Schmitt-Mechulam Lab
LightNews LightNews
tbioc.bsky.social
Schmitt-Mechulam Lab
@tbioc.bsky.social
270 followers 500 following 2 posts
Translation mechanisms team @BIOC @CNRS.bsky.social @Ecole Polytechnique @IP-Paris.bsky.social
Archaea Ribosome Evolution CryoEM
Posts Replies Media Videos
Pinned
tbioc.bsky.social
Schmitt-Mechulam Lab @tbioc.bsky.social · Jan 16
We are pleased to share our work on the evolution of translation initiation now published in Nature Communications. Take a look at leaderless mRNAs and eS26 in the small ribosomal subunit of Saccharolobus solfataricus. rdcu.be/d5pgg
Reposted by Schmitt-Mechulam Lab
cryoclem.bsky.social
Our work on ribosome hibernation in archaea is out!
We identified Hib, a new hibernation factor broadly distributed across archaea.
Check out the preprint 👉 biorxiv.org/content/10.1101/2025.10.11.676729v1
(1/🧵)
October 13, 2025 at 4:26 PM
Reposted by Schmitt-Mechulam Lab
wilsonlab.bsky.social
www.nature.com/articles/s41...
A broad-spectrum lasso peptide antibiotic targeting the bacterial ribosome - Nature
A new lasso peptide antibiotic exhibits broad-spectrum activity against Gram-negative and Gram-positive bacteria by interfering with bacterial protein synthesis, is unaffected by common resistanc...
www.nature.com
March 26, 2025 at 6:07 PM
Reposted by Schmitt-Mechulam Lab
sergeymelnikov.bsky.social
Here we unexpectedly find that the ribosomal protein S20/L26—identified at the dawn of ribosome research but later deemed a biochemical artifact—is indeed a genuine component of the large ribosomal subunit. More on this ribosome content variation is here: www.nature.com/articles/s41...
Structurally heterogeneous ribosomes cooperate in protein synthesis in bacterial cells - Nature Communications
Cells can simultaneously produce structurally dissimilar ribosomes, suggesting functional specialization of distinct ribosome populations. Here, the authors show that distinct ribosomes cooperate rath...
www.nature.com
March 20, 2025 at 10:05 PM
Reposted by Schmitt-Mechulam Lab
manuelthery.bsky.social
Unique opportunity to join the CytoMorpho Lab (in Paris ❤️) as a postdoc to work on the self-organization and polarization of reconstituted networks made of microtubules, motors and actin filaments in vitro. Experience required.
Please Repost 🙏 thanks !
March 5, 2025 at 5:20 PM
Reposted by Schmitt-Mechulam Lab
dchretien.bsky.social
Scrat (JEOL ARM 200) is now installed in Rennes with a Direct Electron Apollo camera. Don't hesitate to get in touch if you need nice SPA or cryo-electron tomography (single and dual axis) data 😍
biosit.univ-rennes.fr/en/tem2c
#CryoEM
This image shows the new Cryo-electron microscope JEOL ARM 200 installed on the TEM2C platform in Rennes, France, together with Reynald Gillet (Left, Director of the Institute of Genetics and Development of Rennes), and Denis Chrétien (right, in charge of the project).
March 13, 2025 at 5:32 PM
Reposted by Schmitt-Mechulam Lab
joachim123.bsky.social
I think it's important to reach out to your own community and explain what the funding cuts mean in practice.
March 9, 2025 at 12:24 AM
Reposted by Schmitt-Mechulam Lab
natrevgenet.nature.com
FYI: New online! Cytoplasmic mRNA decay and quality control machineries in eukaryotes
Cytoplasmic mRNA decay and quality control machineries in eukaryotes
Nature Reviews Genetics, Published online: 27 January 2025; doi:10.1038/s41576-024-00810-1In this Review, Dowdle and Lykke-Andersen discuss advances in our understanding of the machinery and mechanisms involved in the control of cytoplasmic mRNA decay and…
www.nature.com
February 17, 2025 at 2:27 PM
Reposted by Schmitt-Mechulam Lab
acharlesorszag.bsky.social
Mark your calendars! Archaea power hour is back!
archaeapowerhour.bsky.social Archaea Power Hour @archaeapowerhour.bsky.social · Feb 5
Archaea Power Hour is back next week on WEDNESDAY, Feb. 12th at 10 AM EST / 4 PM CET! Make sure to attend and show your love for archaea this coming Valentine's week 😍🥰♥️!!! Join our mailing list to receive the Zoom link: t.co/b17JFAaZQ6.
February 5, 2025 at 6:38 PM
Reposted by Schmitt-Mechulam Lab
molecularmicro.bsky.social
New Review: DNA topoisomerase in Archaea; from Paul Villain and Tamara Basta...featured in a forthcoming special issue on Prokaryotic Chromosome Organization!
#MicroSky

