Rashmi Agrata
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rashmiagrata.bsky.social
Rashmi Agrata
@rashmiagrata.bsky.social
200 followers 160 following 12 posts
Postdoc in Komander lab @wehi-research.bsky.social | Protein Structure-Function | Ubiquitin
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Rashmi Agrata @rashmiagrata.bsky.social · Jan 17
New to #ubiquitin? Been with it for a while? Either way this review may be for you 🤩

Excited to share our review article in @molcell.bsky.social, diving deep into everything #ubiquitin
Read here 👉: kwnsfk27.r.eu-west-1.awstrack.me/L0/https:%2F...

@cellpress.bsky.social
@wehi-research.bsky.social
'Ubiquitin Lysine-Linkages' from the review 'Ubiquitin: a structural perspective' in Molecular Cell
Reposted by Rashmi Agrata
ausub.bsky.social
📢 All ubiquitin aficionados! 📢

We are gearing up for the first Australian Ubiquitin Summit in three weeks 🤩🗓️
Are you ready for talking ubiquitin by the bay?

🗓️ 20-23 Nov
📍Mantra, Lorne, VIC
Chaired by David Komander (@komanderlab.bsky.social)

#AusUb2025
A poster advertising the Australian Ubiquitin Summit in Lorne from the 20th - 23rd of November. The logo of the conference, as well as a note that there is a Targeted Protein Degradation Day are displayed at the top of the poster. The rest of the poster contains a photo of the bay at Lorne, looking out from rock pools into the ocean. Sitting atop this image is a list of the invited speakers (available on the Lorne Ubiquitin website), and below a note that the meeting is being organised in conjunction with the International Symposium on Autophagy, held on the 16th - 20th of November.
October 31, 2025 at 7:10 AM
Reposted by Rashmi Agrata
ncbsbangalore.bsky.social
#ResearchExplained!
Using BEST-HSQC NMR, Dr Rashmi Agrata from Dr Ranabir Das's team at NCBS team tracked ubiquitin deamidation in real-time, revealing varied deamidase efficiencies despite similar structures.

Read here: bit.ly/3L56RIR

✏️Christeen Paulson
October 27, 2025 at 9:30 AM
Reposted by Rashmi Agrata
nmr-epr-dnp-papers.bsky.social
#NMRchat Monitoring Protein Deamidation in Real Time Using NMR https://analyticalsciencejournals.onlinelibrary.wiley.com/doi/10.1002/mrc.70045?af=R
September 19, 2025 at 12:25 PM
Reposted by Rashmi Agrata
wehi-research.bsky.social
Researchers from WEHI’s Parkinson Disease Research Centre have won the 2025 UNSW Eureka Prize for Scientific Research. The team has been honoured for their research unravelling how PINK1, a key protein linked to early-onset Parkinson’s disease, works.

🔗 www.wehi.edu.au/news/eureka-...
📸 L–R: Professor David Komander, Dr Nicholas Kirk, Dr Sylvie Callegari and Dr Alisa Glukhova. 
September 3, 2025 at 9:54 PM
rashmiagrata.bsky.social
Australia’s First Ubiquitin Summit is here! 🥳
📍Lorne, Victoria | 🗓️ 20–23 November 2025

Join us on the scenic coastline of Lorne for 4 days of cutting-edge ubiquitin science, featuring a fantastic lineup of international speakers covering all corners of the Ub world—from mechanisms to therapeutics
July 4, 2025 at 1:27 PM
Reposted by Rashmi Agrata
thanhrnguyen.bsky.social
Michael Lazarou and I will be chairing the 11th International Symposium on Autophagy (ISA) in Australia from 16-20 Nov 2025!
📍 Location: Lorne, Victoria, Australia
🌐 Register now: www.isa11.org
Join us for five inspiring days of cutting-edge autophagy research and networking opportunities.
May 31, 2025 at 3:58 AM
Reposted by Rashmi Agrata
komanderlab.bsky.social
Excited to share news from the lab out in Nature Communications – A novel PLpro inhibitor improves outcomes in a pre-clinical model of long COVID
www.nature.com/articles/s41...
@wehi-research.bsky.social
A novel PLpro inhibitor improves outcomes in a pre-clinical model of long COVID - Nature Communications
A novel antiviral targeting the SARS-CoV-2 PLpro protease shows strong efficacy in a mouse model, preventing lung pathology and reducing brain dysfunction. The study provides proof-of-principle that P...
www.nature.com
April 8, 2025 at 10:30 PM
Reposted by Rashmi Agrata
mrclmb.bsky.social
How do cytosol-invading bacteria evade LPS ubiquitylation by the host's defence machinery?

