A/Prof Sam Stehbens PhD (She/Her)
@samstehbens.bsky.social
Everything microtubules, movement, and microscopy. ARC Future Fellow, lab head University of Queensland #CatsOfAcademia advoCATe. UCSF Wittmann lab alumni.
Pinned
What we do: work out how cells move by watching them. (Movies by Robert Ju; you can check out his work (art?) here: www.nature.com/articles/s41...
> I'll repost the paper tutorial later for those who are interested). #microscopy #microtubules #cytoskeleton #cellmigration #confinement
> I'll repost the paper tutorial later for those who are interested). #microscopy #microtubules #cytoskeleton #cellmigration #confinement
Reposted by A/Prof Sam Stehbens PhD (She/Her)
Peiyao Fan, Yang Chen et al. @pku1898.bsky.social show that tubular ER extends into retraction fibers and #migrasomes through #microtubule-dependent ER extension and ER-plasma membrane contact sites in migrating cells. rupress.org/jcb/article/...
#ER_literature #Migration #Organelles
#ER_literature #Migration #Organelles
November 6, 2025 at 5:00 PM
Peiyao Fan, Yang Chen et al. @pku1898.bsky.social show that tubular ER extends into retraction fibers and #migrasomes through #microtubule-dependent ER extension and ER-plasma membrane contact sites in migrating cells. rupress.org/jcb/article/...
#ER_literature #Migration #Organelles
#ER_literature #Migration #Organelles
Reposted by A/Prof Sam Stehbens PhD (She/Her)
I love to see the endoplasmic reticulum (ER, cyan) hitchhiking over microtubules (MTs, orange).
Also the membrane dynamics are lovely.
It's been a while, but here we are for a late #fluorescencefriday with some #microscopy
#scicomm #scisky @cellcommlab.bsky.social focalplane.bsky.social 🧪🔬
Also the membrane dynamics are lovely.
It's been a while, but here we are for a late #fluorescencefriday with some #microscopy
#scicomm #scisky @cellcommlab.bsky.social focalplane.bsky.social 🧪🔬
November 7, 2025 at 9:25 PM
I love to see the endoplasmic reticulum (ER, cyan) hitchhiking over microtubules (MTs, orange).
Also the membrane dynamics are lovely.
It's been a while, but here we are for a late #fluorescencefriday with some #microscopy
#scicomm #scisky @cellcommlab.bsky.social focalplane.bsky.social 🧪🔬
Also the membrane dynamics are lovely.
It's been a while, but here we are for a late #fluorescencefriday with some #microscopy
#scicomm #scisky @cellcommlab.bsky.social focalplane.bsky.social 🧪🔬
Reposted by A/Prof Sam Stehbens PhD (She/Her)
#Tubulin regulates stability and localization of STMN2 by binding preferentially to its soluble form, say Xiang Deng, Timothy Mitchison and colleagues @harvardmed.bsky.social: rupress.org/jcb/article/...
#ProteinHomeostasis #Neuroscience #Biochemistry #Cytoskeleton #Neurodegeneration #ALS
#ProteinHomeostasis #Neuroscience #Biochemistry #Cytoskeleton #Neurodegeneration #ALS
November 7, 2025 at 7:30 PM
#Tubulin regulates stability and localization of STMN2 by binding preferentially to its soluble form, say Xiang Deng, Timothy Mitchison and colleagues @harvardmed.bsky.social: rupress.org/jcb/article/...
#ProteinHomeostasis #Neuroscience #Biochemistry #Cytoskeleton #Neurodegeneration #ALS
#ProteinHomeostasis #Neuroscience #Biochemistry #Cytoskeleton #Neurodegeneration #ALS
Reposted by A/Prof Sam Stehbens PhD (She/Her)
ICYMI: New Online! Microtubules provide a mechanical link for YAP/TAZ signalling
Microtubules provide a mechanical link for YAP/TAZ signalling
Nature Reviews Molecular Cell Biology, Published online: 05 November 2025; doi:10.1038/s41580-025-00929-xA study finds that mechanical activation leads to microtubule rearrangement, facilitating the proteasomal degradation of an inhibitor of YAP/TAZ, thus promoting YAP/TAZ nuclear translocation.
bit.ly
November 8, 2025 at 3:54 PM
ICYMI: New Online! Microtubules provide a mechanical link for YAP/TAZ signalling
Trying to catch up on some missed work on the weekend. Phoebe is not helping. #CatsOfAcademia #AustralianMist
November 8, 2025 at 3:19 AM
Trying to catch up on some missed work on the weekend. Phoebe is not helping. #CatsOfAcademia #AustralianMist
Reposted by A/Prof Sam Stehbens PhD (She/Her)
Research | Amiad Pavlov, Heffler et al. demonstrate that stress transmitted to the cardiomyocyte nucleus by the microtubule cage drives LMNA-associated cardiomyopathy and may represent a promising therapeutic target.
