Valentine Comaills
@valcomaills.bsky.social
PI at University of Seville, cell biology dept. Spain 💃🏻. Chromosomal instability and cellular plasticity mostly in cancer. #newPI
https://www.departamento.us.es/dbiocel/investigacion/ingeplascecan.htm
https://www.departamento.us.es/dbiocel/investigacion/ingeplascecan.htm
😱🤩What a beautiful conference coming up (2026)! 😍
Chromosomes in crisis: From chromosomal Instability to Catastrophes in Cancer Genomes — join the EACR in Berlin, 3–5 Nov 2026!
Thanks to @helloeacr.bsky.social and the brilliant speakers for organizing this beauty!
Chromosomes in crisis: From chromosomal Instability to Catastrophes in Cancer Genomes — join the EACR in Berlin, 3–5 Nov 2026!
Thanks to @helloeacr.bsky.social and the brilliant speakers for organizing this beauty!
October 30, 2025 at 2:49 PM
😱🤩What a beautiful conference coming up (2026)! 😍
Chromosomes in crisis: From chromosomal Instability to Catastrophes in Cancer Genomes — join the EACR in Berlin, 3–5 Nov 2026!
Thanks to @helloeacr.bsky.social and the brilliant speakers for organizing this beauty!
Chromosomes in crisis: From chromosomal Instability to Catastrophes in Cancer Genomes — join the EACR in Berlin, 3–5 Nov 2026!
Thanks to @helloeacr.bsky.social and the brilliant speakers for organizing this beauty!
Reposted by Valentine Comaills
La #AEI @ageinves.bsky.social del #MICIU publica la resolución de los proyectos #PID2024. Lo principal:
- El número de solicitudes de proyectos sube un 1️⃣0️⃣%. Genial, ¿no?? La ciencia crece en España, ¿no?? 😀
Pues no... 😕
- La financiación total se estanca.
- La financiación por proyecto baja.
- El número de solicitudes de proyectos sube un 1️⃣0️⃣%. Genial, ¿no?? La ciencia crece en España, ¿no?? 😀
Pues no... 😕
- La financiación total se estanca.
- La financiación por proyecto baja.
July 29, 2025 at 3:33 PM
La #AEI @ageinves.bsky.social del #MICIU publica la resolución de los proyectos #PID2024. Lo principal:
- El número de solicitudes de proyectos sube un 1️⃣0️⃣%. Genial, ¿no?? La ciencia crece en España, ¿no?? 😀
Pues no... 😕
- La financiación total se estanca.
- La financiación por proyecto baja.
- El número de solicitudes de proyectos sube un 1️⃣0️⃣%. Genial, ¿no?? La ciencia crece en España, ¿no?? 😀
Pues no... 😕
- La financiación total se estanca.
- La financiación por proyecto baja.
Reposted by Valentine Comaills
Nature research paper: Ongoing genome doubling shapes evolvability and immunity in ovarian cancer
go.nature.com/40qLLcJ
go.nature.com/40qLLcJ
Ongoing genome doubling shapes evolvability and immunity in ovarian cancer - Nature
A single-cell sequencing study using more than 30,000 tumour genomes from human ovarian cancers shows that whole-genome doubling is an ongoing mutational process that drives tumour evolution and disrupts immunity.
go.nature.com
July 21, 2025 at 5:47 PM
Nature research paper: Ongoing genome doubling shapes evolvability and immunity in ovarian cancer
go.nature.com/40qLLcJ
go.nature.com/40qLLcJ
Reposted by Valentine Comaills
Great discussion at the #EACR2025. Thanks to everyone who came to my poster yesterday for the feedback! @valcomaills.bsky.social @unisevilla.bsky.social
June 18, 2025 at 5:03 PM
Great discussion at the #EACR2025. Thanks to everyone who came to my poster yesterday for the feedback! @valcomaills.bsky.social @unisevilla.bsky.social
So much fun at Lisbon for the #eacr2025! Former and current investigators from @unisevilla.bsky.social 💃🏻👩🏻🔬 @helloeacr.bsky.social @livialopez.bsky.social and Sonia Silva from I3S.
June 16, 2025 at 8:38 PM
So much fun at Lisbon for the #eacr2025! Former and current investigators from @unisevilla.bsky.social 💃🏻👩🏻🔬 @helloeacr.bsky.social @livialopez.bsky.social and Sonia Silva from I3S.
