Marco Trujillo
trujillolab.bsky.social
Marco Trujillo
@trujillolab.bsky.social
Fascinated by ubiquitination. Works at the RWTH Aachen University. Tweets are my own.
Pinned
Big news! Our group has joined the University of Hamburg — we’re excited for the opportunities and collaborations ahead! #Hamburg
Reposted by Marco Trujillo
Rewriting the code of plant immunity go.nature.com/475WgV7
October 14, 2025 at 8:25 PM
Reposted by Marco Trujillo
Proud to be involved in this great paper describing a novel mechanism of #synuclein aggregation with implications for potential #PD treatment, don’t miss it! 👇🏼👇🏼👇🏼
Congratulations to the team!

www.embopress.org/doi/full/10....
Ubiquilin-2 liquid droplets catalyze α-synuclein fibril formation | The EMBO Journal
imageimageFibril formation of α-synuclein is central to Parkinson’s disease (PD) pathology. This study shows that UBQLN2 droplets catalyze α-synuclein fibrillization via their liquid-gel/solid transition, while a small molecule targeting UBQLN2 ...
www.embopress.org
October 15, 2025 at 9:14 AM
Big news! Our group has joined the University of Hamburg — we’re excited for the opportunities and collaborations ahead! #Hamburg
October 7, 2025 at 1:41 PM
Reposted by Marco Trujillo
You know ubiquitination, you may know ADP-ribosylation... But ubiquitination of ADP-ribose aka MARubylation???

Read our brief spotlight on @michaelnadbio.bsky.social and @jnpruneda.bsky.social 's recent work describing this dual modification here!
April 25, 2025 at 8:16 AM
Reposted by Marco Trujillo
Happy to see our review out in ChemBioChem @chemistryeurope.bsky.social in which we describe the tools and strategies for deciphering linkage type-specific #ubiquitin signalling: doi.org/10.1002/cbic.... Thanks to Julian for spearheading this, and to Camilla and Dominik for important contributions.
April 22, 2025 at 11:31 AM
Reposted by Marco Trujillo
Happy to see my Postdoc work out @natbiotech.nature.com. Using HaloTag and synthetic fluorophores instead of FPs enables us to shift the spectral properties of kinase activity reporters (KARs) to the far-red 🔬. Huge thanks to everyone involved @jinzhanglab.bsky.social!
www.nature.com/articles/s41...
Far-red chemigenetic kinase biosensors enable multiplexed and super-resolved imaging of signaling networks - Nature Biotechnology
Far-red kinase biosensors are applied to image kinase signaling networks at super resolution.
www.nature.com
April 21, 2025 at 9:28 AM
Reposted by Marco Trujillo
Amazing !! Antiproteolysis peptides (APPs), identified by artificial intelligence, stabilized TF by inhibiting E3 ligase to induce resistance. Targeted Inhibition of Protein Degradation #TIPD #PPSTasis www.science.org/doi/10.1126/...
Commentary www.science.org/doi/10.1126/...
April 11, 2025 at 6:48 AM
Reposted by Marco Trujillo
Excited to share our latest work, now out in @lsajournal.org. we show that the E3 ligase HOIL-1 can ubiquitinate many different saccharides and describe a chemoenzymatic platform to generate ubiquitinated sugars as tools for studying non-proteinaceous ubiquitination.
The RBR E3 ligase HOIL-1 ubiquitinates Ser/Thr-residues and various disaccharides in vitro and can be used to generate ubiquitinated sugars as tools to study non-proteinaceous ubiquitination
@lechtenberglab.bsky.social @wehi-research.bsky.social
www.life-science-alliance.org/content/8/6/...
April 10, 2025 at 7:49 AM
Reposted by Marco Trujillo
www.ft.com/content/6328... Greenpeace has blocked
cultivation of Golden Rice braking an innovation slated to
save lives by enriching diets w/ vitamin A. In a world
beset by food insecurity,climate change,water scarcity &
conflict,the future of rice is
mired in a stew of science, politics & economics
We face a looming rice crisis
The future of one of the world’s most important foodstuffs is mired in a stew of science, politics and economics
www.ft.com
April 10, 2025 at 7:18 AM
Reposted by Marco Trujillo
How do cytosol-invading bacteria evade LPS ubiquitylation by the host's defence machinery?

@felixrandow.bsky.social's group determined that Shigella flexneri uses IpaH1.4 to degrade the LPS ligase RNF213, inhibiting the cell's ubiquitylation abilities.
Read more: tinyurl.com/3y4kv2bp

#LMBResearch🧪
April 9, 2025 at 9:09 AM
Reposted by Marco Trujillo
🥳 Out now @embojournal.org!
Interferon induces a new class of p62 bodies, with #antiviral & #immunotherapy implications.
p62 is usually linked to #autophagy — but not here.
These are driven by PARP14-mediated ADP-ribosylation & rely on #ubiquitin #proteasome system. www.embopress.org/doi/full/10....
Interferon-induced PARP14-mediated ADP-ribosylation in p62 bodies requires the ubiquitin-proteasome system | The EMBO Journal
imageimageInterferon induces the formation of ADP-ribosylation (ADPr)-enriched p62 bodies, requiring PARP14 and p62. Unlike canonical p62 bodies, these ADPr-enriched structures are independent of auto...
www.embopress.org
April 8, 2025 at 1:43 AM
Reposted by Marco Trujillo
Protein N-terminal modifications - Feature Review and cover in the recent issue of @cp-trendsbiochem.bsky.social Thanks to all authors, Editor @sanniejculbertson.bsky.social and reviewers for great work and support! @ispt-proteinterm.bsky.social www.cell.com/trends/bioch...
April 3, 2025 at 2:54 PM
Reposted by Marco Trujillo
#HeardToday “You can’t solve mechanisms with genomics. For that you need to go to the trenches and do BIOCHEMISTRY!”
two men in military uniforms are standing next to each other and one has a badge on his arm that says ' a '
ALT: two men in military uniforms are standing next to each other and one has a badge on his arm that says ' a '
media.tenor.com
April 3, 2025 at 2:53 PM
Reposted by Marco Trujillo
2 papers in @science.org this week uncover wheat tandem kinase function. Working in parallel, the authors of each paper show that two different tandem kinases converge to activate the same NLR!
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...