onlinelibrary.wiley.com/doi/10.1111/...
Regulation of DNA Topology in Archaea: State of the Art and Perspectives
DNA topoisomerases are ubiquitous enzymes that play a crucial role in regulating DNA supercoiling which affects fundamental biological processes involving DNA. In this review, we summarize the curren...
onlinelibrary.wiley.com
February 4, 2025 at 1:27 PM
Reposted by Schmitt-Mechulam Lab
cryoclem.bsky.social
First ribosome purification using poly-lysine beads (RAPPL, developed by @djuranoviclab.bsky.social & collaborators: www.biorxiv.org/content/10.1...). Full process—from lysis to grid prep—in just 3 hours. Look how pretty it is (even if a bit too diluted)! This is a game-changer🚀.
January 30, 2025 at 10:54 AM
Reposted by Schmitt-Mechulam Lab
davidmcquarrie.bsky.social
NSUN6 inhibitor discovery guided by its mRNA substrate bound crystal structure
doi.org/10.1016/j.st...

#RNA #RNAsky #RNAbiology
NSUN6 inhibitor discovery guided by its mRNA substrate bound crystal structure
In their structural analysis of the NSUN6-SFG-mRNA ternary complex, Zhong et al. identified a compound known as thiamine disulfide through NMR and virtual screening. This compound has subsequently bee...
www.cell.com
January 28, 2025 at 12:57 AM
Reposted by Schmitt-Mechulam Lab
fronzeslab.bsky.social
Voici un exemple concret des conséquences du manque de crédit dans la recherche française.
Nous avons deux microscopes électroniques de pointe à Bordeaux pour la biologie structurale et cellulaire.

Faute de moyens suffisants, nous devrons très probablement arrêter l'un des deux instruments…
January 28, 2025 at 7:56 AM
Reposted by Schmitt-Mechulam Lab
actin-paris-saclay.bsky.social
The Institute for Integrative Biology of the Cell (I2BC) is recruiting group leaders in cell biology.

Don't miss the opportunity to start your team in the vibrant environment of Paris-Saclay University.

Application deadline: Feb 28, 2025

www.i2bc.paris-saclay.fr @i2bcparissaclay.bsky.social
January 27, 2025 at 10:29 AM
Reposted by Schmitt-Mechulam Lab
jcamthrash.bsky.social
The Asgard archaeal origins of Arf family GTPases involved in eukaryotic organelle dynamics www.nature.com/articles/s41... #jcampubs
The Asgard archaeal origins of Arf family GTPases involved in eukaryotic organelle dynamics - Nature Microbiology
Eukaryotic Arf family proteins involved in endomembrane organelle dynamics arose from the Asgard archaeal ArfR GTPases, indicating this capability likely originated in the archaeal ancestor of eukaryo...
www.nature.com
January 23, 2025 at 1:46 PM
Reposted by Schmitt-Mechulam Lab
soreklab.bsky.social
Our paper out @CellCellPress: Structure guided discovery of viral proteins that inhibit host immunity

Congrats Erez Yirmiya, Azita Leavitt, Gil Amitai, our collaborators at the Kranzusch lab, and coauthors

A 🧵 1/10

www.cell.com/cell/abstrac...
Structure-guided discovery of viral proteins that inhibit host immunity
Large-scale, structure-guided computational pipeline sifts through millions of phage proteins to identify those that bind and antagonize host immune proteins. Detected proteins are shown to inhibit no...
www.cell.com
January 23, 2025 at 4:12 PM
Reposted by Schmitt-Mechulam Lab
aribio.bsky.social
Bonjour, nous avons un poste d´IE en biochimie et biologie moléculaire ouvert en mobilité interne (FSEP) au laboratoire de biologie structurale de la cellule (BIOC) située au sein de l´École polytechnique (Palaiseau) .