Reposted by Valentine Comaills
Andy Moore @hhmijanelia.bsky.social created this video showing a cytoskeletal mechanism called an actin wave in a so-called HeLa cell. In orange are the actin filaments and in blue are the mitochondria, some of which appear to move with or be shifted by the active wave.
June 3, 2025 at 3:33 PM
Andy Moore @hhmijanelia.bsky.social created this video showing a cytoskeletal mechanism called an actin wave in a so-called HeLa cell. In orange are the actin filaments and in blue are the mitochondria, some of which appear to move with or be shifted by the active wave.
Reposted by Valentine Comaills
Inkscape plugin to rescale figures without distorting the text, and other useful features!
github.com/burghoff/Sci...
github.com/burghoff/Sci...
June 2, 2025 at 12:15 PM
Inkscape plugin to rescale figures without distorting the text, and other useful features!
github.com/burghoff/Sci...
github.com/burghoff/Sci...
Huge shoutout to Javi (Fzco Javier Mendoza León), our Ph.D. student, for being awarded the AECC Predoctoral Fellowship 2025-Sevilla! 🎉 We hit the jackpot having you on the team!
Thank you so much @contracancerinv.bsky.social with @unisevilla.bsky.social
¡Enhorabuena a Javi! 👏
Thank you so much @contracancerinv.bsky.social with @unisevilla.bsky.social
¡Enhorabuena a Javi! 👏
April 23, 2025 at 2:42 PM
Huge shoutout to Javi (Fzco Javier Mendoza León), our Ph.D. student, for being awarded the AECC Predoctoral Fellowship 2025-Sevilla! 🎉 We hit the jackpot having you on the team!
Thank you so much @contracancerinv.bsky.social with @unisevilla.bsky.social
¡Enhorabuena a Javi! 👏
Thank you so much @contracancerinv.bsky.social with @unisevilla.bsky.social
¡Enhorabuena a Javi! 👏
Reposted by Valentine Comaills
new out in @nature.com www.nature.com/articles/s41...
Evolutionary fingerprints of epithelial-to-mesenchymal transition - Nature
Malignant cells with mesenchymal features display increased chromatin accessibility, particularly in the pericentromeric and centromeric regions, in turn resulting in delayed mitosis and catastrophic ...
www.nature.com
March 6, 2025 at 8:26 AM
new out in @nature.com www.nature.com/articles/s41...
Reposted by Valentine Comaills
The 7 new #CancerGrandChallenges have just been announced! Read about them now in Cancer Discovery: doi.org/10.1158/2159...
@cancergrand.bsky.social
@cancergrand.bsky.social
March 5, 2025 at 3:32 PM
The 7 new #CancerGrandChallenges have just been announced! Read about them now in Cancer Discovery: doi.org/10.1158/2159...
@cancergrand.bsky.social
@cancergrand.bsky.social
Ayer estuve en el II Encuentro de Investigadores AECC! 🔬💙
Gracias ♥️ @ContraCancerEs, @contracancerINV y voluntarios por hacerlo posible. Un día increíble para conectar, compartir ideas y recordar que nuestra investigación tiene un impacto real en los pacientes. 🚀 #encuentroinvestigadoresaecc!
Gracias ♥️ @ContraCancerEs, @contracancerINV y voluntarios por hacerlo posible. Un día increíble para conectar, compartir ideas y recordar que nuestra investigación tiene un impacto real en los pacientes. 🚀 #encuentroinvestigadoresaecc!
March 5, 2025 at 3:09 PM
Ayer estuve en el II Encuentro de Investigadores AECC! 🔬💙
Gracias ♥️ @ContraCancerEs, @contracancerINV y voluntarios por hacerlo posible. Un día increíble para conectar, compartir ideas y recordar que nuestra investigación tiene un impacto real en los pacientes. 🚀 #encuentroinvestigadoresaecc!
Gracias ♥️ @ContraCancerEs, @contracancerINV y voluntarios por hacerlo posible. Un día increíble para conectar, compartir ideas y recordar que nuestra investigación tiene un impacto real en los pacientes. 🚀 #encuentroinvestigadoresaecc!
So beautiful to see...
Unbelievable news.
Pancreatic is one of the deadliest cancers.
New paper shows personalized mRNA vaccines can induce durable T cells that attack pancreatic cancer, with 75% of patients cancer free at three years—far, far better than standard of care.
www.nature.com/articles/s41...
Pancreatic is one of the deadliest cancers.
New paper shows personalized mRNA vaccines can induce durable T cells that attack pancreatic cancer, with 75% of patients cancer free at three years—far, far better than standard of care.
www.nature.com/articles/s41...
