Zoher Gueroui 🦠🔬
@zgueroui.bsky.social
Senior scientist at #CNRS, #ENS.
#Biophysics. Physical Chemistry for #LifeScience. #Organelles. #RNA #condensate
#Biophysics. Physical Chemistry for #LifeScience. #Organelles. #RNA #condensate
Pinned
Zoher Gueroui 🦠🔬
@zgueroui.bsky.social
· May 21
What if we could trap Lipid Droplets and control their dynamics in cells?
Our latest work does just that, using Engineered Condensates to manipulate LD behavior.
Exciting results by Chems Amari and the team!
Great collab with @abdourachidthiam.bsky.social
#Organelles #Condensates
rdcu.be/emYpU
Our latest work does just that, using Engineered Condensates to manipulate LD behavior.
Exciting results by Chems Amari and the team!
Great collab with @abdourachidthiam.bsky.social
#Organelles #Condensates
rdcu.be/emYpU
Reposted by Zoher Gueroui 🦠🔬
Postdoctoral position in the team of Alessandro Barducci in the CBS, focusing on multiscale simulations of RNA-driven condensates, with applications in synthetic biology.
More information :
www.cbs.cnrs.fr/images/jobs/...
The position is expected to start in early 2026, with some flexibility.
More information :
www.cbs.cnrs.fr/images/jobs/...
The position is expected to start in early 2026, with some flexibility.
November 5, 2025 at 5:43 PM
Postdoctoral position in the team of Alessandro Barducci in the CBS, focusing on multiscale simulations of RNA-driven condensates, with applications in synthetic biology.
More information :
www.cbs.cnrs.fr/images/jobs/...
The position is expected to start in early 2026, with some flexibility.
More information :
www.cbs.cnrs.fr/images/jobs/...
The position is expected to start in early 2026, with some flexibility.
Reposted by Zoher Gueroui 🦠🔬
Excited to share our study out in @natcellbio.nature.com! Led by @mikelangelipid.bsky.social, we identify the first #LipidDroplet lipid quality control pathway: LD-localized FSP1 protects stored lipids from oxidative damage and prevents LD-initiated #ferroptosis.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
FSP1-mediated lipid droplet quality control prevents neutral lipid peroxidation and ferroptosis - Nature Cell Biology
Lange et al. identify a lipid droplet quality control pathway in which FSP1 safeguards stored neutral lipids from lipid peroxidation, thereby preventing the induction of ferroptosis.
www.nature.com
October 29, 2025 at 5:21 PM
Excited to share our study out in @natcellbio.nature.com! Led by @mikelangelipid.bsky.social, we identify the first #LipidDroplet lipid quality control pathway: LD-localized FSP1 protects stored lipids from oxidative damage and prevents LD-initiated #ferroptosis.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Zoher Gueroui 🦠🔬
Excited to share my postdoc work @olzmannlab.bsky.social! We found lipid droplets, the cell’s lipid storage depots, are subject to oxidative damage and are protected by FSP1. Loss of FSP1 triggers droplet peroxidation and cell death, revealing a new layer of lipid quality control!
shorturl.at/B5XYD
shorturl.at/B5XYD
FSP1-mediated lipid droplet quality control prevents neutral lipid peroxidation and ferroptosis - Nature Cell Biology
Lange et al. identify a lipid droplet quality control pathway in which FSP1 safeguards stored neutral lipids from lipid peroxidation, thereby preventing the induction of ferroptosis.
www.nature.com
October 29, 2025 at 8:45 PM
Excited to share my postdoc work @olzmannlab.bsky.social! We found lipid droplets, the cell’s lipid storage depots, are subject to oxidative damage and are protected by FSP1. Loss of FSP1 triggers droplet peroxidation and cell death, revealing a new layer of lipid quality control!
shorturl.at/B5XYD
shorturl.at/B5XYD
Reposted by Zoher Gueroui 🦠🔬
P-bodies , microRNAs and cell fate ! Not everything is transcription in cell fate decisions ;)
Selective RNA sequestration in biomolecular condensates directs cell fate transitions - Nature Biotechnology
Stem cell differentiation is controlled by manipulating RNA condensates.
www.nature.com
October 29, 2025 at 8:06 PM
P-bodies , microRNAs and cell fate ! Not everything is transcription in cell fate decisions ;)
Reposted by Zoher Gueroui 🦠🔬
🚀 Our new paper is out @natmethods.nature.com!