doi.org/10.1038/s441...
rdcu.be/eOeTA
doi.org/10.1038/s441...
rdcu.be/eOeTA
Microtubule forces drive nuclear damage in LMNA cardiomyopathy - Nature Cardiovascular Research
Amiad Pavlov, Heffler, et al. demonstrate that stress transmitted to the cardiomyocyte nucleus by the microtubule cage drives LMNA-associated cardiomyopathy and may represent a promising therapeutic t...
doi.org
November 4, 2025 at 2:56 PM
Research | Amiad Pavlov, Heffler et al. demonstrate that stress transmitted to the cardiomyocyte nucleus by the microtubule cage drives LMNA-associated cardiomyopathy and may represent a promising therapeutic target.
doi.org/10.1038/s441...
rdcu.be/eOeTA
doi.org/10.1038/s441...
rdcu.be/eOeTA
@charlesdcox.bsky.social defining what makes a ‘Piezo fanatic’ at #MechBio2025 #AusMB 👉 @ardemp.bskyverified.social ‘s commitment #STEM (it is a bit kettle-Pot really 😂 ).
November 5, 2025 at 4:40 AM
@charlesdcox.bsky.social defining what makes a ‘Piezo fanatic’ at #MechBio2025 #AusMB 👉 @ardemp.bskyverified.social ‘s commitment #STEM (it is a bit kettle-Pot really 😂 ).
Reposted by A/Prof Sam Stehbens PhD (She/Her)
☕Vanni et al. show a role for #microtubules in YAP/TAZ mechanosignalling. Mechanoresponsive microtubule reorganization into centrosomal arrays allows for AMOT delivery to pericentrosomal proteasomes and degradation, leading to YAP/TAZ activation. #mechanobiology #cytoskeleton
bit.ly/4oS2Ju3
bit.ly/4oS2Ju3
Microtubule architecture connects AMOT stability to YAP/TAZ mechanotransduction and Hippo signalling - Nature Cell Biology
Vanni et al. show a role for microtubules in YAP/TAZ mechanosignalling. Mechanoresponsive microtubule reorganization into centrosomal arrays allows for AMOT delivery to pericentrosomal proteasomes and...
bit.ly
November 4, 2025 at 6:35 PM
☕Vanni et al. show a role for #microtubules in YAP/TAZ mechanosignalling. Mechanoresponsive microtubule reorganization into centrosomal arrays allows for AMOT delivery to pericentrosomal proteasomes and degradation, leading to YAP/TAZ activation. #mechanobiology #cytoskeleton
bit.ly/4oS2Ju3
bit.ly/4oS2Ju3
Looking forward to all things Australian #Mechanobiology tomorrow! #OzMechBio #ausmb. ausmb.org/meetings_202...
Mechanobiology2025
Join us for MechBio2025, the annual meeting of the Australian Society for Mechanobiology. November 5-7, 2025 at the University of Queensland, Brisbane. Featuring international keynote speakers and sho...
ausmb.org
November 4, 2025 at 11:04 AM
Looking forward to all things Australian #Mechanobiology tomorrow! #OzMechBio #ausmb. ausmb.org/meetings_202...
Reposted by A/Prof Sam Stehbens PhD (She/Her)
A single-component optogenetic toolkit for programmable control of microtubule https://www.biorxiv.org/content/10.1101/2025.10.31.685931v1
November 3, 2025 at 10:30 AM
A single-component optogenetic toolkit for programmable control of microtubule https://www.biorxiv.org/content/10.1101/2025.10.31.685931v1
Reposted by A/Prof Sam Stehbens PhD (She/Her)
How augmin establishes the angle of the microtubule branch site
www.nature.com/articles/s41...
www.nature.com/articles/s41...
How augmin establishes the angle of the microtubule branch site - Nature Communications
Here, authors report the structure of the augmin’s CH domain bound to the microtubule lattice and show that its Haus8 subunit binds tubulin tails. Both domains are critical for microtubule binding and...
