Rémi Fronzes
@fronzeslab.bsky.social
🔬 CNRS Research Director, Bordeaux
| Structural biologist & microbiologist
🚴♂️ Cyclist (mostly Velotaf) & runner (just for fun)
⛰️ Mountain & nature lover
🎓 UCL/Birkbeck & Institut Pasteur alumnus
🔬 fronzeslab.cnrs.fr
#cryoEM #cryoET #microsky
| Structural biologist & microbiologist
🚴♂️ Cyclist (mostly Velotaf) & runner (just for fun)
⛰️ Mountain & nature lover
🎓 UCL/Birkbeck & Institut Pasteur alumnus
🔬 fronzeslab.cnrs.fr
#cryoEM #cryoET #microsky
Pinned
Rémi Fronzes
@fronzeslab.bsky.social
· Jan 26
Reposted by Rémi Fronzes
Fucking magnates, how do they work
November 10, 2025 at 10:32 PM
Fucking magnates, how do they work
NMR spectroscopists according to the President of the USA (and let's be honest, according to everyone else) 😁
a young boy in a plaid shirt is holding a wand in his hand
ALT: a young boy in a plaid shirt is holding a wand in his hand
media.tenor.com
November 10, 2025 at 10:27 PM
NMR spectroscopists according to the President of the USA (and let's be honest, according to everyone else) 😁
"nobody knows what magnets are" DJT
a man with long curly hair and a mustache is wearing a pink unicorn shirt .
ALT: a man with long curly hair and a mustache is wearing a pink unicorn shirt .
media.tenor.com
November 10, 2025 at 9:56 PM
"nobody knows what magnets are" DJT
Reposted by Rémi Fronzes
Reposted by Rémi Fronzes
I am seeing a lot of posts about Rosalind Franklin that themselves ignore her publication record on DNA!
In fact Franklin and Gosling's paper, including the famous Photograph #51, was published, along with Wilkins's paper, back-to-back with the Watson and Crick paper in Nature in 1953.
In fact Franklin and Gosling's paper, including the famous Photograph #51, was published, along with Wilkins's paper, back-to-back with the Watson and Crick paper in Nature in 1953.
November 9, 2025 at 6:43 PM
I am seeing a lot of posts about Rosalind Franklin that themselves ignore her publication record on DNA!
In fact Franklin and Gosling's paper, including the famous Photograph #51, was published, along with Wilkins's paper, back-to-back with the Watson and Crick paper in Nature in 1953.
In fact Franklin and Gosling's paper, including the famous Photograph #51, was published, along with Wilkins's paper, back-to-back with the Watson and Crick paper in Nature in 1953.
I learned a lot from reading the posts over the last 2 days. I was struck by how much we are influenced by scientific mythology, some of it rooted in what we learned as far back as high school.
November 8, 2025 at 11:19 PM
I learned a lot from reading the posts over the last 2 days. I was struck by how much we are influenced by scientific mythology, some of it rooted in what we learned as far back as high school.
Just read the full letter. Wow !
« But the point of science is what is discovered, not how it was discovered or by whom. It is the results which need to be brought home to the public. »
F. Crick.
« But the point of science is what is discovered, not how it was discovered or by whom. It is the results which need to be brought home to the public. »
F. Crick.
November 8, 2025 at 11:10 PM
Just read the full letter. Wow !
« But the point of science is what is discovered, not how it was discovered or by whom. It is the results which need to be brought home to the public. »
F. Crick.
« But the point of science is what is discovered, not how it was discovered or by whom. It is the results which need to be brought home to the public. »
F. Crick.
I recommend reading this thread from F. Crick’s granddaughter.
Apparently even the scene at the Eagle pub, where we all went as scientific pilgrims, is not true?
Just mythology
Apparently even the scene at the Eagle pub, where we all went as scientific pilgrims, is not true?
Just mythology
"If you publish your book now, in the teeth of my opposition, history will condemn you”
“the tone used to describe Rosalind's work in the Epilogue
is perfectly reasonable,
but contrasts ludicrously with
the descriptions of her
in the text itself.”
-Francis Crick
Letter criticizing Watson’s book 🧪
“the tone used to describe Rosalind's work in the Epilogue
is perfectly reasonable,
but contrasts ludicrously with
the descriptions of her
in the text itself.”
-Francis Crick
Letter criticizing Watson’s book 🧪
November 8, 2025 at 10:47 PM
I recommend reading this thread from F. Crick’s granddaughter.
Apparently even the scene at the Eagle pub, where we all went as scientific pilgrims, is not true?
Just mythology
Apparently even the scene at the Eagle pub, where we all went as scientific pilgrims, is not true?
Just mythology
You know what? I did not read “The Double Helix.”
I was converted to molecular biology by the books from Monod and Jacob, real decent and courageous men in addition to being exceptional scientists. For me, one cannot go without the other!!