Kuffer & Marzilli engineered conditionally stable MS2 & PP7 coat proteins (dMCP & dPCP) that degrade unless bound to RNA, enabling ultra–low-background, single-mRNA imaging in live cells.
🔗 www.nature.com/articles/s41...
🧬 www.addgene.org/John_Ngo/
Kuffer & Marzilli engineered conditionally stable MS2 & PP7 coat proteins (dMCP & dPCP) that degrade unless bound to RNA, enabling ultra–low-background, single-mRNA imaging in live cells.
🔗 www.nature.com/articles/s41...
🧬 www.addgene.org/John_Ngo/
September 22, 2025 at 6:27 PM
🚀 Our new paper is out @natmethods.nature.com!
Kuffer & Marzilli engineered conditionally stable MS2 & PP7 coat proteins (dMCP & dPCP) that degrade unless bound to RNA, enabling ultra–low-background, single-mRNA imaging in live cells.
🔗 www.nature.com/articles/s41...
🧬 www.addgene.org/John_Ngo/
Kuffer & Marzilli engineered conditionally stable MS2 & PP7 coat proteins (dMCP & dPCP) that degrade unless bound to RNA, enabling ultra–low-background, single-mRNA imaging in live cells.
🔗 www.nature.com/articles/s41...
🧬 www.addgene.org/John_Ngo/
Reposted by Zoher Gueroui 🦠🔬
Wonderful to see our paper on the #organelle signatures of #neurons and #astrocytes out in final form - congratulations, Shannon Rhoads and team!🎉 t.co/BPxKlbU6Ou
September 17, 2025 at 5:38 PM
Wonderful to see our paper on the #organelle signatures of #neurons and #astrocytes out in final form - congratulations, Shannon Rhoads and team!🎉 t.co/BPxKlbU6Ou
Reposted by Zoher Gueroui 🦠🔬
Which city is the best for Cytoskeleton research?
Dresden? Barcelona? Cambridge ? Noooo ... you all know its Paris, right? 😎
Registering to the annual meeting on Friday 14th of November is now open:
pcd2025.sciencesconf.org
Keynote speeches by @carter-lab.bsky.social and Verena Ruprecht !
Dresden? Barcelona? Cambridge ? Noooo ... you all know its Paris, right? 😎
Registering to the annual meeting on Friday 14th of November is now open:
pcd2025.sciencesconf.org
Keynote speeches by @carter-lab.bsky.social and Verena Ruprecht !
Paris Cytoskeleton Day 2025 - Sciencesconf.org
pcd2025.sciencesconf.org
September 9, 2025 at 12:32 PM
Which city is the best for Cytoskeleton research?
Dresden? Barcelona? Cambridge ? Noooo ... you all know its Paris, right? 😎
Registering to the annual meeting on Friday 14th of November is now open:
pcd2025.sciencesconf.org
Keynote speeches by @carter-lab.bsky.social and Verena Ruprecht !
Dresden? Barcelona? Cambridge ? Noooo ... you all know its Paris, right? 😎
Registering to the annual meeting on Friday 14th of November is now open:
pcd2025.sciencesconf.org
Keynote speeches by @carter-lab.bsky.social and Verena Ruprecht !
Big Thanks @lisaheinke.bsky.social and Nature Reviews Molecular Cell Biology @natrevmcb.nature.com for the opportunity for our students, Chems and Emma, to write a Tools of the Trade piece on our recently published ControLD technique.
ICYMI: New Online! Condensate-mediated intracellular organelle sequestration
Condensate-mediated intracellular organelle sequestration
Nature Reviews Molecular Cell Biology, Published online: 31 July 2025; doi:10.1038/s41580-025-00880-xIn this Tools of the Trade article, Pasquier and Amari (Gueroui lab) describe the development of ControLD, which allows the intracellular sequestration of organelles through condensate formation, enabling the control of inter-organelle communication.
bit.ly
September 9, 2025 at 11:13 AM
Big Thanks @lisaheinke.bsky.social and Nature Reviews Molecular Cell Biology @natrevmcb.nature.com for the opportunity for our students, Chems and Emma, to write a Tools of the Trade piece on our recently published ControLD technique.
Reposted by Zoher Gueroui 🦠🔬
Do you know what happens if you squeeze a #cell?
If the #confinement is high, the nucleus (green) will be super tense & the compressed cells will react like this👇🏽changing their #cytoskeleton (magenta)
Full: www.science.org/doi/10.1126/...
