Chinthalapudi Lab
@chinthalapudi-lab.bsky.social
Asst Professor@OSU
Pinned
Structural basis of human Nav1.5 gating mechanisms | PNAS
Voltage-gated Nav1.5 channels are central to the generation and propagation of cardiac
action potentials. Aberrations in their function are associa...
www.pnas.org
Structural basis of human Nav1.5 gating mechanisms | PNAS www.pnas.org/doi/10.1073/...
Reposted by Chinthalapudi Lab
Structural basis of nonmuscle myosin-2 autoinhibition mechanisms
- another interesting paper on the myosin-2 shutdown state, this one from the Heissler and Chinthalapudi groups.
www.biorxiv.org/content/10.1...
- another interesting paper on the myosin-2 shutdown state, this one from the Heissler and Chinthalapudi groups.
www.biorxiv.org/content/10.1...
Structural basis of nonmuscle myosin-2 autoinhibition mechanisms
Nonmuscle myosin-2 (NM2) is a fundamental actin-based mechanochemical ATPase that regulates cellular architecture, migration, adhesion, and force generation across diverse biological contexts. NM2 fun...
www.biorxiv.org
October 25, 2025 at 11:04 AM
Structural basis of nonmuscle myosin-2 autoinhibition mechanisms
- another interesting paper on the myosin-2 shutdown state, this one from the Heissler and Chinthalapudi groups.
www.biorxiv.org/content/10.1...
- another interesting paper on the myosin-2 shutdown state, this one from the Heissler and Chinthalapudi groups.
www.biorxiv.org/content/10.1...
Structural basis of human Nav1.5 gating mechanisms | PNAS www.pnas.org/doi/10.1073/...
Structural basis of human Nav1.5 gating mechanisms | PNAS
Voltage-gated Nav1.5 channels are central to the generation and propagation of cardiac
action potentials. Aberrations in their function are associa...
www.pnas.org
May 15, 2025 at 12:22 AM
Structural basis of human Nav1.5 gating mechanisms | PNAS www.pnas.org/doi/10.1073/...
Structural basis of human Nav1.5 gating mechanisms | PNAS www.pnas.org/doi/10.1073/...
Check our work on sodium channel. We are very proud of this study.
Check our work on sodium channel. We are very proud of this study.
PNAS
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...
www.pnas.org
May 14, 2025 at 3:52 PM
Structural basis of human Nav1.5 gating mechanisms | PNAS www.pnas.org/doi/10.1073/...
Check our work on sodium channel. We are very proud of this study.
Check our work on sodium channel. We are very proud of this study.
Reposted by Chinthalapudi Lab
I'm super happy that our story is now published!
📖 www.science.org/doi/10.1126/...
But what changed compared to the original preprint?
Also, I feel i should post Movie 1 🎥, that inspired the cover. Back when I did the original bluesky thread, movies were not available.
📖 www.science.org/doi/10.1126/...
But what changed compared to the original preprint?
Also, I feel i should post Movie 1 🎥, that inspired the cover. Back when I did the original bluesky thread, movies were not available.
March 21, 2025 at 2:09 PM
I'm super happy that our story is now published!
📖 www.science.org/doi/10.1126/...
But what changed compared to the original preprint?
Also, I feel i should post Movie 1 🎥, that inspired the cover. Back when I did the original bluesky thread, movies were not available.
📖 www.science.org/doi/10.1126/...
But what changed compared to the original preprint?
Also, I feel i should post Movie 1 🎥, that inspired the cover. Back when I did the original bluesky thread, movies were not available.
Reposted by Chinthalapudi Lab
In Memoriam: Wolfenson, Giannone, and Schwartz recall the life and many contributions of Michael Sheetz, who passed away on January 30, 2025. rupress.org/jcb/article/...
March 21, 2025 at 4:18 PM
In Memoriam: Wolfenson, Giannone, and Schwartz recall the life and many contributions of Michael Sheetz, who passed away on January 30, 2025. rupress.org/jcb/article/...
Reposted by Chinthalapudi Lab
Congrats 👏 Hsiang-Ling Huang, Giovanna Grandinetti, Sarah Heissler & Krishna Chinthalapudi on the wwPDB Foundation award at the 2025 @BiophysicalSociety Meeting for their work on mechanisms of dysferlin-mediated membrane repair!
🔗 www.wwpdb.org/news/news?ye...
#bps2025 #BPSAnnualMeeting
🔗 www.wwpdb.org/news/news?ye...