February 28, 2025 at 8:22 AM
So beautiful to see...
Reposted by Valentine Comaills
This study found that RNA vaccines can induce an immune response in patients with pancreatic cancer
https://go.nature.com/4hI3XVL
https://go.nature.com/4hI3XVL
Bespoke vaccines can elicit long-lived immune activity against pancreatic cancer
T cells induced by personalized pancreatic-cancer vaccines last for years.
go.nature.com
February 24, 2025 at 11:46 AM
This study found that RNA vaccines can induce an immune response in patients with pancreatic cancer
https://go.nature.com/4hI3XVL
https://go.nature.com/4hI3XVL
Reposted by Valentine Comaills
Hello, Bluesky! ☀️
We fund frontier research in Europe—bold ideas, unexpected discoveries and science that shapes the future. So it’s only fitting we’ve landed here. Sorry for being late.
Follow us for updates on ERC funding, research policy, and our grantees' discoveries.
We fund frontier research in Europe—bold ideas, unexpected discoveries and science that shapes the future. So it’s only fitting we’ve landed here. Sorry for being late.
Follow us for updates on ERC funding, research policy, and our grantees' discoveries.
February 7, 2025 at 8:16 AM
Hello, Bluesky! ☀️
We fund frontier research in Europe—bold ideas, unexpected discoveries and science that shapes the future. So it’s only fitting we’ve landed here. Sorry for being late.
Follow us for updates on ERC funding, research policy, and our grantees' discoveries.
We fund frontier research in Europe—bold ideas, unexpected discoveries and science that shapes the future. So it’s only fitting we’ve landed here. Sorry for being late.
Follow us for updates on ERC funding, research policy, and our grantees' discoveries.
Reposted by Valentine Comaills
"Imagine a DAPI-like stain, but for the extracellular matrix." That's basically how this work was pitched to me by Kayvon and Antonio a year or so ago. Now the final product really delivers. Read about their versatile label for ECM in living tissues here: www.nature.com/articles/s41...
February 6, 2025 at 4:02 PM
"Imagine a DAPI-like stain, but for the extracellular matrix." That's basically how this work was pitched to me by Kayvon and Antonio a year or so ago. Now the final product really delivers. Read about their versatile label for ECM in living tissues here: www.nature.com/articles/s41...
Personalized cancer vaccines are a game-changer! The results are incredibly promising—so encouraging to see!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
A neoantigen vaccine generates antitumour immunity in renal cell carcinoma - Nature
A phase I trial of a neoantigen-targeting personalized cancer vaccine led to durable and polyfunctional T cell responses and antitumour recognition, and was associated with no recurrence in patie...
www.nature.com
February 6, 2025 at 3:31 PM
Personalized cancer vaccines are a game-changer! The results are incredibly promising—so encouraging to see!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Valentine Comaills
Big if true: do cancer cells transfer mutated mitochondria into tumor infiltrating lymphocytes to impair their function? mtDNA is challenging to work with, so looking forward to see this finding confirmed. But cool concept and big congrats to the authors!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Immune evasion through mitochondrial transfer in the tumour microenvironment - Nature
Mitochondria with mutations in their DNA from cancer cells can be transferred to T cells in the tumour microenvironment, which leads to T cell dysfunction and impaired antitumour immunity.
www.nature.com
January 22, 2025 at 7:41 PM
Big if true: do cancer cells transfer mutated mitochondria into tumor infiltrating lymphocytes to impair their function? mtDNA is challenging to work with, so looking forward to see this finding confirmed. But cool concept and big congrats to the authors!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Valentine Comaills
Registration is now OPEN for the cancer research community to join us for the EACR 2025 Congress! 🥳
Don't miss the opportunity to take advantage of our discounted early registration rate to attend, available until 28 April.
2025.eacr.org
Don't miss the opportunity to take advantage of our discounted early registration rate to attend, available until 28 April.
2025.eacr.org
January 7, 2025 at 11:20 AM
Registration is now OPEN for the cancer research community to join us for the EACR 2025 Congress! 🥳
Don't miss the opportunity to take advantage of our discounted early registration rate to attend, available until 28 April.
2025.eacr.org
Don't miss the opportunity to take advantage of our discounted early registration rate to attend, available until 28 April.
