@ivanraimondi.bsky.social
Sharper footprints, cleaner insights? Yuxuan Lin at the University of Pennsylvania explores a new approach that corrects Tn5 bias for bulk & single-cell ATAC-seq, boosting the accuracy of transcription-factor binding 🔬
👉 www.biorxiv.org/content/10.1...
#SingleCell #Epigenomics #ATACseq
👉 www.biorxiv.org/content/10.1...
#SingleCell #Epigenomics #ATACseq
Robust footprinting with sample-specific Tn5 bias correction for bulk and single cell ATAC-seq
Footprint analysis of assay for transposase-accessible chromatin via sequencing (ATAC-seq) enables base resolution mapping of regulatory elements but is often underpowered and prone to false positives...
www.biorxiv.org
October 19, 2025 at 2:44 PM
Sharper footprints, cleaner insights? Yuxuan Lin at the University of Pennsylvania explores a new approach that corrects Tn5 bias for bulk & single-cell ATAC-seq, boosting the accuracy of transcription-factor binding 🔬
👉 www.biorxiv.org/content/10.1...
#SingleCell #Epigenomics #ATACseq
👉 www.biorxiv.org/content/10.1...
#SingleCell #Epigenomics #ATACseq
🚀 Excited to share SMART-PTA (miniaturized Primary Template Amplification) a high-throughput single-cell whole-genome amplification method that preserves clonal lineage information while enabling deep genomic and transcriptomic profiling.
Shout out to Tamara Prieto, Dennis Yuan, John Zinno and @ivanraimondi.bsky.social . Thank you to our funders at @themarkfdn.bsky.social
October 14, 2025 at 2:42 PM
🚀 Excited to share SMART-PTA (miniaturized Primary Template Amplification) a high-throughput single-cell whole-genome amplification method that preserves clonal lineage information while enabling deep genomic and transcriptomic profiling.
🧬 We’re excited to introduce D&D-seq, a single-cell technology that maps DNA:Protein interactions through molecular footprinting. Check it out here: biorxiv.org/content/10.1... #Genomics #Epigenetics
Single-cell mapping of regulatory DNA:Protein interactions
Gene expression is coordinated by a multitude of transcription factors (TFs), whose binding to the genome is directed through multiple interconnected epigenetic signals, including chromatin accessibil...
biorxiv.org
January 2, 2025 at 9:10 PM
🧬 We’re excited to introduce D&D-seq, a single-cell technology that maps DNA:Protein interactions through molecular footprinting. Check it out here: biorxiv.org/content/10.1... #Genomics #Epigenetics