#bps2025 #BPSAnnualMeeting
March 13, 2025 at 10:00 AM
Congrats 👏 Hsiang-Ling Huang, Giovanna Grandinetti, Sarah Heissler & Krishna Chinthalapudi on the wwPDB Foundation award at the 2025 @BiophysicalSociety Meeting for their work on mechanisms of dysferlin-mediated membrane repair!
🔗 www.wwpdb.org/news/news?ye...
#bps2025 #BPSAnnualMeeting
🔗 www.wwpdb.org/news/news?ye...
#bps2025 #BPSAnnualMeeting
Reposted by Chinthalapudi Lab
The National Institutes of Health had to stop considering new grant applications, delaying funding for research into diseases ranging from heart disease and cancer to Alzheimer's and allergies.
NIH funding freeze stalls applications on $1.5 billion in medical research funds
The National Institutes of Health had to stop considering new grant applications, delaying funding for research into diseases ranging from heart disease and cancer to Alzheimer's and allergies.
www.npr.org
February 22, 2025 at 6:39 PM
The National Institutes of Health had to stop considering new grant applications, delaying funding for research into diseases ranging from heart disease and cancer to Alzheimer's and allergies.
Reposted by Chinthalapudi Lab
I started my lab more then 4 years ago, and we have endured some very challenging times ever since.…I am very excited to share the first paper from my lab, published now in @naturemethods.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Genetically encoded biosensor for fluorescence lifetime imaging of PTEN dynamics in the intact brain - Nature Methods
A first-in-class fluorescence lifetime-based FRET sensor for phosphatase and tensin homolog (PTEN) enables the dynamic monitoring of PTEN activity in cultured cells and in vivo with high spatiotempora...
www.nature.com
February 20, 2025 at 1:10 PM
I started my lab more then 4 years ago, and we have endured some very challenging times ever since.…I am very excited to share the first paper from my lab, published now in @naturemethods.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Chinthalapudi Lab
The "schedule" of upcoming National Advisory Council meetings (based on posted dates)
No special meetings have been posted. These meetings must be announced at least 15 days in advance in the Federal Register
Once communications and Federal Register posting bans are lifted these may change...
No special meetings have been posted. These meetings must be announced at least 15 days in advance in the Federal Register
Once communications and Federal Register posting bans are lifted these may change...
February 18, 2025 at 7:35 AM
The "schedule" of upcoming National Advisory Council meetings (based on posted dates)
No special meetings have been posted. These meetings must be announced at least 15 days in advance in the Federal Register
Once communications and Federal Register posting bans are lifted these may change...
No special meetings have been posted. These meetings must be announced at least 15 days in advance in the Federal Register
Once communications and Federal Register posting bans are lifted these may change...
Reposted by Chinthalapudi Lab
Reposted by Chinthalapudi Lab
It’s been a tough few weeks. My 10yo daughter was diagnosed with a very rare, aggressive cancer called interdigitating dendritic cell sarcoma (IDCS). I’m reaching out to identify clinicians/patients who have encountered pediatric IDCS or other (non-LCH) dendritic or histiocytic sarcomas cases.
February 8, 2025 at 9:21 PM
It’s been a tough few weeks. My 10yo daughter was diagnosed with a very rare, aggressive cancer called interdigitating dendritic cell sarcoma (IDCS). I’m reaching out to identify clinicians/patients who have encountered pediatric IDCS or other (non-LCH) dendritic or histiocytic sarcomas cases.
Reposted by Chinthalapudi Lab
I'd like to draw your attention to this truly excellent paper from the Taraska lab on cryoET of plasma membrane associated proteins. Everyone who is thinking about probes in the cryoET space should also see what they could do with ferritag (fig 6) www.nature.com/articles/s41...
January 22, 2025 at 4:40 PM
I'd like to draw your attention to this truly excellent paper from the Taraska lab on cryoET of plasma membrane associated proteins. Everyone who is thinking about probes in the cryoET space should also see what they could do with ferritag (fig 6) www.nature.com/articles/s41...
Reposted by Chinthalapudi Lab
My first post on this forum! 😄
I am happy to share that our #openaccess review on the #molecular mechanisms of #actin filament polymerization and dissasembly is now online @cp-trendscellbio.bsky.social
www.cell.com/trends/cell-...
Big thanks to my amazing colleagues in Dortmund
I am happy to share that our #openaccess review on the #molecular mechanisms of #actin filament polymerization and dissasembly is now online @cp-trendscellbio.bsky.social
www.cell.com/trends/cell-...
Big thanks to my amazing colleagues in Dortmund
January 23, 2025 at 9:08 AM
My first post on this forum! 😄
I am happy to share that our #openaccess review on the #molecular mechanisms of #actin filament polymerization and dissasembly is now online @cp-trendscellbio.bsky.social
www.cell.com/trends/cell-...
