Rémi Fronzes
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fronzeslab.bsky.social
Rémi Fronzes
@fronzeslab.bsky.social
🔬 CNRS Research Director, Bordeaux
| Structural biologist & microbiologist

🏃‍♂️ Runner & 🚴 Cyclist (Velotaf)
⛰️ Mountain & nature lover

🎓 UCL/Birkbeck & Institut Pasteur alumnus

fronzeslab.cnrs.fr

#cryoEM #cryoET #microsky
Pinned
Our latest T7SS study is now out in Science Advances!
We solved the cryoEM structure of the T7SSb core unit (T7bCU) composed of YukB, YukC, and YukD from Bacillus subtilis, revealing how these components assemble within the secretion machinery.

www.science.org/doi/10.1126/...
A ubiquitin-like protein controls assembly of a bacterial type VIIb secretion system
Cryo-EM structure reveals how a ubiquitin-like protein orchestrates assembly of a bacterial weapon system.
www.science.org
Only 14 km left to hit 900 before the year ends. Achievable 😁
December 28, 2025 at 9:27 PM
Check out the PhD work of Clemence (now postdoc in our lab).
Congrats to all the authors for this very interesting work!

rdcu.be/eWBtH
Neisseria meningitidis filamentous phage MDA promotes colonisation by selecting hyperadhesive pili variants
Nature Communications - In Neisseria meningitidis, the filamentous phage MDA is associated with biofilm formation during epithelium colonisation. Here, the authors investigate the relationship...
rdcu.be
December 28, 2025 at 8:59 AM
How I'm walking out of 2025
a cartoon of homer simpson standing in a yard
ALT: a cartoon of homer simpson standing in a yard
media.tenor.com
December 27, 2025 at 10:27 PM
AI: a metaphor
another robot highlight for 2025: man wearing humanoid mocap suit kicks himself in the balls
December 27, 2025 at 6:48 PM
Reposted by Rémi Fronzes
Like, actively deleted the Tweets.

Not just deactivated my account.

If you are still on that platform, X is using your information to feed LLMs for its own benefit and to generate mis- and disinformation in your name with your content.
December 25, 2025 at 5:45 PM
Reposted by Rémi Fronzes
When I quit Twitter/X, I made sure to delete 18 years of Tweets, because I knew this was coming.

If you’re still on that platform, you are enabling sooooo much disinformation.
Users are noticing Twitter/X has added a Grok-powered AI image editor that lets anyone edit any image on the platform, including other people’s artwork using text prompts.

Artists warn there’s no opt-out or consent, raising concerns over unauthorized edits and misuse.
December 25, 2025 at 5:26 PM
Reposted by Rémi Fronzes
A super detailed protocol + video on Cryo-ExM - Cryo-Expansion Microscopy, led by the labs of our former postdocs @marinelap.bsky.social & @ebertiaux.bsky.social.
Clear, practical, and very useful for anyone doing nanoscale imaging 🚀 app.jove.com/t/68595/expa...
December 25, 2025 at 1:41 PM
You've been kidnapped. The characters from the last TV show you watched are trying to rescue you.