#PlantScience
A wheat tandem kinase activates an NLR to trigger immunity
The role of nucleotide-binding leucine-rich repeat (NLR) receptors in plant immunity is well studied, but the function of a class of tandem kinases (TKs) that confer disease resistance in wheat and ba...
www.science.org
March 30, 2025 at 3:18 PM
Reposted by Marco Trujillo
Reposted by Marco Trujillo
Super excited to share our latest work on deciphering the #Ubiquitin Code

“𝗨𝗯𝗶𝗥𝗘𝗔𝗗 𝗱𝗲𝗰𝗶𝗽𝗵𝗲𝗿𝘀 𝗽𝗿𝗼𝘁𝗲𝗮𝘀𝗼𝗺𝗮𝗹 𝗱𝗲𝗴𝗿𝗮𝗱𝗮𝘁𝗶𝗼𝗻 𝗰𝗼𝗱𝗲 𝗼𝗳 𝗵𝗼𝗺𝗼𝘁𝘆𝗽𝗶𝗰 𝗮𝗻𝗱 𝗯𝗿𝗮𝗻𝗰𝗵𝗲𝗱 𝗞48 𝗮𝗻𝗱 𝗞63 𝘂𝗯𝗶𝗾𝘂𝗶𝘁𝗶𝗻 𝗰𝗵𝗮𝗶𝗻𝘀”

@cp-molcell.bsky.social

1/8

www.cell.com/molecular-ce...
UbiREAD deciphers proteasomal degradation code of homotypic and branched K48 and K63 ubiquitin chains
Ubiquitin chains determine the fates of their modified proteins, including proteasomal degradation. Kiss et al. present UbiREAD, a technology to monitor cellular degradation and deubiquitination at hi...
www.cell.com
March 24, 2025 at 2:54 PM
Reposted by Marco Trujillo
The next frontier in #autophagy is understanding how it functions across cell types to maintain organismal homeostasis. w/ @moritznowack.bsky.social lab, we present TWO #preprint on cell type spec. autophagy in root hairs‼️ #plantscience www.biorxiv.org/content/10.1... www.biorxiv.org/content/10.1...
a penguin wearing a bear hat and a blue sweater is jumping in the air
ALT: a penguin wearing a bear hat and a blue sweater is jumping in the air
media.tenor.com
March 19, 2025 at 2:48 PM
Reposted by Marco Trujillo
Back-to-back on bioRxiv by @plantophagy.bsky.social and @moritznowack.bsky.social

Cell-type specific upregulation of autophagy in Arabidopsis root hair cells promotes

1) root hair lifespan by suppressing cell death
2) plant salt stress resilience by ion sequestration

See links to 2 papers below!
March 19, 2025 at 2:45 PM
Reposted by Marco Trujillo
#PlantSciJobs #PlantSciJob
10 PhD positions: Communication + Dynamics of Plant Cell Compartments

Research Training Group @unihalle.bsky.social and @ipbhalle.bsky.social

Start: July 2025
Deadline: 31 March 2025
www.deutsche-botanische-gesellschaft.de/en/job-openi...
Job Openings
www.deutsche-botanische-gesellschaft.de
March 18, 2025 at 2:10 PM
Reposted by Marco Trujillo
Yeii! nice to see our molecular pharming manuscript in its final form. Congrats to all authors!
Thrilled to see this out! 🎉 doi.org/10.1111/pbi....

🌿🧬 Silencing immunity genes boosts transient expression in Nicotiana benthamiana!

Congrats to all involved! A #PlantChemetics story first on @biorxivpreprint.bsky.social, now in @PlantBiotechJ.

#TransientExpression #MolecularPharming
Immunity gene silencing increases transient protein expression in Nicotiana benthamiana
Click on the article title to read more.
doi.org
March 14, 2025 at 1:30 PM
Viral coat proteins are perceived by the RING1–IBR–RING2-type ubiquitin ligase (RBRL) #PlantSci #Ubiquitin #proteostasis
www.nature.com/articles/s41...
Perception of viral infections and initiation of antiviral defence in rice - Nature
Viral coat proteins are perceived by the RING1–IBR–RING2-type ubiquitin ligase, initiating the first step of the natural antiviral response in rice.
www.nature.com
March 13, 2025 at 7:21 AM
Reposted by Marco Trujillo
Vector-borne viral pathogens are threats to crops, and so trigger plant immune responses. Studying rice, authors @nature provide molecular-level insights into the first steps of plant antiviral response.

www.nature.com/articles/s41...
Perception of viral infections and initiation of antiviral defence in rice - Nature
Viral coat proteins are perceived by the RING1–IBR–RING2-type ubiquitin ligase, initiating the first step of the natural antiviral response in rice.
www.nature.com
March 12, 2025 at 7:47 PM