Big thanks to my amazing colleagues in Dortmund
I am happy to share that our #openaccess review on the #molecular mechanisms of #actin filament polymerization and dissasembly is now online @cp-trendscellbio.bsky.social
www.cell.com/trends/cell-...
Big thanks to my amazing colleagues in Dortmund
Reposted by Chinthalapudi Lab
I was looking forward to this one! An open source software for fast reconstruction of 3D structured illumination microscopy (SIM) from Xi Peng's lab : www.cell.com/the-innovati...
Matlab-based, code here: github.com/Cao-ruijie/F...
Matlab-based, code here: github.com/Cao-ruijie/F...
January 13, 2025 at 12:10 PM
I was looking forward to this one! An open source software for fast reconstruction of 3D structured illumination microscopy (SIM) from Xi Peng's lab : www.cell.com/the-innovati...
Matlab-based, code here: github.com/Cao-ruijie/F...
Matlab-based, code here: github.com/Cao-ruijie/F...
Reposted by Chinthalapudi Lab
MIRO2 promotes cancer invasion and metastasis via MYO9B suppression of RhoA activity
www.cell.com/cell-reports...
www.cell.com/cell-reports...
MIRO2 promotes cancer invasion and metastasis via MYO9B suppression of RhoA activity
Boulton et al. report that MIRO2 is required for breast and prostate cancer invasion and metastasis. This role is mediated via interaction with MYO9B and repression of RhoA activation. This signaling may be relevant in patients, as higher MIRO2 expression is associated with downregulation of RhoA-specific genes.
www.cell.com
December 27, 2024 at 1:13 PM
MIRO2 promotes cancer invasion and metastasis via MYO9B suppression of RhoA activity
www.cell.com/cell-reports...
www.cell.com/cell-reports...
Reposted by Chinthalapudi Lab
#TeamTomo visits the centrosome. I remember the centrosome and PCM being one of Julia's first targets when we were postdocs together at @mpibiochem.bsky.social. It's cool seeing the progress here in worms with Jeff. Beautiful #CryoET across the cell cycle. @centriolelab.bsky.social take a look! 🧪🧶🧬
Mahamid and Woodruff labs use cryo-ET to look at mitotic centrosomes: Stunned to see the pericentriolar matrix taking shape, and what seem to be ‚S size’ gamma-tubulin complex oligomers capping the end of 11-pf microtubules.
www.cell.com/developmenta...
www.cell.com/developmenta...
Molecular architectures of centrosomes in C. elegans embryos visualized by cryo-electron tomography
Tollervey et al. use cryo-electron tomography to capture 3D snapshots of centrosomes at molecular resolution in their near-native state inside embryonic C. elegans cells in different stages of cell division. They characterize structural features of centrioles during their assembly and of a disordered matrix that nucleates and organizes mitotic spindle microtubules.
www.cell.com
December 25, 2024 at 6:40 PM
#TeamTomo visits the centrosome. I remember the centrosome and PCM being one of Julia's first targets when we were postdocs together at @mpibiochem.bsky.social. It's cool seeing the progress here in worms with Jeff. Beautiful #CryoET across the cell cycle. @centriolelab.bsky.social take a look! 🧪🧶🧬
Reposted by Chinthalapudi Lab
Could one envision a synthetic receptor technology that is fully programmable, able to detect diverse extracellular antigens – both soluble and cell-attached – and convert that recognition into a wide range of intracellular responses, from gene expression and real-time fluorescence to modulation..
December 4, 2024 at 4:05 PM
Could one envision a synthetic receptor technology that is fully programmable, able to detect diverse extracellular antigens – both soluble and cell-attached – and convert that recognition into a wide range of intracellular responses, from gene expression and real-time fluorescence to modulation..
Reposted by Chinthalapudi Lab
super cool work showing important role for Myo1B, an UNC45A binding partner, in several aspect of intestinal morphogenesis!
www.cell.com/cell-reports...
www.cell.com/cell-reports...
Myosin 1b regulates intestinal epithelial morphogenesis via interaction with UNC45A
Revenu et al. show the function of myosin 1b (Myo1b) in intestinal epithelia. In human cells, MYO1B is part of the UNC45A interactome and contributes to lumenogenesis by modulating spindle orientation in vitro. In zebrafish Myo1b is important for intestinal epithelium folding during the development of the intestinal bulb.
www.cell.com
December 4, 2024 at 7:32 PM
super cool work showing important role for Myo1B, an UNC45A binding partner, in several aspect of intestinal morphogenesis!
www.cell.com/cell-reports...
www.cell.com/cell-reports...
