Reposted by Alexandre Schaeffer
And here is the link to access the whole pdf. Enjoy!
I strongly believe that focusing on information & computation during Development provides an important framework, that encapsulates the genetic, chemistry & mechanics, but focusses on organisation, dynamics & logic.
PDF: tinyurl.com/4hn34t8w
I strongly believe that focusing on information & computation during Development provides an important framework, that encapsulates the genetic, chemistry & mechanics, but focusses on organisation, dynamics & logic.
PDF: tinyurl.com/4hn34t8w
November 24, 2025 at 9:54 AM
And here is the link to access the whole pdf. Enjoy!
I strongly believe that focusing on information & computation during Development provides an important framework, that encapsulates the genetic, chemistry & mechanics, but focusses on organisation, dynamics & logic.
PDF: tinyurl.com/4hn34t8w
I strongly believe that focusing on information & computation during Development provides an important framework, that encapsulates the genetic, chemistry & mechanics, but focusses on organisation, dynamics & logic.
PDF: tinyurl.com/4hn34t8w
Reposted by Alexandre Schaeffer
Very happy to share video of 1st lecture @college-de-france.fr on Biological computation 😊. I defend the necessity to access Algorithmic & Computational levels of analysis in cell & developmental biol. proposed by David Marr in neuroscience. Logic & Function matter 🤩.
Video: tinyurl.com/55yejk5f
Video: tinyurl.com/55yejk5f
Qu’est-ce que l’information biologique (suite) ? (1) - Thomas Lecuit (2025-2026)
Enseignement 2025-2026 : Qu’est-ce que l’information biologique (suite) ? Cours du 20 décembre 2025 : Introduction : approche computationelle du vivant Professeur : Thomas Lecuit Chaire Dynamiques du vivant Retrouvez les enregistrements audios et vidéos du cycle : https://www.college-de-france.fr/fr/agenda/cours/qu-est-ce-que-information-biologique Tous les enseignements du Pr Thomas Lecuit : https://www.college-de-france.fr/chaire/thomas-lecuit-dynamiques-du-vivant-chaire-statutaire https://www.youtube.com/playlist?list=PLOj9pZ2YNGZ84uMY6DhPnqpL1rq5qNAVJ Le Collège de France est une institution de recherche fondamentale dans tous les domaines de la connaissance et un lieu de diffusion du « savoir en train de se faire » ouvert à tous. Les cours, séminaires, colloques sont enregistrés puis mis à disposition du public sur le site internet du Collège de France. Découvrez toutes les ressources du Collège de France : https://www.college-de-france.fr Soutenir le Collège de France : https://www.fondation-cdf.fr/faire-un-don Suivez-nous sur : Threads : https://www.threads.net/@collegedefrance Bluesky : https://bsky.app/profile/college-de-france.fr Facebook : https://www.facebook.com/College.de.France Instagram : https://www.instagram.com/collegedefrance LinkedIn : https://fr.linkedin.com/company/coll%C3%A8gedefrance
tinyurl.com
November 24, 2025 at 9:42 AM
Very happy to share video of 1st lecture @college-de-france.fr on Biological computation 😊. I defend the necessity to access Algorithmic & Computational levels of analysis in cell & developmental biol. proposed by David Marr in neuroscience. Logic & Function matter 🤩.
Video: tinyurl.com/55yejk5f
Video: tinyurl.com/55yejk5f
Reposted by Alexandre Schaeffer
Kinesin-1-driven microtubule sliding helps pancreatic β cells reorganise their cytoskeleton in response to glucose.
buff.ly/r3BlzFj
buff.ly/r3BlzFj
November 23, 2025 at 11:28 PM
Kinesin-1-driven microtubule sliding helps pancreatic β cells reorganise their cytoskeleton in response to glucose.
