Calum Gabbutt
@calumgabbutt.bsky.social
Computational biologist interested in cancer evolution, maths modelling and Bayesian stats.
Reposted by Calum Gabbutt
Studying cancer evolution needs multi-region or single cell seq for phylogenetics, right? Amazingly (I think!) we found single-sample bulk methylation suffices, via analysis of "fluctuating methylation". In @nature.com today led by brilliant @calumgabbutt.bsky.social www.nature.com/articles/s41...
Fluctuating DNA methylation tracks cancer evolution at clinical scale - Nature
Cancer evolutionary dynamics are quantitatively inferred using a method, EVOFLUx, applied to fluctuating DNA methylation.
www.nature.com
September 10, 2025 at 3:21 PM
Studying cancer evolution needs multi-region or single cell seq for phylogenetics, right? Amazingly (I think!) we found single-sample bulk methylation suffices, via analysis of "fluctuating methylation". In @nature.com today led by brilliant @calumgabbutt.bsky.social www.nature.com/articles/s41...
Cancer is an evolutionary disease, but does knowing a cancer’s evolutionary past help predict its future? Out today in @nature, we learnt the evolution of 2000 lymphoid cancers and found it was highly correlated with clinical outcomes! (1/7)
rdcu.be/eFrrc
rdcu.be/eFrrc
Fluctuating DNA methylation tracks cancer evolution at clinical scale
Nature - Cancer evolutionary dynamics are quantitatively inferred using a method, EVOFLUx, applied to fluctuating DNA methylation.
rdcu.be
September 10, 2025 at 4:17 PM
Cancer is an evolutionary disease, but does knowing a cancer’s evolutionary past help predict its future? Out today in @nature, we learnt the evolution of 2000 lymphoid cancers and found it was highly correlated with clinical outcomes! (1/7)
rdcu.be/eFrrc
rdcu.be/eFrrc
Reposted by Calum Gabbutt
🚀 AI in Science Fellowships – Applications Now Open!
The I-X Centre for AI in Science is recruiting up to 19 fellows to join their prestigious programme and accelerate artificial intelligence research in Engineering, Natural and Mathematical Sciences.
1/5
The I-X Centre for AI in Science is recruiting up to 19 fellows to join their prestigious programme and accelerate artificial intelligence research in Engineering, Natural and Mathematical Sciences.
1/5
LinkedIn
This link will take you to a page that’s not on LinkedIn
lnkd.in
July 18, 2025 at 9:36 AM
🚀 AI in Science Fellowships – Applications Now Open!
The I-X Centre for AI in Science is recruiting up to 19 fellows to join their prestigious programme and accelerate artificial intelligence research in Engineering, Natural and Mathematical Sciences.
1/5
The I-X Centre for AI in Science is recruiting up to 19 fellows to join their prestigious programme and accelerate artificial intelligence research in Engineering, Natural and Mathematical Sciences.
1/5
Imperial's Schmidt AI in Science fellowships are now open! As a current fellow, I can highly recommend applying for these prestigious and enriching awards. No prior AI experience needed, just a scientific problem suited to AI. For cancer researchers there are dedicated joint positions with the ICR.
Apply | Research groups | Imperial College London
www.imperial.ac.uk
July 18, 2025 at 11:11 AM
Imperial's Schmidt AI in Science fellowships are now open! As a current fellow, I can highly recommend applying for these prestigious and enriching awards. No prior AI experience needed, just a scientific problem suited to AI. For cancer researchers there are dedicated joint positions with the ICR.
Reposted by Calum Gabbutt
Schmidt Fellowships for #AI in #cancer research 2025 round is now open. These are pathway to independence fellowships between @icr.ac.uk & @imperialcollegeldn.bsky.social that support fellows to be competitive for faculty jobs at the end of the 2 year funding. www.imperial.ac.uk/jobs/search-...
Search jobs for external candidates | Jobs | Imperial College London
www.imperial.ac.uk
July 15, 2025 at 8:01 AM
Schmidt Fellowships for #AI in #cancer research 2025 round is now open. These are pathway to independence fellowships between @icr.ac.uk & @imperialcollegeldn.bsky.social that support fellows to be competitive for faculty jobs at the end of the 2 year funding. www.imperial.ac.uk/jobs/search-...
Reposted by Calum Gabbutt
New preprint! Let me tell you a story about trees, caterpillars, brooms, entropy, and getting scooped by 50 years.
Rooted trees of all shapes and sizes crop up all over biology, computing and elsewhere. How can we best compare the shapes of these myriad trees? 1/14
arxiv.org/abs/2507.08615
Rooted trees of all shapes and sizes crop up all over biology, computing and elsewhere. How can we best compare the shapes of these myriad trees? 1/14
arxiv.org/abs/2507.08615
July 14, 2025 at 9:43 AM
New preprint! Let me tell you a story about trees, caterpillars, brooms, entropy, and getting scooped by 50 years.