#scicomm #microscopy #sciencesky @focalplane.bsky.social 🧪🔬
If the #confinement is high, the nucleus (green) will be super tense & the compressed cells will react like this👇🏽changing their #cytoskeleton (magenta)
Full: www.science.org/doi/10.1126/...
#scicomm #microscopy #sciencesky @focalplane.bsky.social 🧪🔬
June 28, 2025 at 12:32 PM
Do you know what happens if you squeeze a #cell?
If the #confinement is high, the nucleus (green) will be super tense & the compressed cells will react like this👇🏽changing their #cytoskeleton (magenta)
Full: www.science.org/doi/10.1126/...
#scicomm #microscopy #sciencesky @focalplane.bsky.social 🧪🔬
If the #confinement is high, the nucleus (green) will be super tense & the compressed cells will react like this👇🏽changing their #cytoskeleton (magenta)
Full: www.science.org/doi/10.1126/...
#scicomm #microscopy #sciencesky @focalplane.bsky.social 🧪🔬
Reposted by Zoher Gueroui 🦠🔬
The 2025 @cnrs.fr medal are out! Bronze medals for early career researchers: congrats to Aurélie Tchoghandjian at our institute @inp-marseille.bsky.social, and to @alexandra-colin.bsky.social who was nominated by the Cell biology section 🎉
June 16, 2025 at 1:02 PM
The 2025 @cnrs.fr medal are out! Bronze medals for early career researchers: congrats to Aurélie Tchoghandjian at our institute @inp-marseille.bsky.social, and to @alexandra-colin.bsky.social who was nominated by the Cell biology section 🎉
Reposted by Zoher Gueroui 🦠🔬
A condensate-based approach reversibly sequesters lipid droplets (LDs) in cells, temporarily halting their functions and enabling detailed study of LD biology and the interactions of LDs with other cellular structures
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Controlling lipid droplet dynamics via tether condensates - Nature Chemical Biology
Amari et al. developed a condensate-based approach, named ControLD, for reversible trapping and release of lipid droplets inside living cells, temporarily halting their functions, enabling detailed st...
www.nature.com
May 21, 2025 at 5:11 PM
A condensate-based approach reversibly sequesters lipid droplets (LDs) in cells, temporarily halting their functions and enabling detailed study of LD biology and the interactions of LDs with other cellular structures
www.nature.com/articles/s41...
www.nature.com/articles/s41...
What if we could trap Lipid Droplets and control their dynamics in cells?
Our latest work does just that, using Engineered Condensates to manipulate LD behavior.
Exciting results by Chems Amari and the team!
Great collab with @abdourachidthiam.bsky.social
#Organelles #Condensates
rdcu.be/emYpU
Our latest work does just that, using Engineered Condensates to manipulate LD behavior.
Exciting results by Chems Amari and the team!
Great collab with @abdourachidthiam.bsky.social
#Organelles #Condensates
rdcu.be/emYpU
May 21, 2025 at 11:10 AM
What if we could trap Lipid Droplets and control their dynamics in cells?
Our latest work does just that, using Engineered Condensates to manipulate LD behavior.
Exciting results by Chems Amari and the team!
Great collab with @abdourachidthiam.bsky.social
#Organelles #Condensates
rdcu.be/emYpU
Our latest work does just that, using Engineered Condensates to manipulate LD behavior.
Exciting results by Chems Amari and the team!
Great collab with @abdourachidthiam.bsky.social
#Organelles #Condensates
rdcu.be/emYpU
Reposted by Zoher Gueroui 🦠🔬
Hiro's paper is out! @hiro-cg5445.bsky.social
Collaboration and Tour de Force with Richard Wheeler @zephyris-science.bsky.social and many other coauthors.
Big congratulations and thank you to anyone involved!
www.nature.com/articles/s41...
Collaboration and Tour de Force with Richard Wheeler @zephyris-science.bsky.social and many other coauthors.
Big congratulations and thank you to anyone involved!
www.nature.com/articles/s41...
Small-molecule dissolution of stress granules by redox modulation benefits ALS models - Nature Chemical Biology
Uechi et al. found that a small-molecule lipoamide dissolves stress granules (SGs) by targeting SFPQ, a redox-sensitive disordered SG protein, alleviating pathological phenotypes caused by amyotrophic...
www.nature.com
May 14, 2025 at 2:44 PM
Hiro's paper is out! @hiro-cg5445.bsky.social
Collaboration and Tour de Force with Richard Wheeler @zephyris-science.bsky.social and many other coauthors.
