Parijat Biswas
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bparijat.bsky.social
Parijat Biswas
@bparijat.bsky.social
70 followers 150 following 3 posts
Just another cytoskeleton enthusiast. Postdoc at Lappalainen lab, University of Helsinki
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Reposted by Parijat Biswas
aaandmoore.bsky.social
Attempt number seven at uploading this video of intermediate filaments in an enormous COS7 cell. I have a feeling the BlueSky compression will not do it any favors.
November 21, 2025 at 3:54 AM
Reposted by Parijat Biswas
www.biorxiv.org/content/10.1...
Vimentin promotes actin assembly by stabilizing ATP-actin subunits at the barbed end
Vimentin intermediate filaments play essential roles in maintaining cell integrity and regulating numerous cellular functions. In particular, vimentin cooperates with the actin cytoskeleton in key cel...
www.biorxiv.org
November 18, 2025 at 12:15 PM
Reposted by Parijat Biswas
biorxiv-biophys.bsky.social
Spatial deconstruction of the plasma membrane https://www.biorxiv.org/content/10.1101/2025.11.14.688519v1
November 15, 2025 at 3:48 AM
Reposted by Parijat Biswas
gerryhammond.bsky.social
Announcing our new PA biosensor, PILS-Nir1 – seen here in HeLa cells during PLC activation #lipidtime #phospholipids

Read the OA paper in JCB
September 10, 2025 at 7:56 PM
Reposted by Parijat Biswas
Non-muscle Myosin II acts as a negative feedback mediator to control cell contraction dynamics

www.biorxiv.org/content/10.1...
Non-muscle Myosin II acts as a negative feedback mediator to control cell contraction dynamics
Local cell contraction dynamics play a crucial role in tissue and cell morphogenesis. Contractions near the cell edge drive highly dynamic cell shape changes during cell migration and contraction puls...
www.biorxiv.org
September 13, 2025 at 11:44 AM
Reposted by Parijat Biswas
biorxivpreprint.bsky.social
Kinesin-induced buckling reveals the limits of microtubule self-repair https://www.biorxiv.org/content/10.1101/2025.09.08.672697v1
September 12, 2025 at 9:48 PM
Reposted by Parijat Biswas
kaksonen.bsky.social
How do cells switch on the actin assembly at endocytic sites? How can this on-switch evolve? Check out our new preprint!
www.biorxiv.org/content/10.1...
Localization of WDS proteins and fimbrin in three fungal species.
June 24, 2025 at 7:22 PM
Reposted by Parijat Biswas
elife.bsky.social
How do cells link adhesion to protein synthesis? New findings suggest the protein p130Cas forms droplets that bud from focal adhesions and suppress translation, hinting at a novel mechanism for regulating cell state via phase separation.
buff.ly/2I99ZTc
July 6, 2025 at 8:21 AM
Reposted by Parijat Biswas
kjohnsson.bsky.social
Finally out in Nature Chem Bio:
SNAP-tag2 for faster and brighter protein labeling
www.nature.com/articles/s41...
Thank you Steffi and Veselin.
SNAP-tag2 for faster and brighter protein labeling - Nature Chemical Biology
SNAP-tag is a widespread tool for labeling protein for bioimaging. Now, Kühn et al. report SNAP-tag2 with increased labeling kinetics and brightness, which translates into a better performance in live...
www.nature.com
July 3, 2025 at 7:45 PM
Reposted by Parijat Biswas
biorxiv-cellbio.bsky.social
Endothelial β-PIX (ARHGEF7) drives exocytosis through enabling the dynamic reorganisation of the cytoskeleton https://www.biorxiv.org/content/10.1101/2025.05.06.652370v1
May 7, 2025 at 3:30 PM
Reposted by Parijat Biswas
ryotaiino.bsky.social
DNA-nanoparticle motor.
www.nature.com/articles/s41...
April 23, 2025 at 3:19 AM
Reposted by Parijat Biswas
jcellsci.bsky.social
In their Review, Laura Faure, Valeria Venturini @valeriaventurini.bsky.social and Pere Roca-Cusachs discuss the biological contexts of cell mechanical compression, the associated mechanisms and the experimental systems engineered to compress cells in vitro.
journals.biologists.com/jcs/article/...
Cartoon of techniques to apply one-dimensional, in-plane or volumetric cell compression in vitro.
March 28, 2025 at 11:46 AM
Reposted by Parijat Biswas
biorxiv-cellbio.bsky.social
Alpha-actinin-1 stabilizes focal adhesions to facilitate sarcomere assembly in cardiac myocytes https://www.biorxiv.org/content/10.1101/2025.03.28.645933v1
March 29, 2025 at 8:30 AM
Reposted by Parijat Biswas
biorxiv-biophys.bsky.social
A coarse-grained model for simulations of phosphorylated disordered proteins https://www.biorxiv.org/content/10.1101/2025.03.19.644261v1
March 21, 2025 at 12:47 AM
Reposted by Parijat Biswas
nadlerlab.bsky.social
Are lipids actively sorted during clathrin mediated endocytosis like proteins? @mathilda95.bsky.social addresses this key open question together with our collaborators from the Honigmann and Modes labs using a new Lipid-STED workflow.
www.biorxiv.org/content/10.1...
March 10, 2025 at 11:57 AM
Reposted by Parijat Biswas
jcb.org
Renganathan, Moor, @vgelfand.bsky.social et al. use single-particle tracking to show that #vimentin intermediate filaments display active movement throughout the cell, with individual filaments within a bundle moving independently rupress.org/jcb/article/...