www.nature.com
October 31, 2025 at 3:00 PM
How augmin establishes the angle of the microtubule branch site
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by A/Prof Sam Stehbens PhD (She/Her)
Paul Nurse describing the main job of a PI
(From ‘The Thinking Game’, 2024)
(From ‘The Thinking Game’, 2024)
October 31, 2025 at 8:45 AM
Paul Nurse describing the main job of a PI
(From ‘The Thinking Game’, 2024)
(From ‘The Thinking Game’, 2024)
Reposted by A/Prof Sam Stehbens PhD (She/Her)
📢 Open Call! The Max Perutz Labs invite applications for a Full Professorship in Integrative Structure Biology with a focus on in situ structural biology using cryo-electron tomography (cryo-ET) and related methods. More details ➡️ tinyurl.com/brswbymu
October 31, 2025 at 9:24 AM
📢 Open Call! The Max Perutz Labs invite applications for a Full Professorship in Integrative Structure Biology with a focus on in situ structural biology using cryo-electron tomography (cryo-ET) and related methods. More details ➡️ tinyurl.com/brswbymu
Reposted by A/Prof Sam Stehbens PhD (She/Her)
You've got just a few days left to submit your proposal to join us as a new Group Leader
📅 Applications close 2nd November
Package includes:
🪙Multi-year funding
🧪Core Facility Access
🥼 #Postdoc & #PhD positions
🤝Mentorship
Visit our website to apply:
www.cruk.manchester.ac.uk/career/new-g...
📅 Applications close 2nd November
Package includes:
🪙Multi-year funding
🧪Core Facility Access
🥼 #Postdoc & #PhD positions
🤝Mentorship
Visit our website to apply:
www.cruk.manchester.ac.uk/career/new-g...
October 30, 2025 at 11:47 AM
You've got just a few days left to submit your proposal to join us as a new Group Leader
📅 Applications close 2nd November
Package includes:
🪙Multi-year funding
🧪Core Facility Access
🥼 #Postdoc & #PhD positions
🤝Mentorship
Visit our website to apply:
www.cruk.manchester.ac.uk/career/new-g...
📅 Applications close 2nd November
Package includes:
🪙Multi-year funding
🧪Core Facility Access
🥼 #Postdoc & #PhD positions
🤝Mentorship
Visit our website to apply:
www.cruk.manchester.ac.uk/career/new-g...
Reposted by A/Prof Sam Stehbens PhD (She/Her)
Why fundamental research is fundamental to progress, seeding major breakthroughs
Editorial @nature.com this week
And 7 basic science discoveries that changed the world
nature.com/articles/d41...
nature.com/articles/d41...
Editorial @nature.com this week
And 7 basic science discoveries that changed the world
nature.com/articles/d41...
nature.com/articles/d41...
October 29, 2025 at 12:58 PM
Why fundamental research is fundamental to progress, seeding major breakthroughs
Editorial @nature.com this week
And 7 basic science discoveries that changed the world
nature.com/articles/d41...
nature.com/articles/d41...
Editorial @nature.com this week
And 7 basic science discoveries that changed the world
nature.com/articles/d41...
nature.com/articles/d41...
Reposted by A/Prof Sam Stehbens PhD (She/Her)
Day 2 Session 1 continued with presentations from A/Prof @samstehbens.bsky.social, Dr Gary Tincknell, @drdianaschuhmacher.bsky.social, and Ashna Kumar. #7thOzMRSScientificSymposium
October 29, 2025 at 11:52 PM
Day 2 Session 1 continued with presentations from A/Prof @samstehbens.bsky.social, Dr Gary Tincknell, @drdianaschuhmacher.bsky.social, and Ashna Kumar. #7thOzMRSScientificSymposium
I was just made aware that trans youth no longer have access to #gender affirming care here in qld via our public system. Please take a moment to sign the petition below to end the ban #UQAlly 🏳️⚧️🏳️🌈
equalityaustralia.org.au/our-work/qld...
equalityaustralia.org.au/our-work/qld...
QLD: REINSTATE CARE FOR TRANS YOUNG PEOPLE
Sign the petition to end Queensland's ban on gender affirming care. Let's leave health care to the medical professionals.
equalityaustralia.org.au
October 30, 2025 at 10:38 AM
I was just made aware that trans youth no longer have access to #gender affirming care here in qld via our public system. Please take a moment to sign the petition below to end the ban #UQAlly 🏳️⚧️🏳️🌈
equalityaustralia.org.au/our-work/qld...
equalityaustralia.org.au/our-work/qld...
On my way to the @ozmrs.bsky.social meeting! Looking forward to hearing about new findings in our effort to stop #metastatic #cancer.
October 29, 2025 at 2:22 AM
On my way to the @ozmrs.bsky.social meeting! Looking forward to hearing about new findings in our effort to stop #metastatic #cancer.
Reposted by A/Prof Sam Stehbens PhD (She/Her)
Fresh in @natchemeng.nature.com Growing artificial cytoskeleton in the viscoelastic confinement of DNA Artificial Cells. Brilliant work bey Weixiang! #Syntheticcell #systemschemistry
www.nature.com/articles/s44...
www.nature.com/articles/s44...