Who's coming to save you?
December 22, 2025 at 2:24 AM
Reposted by Rémi Fronzes
Structure and organization of AMPA receptor-TARP complexes in the mammalian cerebellum | Science www.science.org/doi/10.1126/...
Structure and organization of AMPA receptor-TARP complexes in the mammalian cerebellum
AMPA receptors (AMPARs) are multimodal transducers of glutamatergic signals throughout the brain. Their diversity is exemplified in the cerebellum; at afferent synapses, AMPARs mediate high-frequency ...
www.science.org
December 12, 2025 at 5:35 AM
Reposted by Rémi Fronzes
Happy to share the last work of @jmartinkus.bsky.social, led by @dukasju.bsky.social
Immunity arrays associated with Rhs and CDI toxins and linked to a novel genetic element (XPC cassette) confer protection against competitors. @currentbiology.bsky.social
Kudos !!
www.cell.com/current-biol...
Poly-immunity arrays associated with Rhs toxins confer wide protection against competitors
Martinkus et al. show that Photorhabdus and Xenorhabdus species encode arrays of immunity genes whose protein products neutralize toxins secreted by competitors. These arrays, often linked to Xer pass...
www.cell.com
December 15, 2025 at 5:02 PM
Reposted by Rémi Fronzes
Many thanks to my PIs, collaborators, and team! I'm excited to share this paper from my PhD work!
December 15, 2025 at 10:38 PM
So structural biology is not dead after all 😋 Not a big surprise The title of this article is exactly in line with what I think.
Same applies to LLMs for scientific writing.
AlphaFold predictions are valuable hypotheses and accelerate but do not replace experimental structure determination - Nature Methods
An analysis of AlphaFold protein structure predictions shows that while in many cases the predictions are highly accurate, there are also many instances where the predicted structures or parts of pred...
www.nature.com
December 14, 2025 at 4:18 PM
🔬 Just out in @NatureComms!
Using cryo-CLEM and cryo-ET, we reveal the unique ultrastructure of dopaminergic varicosities in the striatum.
Amazing collaboration with @davip-bdx.bsky.social and Etienne Herzog @iins-bordeaux.bsky.social
Congratulations to Paul and Robin for this fantastic work! 🎉
Cryo-correlative light and electron tomography of dopaminergic axonal varicosities reveals non-synaptic modulation of cortico-striatal synapses - Nature Communications
The basic features of dopamine release sites are still largely unknown. Here, the authors determine the ultrastructure of fluorescent dopaminergic and glutamatergic synaptosomes in mouse striatum usin...
www.nature.com
December 13, 2025 at 8:11 PM
a genius! Happy birthday !
December 13, 2025 at 9:28 AM
🤯 indeed !!
December 12, 2025 at 8:51 AM
Reposted by Rémi Fronzes
"there's a new serif in town"
Marco Rubio ordered diplomats to return to using Times New Roman font in official communications, calling his predecessor's decision to adopt Calibri a “wasteful” diversity move
Rubio Stages Font Coup: Times New Roman Ousts Calibri
The secretary of state called it a "wasteful" diversity move, according to an internal department cable seen by Reuters.
www.huffpost.com
December 10, 2025 at 1:06 AM
Reposted by Rémi Fronzes
#LivingArchitectures
We put cells and cytoskeleton filaments on the architecture of the musée d'Orsay.
www.musee-orsay.fr/fr/agenda/ev...
Scientists of the #CytoMorphoLab adapted their protocols to illustrate the questions that keep them awake at night.
-> Two shows on the 24th and 25th of January.
December 5, 2025 at 4:11 PM
Quick survey for fellow scientists abroad: Does your institution block or restrict the use of commercial AI assistants (ChatGPT, Claude, etc.)?
Bientôt plus le droit d'utiliser ChatGPT, Claude, et al. au CNRS
December 2, 2025 at 9:26 PM
Bientôt plus le droit d'utiliser ChatGPT, Claude, et al. au CNRS
December 2, 2025 at 9:16 PM
Reposted by Rémi Fronzes
To celebrate my book of simple 'Bluesky Recipes' and survival tips for 'Difficult Days' winning the Gourmand Award for 'Food & Mental Health', I'm basically giving it away.
UK www.amazon.co.uk/dp/B0DWLYCR96 (99p)
USA www.amazon.com/dp/B0DWLYCR96 ($1.99)

#Cookbook #FoodSky #BookSky #Recipes #Foodie
December 1, 2025 at 9:41 PM
Nice move @cnrs.fr
From 2026, no more Web of Science.
But is the community truly ready for qualitative evaluation? Hiring, promotions, grants… we’ve all been shaped by the metrics we grew up with. Changing the mindset is the real challenge and will take time.
The CNRS is breaking free from the Web of Science
From January 1st 2026, the CNRS will cut access to one of the largest commercial bibliometric databases, Clarivate Analytics'
www.cnrs.fr
December 1, 2025 at 9:44 PM
The title of the conference
J’adore !
"Cell la vie!" meeting is back!📅

The French Society for Cell Biology is pleased to announce that the next edition will take place on October 21-23, 2026 in Paris.

This year will focus on the needs & challenges to explore the life sciences with an highlight on the role of microscopy. 🔬

Stay tuned!
December 1, 2025 at 4:18 PM
Si je peux me permettre, les scientifiques ne "trouvent" pas. Ils découvrent. "Trouver" suppose qu'on savait ce qu'on cherchait. Or nous progressons dans l'inconnu, souvent guidés par l'inattendu.
La phrase est célèbre : "Des chercheurs qui cherchent, on en trouve ; des chercheurs qui trouvent, on en cherche."

"Qu’on cesse de dire cela, car c’est faux ! Si vous regardez les applications récentes qui ont révolutionné la médecine, tout vient de la recherche." ⤵️

1/4
Attaques contre la science aux États-Unis : « Cela m’inquiète profondément », la mise en garde d’une chercheuse française - Le Parisien
Directrice de l’institut Imagine, Bana Jabri décrit les gigantesques avancées de l’ARN messager… et le recul inquiétant des Américains sur l
www.leparisien.fr
December 1, 2025 at 9:40 AM