@felixrandow.bsky.social's group determined that Shigella flexneri uses IpaH1.4 to degrade the LPS ligase RNF213, inhibiting the cell's ubiquitylation abilities.
Read more: tinyurl.com/3y4kv2bp

#LMBResearch🧪
Comparison of Salmonella and Shigella host cell invasion. Salmonella are targeted by the host E3 ligase RNF213, which ubiquitylates bacterial lipopolysaccharide (LPS), marking bacteria for autophagic destruction. Shigella employs its effector proteins IpaH1.4 - an E3 ubiquitin ligase itself - to ubiquitylate RNF213, leading to its proteasomal degradation and thus preventing the host from tagging Shigella for destruction. Cryo-EM structure showing how the leucine-rich repeat (LRR) domain of IpaH1.4 binds to the RING domain of RNF213
April 9, 2025 at 9:09 AM
Reposted by Rashmi Agrata
komanderlab.bsky.social
Join us at the beach for the first Australian Ubiquitin summit from 20-23 Nov! 🏄‍♀️ Check out the amazing speakers here: www.lorneubiquitin.org

And, why not stay a little longer and join the International Symposium on Autophagy from 16-20 Nov, also in beautiful Lorne ☀️. www.isa11.org

See you there!
April 7, 2025 at 10:10 AM
Reposted by Rashmi Agrata
trujillolab.bsky.social
Viral coat proteins are perceived by the RING1–IBR–RING2-type ubiquitin ligase (RBRL) #PlantSci #Ubiquitin #proteostasis
www.nature.com/articles/s41...
Perception of viral infections and initiation of antiviral defence in rice - Nature
Viral coat proteins are perceived by the RING1–IBR–RING2-type ubiquitin ligase, initiating the first step of the natural antiviral response in rice.
www.nature.com
March 13, 2025 at 7:21 AM
Reposted by Rashmi Agrata
komanderlab.bsky.social
Exciting news from the lab out today in Science - the structure of human PINK1 on a TOM-VDAC complex!
@wehi-research.bsky.social
sylviecallegari.bsky.social Sylvie Callegari @sylviecallegari.bsky.social · Mar 13
Thrilled to share the structure of dimerised human PINK1 docked to an endogenous translocase array on the mitochondrial surface, composed of two TOM complexes, bridged by a VDAC2 dimer! Published today in Science www.science.org/doi/10.1126/...

@wehi-research.bsky.social @komanderlab.bsky.social
March 13, 2025 at 7:32 PM
Reposted by Rashmi Agrata
sylviecallegari.bsky.social
Thrilled to share the structure of dimerised human PINK1 docked to an endogenous translocase array on the mitochondrial surface, composed of two TOM complexes, bridged by a VDAC2 dimer! Published today in Science www.science.org/doi/10.1126/...

@wehi-research.bsky.social @komanderlab.bsky.social
March 13, 2025 at 7:20 PM
Reposted by Rashmi Agrata
dyechemist.bsky.social
Come and do some chemistry for biology with us!
ncbsbangalore.bsky.social National Centre for Biological Sciences, Bengaluru @ncbsbangalore.bsky.social · Mar 11
#NewFaculty
Welcome to the campus Dr Pratik!
Dr Pratik is a 'tool builder' working at the intersection of Biology and chemistry.
We look forward to the contributions from his lab.
Know more: news.ncbs.res.in/spotlight/nc...

@dyechemist.bsky.social

🖊️@rupsykhurana.bsky.social
March 12, 2025 at 3:58 AM
Reposted by Rashmi Agrata
clausenlab.bsky.social
DUBs - unsung yet exciting players in the UPS: kay hofmann et al reveal bacterial DUBs with irreversible clippase activity, reshaping our view on ubiquitin dynamics ... and providing a tool to distinguish Ub and ISG15 signals in immune signalling. chapeau! www.sciencedirect.com/science/arti...
A family of bacterial Josephin-like deubiquitinases with an irreversible cleavage mode
Many intracellular bacteria secrete deubiquitinase (DUB) effectors into eukaryotic host cells to keep the bacterial surface or the enclosing vesicle m…
www.sciencedirect.com
March 4, 2025 at 8:40 AM
Reposted by Rashmi Agrata
dyechemist.bsky.social
If making chemical tools for biology excites you, consider applying to the NCBS graduate program! My lab plans to hire 1–2 graduate students this cycle. More info on my lab @ dyecraftlab.com
ncbsbangalore.bsky.social National Centre for Biological Sciences, Bengaluru @ncbsbangalore.bsky.social · Feb 26
#AdmissionsAlert!
The National Centre for Biological Sciences announces the opening of online applications for admission to its PhD programme through National Exam Route.

