@ivanraimondi.bsky.social
🧬 Breaking new ground with single-cell multiomics! 🔗 Linking genotypes and phenotypes using D&D-GoT-ChA in 15,807 PBMCs with IDH2R140Q mutation. Reduced CTCF binding in mutant cells alters insulation at CTCF sites.
January 2, 2025 at 9:10 PM
🧬 Breaking new ground with single-cell multiomics! 🔗 Linking genotypes and phenotypes using D&D-GoT-ChA in 15,807 PBMCs with IDH2R140Q mutation. Reduced CTCF binding in mutant cells alters insulation at CTCF sites.
🧬 By coupling D&D-seq with 10xGenomics scATAC assay, we were able to map transcription factor binding event in single cells. 🔬✨ D&D-seq achieves precise single-cell Protein:DNA profiling!
January 2, 2025 at 9:10 PM
🧬 By coupling D&D-seq with 10xGenomics scATAC assay, we were able to map transcription factor binding event in single cells. 🔬✨ D&D-seq achieves precise single-cell Protein:DNA profiling!
🧬 Why D&D-seq? Existing methods struggle to profile weak/transient DNA:Protein interactions in single cells. We engineered a cutting-edge approach combining nanobody-tethered cytosine base editing to fill this gap. #SingleCell #Innovation
January 2, 2025 at 9:10 PM
🧬 Why D&D-seq? Existing methods struggle to profile weak/transient DNA:Protein interactions in single cells. We engineered a cutting-edge approach combining nanobody-tethered cytosine base editing to fill this gap. #SingleCell #Innovation