buff.ly/r3BlzFj
buff.ly/r3BlzFj
Reposted by Alexandre Schaeffer
🥂Congratulations to @bloodgenes.bsky.social & co for their new study in our journal enhancing the ex vivo expansion and in vivo reconstitution potential of human #hematopoietic #StemCells by inhibiting #ferroptosis . Where? @natcellbio.nature.com ofc!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Inhibiting ferroptosis enhances ex vivo expansion of human haematopoietic stem cells - Nature Cell Biology
della Volpe et al. augment the ex vivo expansion potential of human haematopoietic stem cells (HSCs) by inhibiting ferroptosis with liproxstatin-1 or ferrostatin-1. Treated HSCs have enhanced in vivo ...
www.nature.com
November 22, 2025 at 12:27 AM
🥂Congratulations to @bloodgenes.bsky.social & co for their new study in our journal enhancing the ex vivo expansion and in vivo reconstitution potential of human #hematopoietic #StemCells by inhibiting #ferroptosis . Where? @natcellbio.nature.com ofc!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Alexandre Schaeffer
I am thrilled to share our new article entitled 'Alternative splicing of SORBS1 affects neuromuscular junction integrity in myotonic dystrophy type 1 onlinelibrary.wiley.com/doi/10.1002/...
@cecilemartinat.bsky.social
@cecilemartinat.bsky.social
Alternative Splicing of SORBS1 Affects Neuromuscular Junction Integrity in Myotonic Dystrophy Type 1
Background Myotonic dystrophy type 1 (DM1) is a multisystemic neuromuscular disorder characterized by CTG repeat expansion in the 3′ untranslated region of the dystrophia myotonica protein kinase co...
onlinelibrary.wiley.com
November 21, 2025 at 10:11 AM
I am thrilled to share our new article entitled 'Alternative splicing of SORBS1 affects neuromuscular junction integrity in myotonic dystrophy type 1 onlinelibrary.wiley.com/doi/10.1002/...
@cecilemartinat.bsky.social
@cecilemartinat.bsky.social
Reposted by Alexandre Schaeffer
So proud of Caroline Hermitte, a talented PhD student of our group in #I-Stem on winning the award for the best short presentation at the @fsscr.bsky.social meeting
@morgangazzola.bsky.social
@morgangazzola.bsky.social
November 19, 2025 at 4:56 PM
So proud of Caroline Hermitte, a talented PhD student of our group in #I-Stem on winning the award for the best short presentation at the @fsscr.bsky.social meeting
@morgangazzola.bsky.social
@morgangazzola.bsky.social
Reposted by Alexandre Schaeffer
@ghinabadih.bsky.social 's paper on cell chirality is now out : www.pnas.org/doi/10.1073/... 🥳
Contractile forces direct the chiral swirling of minimal cell collectives | PNAS
Chirality is a conserved biological feature with critical implications in tissue morphogenesis
and embryonic development. In culture, multicellular...
www.pnas.org
November 20, 2025 at 8:55 AM
@ghinabadih.bsky.social 's paper on cell chirality is now out : www.pnas.org/doi/10.1073/... 🥳
Reposted by Alexandre Schaeffer
Go right or left? A question that we encounter very often in our daily lives, and while our decision may sometimes be hindered by the fear of making a mistake, cells DO NOT HESITATE!!! They swirl with the confidence of someone who’s always RIGHT… or LEFT!!!
November 18, 2025 at 5:32 PM
Go right or left? A question that we encounter very often in our daily lives, and while our decision may sometimes be hindered by the fear of making a mistake, cells DO NOT HESITATE!!! They swirl with the confidence of someone who’s always RIGHT… or LEFT!!!
Reposted by Alexandre Schaeffer
For all the twists, turns, and forces behind the swirl, you can sneak a peak at the full article, which I am thrilled to announce is now available @pnas.org: www.pnas.org/doi/10.1073/...
November 18, 2025 at 5:32 PM
For all the twists, turns, and forces behind the swirl, you can sneak a peak at the full article, which I am thrilled to announce is now available @pnas.org: www.pnas.org/doi/10.1073/...