I’m looking for a motivated postdoc to join my lab with a structural biology background. Reach out to me if you are interested in the structure-function studies of actin cytoskeleton and membrane repair processes.
December 3, 2024 at 1:21 PM
I’m looking for a motivated postdoc to join my lab with a structural biology background. Reach out to me if you are interested in the structure-function studies of actin cytoskeleton and membrane repair processes.
Reposted by Chinthalapudi Lab
The real IFT…
intra💥filopodial💥transport.
@vucellimaging.bsky.social
#cytoskeleton #biology #microscopy
intra💥filopodial💥transport.
@vucellimaging.bsky.social
#cytoskeleton #biology #microscopy
November 26, 2024 at 11:09 PM
The real IFT…
intra💥filopodial💥transport.
@vucellimaging.bsky.social
#cytoskeleton #biology #microscopy
intra💥filopodial💥transport.
@vucellimaging.bsky.social
#cytoskeleton #biology #microscopy
Reposted by Chinthalapudi Lab
Nice work from Yasushi Okada and colleagues on the development of fluorescence lifetime biosensors for ATP, cAMP, citrate, and glucose using mTurquoise2
www.cell.com/cell-reports...
www.cell.com/cell-reports...
November 21, 2024 at 6:56 AM
Nice work from Yasushi Okada and colleagues on the development of fluorescence lifetime biosensors for ATP, cAMP, citrate, and glucose using mTurquoise2
www.cell.com/cell-reports...
www.cell.com/cell-reports...
Reposted by Chinthalapudi Lab
New Title Alert: ChemEM- a tool that utilizes information from Cryo-EM density and state-of-the-art small molecule force fields to dock small molecules into protein targets.
Learn more here: https://buff.ly/3NUvcPM
#SBGrid #SBGridsoftware #structuralbiology
Learn more here: https://buff.ly/3NUvcPM
#SBGrid #SBGridsoftware #structuralbiology
ChemEM
ChemEM utilizes information from Cryo-EM density and state-of-the-art small molecule force fields to dock small molecules into protein targets.
buff.ly
November 20, 2024 at 5:06 PM
New Title Alert: ChemEM- a tool that utilizes information from Cryo-EM density and state-of-the-art small molecule force fields to dock small molecules into protein targets.
Learn more here: https://buff.ly/3NUvcPM
#SBGrid #SBGridsoftware #structuralbiology
Learn more here: https://buff.ly/3NUvcPM
#SBGrid #SBGridsoftware #structuralbiology
Reposted by Chinthalapudi Lab
Biochemical and structural insights into the auto-inhibited state of Mical1 and its activation by Rab8
elifesciences.org/reviewed-pre...
elifesciences.org/reviewed-pre...
Biochemical and structural insights into the auto-inhibited state of Mical1 and its activation by Rab8
elifesciences.org
November 19, 2024 at 2:42 AM
Biochemical and structural insights into the auto-inhibited state of Mical1 and its activation by Rab8
elifesciences.org/reviewed-pre...
elifesciences.org/reviewed-pre...
Reposted by Chinthalapudi Lab
I am excited and honored to be named 'Cell Scientist to Watch' by Journal of Cell Science @biologists.bsky.social
Grateful to my team and mentors for their support.
Interested in working on actin? Hiring Postdocs/Grad students!
Grateful to my team and mentors for their support.
Interested in working on actin? Hiring Postdocs/Grad students!
November 15, 2024 at 12:05 PM
I am excited and honored to be named 'Cell Scientist to Watch' by Journal of Cell Science @biologists.bsky.social
Grateful to my team and mentors for their support.
Interested in working on actin? Hiring Postdocs/Grad students!
Grateful to my team and mentors for their support.
Interested in working on actin? Hiring Postdocs/Grad students!
Reposted by Chinthalapudi Lab
Don't run biomedical science as a business!
This was published in Trump's 1st term, but with the 2nd term upon us it is relevant again: "Boom–bust cycles, a feature of the business world, are destabilizing [for science]".
This was published in Trump's 1st term, but with the 2nd term upon us it is relevant again: "Boom–bust cycles, a feature of the business world, are destabilizing [for science]".
November 15, 2024 at 2:08 AM
Don't run biomedical science as a business!
This was published in Trump's 1st term, but with the 2nd term upon us it is relevant again: "Boom–bust cycles, a feature of the business world, are destabilizing [for science]".
This was published in Trump's 1st term, but with the 2nd term upon us it is relevant again: "Boom–bust cycles, a feature of the business world, are destabilizing [for science]".