Rooted trees of all shapes and sizes crop up all over biology, computing and elsewhere. How can we best compare the shapes of these myriad trees? 1/14
arxiv.org/abs/2507.08615
Rooted trees of all shapes and sizes crop up all over biology, computing and elsewhere. How can we best compare the shapes of these myriad trees? 1/14
arxiv.org/abs/2507.08615
Reposted by Calum Gabbutt
Interested in population genetics of cancer?
If so, have a look at our manuscript accepted by @genetics-gsa.bsky.social, in which we provide a theoretical assessment of the genetic makeup of cancers before and after treatment!
If so, have a look at our manuscript accepted by @genetics-gsa.bsky.social, in which we provide a theoretical assessment of the genetic makeup of cancers before and after treatment!
Very happy that @alexsteinresearch.bsky.social manuscript on the patterns of genetic heterogeneity before and after treatment is out now:
academic.oup.com/genetics/adv...
We build on and expand the population genetics theory of gITH.
Very worth a read if you are interested in somatic evolution.
academic.oup.com/genetics/adv...
We build on and expand the population genetics theory of gITH.
Very worth a read if you are interested in somatic evolution.
On the patterns of genetic intra-tumour heterogeneity before and after treatment
Abstract. Genetic intra-tumour heterogeneity (gITH) is a universal property of all cancers. It emerges from the interplay of cell division, mutation accumu
academic.oup.com
May 29, 2025 at 3:22 PM
Interested in population genetics of cancer?
If so, have a look at our manuscript accepted by @genetics-gsa.bsky.social, in which we provide a theoretical assessment of the genetic makeup of cancers before and after treatment!
If so, have a look at our manuscript accepted by @genetics-gsa.bsky.social, in which we provide a theoretical assessment of the genetic makeup of cancers before and after treatment!
Reposted by Calum Gabbutt
Calling data scientists: we have opening in our Data Science core @icr.ac.uk to lead work around cancer spatial biology and single cell analysis. These are staff scientist type positions, ideal for someone who wants to help drive computational research. Apply here: jobs.icr.ac.uk/vacancies/12...
Data Scientist in Sutton | The Institute of Cancer Research
View details and apply for this Data Scientist vacancy in Sutton.
Salary : Salary range £39,805 to £49,023 (depending on the experience)
Reporting to: Professor Trevor Graham
...
jobs.icr.ac.uk
May 22, 2025 at 10:25 AM
Calling data scientists: we have opening in our Data Science core @icr.ac.uk to lead work around cancer spatial biology and single cell analysis. These are staff scientist type positions, ideal for someone who wants to help drive computational research. Apply here: jobs.icr.ac.uk/vacancies/12...
If you're a PhD student interested in using maths to understand cancer, this HCEMM summer school in Szeged, Hungary, is an excellent opportunity.
Registration is free and local costs are covered, so apply before 15th April.
Registration is free and local costs are covered, so apply before 15th April.
March 24, 2025 at 10:35 AM
If you're a PhD student interested in using maths to understand cancer, this HCEMM summer school in Szeged, Hungary, is an excellent opportunity.
Registration is free and local costs are covered, so apply before 15th April.
Registration is free and local costs are covered, so apply before 15th April.
This week-long summer school looks set to be an excellent opportunity for to learn about cancer evolution!
Bursaries are available for those who require financial assistance, deadline 1st April.
Bursaries are available for those who require financial assistance, deadline 1st April.
Working in #CancerBiology?
Join us at our expert-led #EBECancer25 course, to discover how insights on the #evolutionary and ecological aspects of #cancer are shaping the future for improved clinical treatments.💊
📅 30 June-3 July 2025
⏰Apply by 1 April!
📎bit.ly/40nLdDD
@sysbiocurie.bsky.social
Join us at our expert-led #EBECancer25 course, to discover how insights on the #evolutionary and ecological aspects of #cancer are shaping the future for improved clinical treatments.💊
📅 30 June-3 July 2025
⏰Apply by 1 April!
📎bit.ly/40nLdDD
@sysbiocurie.bsky.social
March 12, 2025 at 10:23 AM
This week-long summer school looks set to be an excellent opportunity for to learn about cancer evolution!
Bursaries are available for those who require financial assistance, deadline 1st April.
Bursaries are available for those who require financial assistance, deadline 1st April.
Does the evolutionary history of a cancer predict patient outcome? In our new pre-print, we introduce a powerful new method to measure a cancer’s past using bulk methylation data. In chronic lymphocytic leukaemia (CLL), these inferred histories are highly prognostic! (1/9)
doi.org/10.1101/2023...
doi.org/10.1101/2023...
November 13, 2023 at 10:17 AM
Does the evolutionary history of a cancer predict patient outcome? In our new pre-print, we introduce a powerful new method to measure a cancer’s past using bulk methylation data. In chronic lymphocytic leukaemia (CLL), these inferred histories are highly prognostic! (1/9)
doi.org/10.1101/2023...
doi.org/10.1101/2023...