Reposted by Alexandre Schaeffer
Grateful to everyone who contributed to this work and made it possible! @alex-schaef.bsky.social Ben Vianay Pauline Smilovici @lblanchoin.bsky.social @manuelthery.bsky.social Laëtitia Kurzawa
November 18, 2025 at 5:32 PM
Grateful to everyone who contributed to this work and made it possible! @alex-schaef.bsky.social Ben Vianay Pauline Smilovici @lblanchoin.bsky.social @manuelthery.bsky.social Laëtitia Kurzawa
Reposted by Alexandre Schaeffer
Beta-blocker use after myocardial infarction reduces the risk of death in patients with a reduced ejection fraction, but its benefit is less clear in patients without a reduced ejection fraction. Research findings from the REBOOT trial are summarized in a new Quick Take video. nej.md/47Az6rE
November 15, 2025 at 8:00 PM
Beta-blocker use after myocardial infarction reduces the risk of death in patients with a reduced ejection fraction, but its benefit is less clear in patients without a reduced ejection fraction. Research findings from the REBOOT trial are summarized in a new Quick Take video. nej.md/47Az6rE
Reposted by Alexandre Schaeffer
Kinesin-1-driven microtubule sliding helps pancreatic β cells reorganise their cytoskeleton in response to glucose.
buff.ly/r3BlzFj
buff.ly/r3BlzFj
November 15, 2025 at 11:44 PM
Kinesin-1-driven microtubule sliding helps pancreatic β cells reorganise their cytoskeleton in response to glucose.
buff.ly/r3BlzFj
buff.ly/r3BlzFj
Reposted by Alexandre Schaeffer
Just out! Our work on active transport in epithelial tissues. Congrats to Huiqiong Wu, Greg Arkowitz and Ranjith Chilupuri in collaboration with C. Duclut and J. Prost!
PNAS www.pnas.org/doi/10.1073/...
PNAS www.pnas.org/doi/10.1073/...
November 11, 2025 at 11:01 PM
Just out! Our work on active transport in epithelial tissues. Congrats to Huiqiong Wu, Greg Arkowitz and Ranjith Chilupuri in collaboration with C. Duclut and J. Prost!
PNAS www.pnas.org/doi/10.1073/...
PNAS www.pnas.org/doi/10.1073/...
Reposted by Alexandre Schaeffer
Maximising imaging volumes of expanded tissues for inverted fluorescence microscopy https://www.biorxiv.org/content/10.1101/2025.09.12.675899v1
September 13, 2025 at 3:48 AM
Maximising imaging volumes of expanded tissues for inverted fluorescence microscopy https://www.biorxiv.org/content/10.1101/2025.09.12.675899v1
Reposted by Alexandre Schaeffer
✍️ The Dumont Lab published a new article with contributions from the @minclab.bsky.social Lab
📖 @jcb.org
📃 Mechanical coordination between anaphase A and B drives asymmetric chromosome segregation
🔗 rupress.org/jcb/article-...
📖 @jcb.org
📃 Mechanical coordination between anaphase A and B drives asymmetric chromosome segregation
🔗 rupress.org/jcb/article-...
October 28, 2025 at 10:35 AM
✍️ The Dumont Lab published a new article with contributions from the @minclab.bsky.social Lab
📖 @jcb.org
📃 Mechanical coordination between anaphase A and B drives asymmetric chromosome segregation
🔗 rupress.org/jcb/article-...
📖 @jcb.org
📃 Mechanical coordination between anaphase A and B drives asymmetric chromosome segregation
🔗 rupress.org/jcb/article-...
Reposted by Alexandre Schaeffer
5-color STORM with a single laser using cos/sin filters and phasor plots: www.biorxiv.org/content/10.1...
We discussed along those lines with @malacridalab.bsky.social in Montevideo last year, great to see that it works!
We discussed along those lines with @malacridalab.bsky.social in Montevideo last year, great to see that it works!
October 24, 2025 at 6:51 AM
5-color STORM with a single laser using cos/sin filters and phasor plots: www.biorxiv.org/content/10.1...