#Cytoskeleton #Microscopy
March 10, 2025 at 4:18 PM
Reposted by Parijat Biswas
ankita13jha.bsky.social
As scientist I am going through difficult times (this is understatement of the year for me!!). Past one and half months have been horrible, however I am trying to pick myself up and super excited to share my postdoc work with the community! #cellmigration
www.biorxiv.org/content/10.1...
CD44 and Ezrin restrict EGF receptor mobility to generate a novel spatial arrangement of cytoskeletal signaling modules driving bleb-based migration
Cells under high confinement form highly polarized hydrostatic pressure-driven, stable leader blebs that enable efficient migration in low adhesion, environments. Here we investigated the basis of the...
www.biorxiv.org
March 10, 2025 at 3:36 AM
Reposted by Parijat Biswas
ryotaiino.bsky.social
An excellent review article of MINFLUX.
MINFLUX achieves molecular resolution with minimal photons
Lukas Scheiderer, Zach Marin & Jonas Ries
Nature Photonics, 19, 238–247 (2025)
www.nature.com/articles/s41...
MINFLUX achieves molecular resolution with minimal photons - Nature Photonics
The authors review MINFLUX super-resolution microscopy, outlining its advantages and limitations, recent progress, and an outlook for future developments.
www.nature.com
March 9, 2025 at 9:27 AM
Reposted by Parijat Biswas
epimechfc.bsky.social
This dot is a region that intersect multiple cell junctions in an epithelia. These dots act as tiny anchors of cell contacts and they’re critical for epithelial coherence during homeostasis AND development.

I’m @katecavanaugh.bsky.social and I’ll be your guide on this 🧵 about tricellular vertices.
March 9, 2025 at 6:45 AM
Reposted by Parijat Biswas
christlet.bsky.social
Mechanics of Single Cytoskeletal Filaments - Annual Reviews just out from @romet-jegou-lab.bsky.social @cecileleduc.bsky.social @hugowioland.bsky.social:
www.annualreviews.org/content/jour...
February 13, 2025 at 9:51 AM
Reposted by Parijat Biswas
alushinlab.bsky.social
Jazzed to join the cool kids club and have our paper reporting the reconstitution of zyxin-mediated repair of contractile actin networks appear in @currentbiology.bsky.social ! bit.ly/41enkjo
Force-activated zyxin assemblies coordinate actin nucleation and crosslinking to orchestrate stress fiber repair
Phua et al. report that LIM proteins form force-dependent assemblies that bridge broken filament fragments. Zyxin assemblies coordinate F-actin nucleation by VASP and its crosslinking into aligned bun...
bit.ly
February 13, 2025 at 4:15 PM
Reposted by Parijat Biswas
zwickergroup.bsky.social
We wrote a review on the "Physics of droplet regulation in biological cells": arxiv.org/abs/2501.13639 Beside the basic #physics of phase separation, we discuss three aspects that separate cellular from traditional droplets:
A schematic picture of a cell, showing condensates, a nucleus and the cytoskeleton.
January 24, 2025 at 7:55 AM
Reposted by Parijat Biswas
joachimgoedhart.bsky.social
Accessible and accurate cytometry analysis using fluorescence microscopes by Bo Huang and team:
www.biorxiv.org/content/10.1...
Trypsin treatment improves Cellpose segmentation of brightfield images for adherent cells
January 24, 2025 at 10:57 AM
Reposted by Parijat Biswas
alushinlab.bsky.social
Excited that the peer-reviewed version of our fascin structure paper is now out in NSMB. Thanks very much to the referees for their constructive feedback. rdcu.be/d6Tct
January 21, 2025 at 5:03 PM
Reposted by Parijat Biswas
joachimgoedhart.bsky.social
Digital and Tunable Genetically Encoded Tension Sensors Based on Engineered Coiled-Coils
doi.org/10.1002/ange...
Here, we create a genetically-encoded force probe by engineering a coiled-coil domain flanked by fluorescent proteins that undergo FRET. These probes are fully tunable and calibrated by modeling and single molecule force spectroscopy and allow one to measure forces within living systems.
January 18, 2025 at 10:11 PM