2025.eacr.org
Reposted by Valentine Comaills
Excited to share the first paper from my lab 🤩 - a great collaboration with Dani Fachinetti lab - we discover a #mechanosensitive nuclear envelope #checkpoint that arrests cells directly post chromosome mis-segregation rdcu.be/d5AC9 👇🧵 #cancer #mechanics #p53 #chromatin
January 8, 2025 at 12:14 PM
Excited to share the first paper from my lab 🤩 - a great collaboration with Dani Fachinetti lab - we discover a #mechanosensitive nuclear envelope #checkpoint that arrests cells directly post chromosome mis-segregation rdcu.be/d5AC9 👇🧵 #cancer #mechanics #p53 #chromatin
Reposted by Valentine Comaills
🔥🔥👇🏻👇🏻
Want to know how inherited genome instability contributes to childhood cancers? Checkout this perspective from Jayne Hehir-Kwa and me www.science.org/doi/10.1126/... on the latest brilliant work from @vanallenlab.bsky.social www.science.org/doi/10.1126/... on rare germline SVs in paediatric cancers
Inherited genome instability
Germline structural variants are a risk factor for pediatric extracranial solid tumors
www.science.org
January 3, 2025 at 11:54 AM
🔥🔥👇🏻👇🏻
Reposted by Valentine Comaills
🧪1/ 🚨New paper on ecDNAs from our lab!
We reveal a strategy to engineer extrachromosomal DNA (ecDNA) amplifications in cells & mice. Let's dive in! Let’s dive in! 🧵👇
www.nature.com/articles/s41...
We reveal a strategy to engineer extrachromosomal DNA (ecDNA) amplifications in cells & mice. Let's dive in! Let’s dive in! 🧵👇
www.nature.com/articles/s41...
Engineered extrachromosomal oncogene amplifications promote tumorigenesis - Nature
Large extrachromosomal DNAs are engineered using a CRISPR- and Cre–loxP-based approach and shown to drive cancer in mouse models, with potential applications in determining the role of oncogene a...
www.nature.com
December 18, 2024 at 4:54 PM
🧪1/ 🚨New paper on ecDNAs from our lab!
We reveal a strategy to engineer extrachromosomal DNA (ecDNA) amplifications in cells & mice. Let's dive in! Let’s dive in! 🧵👇
www.nature.com/articles/s41...
We reveal a strategy to engineer extrachromosomal DNA (ecDNA) amplifications in cells & mice. Let's dive in! Let’s dive in! 🧵👇
www.nature.com/articles/s41...
Reposted by Valentine Comaills
One of the biggest questions we get is when will our journals be here. We thank you for your patience.
You can now follow our journals with this starter pack!
You can now follow our journals with this starter pack!
December 18, 2024 at 2:57 PM
One of the biggest questions we get is when will our journals be here. We thank you for your patience.
You can now follow our journals with this starter pack!
You can now follow our journals with this starter pack!
Happy Thanksgiving! I loved going back to Boston when we used to host the 'foreigner' Thanksgiving! Everyone from the lab who didn't have family close by held together and shared food. I made so many friends thanks to it! And we learned how to make bread 'turkey' for our vegetarian Indian friends.
November 28, 2024 at 6:13 PM
Happy Thanksgiving! I loved going back to Boston when we used to host the 'foreigner' Thanksgiving! Everyone from the lab who didn't have family close by held together and shared food. I made so many friends thanks to it! And we learned how to make bread 'turkey' for our vegetarian Indian friends.
Reposted by Valentine Comaills
🔴Comunicado de las Universidades Públicas de Andalucía sobre los incumplimientos reiterados de la Junta en materia de financiación.
Accede 👇 www.uco.es/servicios/ac...
Accede 👇 www.uco.es/servicios/ac...
November 27, 2024 at 11:45 AM
🔴Comunicado de las Universidades Públicas de Andalucía sobre los incumplimientos reiterados de la Junta en materia de financiación.
Accede 👇 www.uco.es/servicios/ac...
Accede 👇 www.uco.es/servicios/ac...
Reposted by Valentine Comaills
Did you know there’s a site to search for starter packs of people to follow? Built by @mubashariqbal.com
blueskydirectory.com/starter-pack...
blueskydirectory.com/starter-pack...
Bluesky Starter Packs - Bluesky Directory
Browse a list of Bluesky Starter Packs. Discover and connect with your community on Bluesky
blueskydirectory.com
November 23, 2024 at 9:43 PM
Did you know there’s a site to search for starter packs of people to follow? Built by @mubashariqbal.com
blueskydirectory.com/starter-pack...
blueskydirectory.com/starter-pack...