We discussed along those lines with @malacridalab.bsky.social in Montevideo last year, great to see that it works!
We discussed along those lines with @malacridalab.bsky.social in Montevideo last year, great to see that it works!
Reposted by Alexandre Schaeffer
Mohammad Amin Eskandari, Timo Betz & colleagues @uni-goettingen.de review the current knowledge on intracellular active forces & viscoelastic properties, which are key to understanding how cells can maintain their intracellular organisation and homeostasis.
journals.biologists.com/jcs/article/...
journals.biologists.com/jcs/article/...
October 22, 2025 at 3:30 PM
Mohammad Amin Eskandari, Timo Betz & colleagues @uni-goettingen.de review the current knowledge on intracellular active forces & viscoelastic properties, which are key to understanding how cells can maintain their intracellular organisation and homeostasis.
journals.biologists.com/jcs/article/...
journals.biologists.com/jcs/article/...
Reposted by Alexandre Schaeffer
Second October issue is online!
www.embopress.org/toc/14693178...
Cover features work by Rajarshi Chakrabarti and co-workers from Thomas Jefferson University showing that peri-mitochondrial #actin inhibits #Parkin assembly by disrupting ER-mitochondria contacts.
www.embopress.org/doi/full/10....
www.embopress.org/toc/14693178...
Cover features work by Rajarshi Chakrabarti and co-workers from Thomas Jefferson University showing that peri-mitochondrial #actin inhibits #Parkin assembly by disrupting ER-mitochondria contacts.
www.embopress.org/doi/full/10....
October 23, 2025 at 5:48 PM
Second October issue is online!
www.embopress.org/toc/14693178...
Cover features work by Rajarshi Chakrabarti and co-workers from Thomas Jefferson University showing that peri-mitochondrial #actin inhibits #Parkin assembly by disrupting ER-mitochondria contacts.
www.embopress.org/doi/full/10....
www.embopress.org/toc/14693178...
Cover features work by Rajarshi Chakrabarti and co-workers from Thomas Jefferson University showing that peri-mitochondrial #actin inhibits #Parkin assembly by disrupting ER-mitochondria contacts.
www.embopress.org/doi/full/10....
Reposted by Alexandre Schaeffer
🤔 #mDia also associates with #microtubules.... (Gundersen team in NatCellBio 2001). @microtubule.bsky.social & I pondered over the #FocalAdhesion splitting & merging phenotype we saw with CLASP-depletion for ages. Great to see someone worked out how to quantitate it!
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
October 22, 2025 at 4:44 AM
🤔 #mDia also associates with #microtubules.... (Gundersen team in NatCellBio 2001). @microtubule.bsky.social & I pondered over the #FocalAdhesion splitting & merging phenotype we saw with CLASP-depletion for ages. Great to see someone worked out how to quantitate it!
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by Alexandre Schaeffer
Perspective from Richard McIntosh describing the history of research on #microtubule polymerization in terms of the ideas, technologies, and observations that have emerged as countless researchers have studied the dynamics of these essential cytoskeletal polymers. rupress.org/jcb/article/...
October 15, 2025 at 4:02 PM
Perspective from Richard McIntosh describing the history of research on #microtubule polymerization in terms of the ideas, technologies, and observations that have emerged as countless researchers have studied the dynamics of these essential cytoskeletal polymers. rupress.org/jcb/article/...
Reposted by Alexandre Schaeffer
1/ 🎉Excited to share our new preprint @vignjeviclab.bsky.social @davidbrueckner.bsky.social :
"Self-organization of tumor heterogeneity and plasticity"
biorxiv.org/content/10.1...
Tumor heterogeneity and plasticity drive metastasis and relapse. How is tumor patterning coordinated?
A thread👇
"Self-organization of tumor heterogeneity and plasticity"
biorxiv.org/content/10.1...
Tumor heterogeneity and plasticity drive metastasis and relapse. How is tumor patterning coordinated?