I was converted to molecular biology by the books from Monod and Jacob, real decent and courageous men in addition to being exceptional scientists. For me, one cannot go without the other!!
November 8, 2025 at 9:32 PM
You know what? I did not read “The Double Helix.”
I was converted to molecular biology by the books from Monod and Jacob, real decent and courageous men in addition to being exceptional scientists. For me, one cannot go without the other!!
I was converted to molecular biology by the books from Monod and Jacob, real decent and courageous men in addition to being exceptional scientists. For me, one cannot go without the other!!
Some still praise James Watson despite his racism. Same with colleagues who won’t condemn Elon Musk’s politics, hiding behind “scientists shouldn’t mix science and politics.”
November 8, 2025 at 12:36 PM
Some still praise James Watson despite his racism. Same with colleagues who won’t condemn Elon Musk’s politics, hiding behind “scientists shouldn’t mix science and politics.”
X
Thinking about Rosalind (and Maurice)
Thinking about Rosalind (and Maurice)
November 7, 2025 at 8:04 PM
X
Thinking about Rosalind (and Maurice)
Thinking about Rosalind (and Maurice)
Not sure to miss him…
James Watson, Co-Discoverer of the Structure of DNA, Is Dead at 97
www.nytimes.com
November 7, 2025 at 7:47 PM
Not sure to miss him…
Reposted by Rémi Fronzes
Many thanks to the folks at the San Diego Supercomputer Center for highlighting our project!
SDSC-housed Protein Data Bank Brings Molecules Up to Size
Molecules — the unseen architects that form everything from the DNA in your cells to the planets in distant galaxies, crafting the very fabric of reality while remaining too small for the human eye to glimpse. But thanks to the Protein Data Bank we can now “see” these hidden wonders.
today.ucsd.edu
November 6, 2025 at 8:44 PM
Many thanks to the folks at the San Diego Supercomputer Center for highlighting our project!
Reposted by Rémi Fronzes
Great collaboration with @guo-lab.bsky.social to determine an in situ architectural model of the Tad pilus machine. Be on the lookout soon for a preprint on the same topic by Grant Jensen and @viollierpat.bsky.social. #microsky
November 6, 2025 at 3:51 PM
Great collaboration with @guo-lab.bsky.social to determine an in situ architectural model of the Tad pilus machine. Be on the lookout soon for a preprint on the same topic by Grant Jensen and @viollierpat.bsky.social. #microsky
panic mode activated.
Deadline @erc.europa.eu Synergy grant deadline <24h !
Deadline @erc.europa.eu Synergy grant deadline <24h !
November 4, 2025 at 5:48 PM
panic mode activated.
Deadline @erc.europa.eu Synergy grant deadline <24h !
Deadline @erc.europa.eu Synergy grant deadline <24h !
Reposted by Rémi Fronzes
Please RT. Post-doc opportunity alert! 💥 closing 10th December.. Come join our team (www.thelowlab.org) at Imperial, London, working on the structure and mechanism of bacterial secretion systems.
For more details and to apply please see
www.imperial.ac.uk/jobs/search-...
For more details and to apply please see
www.imperial.ac.uk/jobs/search-...
October 29, 2025 at 5:11 PM
Please RT. Post-doc opportunity alert! 💥 closing 10th December.. Come join our team (www.thelowlab.org) at Imperial, London, working on the structure and mechanism of bacterial secretion systems.
For more details and to apply please see
www.imperial.ac.uk/jobs/search-...
For more details and to apply please see
www.imperial.ac.uk/jobs/search-...
Reposted by Rémi Fronzes
christoph: 👇made my day 👏
October 22, 2025 at 10:52 AM
christoph: 👇made my day 👏
Reposted by Rémi Fronzes
Congratulations to the new Doctor Chloé Dugelay !
Massive thanks to all collaborators @xavierdebolle.bsky.social @suzanasalcedo.bsky.social @cascaleslab.bsky.social J.Celli and J. Ugalde.
Thanks to the excellent jury members
@fronzeslab.bsky.social R.Vouillhoux, P.Doublet and L.Journet
Massive thanks to all collaborators @xavierdebolle.bsky.social @suzanasalcedo.bsky.social @cascaleslab.bsky.social J.Celli and J. Ugalde.
Thanks to the excellent jury members
@fronzeslab.bsky.social R.Vouillhoux, P.Doublet and L.Journet
October 19, 2025 at 4:38 PM
Congratulations to the new Doctor Chloé Dugelay !
Massive thanks to all collaborators @xavierdebolle.bsky.social @suzanasalcedo.bsky.social @cascaleslab.bsky.social J.Celli and J. Ugalde.
Thanks to the excellent jury members
@fronzeslab.bsky.social R.Vouillhoux, P.Doublet and L.Journet
Massive thanks to all collaborators @xavierdebolle.bsky.social @suzanasalcedo.bsky.social @cascaleslab.bsky.social J.Celli and J. Ugalde.