Big congratulations and thank you to anyone involved!
www.nature.com/articles/s41...
Collaboration and Tour de Force with Richard Wheeler @zephyris-science.bsky.social and many other coauthors.
Big congratulations and thank you to anyone involved!
www.nature.com/articles/s41...
Reposted by Zoher Gueroui 🦠🔬
Excited to see our N&V w/ @mikelangelipid.bsky.social published in Nature, highlighting new work from Raphael Rodriguez and team. A heterofunctional molecule that activates lysosomal iron triggers lipid peroxidation and ferroptosis in therapy-resistant cancer cells. www.nature.com/articles/d41...
Lipid-degrading small molecule kills cancer cells by ferroptosis
A molecule designed to activate iron locked up in organelles called lysosomes and thereby induce cell death might offer a way to tackle treatment-resistant cancer.
www.nature.com
May 7, 2025 at 10:17 PM
Excited to see our N&V w/ @mikelangelipid.bsky.social published in Nature, highlighting new work from Raphael Rodriguez and team. A heterofunctional molecule that activates lysosomal iron triggers lipid peroxidation and ferroptosis in therapy-resistant cancer cells. www.nature.com/articles/d41...
Reposted by Zoher Gueroui 🦠🔬
Oligo-LiveFISH enables high-res, live imaging of non-repetitive DNA loci in 3D across cell types, overcoming past limitations in dynamic genome studies. PMID:40239646, Cell 2025, @Cell https://www.cell.com/cell/fulltext/S0092-8674(25)00350-2 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪
https://www.cell.com/cell/fulltext/S0092-8674(25)00350-2
No description available
www.cell.com
April 30, 2025 at 9:10 AM
Reposted by Zoher Gueroui 🦠🔬
I am excited to share the latest paper from my lab where we leverage the selection bias of condensate-promoting oncofusions to uncover molecular rules governing condensate specificity and function. www.cell.com/cell/fulltex....
April 25, 2025 at 5:43 PM
I am excited to share the latest paper from my lab where we leverage the selection bias of condensate-promoting oncofusions to uncover molecular rules governing condensate specificity and function. www.cell.com/cell/fulltex....
Reposted by Zoher Gueroui 🦠🔬
How can a cell control the size of its organelles?
Excited to share a mechanism to control droplet size we recently found.
a 🧵
www.nature.com/articles/s41...
Excited to share a mechanism to control droplet size we recently found.
a 🧵
www.nature.com/articles/s41...
April 25, 2025 at 12:32 PM
How can a cell control the size of its organelles?
Excited to share a mechanism to control droplet size we recently found.
a 🧵
www.nature.com/articles/s41...
Excited to share a mechanism to control droplet size we recently found.
a 🧵
www.nature.com/articles/s41...
Reposted by Zoher Gueroui 🦠🔬
We’re excited to share our work where we investigated the mechanisms of chromosome motion by tracking all #chromosomes, mapping their interactions, and live cell karyotyping, using #AI based denoising, segmentation and registration, published in Nature Cell Biology.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
April 7, 2025 at 1:01 PM
We’re excited to share our work where we investigated the mechanisms of chromosome motion by tracking all #chromosomes, mapping their interactions, and live cell karyotyping, using #AI based denoising, segmentation and registration, published in Nature Cell Biology.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Zoher Gueroui 🦠🔬
Which synapses get stronger when we form a memory? We developed a technique to tag recently potentiated synapses in live mice. Pulse-chase labeling with membrane-impermeable HaloLigand dyes distinguishes fresh AMPA receptors from old ones. www.nature.com/articles/s41...
EPSILON: a method for pulse-chase labeling to probe synaptic AMPAR exocytosis during memory formation - Nature Neuroscience
Kim and coworkers describe a technique, EPSILON, to map AMPA receptor exocytosis, a proxy for synaptic plasticity, in mice. The authors demonstrated a correlation between AMPA receptor exocytosis and ...
www.nature.com
March 31, 2025 at 9:10 PM
Which synapses get stronger when we form a memory? We developed a technique to tag recently potentiated synapses in live mice. Pulse-chase labeling with membrane-impermeable HaloLigand dyes distinguishes fresh AMPA receptors from old ones. www.nature.com/articles/s41...
Reposted by Zoher Gueroui 🦠🔬
Very happy to share the recent paper of Lina El Hajji in Arnaud
Gautier's team on the development of a tunable chemogenetic
near-infrared fluorescent reporter for imaging proteins in live cells and organisms
www.nature.com/articles/s41...
