Zivojin Jevtic
@zivojinjevtic.bsky.social
Investigating chromatin states in acute myeloid leukemia in mice and humans; Postdoc in the Childhood Leukemia Group at the Department of Biomedicine, University of Basel, Switzerland.
Congrats to the authors, these are very interesting findings!
Here is a copy of last year's Twitter thread explaining our preprint - jump to (21) for the new stuff 👀
Synergy between cis-regulatory elements can render cohesin dispensable for distal enhancer function
now revised and journal accepted at www.science.org/doi/10.1126/...
🧵👇
Synergy between cis-regulatory elements can render cohesin dispensable for distal enhancer function
now revised and journal accepted at www.science.org/doi/10.1126/...
🧵👇
November 28, 2025 at 8:18 AM
Congrats to the authors, these are very interesting findings!
Reposted by Zivojin Jevtic
Our latest paper has just been published in Cell!
doi.org/10.1016/j.ce...
We developed a new method called MCC ultra, which allows 3D chromatin structure to be visualised with a 1 base pair pixel size.
doi.org/10.1016/j.ce...
We developed a new method called MCC ultra, which allows 3D chromatin structure to be visualised with a 1 base pair pixel size.
November 5, 2025 at 5:20 PM
Our latest paper has just been published in Cell!
doi.org/10.1016/j.ce...
We developed a new method called MCC ultra, which allows 3D chromatin structure to be visualised with a 1 base pair pixel size.
doi.org/10.1016/j.ce...
We developed a new method called MCC ultra, which allows 3D chromatin structure to be visualised with a 1 base pair pixel size.
Reposted by Zivojin Jevtic
Looks like a great couple of months of seminars! Come check out my talk on November 5th if you want to learn about our progress in mapping the nucleotide-resolved structure and function of cis-regulatory DNA elements across thousands of cell types and states.
We're super excited to announce the entire lineup for the Fall season of Fragile Nucleosome Seminars, starting on Sept 10th at 1200 EDT / 1600 UTC with @gracebower.bsky.social and @creminslab.bsky.social!
register here for the entire series: us06web.zoom.us/webinar/regi...
register here for the entire series: us06web.zoom.us/webinar/regi...
September 1, 2025 at 5:31 PM
Looks like a great couple of months of seminars! Come check out my talk on November 5th if you want to learn about our progress in mapping the nucleotide-resolved structure and function of cis-regulatory DNA elements across thousands of cell types and states.
Reposted by Zivojin Jevtic
new out in Nature www.nature.com/articles/s41...
NSD2 inhibitors rewire chromatin to treat lung and pancreatic cancers - Nature
A highly potent and selective small-molecule catalytic inhibitor of the protein lysine methyltransferase NSD2 shows therapeutic efficacy in preclinical models of KRAS-driven pancreatic cancer and...
www.nature.com
August 8, 2025 at 10:24 AM
new out in Nature www.nature.com/articles/s41...
Reposted by Zivojin Jevtic
Very excited to share our latest work in #MolCell showing NPM1 stabilizing the association of nucleolus associated domains (NADs) and recruiting G9a to establish their repressive chromatin states. www.sciencedirect.com/science/arti...
May 24, 2025 at 11:12 AM
Very excited to share our latest work in #MolCell showing NPM1 stabilizing the association of nucleolus associated domains (NADs) and recruiting G9a to establish their repressive chromatin states. www.sciencedirect.com/science/arti...
Reposted by Zivojin Jevtic
Our work on lineage tracing with somatic epimutations is finally out in @nature.com!
Check out the thread by @larsplus.bsky.social below.
EPI-clone is a revolutionary technique for lineage tracing and it will immediately impact how we trace clones everywhere.
Detailed protocols coming out soon!
Check out the thread by @larsplus.bsky.social below.
EPI-clone is a revolutionary technique for lineage tracing and it will immediately impact how we trace clones everywhere.
Detailed protocols coming out soon!
Out @nature.com: Clonal tracing with somatic epimutations
🧬 Single cell methylome encodes cell state & clonal identity
🔨 EPI-Clone reads out both (+mutations, +RNA) at scale
🩸 Clonal expansions of HSCs are universal from age 50, not driven by CH mutations
doi.org/10.1038/s415...
🧵
🧬 Single cell methylome encodes cell state & clonal identity
🔨 EPI-Clone reads out both (+mutations, +RNA) at scale
🩸 Clonal expansions of HSCs are universal from age 50, not driven by CH mutations
doi.org/10.1038/s415...
🧵
Clonal tracing with somatic epimutations reveals dynamics of blood ageing - Nature
The discovery that DNA methylation of different CpG sites can serve as digital barcodes of clonal identity led to the development of EPI-Clone, an algorithm that enables single-cell lineage tracing th...
doi.org
May 21, 2025 at 4:06 PM
Our work on lineage tracing with somatic epimutations is finally out in @nature.com!
Check out the thread by @larsplus.bsky.social below.
EPI-clone is a revolutionary technique for lineage tracing and it will immediately impact how we trace clones everywhere.
Detailed protocols coming out soon!
Check out the thread by @larsplus.bsky.social below.
EPI-clone is a revolutionary technique for lineage tracing and it will immediately impact how we trace clones everywhere.
Detailed protocols coming out soon!
Looking forward to hearing Friday's talk on Cambridge Chromatin Epigenetics Club!
Very happy to share the peer-reviewed version of our paper in which we study the formation and function of pair-wise and multi-way enhancer-promoter interactions in gene regulation (see thread below): www.nature.com/articles/s41...
May 13, 2025 at 12:53 PM
Looking forward to hearing Friday's talk on Cambridge Chromatin Epigenetics Club!