Application Deadline: 24th March 2025
Joining: 1st August 2025

Apply here: bit.ly/4igBGFK
February 28, 2025 at 8:59 AM
Reposted by Rashmi Agrata
carolynbertozzi.bskyverified.social
Check it out! Another novel RNA modification - ADP-ribosylation - that was previously only known on proteins. A cousin to #glycoRNA 👏

www.nature.com/articles/s41...
Graphic showing modification of mRNA with ADP-ribose mediated by bacterial enzyme cmdTAC
February 6, 2025 at 7:38 PM
Reposted by Rashmi Agrata
lindorfflarsen.bsky.social
There are lots of hydrophobicity scales and perhaps the most well known and used is that from Kyte & Doolittle

If you ever use that scale, I recommend reading the original paper and noting the authors' pragmatism and honesty about manual adjustments and using intuition

doi.org/10.1016/0022...
Text from the paper discussing various manual adjustments and choices of the hydrophobicity scale
February 6, 2025 at 9:37 PM
Reposted by Rashmi Agrata
lindorfflarsen.bsky.social
The variability across the 20 conformations in a typical NMR ensemble in the PDB represents the uncertainty from the lack of experimental data and not the dynamics of the protein in solution

Thanks for coming to my TED talk
January 31, 2025 at 7:17 PM
Reposted by Rashmi Agrata
grk2243.bsky.social
🚨 The #Ubiquitin Congress is back in Würzburg! 🚨
Excited to host it again, June 2-4, 2025! 🌟

✨ Still time to submit your abstract for a Short Talk!

🗓️ Registration Deadline: March 1st
📝 Abstract Submission Deadline: April 15th

Don’t miss out—register now!
➡️ www.ubiquitin-wuerzburg-2025.de
January 27, 2025 at 11:25 AM
Reposted by Rashmi Agrata
sjorsscheres.bsky.social
We have an exciting opportunity for a new independent group leader with an interest in structural/molecular biology and machine learning to join our Division of Structural Studies at the @mrclmb.bsky.social! 🥳
Re-posts appreciated.

www.nature.com/naturecareer...
Research Group Leader Tenure Track - Structural Studies - LMB 2549 - Cambridgeshire job with MRC Laboratory of Molecular Biology | 12835196
Research Group Leader Tenure Track Starting Salary £65,940 to £74,448 per annum MRC Laboratory of Molecular Biology, Cambridge, UK
www.nature.com
January 27, 2025 at 9:38 AM
Reposted by Rashmi Agrata
janedudley.bsky.social
Really enjoying kicking off the week with this new, excellently-written review on #ubiquitin from a structural perspective - so useful to step back every now and again and get an eagle's eye view on the field! www.cell.com/molecular-ce...
Ubiquitin—A structural perspective
Ubiquitin is a cellular modification that comes in many forms. In this review, Agrata and Komander analyze the 240 available PDB structures of ubiquitin and polyubiquitin, alongside ensemble and molec...
www.cell.com
January 20, 2025 at 11:40 AM
Reposted by Rashmi Agrata
aniruddhad.bsky.social
"The current knowledge of ubiquitin signals through a ubiquitin-centric, structural biology lens." Useful resource for ubiuitin-lovers.

www.cell.com/molecular-ce...
Ubiquitin—A structural perspective
Ubiquitin is a cellular modification that comes in many forms. In this review, Agrata and Komander analyze the 240 available PDB structures of ubiquitin and polyubiquitin, alongside ensemble and molec...
www.cell.com
January 17, 2025 at 4:29 AM
Reposted by Rashmi Agrata
labwaggoner.bsky.social
Review: Ubiquitin—A structural perspective
@rashmiagrata.bsky.social
www.cell.com/molecular-ce...
January 16, 2025 at 10:40 PM
rashmiagrata.bsky.social
New to #ubiquitin? Been with it for a while? Either way this review may be for you 🤩

Excited to share our review article in @molcell.bsky.social, diving deep into everything #ubiquitin
Read here 👉: kwnsfk27.r.eu-west-1.awstrack.me/L0/https:%2F...

@cellpress.bsky.social
@wehi-research.bsky.social
'Ubiquitin Lysine-Linkages' from the review 'Ubiquitin: a structural perspective' in Molecular Cell
January 17, 2025 at 2:19 AM