein structure prediction is now online 🚀: www.youtube.com/watch?v=_29C...

Thank you to the many of you who attended and stayed overtime for more Q&A, and especially to @sbgrid.bsky.social for hosting us last week!

We'll cover our latest work on low resolution applications, a run-through of our codebase, and tutorials of how to run ROCKET on your own data. Join if you're interested!! 🚀

Structural biology is in an era of dynamics & assemblies but turning raw experimental data into atomic models at scale remains challenging. @minhuanli.bsky.social and I present ROCKET🚀: an AlphaFold augmentation that integrates crystallographic and cryoEM/ET data with room for more! 1/14.