A thread👇
October 16, 2025 at 9:55 PM
1/ 🎉Excited to share our new preprint @vignjeviclab.bsky.social @davidbrueckner.bsky.social :
"Self-organization of tumor heterogeneity and plasticity"
biorxiv.org/content/10.1...
Tumor heterogeneity and plasticity drive metastasis and relapse. How is tumor patterning coordinated?
A thread👇
"Self-organization of tumor heterogeneity and plasticity"
biorxiv.org/content/10.1...
Tumor heterogeneity and plasticity drive metastasis and relapse. How is tumor patterning coordinated?
A thread👇
Reposted by Alexandre Schaeffer
Just out in @science.org: Together with the lab of @johanneszuber.bsky.social, we used sequential in-vitro/in-vivo screens to decipher metabolic adaptations in tumors. We find that acidosis is a dominant factor that shapes energy metabolism and stress resilience. www.science.org/doi/10.1126/...
October 9, 2025 at 8:12 PM
Just out in @science.org: Together with the lab of @johanneszuber.bsky.social, we used sequential in-vitro/in-vivo screens to decipher metabolic adaptations in tumors. We find that acidosis is a dominant factor that shapes energy metabolism and stress resilience. www.science.org/doi/10.1126/...
Reposted by Alexandre Schaeffer
First, check out my recent bioRxiv preprint w/ @oweinerlab.bsky.social: www.biorxiv.org/content/10.1...
We find contractility shifts the proportion of implantation-competent embryos from young and aged females. Keep reading this for more info!
We find contractility shifts the proportion of implantation-competent embryos from young and aged females. Keep reading this for more info!
A mechanical origin for implantation defects in embryos from aged females
Women over 35 experience a marked reduction in fertility. The origin of these fertility defects appears to reside in the implantation capacity of the embryo itself, but the mechanistic basis of this i...
www.biorxiv.org
October 1, 2025 at 6:21 PM
First, check out my recent bioRxiv preprint w/ @oweinerlab.bsky.social: www.biorxiv.org/content/10.1...
We find contractility shifts the proportion of implantation-competent embryos from young and aged females. Keep reading this for more info!
We find contractility shifts the proportion of implantation-competent embryos from young and aged females. Keep reading this for more info!
Reposted by Alexandre Schaeffer
Monoclonal gammopathy of undetermined significance is a common, asymptomatic plasma-cell disorder in older adults that can progress to cancer or systemic illness. Diagnosis warrants follow-up, but treatment is not required unless progression is confirmed. Learn more: nej.md/473uOsj
October 1, 2025 at 9:10 PM
Monoclonal gammopathy of undetermined significance is a common, asymptomatic plasma-cell disorder in older adults that can progress to cancer or systemic illness. Diagnosis warrants follow-up, but treatment is not required unless progression is confirmed. Learn more: nej.md/473uOsj
Reposted by Alexandre Schaeffer
🚨
New Preprint!
Ex-dSTORM resolves fine details of the molecular architecture of CCPs, the 8-nm periodicity of microtubules, and the docking site of synaptic vesicles at the presynapse of hippocampal neurons.
▶️ www.biorxiv.org/content/10.1...
New Preprint!
Ex-dSTORM resolves fine details of the molecular architecture of CCPs, the 8-nm periodicity of microtubules, and the docking site of synaptic vesicles at the presynapse of hippocampal neurons.
▶️ www.biorxiv.org/content/10.1...
August 19, 2025 at 3:32 PM
🚨
New Preprint!
Ex-dSTORM resolves fine details of the molecular architecture of CCPs, the 8-nm periodicity of microtubules, and the docking site of synaptic vesicles at the presynapse of hippocampal neurons.
▶️ www.biorxiv.org/content/10.1...
New Preprint!
Ex-dSTORM resolves fine details of the molecular architecture of CCPs, the 8-nm periodicity of microtubules, and the docking site of synaptic vesicles at the presynapse of hippocampal neurons.
▶️ www.biorxiv.org/content/10.1...