Growing functional artificial cytoskeletons in the viscoelastic confinement of DNA synthetic cells - Nature Chemical Engineering
Engineering structurally and functionally complex synthetic cells remains a key challenge. Here DNA condensate synthetic cells combine phase separation and DNA nanostructures to reveal how switchable ...
www.nature.com
October 23, 2025 at 3:25 PM
Fresh in @natchemeng.nature.com Growing artificial cytoskeleton in the viscoelastic confinement of DNA Artificial Cells. Brilliant work bey Weixiang! #Syntheticcell #systemschemistry
www.nature.com/articles/s44...
www.nature.com/articles/s44...
Excess surface area of the nuclear lamina enables unhindered cell migration through constrictions | Science Advances www.science.org/doi/10.1126/...
Excess surface area of the nuclear lamina enables unhindered cell migration through constrictions
Excess area of the nuclear lamina, observed as wrinkles in a round nucleus, enables cell migration through constricting channels.
www.science.org
October 24, 2025 at 9:09 AM
Excess surface area of the nuclear lamina enables unhindered cell migration through constrictions | Science Advances www.science.org/doi/10.1126/...
Reposted by A/Prof Sam Stehbens PhD (She/Her)
It's mid-October & ARC haven't updated us since mid-July on the Brand New Grants System.
When will we be told?
What schemes will even run?
ARC "paused" (cancelled?) the only Indigenous scheme, plus Laureates & all Industry Fellowships, and so far there's no replacements.
ARC? Anyone?
When will we be told?
What schemes will even run?
ARC "paused" (cancelled?) the only Indigenous scheme, plus Laureates & all Industry Fellowships, and so far there's no replacements.
ARC? Anyone?
October 12, 2025 at 11:57 PM
It's mid-October & ARC haven't updated us since mid-July on the Brand New Grants System.
When will we be told?
What schemes will even run?
ARC "paused" (cancelled?) the only Indigenous scheme, plus Laureates & all Industry Fellowships, and so far there's no replacements.
ARC? Anyone?
When will we be told?
What schemes will even run?
ARC "paused" (cancelled?) the only Indigenous scheme, plus Laureates & all Industry Fellowships, and so far there's no replacements.
ARC? Anyone?
Reposted by A/Prof Sam Stehbens PhD (She/Her)
In @jcb.org, Avilov, @plenart.bsky.social et al. @maxplanck.de used quantitative phosphoproteomics in #starfish #oocytes to identify downstream targets of the conserved Mos–MAPK pathway. rupress.org/jcb/article/...
#Cytoskeleton #CellCycle #CellDivision #Physiology
#Cytoskeleton #CellCycle #CellDivision #Physiology
October 22, 2025 at 7:15 PM
In @jcb.org, Avilov, @plenart.bsky.social et al. @maxplanck.de used quantitative phosphoproteomics in #starfish #oocytes to identify downstream targets of the conserved Mos–MAPK pathway. rupress.org/jcb/article/...
#Cytoskeleton #CellCycle #CellDivision #Physiology
#Cytoskeleton #CellCycle #CellDivision #Physiology
Reposted by A/Prof Sam Stehbens PhD (She/Her)
1/ 🎉Excited to share our new preprint @vignjeviclab.bsky.social @davidbrueckner.bsky.social :
"Self-organization of tumor heterogeneity and plasticity"
biorxiv.org/content/10.1...
Tumor heterogeneity and plasticity drive metastasis and relapse. How is tumor patterning coordinated?
A thread👇
"Self-organization of tumor heterogeneity and plasticity"
biorxiv.org/content/10.1...
Tumor heterogeneity and plasticity drive metastasis and relapse. How is tumor patterning coordinated?
A thread👇
October 16, 2025 at 9:55 PM
1/ 🎉Excited to share our new preprint @vignjeviclab.bsky.social @davidbrueckner.bsky.social :
"Self-organization of tumor heterogeneity and plasticity"
biorxiv.org/content/10.1...
Tumor heterogeneity and plasticity drive metastasis and relapse. How is tumor patterning coordinated?
A thread👇
"Self-organization of tumor heterogeneity and plasticity"
biorxiv.org/content/10.1...
Tumor heterogeneity and plasticity drive metastasis and relapse. How is tumor patterning coordinated?
A thread👇
Looks like a job for Mr Squiggle. A bit of #xennial #AustralianKitsch …
October 22, 2025 at 9:39 AM
Looks like a job for Mr Squiggle. A bit of #xennial #AustralianKitsch …
🤔 #mDia also associates with #microtubules.... (Gundersen team in NatCellBio 2001). @microtubule.bsky.social & I pondered over the #FocalAdhesion splitting & merging phenotype we saw with CLASP-depletion for ages. Great to see someone worked out how to quantitate it!
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
October 22, 2025 at 4:44 AM
🤔 #mDia also associates with #microtubules.... (Gundersen team in NatCellBio 2001). @microtubule.bsky.social & I pondered over the #FocalAdhesion splitting & merging phenotype we saw with CLASP-depletion for ages. Great to see someone worked out how to quantitate it!
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...