Gautier's team on the development of a tunable chemogenetic
near-infrared fluorescent reporter for imaging proteins in live cells and organisms
www.nature.com/articles/s41...
A tunable and versatile chemogenetic near-infrared fluorescent reporter - Nature Communications
This paper reports the engineering of nirFAST, a near-infrared fluorescent chemogenetic reporter suitable for multi-color protein imaging in cells and organisms, as well as for the design of cellular ...
www.nature.com
March 25, 2025 at 6:26 PM
Very happy to share the recent paper of Lina El Hajji in Arnaud
Gautier's team on the development of a tunable chemogenetic
near-infrared fluorescent reporter for imaging proteins in live cells and organisms
www.nature.com/articles/s41...
Gautier's team on the development of a tunable chemogenetic
near-infrared fluorescent reporter for imaging proteins in live cells and organisms
www.nature.com/articles/s41...
Reposted by Zoher Gueroui 🦠🔬
Excited to share our first story on nuclear paraspeckles! Led by @sneadlab.bsky.social, this is the culmination of a ~4 year effort in collab. with @shrinivaslab.bsky.social. Can’t wait to see more paraspeckle stories from the future Snead Lab at Northwestern 🫧 www.biorxiv.org/content/10.1...
Immiscible proteins compete for RNA binding to order condensate layers
Biomolecular condensates mediate diverse and essential cellular functions by compartmentalizing biochemical pathways. Many condensates have internal subdomains with distinct compositional identities. ...
www.biorxiv.org
March 19, 2025 at 7:09 PM
Excited to share our first story on nuclear paraspeckles! Led by @sneadlab.bsky.social, this is the culmination of a ~4 year effort in collab. with @shrinivaslab.bsky.social. Can’t wait to see more paraspeckle stories from the future Snead Lab at Northwestern 🫧 www.biorxiv.org/content/10.1...
Reposted by Zoher Gueroui 🦠🔬
Axonal RNA localization is essential for long-term memory
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Axonal RNA localization is essential for long-term memory - Nature Communications
Axonal transcriptomes have been characterized, but their regulation and role in neuronal circuits remain unclear. Here authors uncover activity-dependent RNA localization in axons important for memory...
www.nature.com
March 15, 2025 at 9:23 PM
Axonal RNA localization is essential for long-term memory
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Zoher Gueroui 🦠🔬
New paper out! Why do condensates prefer some surfaces and not others? Check it out here: doi.org/10.1063/5.02...
Intrinsic hydrophobicity of IDP-based biomolecular condensates drives their partial drying on membrane surfaces
The localization of biomolecular condensates to intracellular membrane surfaces has emerged as an important feature of sub-cellular organization. In this work,
doi.org
March 17, 2025 at 5:53 PM
New paper out! Why do condensates prefer some surfaces and not others? Check it out here: doi.org/10.1063/5.02...
Reposted by Zoher Gueroui 🦠🔬
@science.org Cryo-EM reveals mechanisms of natural RNA multivalency | Science www.science.org/doi/10.1126/...
#RNAsky #RNAbiology #Cryo-EM
#RNAsky #RNAbiology #Cryo-EM
March 13, 2025 at 6:09 PM
@science.org Cryo-EM reveals mechanisms of natural RNA multivalency | Science www.science.org/doi/10.1126/...
#RNAsky #RNAbiology #Cryo-EM
#RNAsky #RNAbiology #Cryo-EM
Reposted by Zoher Gueroui 🦠🔬
A small but special moment: My illustration is on the cover of the March issue of Nature Methods!
A huge hug to @anwaiarchit.bsky.social and @cppape.bsky.social — it was a pleasure to work alongside you on this!
www.nature.com/nmeth/volume...
A huge hug to @anwaiarchit.bsky.social and @cppape.bsky.social — it was a pleasure to work alongside you on this!
www.nature.com/nmeth/volume...
March 13, 2025 at 8:08 AM
A small but special moment: My illustration is on the cover of the March issue of Nature Methods!
A huge hug to @anwaiarchit.bsky.social and @cppape.bsky.social — it was a pleasure to work alongside you on this!
www.nature.com/nmeth/volume...
A huge hug to @anwaiarchit.bsky.social and @cppape.bsky.social — it was a pleasure to work alongside you on this!
www.nature.com/nmeth/volume...