van der Net et al. show that mechanical interactions with the stromal component collagen I trigger reprogramming of colorectal cancer cells into a fetal-like state, through mechanosensitive integrins ...

Traction force and FAK signaling exhibit oscillatory temporal coupling in adhesive structures.

Mathematical models have become essential tools for exploring the complex interplay between cancer cells and their microenvironment, but require multidisciplinary expertise and abundant biological dat...

BACKGROUND Single ventricle congenital heart disease (SV-CHD) is a uniformly lethal condition. Survival depends upon the Glenn surgery, which shunts venous blood directly to the pulmonary arteries wit...

A study presents EndoMAP.v1, a resource that combines information on protein interactions and crosslink-supported structural predictions to map the interaction landscape of early endosomes.

A study of dependencies associated with cancer-causing mutations has identified a small molecule that binds to SHOC2 and inhibits RAS signalling in cells carrying NRAS Q61 mutations, a common onc...

Some cancer cells exhibit high loads of reactive iron in lysosomes, and this feature is exploited by using fentomycin-1, a newly developed small molecule, to induce ferroptosis.

Extracting quantitative information on biomolecular oligomerisation with high resolution remains a significant challenge. Here, the authors propose SPINNA, a framework that compares nearest-neighbour ...

Extracellular matrices are viscoelastic, yet how matrix viscoelasticity regulates the epigenome remains unclear. Here, the authors show that cells cultured on viscoelastic matrices exhibit changes in ...

Arce et al. show that KRIT1 heterozygous mutations drive cavernoma-like structures in vascularized organoids and alter endothelial cell-cell junctions. KRIT1-deficient vascular cells reshaped brain vasculature through extracellular matrix organization, proliferation, and mesenchymal transition. The endothelial progenitor marker PEG3 was highly expressed in CCM patient-derived endothelial cells and patient cavernoma biopsies.

Nature Physics - Blood flow through a vessel deforms vessel walls. Cells lining these walls sense the changes in pressure as blood flows and reorient their actin fibres in the direction of largest...