Polard lab - Toulouse
@polardlab.bsky.social
We study all aspects of competence and natural genetic transformation using the human pathogen Streptococcus pneumoniae as a model organism.
CNRS research team housed in the LMGM at the CBI in Toulouse.
https://cbi-toulouse.fr/eng/equipe-polard
CNRS research team housed in the LMGM at the CBI in Toulouse.
https://cbi-toulouse.fr/eng/equipe-polard
Reposted by Polard lab - Toulouse
New paper from our lab up on Biorxiv, showing how a toxin targets replication to induce competence. 👇
A toxin/antitoxin system targeting the replication sliding-clamp induces competence in Streptococcus pneumoniae. https://www.biorxiv.org/content/10.1101/2025.09.02.673660v1
September 3, 2025 at 11:12 AM
New paper from our lab up on Biorxiv, showing how a toxin targets replication to induce competence. 👇
Here's a new preprint from our lab on the mechanism of DNA uptake during transformation. Collaboration with Guerois and Radicella labs.
Pleased to share a new preprint - a great collaboration with @jessicaandreani.bsky.social and the Guerois lab at I2BC, and the Radicella lab at the CEA. Using stuctural modelling, we reveal & validate a 3 protein complex involved in DNA import during transformation.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
A tripartite protein complex promotes DNA transport during natural transformation in firmicutes.
Natural genetic transformation is a conserved mechanism of bacterial horizontal gene transfer, which is directed entirely by the recipient cell and facilitates the acquisition of new genetic traits su...
www.biorxiv.org
May 12, 2025 at 7:12 AM
Here's a new preprint from our lab on the mechanism of DNA uptake during transformation. Collaboration with Guerois and Radicella labs.
Happy to share a recent paper from our lab in collaboration with Rémi and his team 👇
Very happy to share our latest paper published today in EMBO Journal !!
www.embopress.org/doi/full/10....
www.embopress.org/doi/full/10....
Structural insights into the mechanism of DNA branch migration during homologous recombination in bacteria | The EMBO Journal
imageimageThe bacterial hexameric ATPases RadA and ComM mediate DNA branch migration in the
homologous recombination pathway of genetic transformation in distinct bacterial species.
This study offers ...
www.embopress.org
December 2, 2024 at 11:04 AM
Happy to share a recent paper from our lab in collaboration with Rémi and his team 👇
Hello Bluesky! As a first post on this platform, we are happy to share the latest paper from our lab exporing links between competence, homologous recombination and genotoxic stress.
Please like/repost/follow to get us going on this platform!
Please like/repost/follow to get us going on this platform!
Really proud of our new paper, my first as last author. We explored the importance of homologous recombination genes in transformation and genotoxic stress tolerance during competence. Give it a read/like! 🙂
journals.asm.org/doi/10.1128/...
journals.asm.org/doi/10.1128/...
Competence induction of homologous recombination genes protects pneumococcal cells from genotoxic stress | mBio
Homologous recombination (HR) is a mechanism of DNA strand exchange important for
both the maintenance and plasticity of bacterial genomes. Bacterial HR is driven by
the recombinase RecA along with ma...
journals.asm.org
December 2, 2024 at 9:09 AM
Hello Bluesky! As a first post on this platform, we are happy to share the latest paper from our lab exporing links between competence, homologous recombination and genotoxic stress.
Please like/repost/follow to get us going on this platform!
Please like/repost/follow to get us going on this platform!