emploi.cnrs.fr/Offres/MOBIN...
Portail Emploi CNRS - Offre d'emploi - Ingénieur d'études en biochimie et en biologie moléculaire H/F
emploi.cnrs.fr
December 6, 2024 at 9:38 AM
Reposted by Schmitt-Mechulam Lab
cryoclem.bsky.social
A new year, a new social network and a new article in @naturecomms.bsky.social ! It unveils how archaeal RPA orchestrates the recruitment of key players in 🧬 replication primase and polD through its WH domain, with structures of both complexes!!
rdcu.be/d6GAY
Communication between DNA polymerases and Replication Protein A within the archaeal replisome
Nature Communications - The single stranded DNA binding protein RPA plays a pivotal role in DNA replication. The archaeal RPA hosts a WH domain that interacts with the DNA primase and the...
rdcu.be
January 18, 2025 at 6:30 AM
Reposted by Schmitt-Mechulam Lab
rashmiagrata.bsky.social
New to #ubiquitin? Been with it for a while? Either way this review may be for you 🤩

Excited to share our review article in @molcell.bsky.social, diving deep into everything #ubiquitin
Read here 👉: kwnsfk27.r.eu-west-1.awstrack.me/L0/https:%2F...

@cellpress.bsky.social
@wehi-research.bsky.social
'Ubiquitin Lysine-Linkages' from the review 'Ubiquitin: a structural perspective' in Molecular Cell
January 17, 2025 at 2:19 AM
Reposted by Schmitt-Mechulam Lab
djuranoviclab.bsky.social
More ribosome structures solved by RAPPL (collaboration with Pavlovic Djuranovic and Hashem Labs). This one is bacterial from 2ml culture and using method described in our preprint.

www.biorxiv.org/content/10.1...
December 16, 2024 at 3:34 AM
Reposted by Schmitt-Mechulam Lab
koenig-lab.bsky.social
Check out our recent work on CDS #m6A mediated RNA decay (CMD)! Decay relies on ribosome pausing at m6A containing codons. Great collab with the Zarnack lab & colleagues. Thank you @uniwuerzburg.bsky.social , @imbmainz.bsky.social and RMap🥳

www.cell.com/molecular-ce...
January 15, 2025 at 10:00 AM
Reposted by Schmitt-Mechulam Lab
korostelevlab.bsky.social
Gabriel Demo and colleagues found how a small archaeal protein (aRDF) dimerizes 30S subunits to prevent ribosome formation:
January 13, 2025 at 10:49 PM
Reposted by Schmitt-Mechulam Lab
tamarabasta.bsky.social
I am happy to share that the review my former PhD student Paul Villain and I wrote was published: doi.org/10.1111/mmi....
#Archaea
#I2BC
Regulation of DNA Topology in Archaea: State of the Art and Perspectives
DNA topoisomerases are ubiquitous enzymes that play a crucial role in regulating DNA supercoiling which affects fundamental biological processes involving DNA. In this review, we summarize the curren....
doi.org
January 14, 2025 at 8:31 PM
Reposted by Schmitt-Mechulam Lab
lucbuee.bsky.social
Mapt mutations are found in brain disorders. Most of them are located in sequences encoding microtubule-binding domains. However, some are in the 5'UTR tau mRNAs. Understanding the effect of mutations in the amino-terminal part of tau and the role of N-truncated tau academic.oup.com/narmolmed/ar...
FTLD-MAPT mutations and short 5′UTR Tau mRNAs increase Tau translation
Abstract. Tau protein plays a central role in Alzheimer’s disease (AD) and other tauopathies. Tau proteins aggregate in degenerating neurons and their expr
academic.oup.com
January 11, 2025 at 11:33 AM
tbioc.bsky.social
We are pleased to share our work on the evolution of translation initiation now published in Nature Communications. Take a look at leaderless mRNAs and eS26 in the small ribosomal subunit of Saccharolobus solfataricus. rdcu.be/d5pgg
January 16, 2025 at 1:30 PM