Reposted by Zivojin Jevtic
Out in Cell @cp-cell.bsky.social: Design principles of cell-state-specific enhancers in hematopoiesis
🧬🩸 screen of fully synthetic enhancers in blood progenitors
🤖 AI that creates new cell state specific enhancers
🔍 negative synergies between TFs lead to specificity!
www.cell.com/cell/fulltex...
🧵
🧬🩸 screen of fully synthetic enhancers in blood progenitors
🤖 AI that creates new cell state specific enhancers
🔍 negative synergies between TFs lead to specificity!
www.cell.com/cell/fulltex...
🧵
Design principles of cell-state-specific enhancers in hematopoiesis
Screen of minimalistic enhancers in blood progenitor cells demonstrates widespread
dual activator-repressor function of transcription factors (TFs) and enables the model-guided
design of cell-state-sp...
www.cell.com
May 8, 2025 at 4:07 PM
Out in Cell @cp-cell.bsky.social: Design principles of cell-state-specific enhancers in hematopoiesis
🧬🩸 screen of fully synthetic enhancers in blood progenitors
🤖 AI that creates new cell state specific enhancers
🔍 negative synergies between TFs lead to specificity!
www.cell.com/cell/fulltex...
🧵
🧬🩸 screen of fully synthetic enhancers in blood progenitors
🤖 AI that creates new cell state specific enhancers
🔍 negative synergies between TFs lead to specificity!
www.cell.com/cell/fulltex...
🧵
Reposted by Zivojin Jevtic
New in STM, check out our integrative bulk & single-cell long-read analysis to discover and test new therapies in leukemia. We developed OncoSplice, to define new splicing defined subtypes and predict regulators. PRMT5 inhibition partially rescued mis-splicing & inhibited leukemic growth. More soon!
Splicing regulatory dynamics for precision analysis and treatment of heterogeneous leukemias
Broad dysregulated splicing in AML partially phenocopies splicing factor mutations, is prognostic, and can be pharmacologically reversed.
www.science.org
May 7, 2025 at 11:05 PM
New in STM, check out our integrative bulk & single-cell long-read analysis to discover and test new therapies in leukemia. We developed OncoSplice, to define new splicing defined subtypes and predict regulators. PRMT5 inhibition partially rescued mis-splicing & inhibited leukemic growth. More soon!
Great paper, congrats to the authors!
Excited to share Benson’s and Maria’s work in collab w/Kostas Tzelepis: we found the nucleolar protein NPM1 is a marker of AML and can be targeted therapeutically
connecting ‘cell surface RNA biology’ to cancer biology
@natbiotech.nature.com
www.nature.com/articles/s41...
connecting ‘cell surface RNA biology’ to cancer biology
@natbiotech.nature.com
www.nature.com/articles/s41...
April 23, 2025 at 2:35 PM
Great paper, congrats to the authors!
Reposted by Zivojin Jevtic
A(G)I and slop: https://blog.miljko.org/2025/04/19/agi-and-slop.html
April 19, 2025 at 1:52 PM
A(G)I and slop: https://blog.miljko.org/2025/04/19/agi-and-slop.html
Reposted by Zivojin Jevtic
A unified model for cohesin function in sisterchromatid cohesion and chromatin loop formation: Molecular Cell www.cell.com/molecular-ce...
A unified model for cohesin function in sisterchromatid cohesion and chromatin loop formation
Structural maintenance of chromosomes (SMC) complexes are thought to shape genomes
by extruding DNA loops, but recent genetic tests have challenged the “loop extrusion
hypothesis.” Here, Uhlmann explo...
www.cell.com
March 21, 2025 at 1:28 AM
A unified model for cohesin function in sisterchromatid cohesion and chromatin loop formation: Molecular Cell www.cell.com/molecular-ce...
Major breakthrough - very different from Chip technologies, single-cell mapping of protein:DNA interactions, which one can couple with other single-cell multiomics.
Excited to share a major breakthrough from the lab! D&D-seq is a new technology that bridges a key gap in single-cell multi-omics/genomics : the ability to map DNA:Protein interactions (e.g., TFs or chromatin remodellers). Led by Ivan Raimondi, Wei-Yu Chi and Sang-Ho Yoon
🧬 We’re excited to introduce D&D-seq, a single-cell technology that maps DNA:Protein interactions through molecular footprinting. Check it out here: biorxiv.org/content/10.1... #Genomics #Epigenetics
January 23, 2025 at 9:10 AM
Major breakthrough - very different from Chip technologies, single-cell mapping of protein:DNA interactions, which one can couple with other single-cell multiomics.
Reposted by Zivojin Jevtic
This. Is. Beautiful.
The Internet can still give us lovely things!
The Internet can still give us lovely things!
January 13, 2025 at 9:30 PM
This. Is. Beautiful.
The Internet can still give us lovely things!
The Internet can still give us lovely things!
All you want to know about Transcription Elongation - many important and useful reviews in this thread.
As you make have seen, there is a special issue of JMB on "Controlling Transcription Elongation and Termination: More Than a Means to An End" curated by my colleague here at Pitt Karen Arndt and by Steve Buratowski from Harvard Medical School 🧪🧵 1/ www.sciencedirect.com/science/arti...
Controlling Transcription Elongation and Termination: More Than a Means to An End
www.sciencedirect.com
November 28, 2024 at 8:51 AM
All you want to know about Transcription Elongation - many important and useful reviews in this thread.
Reposted by Zivojin Jevtic
Leonid Mirny and I wrote this for all interested in chromosomes: "The chromosome folding problem and how cells solve it"
www.cell.com/action/showP...
www.cell.com/action/showP...
www.cell.com
November 14, 2024 at 4:02 PM
Leonid Mirny and I wrote this for all interested in chromosomes: "The chromosome folding problem and how cells solve it"
www.cell.com/action/showP...
www.cell.com/action/showP...