Geoff Macintyre
@gmaci.bsky.social
Group leader in computational oncology at CNIO, Madrid. CSO at Tailor Bio. Chromosomal instability and tumour evolution. www.macintyrelab.org
Reposted by Geoff Macintyre
Cancer is an evolutionary disease, but does knowing a cancer’s evolutionary past help predict its future? Out today in @nature, we learnt the evolution of 2000 lymphoid cancers and found it was highly correlated with clinical outcomes! (1/7)
rdcu.be/eFrrc
rdcu.be/eFrrc
Fluctuating DNA methylation tracks cancer evolution at clinical scale
Nature - Cancer evolutionary dynamics are quantitatively inferred using a method, EVOFLUx, applied to fluctuating DNA methylation.
rdcu.be
September 10, 2025 at 4:17 PM
Cancer is an evolutionary disease, but does knowing a cancer’s evolutionary past help predict its future? Out today in @nature, we learnt the evolution of 2000 lymphoid cancers and found it was highly correlated with clinical outcomes! (1/7)
rdcu.be/eFrrc
rdcu.be/eFrrc
🚨Chemo treatment upgrade!🚨
Check out our approach to modernise chemotherapy treatment published today in @natgenet.nature.com. From @cniostopcancer.bsky.social #TailorBio @cruk-ci.bsky.social www.nature.com/articles/s41... More details 👇
Check out our approach to modernise chemotherapy treatment published today in @natgenet.nature.com. From @cniostopcancer.bsky.social #TailorBio @cruk-ci.bsky.social www.nature.com/articles/s41... More details 👇
www.nature.com
June 23, 2025 at 9:03 AM
🚨Chemo treatment upgrade!🚨
Check out our approach to modernise chemotherapy treatment published today in @natgenet.nature.com. From @cniostopcancer.bsky.social #TailorBio @cruk-ci.bsky.social www.nature.com/articles/s41... More details 👇
Check out our approach to modernise chemotherapy treatment published today in @natgenet.nature.com. From @cniostopcancer.bsky.social #TailorBio @cruk-ci.bsky.social www.nature.com/articles/s41... More details 👇
If tumour genome evolution is deterministic, can we forecast genomic changes? Yes we can! At least for oncogene amps and tumour suppressor dels. @bhernando.bsky.social Angel Fernandez-Sanroman present our method for forecasting driver gene copy number change. Preprint: bit.ly/4kxF14y ⬇️1/
Forecasting oncogene amplification and tumour suppressor deletion
Oncogene amplification and tumour suppressor deletion can drive tumour initiation, progression and treatment resistance. Detection at diagnosis often signals poor prognosis, but it can also enable opp...
bit.ly
June 10, 2025 at 2:15 PM
If tumour genome evolution is deterministic, can we forecast genomic changes? Yes we can! At least for oncogene amps and tumour suppressor dels. @bhernando.bsky.social Angel Fernandez-Sanroman present our method for forecasting driver gene copy number change. Preprint: bit.ly/4kxF14y ⬇️1/
If you are at AACR and want to find out how we are turning chemotherapies into precision medicines, come to my talk on Tuesday! www.abstractsonline.com/pp8/#!/20273...
April 27, 2025 at 10:37 PM
If you are at AACR and want to find out how we are turning chemotherapies into precision medicines, come to my talk on Tuesday! www.abstractsonline.com/pp8/#!/20273...
One more day left to apply! Come join us in our efforts to turn chemotherapy into a precision medicine.
We are hiring! Opportunity for a project manager to oversee all aspects of a multi-centre clinical research project to implement an AI-based genomic test that predicts resistance to chemotherapy - Madrid, Spain. PM for more details. Deadline 25 January! www.cnio.es/en/empleo/re...
January 24, 2025 at 9:06 AM
One more day left to apply! Come join us in our efforts to turn chemotherapy into a precision medicine.
We are hiring! Opportunity for a project manager to oversee all aspects of a multi-centre clinical research project to implement an AI-based genomic test that predicts resistance to chemotherapy - Madrid, Spain. PM for more details. Deadline 25 January! www.cnio.es/en/empleo/re...
January 16, 2025 at 5:38 PM
We are hiring! Opportunity for a project manager to oversee all aspects of a multi-centre clinical research project to implement an AI-based genomic test that predicts resistance to chemotherapy - Madrid, Spain. PM for more details. Deadline 25 January! www.cnio.es/en/empleo/re...
Want to know how inherited genome instability contributes to childhood cancers? Checkout this perspective from Jayne Hehir-Kwa and me www.science.org/doi/10.1126/... on the latest brilliant work from @vanallenlab.bsky.social www.science.org/doi/10.1126/... on rare germline SVs in paediatric cancers
Inherited genome instability
Germline structural variants are a risk factor for pediatric extracranial solid tumors
www.science.org
January 3, 2025 at 9:57 AM
Want to know how inherited genome instability contributes to childhood cancers? Checkout this perspective from Jayne Hehir-Kwa and me www.science.org/doi/10.1126/... on the latest brilliant work from @vanallenlab.bsky.social www.science.org/doi/10.1126/... on rare germline SVs in paediatric cancers
Reposted by Geoff Macintyre
🚨So proud to present the first study from our @ccg-ucl.bsky.social group together with @charlesswanton.bsky.social @NnennayaKanu and led by @ojlucas.bsky.social with key collaboration @sophie-ward.bsky.social and fundamental support @rijazaidi.bsky.social @abibunkum.bsky.social & others
Out now👇
🧵👇
Out now👇
🧵👇
Characterizing the evolutionary dynamics of cancer proliferation in single-cell clones with SPRINTER - Nature Genetics
Single-cell Proliferation Rate Inference in Non-homogeneous Tumors through Evolutionary Routes (SPRINTER) allows users to infer proliferation rates of individual clones within a tumor from single-cell...
doi.org
November 29, 2024 at 1:25 PM
🚨So proud to present the first study from our @ccg-ucl.bsky.social group together with @charlesswanton.bsky.social @NnennayaKanu and led by @ojlucas.bsky.social with key collaboration @sophie-ward.bsky.social and fundamental support @rijazaidi.bsky.social @abibunkum.bsky.social & others
Out now👇
🧵👇
Out now👇
🧵👇
Reposted by Geoff Macintyre
Huge resource of MSK-IMPACT "genomes", what a treasure trove! Automated real-world data integration improves cancer outcome prediction www.nature.com/articles/s41...
Automated real-world data integration improves cancer outcome prediction - Nature
A study generates a clinicogenomics dataset resource, MSK-CHORD, that combines natural language processing-derived clinical annotations with patient medical data from various sources to improve m...
www.nature.com
November 18, 2024 at 1:23 PM
Huge resource of MSK-IMPACT "genomes", what a treasure trove! Automated real-world data integration improves cancer outcome prediction www.nature.com/articles/s41...
Reposted by Geoff Macintyre
Announcing the next EMBO Chromosome Segregation and Aneuploidy Meeting! Italy 2025. Please register and join us for another exciting and friendly meeting in a beautiful location meetings.embo.org/event/25-ane...
Chromosome Segregation and Aneuploidy
Aneuploidy is a hallmark of cancer and developmental disorders such as Down syndrome. Understanding how cells accomplish faithful chromosome segregation and how chromosomal instability (CIN) impacts …
meetings.embo.org
November 14, 2024 at 7:43 AM
Announcing the next EMBO Chromosome Segregation and Aneuploidy Meeting! Italy 2025. Please register and join us for another exciting and friendly meeting in a beautiful location meetings.embo.org/event/25-ane...