Thanks to the excellent jury members
@fronzeslab.bsky.social R.Vouillhoux, P.Doublet and L.Journet
Reposted by Rémi Fronzes
Structures of rotary ATP synthase from Thermus thermophilus during proton powered ATP synthesis | Science Advances www.science.org/doi/10.1126/...
Structures of rotary ATP synthase from Thermus thermophilus during proton powered ATP synthesis
Cryo-EM snapshots of the ATP synthase driven by proton motive force reveal the torsional deformation during ATP synthesis.
www.science.org
October 18, 2025 at 7:42 PM
Structures of rotary ATP synthase from Thermus thermophilus during proton powered ATP synthesis | Science Advances www.science.org/doi/10.1126/...
Reposted by Rémi Fronzes
Folks, this is really important:
Humanity AI Commits $500 Million to Build a People-Centered Future for AI
A broad coalition of philanthropic leaders today announced Humanity AI, a $500M 5-year initiative dedicated to making sure people have a stake in the future of artificial intelligence (AI).
Humanity AI Commits $500 Million to Build a People-Centered Future for AI
A broad coalition of philanthropic leaders today announced Humanity AI, a $500M 5-year initiative dedicated to making sure people have a stake in the future of artificial intelligence (AI).
Humanity AI Commits $500 Million to Build a People-Centered Future for AI
www.macfound.org
October 14, 2025 at 4:49 PM
Folks, this is really important:
Humanity AI Commits $500 Million to Build a People-Centered Future for AI
A broad coalition of philanthropic leaders today announced Humanity AI, a $500M 5-year initiative dedicated to making sure people have a stake in the future of artificial intelligence (AI).
Humanity AI Commits $500 Million to Build a People-Centered Future for AI
A broad coalition of philanthropic leaders today announced Humanity AI, a $500M 5-year initiative dedicated to making sure people have a stake in the future of artificial intelligence (AI).
@iecb.bsky.social fête la science.
Atelier fluorescence, cryo-microcopie électronique et extraction d’ADN par des membres de notre équipe.
Atelier fluorescence, cryo-microcopie électronique et extraction d’ADN par des membres de notre équipe.
October 13, 2025 at 4:31 PM
@iecb.bsky.social fête la science.
Atelier fluorescence, cryo-microcopie électronique et extraction d’ADN par des membres de notre équipe.
Atelier fluorescence, cryo-microcopie électronique et extraction d’ADN par des membres de notre équipe.
Reposted by Rémi Fronzes
Entretien pour Brut sur la vie Miroir, l'ingénierie génétique et l'éthique de ces recherches: www.brut.media/fr/videos/sc...
Manipulations génétiques, virus créés par l’IA, bactéries miroirs : quelles limites à la recherche scientifique ?
Elles pourraient aider à lutter contre les cancers… mais aussi détruire toute trace de vie sur Terre ! Ce sont les bactéries miroirs. En avez-vous déjà entendu parler ? Et la vie miroir, ça vous dit q...
www.brut.media
October 11, 2025 at 1:30 PM
Entretien pour Brut sur la vie Miroir, l'ingénierie génétique et l'éthique de ces recherches: www.brut.media/fr/videos/sc...
Reposted by Rémi Fronzes
A recent cool preprint by John Whitney's lab on a new family of antibacterial proteins secreted by Gram-positive bacteria that enter and kill a broad spectrum of bacteria. Cell entry is receptor-independent and relies on cleavage by a co-secreted protease and the PMF.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Proteolytically activated antibacterial toxins inhibit the growth of diverse Gram-positive bacteria
Many species of bacteria produce small-molecule antibiotics that enter and kill a wide range of competitor microbes. However, diffusible antibacterial proteins that share this broad-spectrum activity ...
www.biorxiv.org
September 23, 2025 at 8:28 PM
A recent cool preprint by John Whitney's lab on a new family of antibacterial proteins secreted by Gram-positive bacteria that enter and kill a broad spectrum of bacteria. Cell entry is receptor-independent and relies on cleavage by a co-secreted protease and the PMF.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
20 years of hard work by the Waksman group in London.
So happy that I could modestly contribute to this scientific adventure.
So happy that I could modestly contribute to this scientific adventure.
Type IV secretion systems: from structures to mechanisms
Kévin Macé and colleagues summarize recent structural insights into the assembly and function of bacterial type IV secretion systems
www.embopress.org/doi/full/10....
Kévin Macé and colleagues summarize recent structural insights into the assembly and function of bacterial type IV secretion systems
www.embopress.org/doi/full/10....
October 10, 2025 at 1:29 PM
20 years of hard work by the Waksman group in London.
So happy that I could modestly contribute to this scientific adventure.
So happy that I could modestly contribute to this scientific adventure.