RNA & Ribosome Homeostasis Lab @École Polytechnique / @CNRS
@aribio.bsky.social
In Ribosome we Trust!!!
Ferreira-Cerca group at the Structural Biology of the Cell laboratory (BIOC) @CNRS / @École polytechnique
More information available at https://ferreiracercalab.com/
#archaea #Ribosome #RNA
Ferreira-Cerca group at the Structural Biology of the Cell laboratory (BIOC) @CNRS / @École polytechnique
More information available at https://ferreiracercalab.com/
#archaea #Ribosome #RNA
Pinned
RNase W, a conserved ribonuclease family with a novel active site
Abstract. Ribosome biogenesis is a complex process requiring multiple precursor ribosomal RNA (rRNA) cleavage steps. In archaea, the full set of ribonuclea
academic.oup.com
Check out our latest publication: academic.oup.com/nar/advance-...
#archaea #ribosome #RNA #Ribonuclease
#archaea #ribosome #RNA #Ribonuclease
Reposted by RNA & Ribosome Homeostasis Lab @École Polytechnique / @CNRS
Phylogenetic reconciliation supports a methanogenic ancestor of the Archaea and a derived origin for host-associated lineages https://www.biorxiv.org/content/10.1101/2025.11.11.687807v1
November 12, 2025 at 11:32 PM
Phylogenetic reconciliation supports a methanogenic ancestor of the Archaea and a derived origin for host-associated lineages https://www.biorxiv.org/content/10.1101/2025.11.11.687807v1
Reposted by RNA & Ribosome Homeostasis Lab @École Polytechnique / @CNRS
The halophilic archaeon Halogranum roseipondis sp. nov. is susceptible to a virus carrying an exceptionally high number of viral tRNA genes https://www.biorxiv.org/content/10.1101/2025.11.07.687168v1
November 8, 2025 at 2:18 AM
The halophilic archaeon Halogranum roseipondis sp. nov. is susceptible to a virus carrying an exceptionally high number of viral tRNA genes https://www.biorxiv.org/content/10.1101/2025.11.07.687168v1
Reposted by RNA & Ribosome Homeostasis Lab @École Polytechnique / @CNRS
The SPATA5-SPATA5L1-CINP-C1ORF109 complex is essential for cytoplasmic pre-60S ribosome maturation https://www.biorxiv.org/content/10.1101/2025.11.07.687187v1
November 8, 2025 at 2:45 AM
The SPATA5-SPATA5L1-CINP-C1ORF109 complex is essential for cytoplasmic pre-60S ribosome maturation https://www.biorxiv.org/content/10.1101/2025.11.07.687187v1
Reposted by RNA & Ribosome Homeostasis Lab @École Polytechnique / @CNRS
An Asgard archaeon with internal membrane compartments
Brilliant study led by @fmacleod.bsky.social and Andriko von Kügelgen. Tight collaboration with @buzzbaum.bsky.social and lab. Congrats to all authors!
www.biorxiv.org/content/10.1...
Brilliant study led by @fmacleod.bsky.social and Andriko von Kügelgen. Tight collaboration with @buzzbaum.bsky.social and lab. Congrats to all authors!
www.biorxiv.org/content/10.1...
November 7, 2025 at 10:44 AM
An Asgard archaeon with internal membrane compartments
Brilliant study led by @fmacleod.bsky.social and Andriko von Kügelgen. Tight collaboration with @buzzbaum.bsky.social and lab. Congrats to all authors!
www.biorxiv.org/content/10.1...
Brilliant study led by @fmacleod.bsky.social and Andriko von Kügelgen. Tight collaboration with @buzzbaum.bsky.social and lab. Congrats to all authors!
www.biorxiv.org/content/10.1...
Reposted by RNA & Ribosome Homeostasis Lab @École Polytechnique / @CNRS
Our latest paper has just been published in Cell!
doi.org/10.1016/j.ce...
We developed a new method called MCC ultra, which allows 3D chromatin structure to be visualised with a 1 base pair pixel size.
doi.org/10.1016/j.ce...
We developed a new method called MCC ultra, which allows 3D chromatin structure to be visualised with a 1 base pair pixel size.
November 5, 2025 at 5:20 PM
Our latest paper has just been published in Cell!
doi.org/10.1016/j.ce...
We developed a new method called MCC ultra, which allows 3D chromatin structure to be visualised with a 1 base pair pixel size.
doi.org/10.1016/j.ce...
We developed a new method called MCC ultra, which allows 3D chromatin structure to be visualised with a 1 base pair pixel size.
Reposted by RNA & Ribosome Homeostasis Lab @École Polytechnique / @CNRS
The evolution lifecycle of ribosome hibernation factors https://www.biorxiv.org/content/10.1101/2025.11.04.686544v1
November 5, 2025 at 1:18 AM
The evolution lifecycle of ribosome hibernation factors https://www.biorxiv.org/content/10.1101/2025.11.04.686544v1
Reposted by RNA & Ribosome Homeostasis Lab @École Polytechnique / @CNRS
📢 Open Call! The Max Perutz Labs invite applications for a Full Professorship in Integrative Structure Biology with a focus on in situ structural biology using cryo-electron tomography (cryo-ET) and related methods. More details ➡️ tinyurl.com/brswbymu
October 31, 2025 at 9:24 AM
📢 Open Call! The Max Perutz Labs invite applications for a Full Professorship in Integrative Structure Biology with a focus on in situ structural biology using cryo-electron tomography (cryo-ET) and related methods. More details ➡️ tinyurl.com/brswbymu
Reposted by RNA & Ribosome Homeostasis Lab @École Polytechnique / @CNRS
In @nature.com: Using AI and other cutting-edge techniques, the Klinge lab has captured the first near-continuous "molecular movie" of ribosome formation—revealing, frame by frame, how cells build the protein factories that make life possible.
More here: https://bit.ly/3LbHTaF
More here: https://bit.ly/3LbHTaF
October 29, 2025 at 5:22 PM
In @nature.com: Using AI and other cutting-edge techniques, the Klinge lab has captured the first near-continuous "molecular movie" of ribosome formation—revealing, frame by frame, how cells build the protein factories that make life possible.
More here: https://bit.ly/3LbHTaF
More here: https://bit.ly/3LbHTaF
Reposted by RNA & Ribosome Homeostasis Lab @École Polytechnique / @CNRS
Transcription profiling and functional analysis of spRNAs and their corresponding asRNAs in Methanosarcina mazei https://www.biorxiv.org/content/10.1101/2025.10.28.685009v1
October 29, 2025 at 2:18 AM
Transcription profiling and functional analysis of spRNAs and their corresponding asRNAs in Methanosarcina mazei https://www.biorxiv.org/content/10.1101/2025.10.28.685009v1
Reposted by RNA & Ribosome Homeostasis Lab @École Polytechnique / @CNRS
Lab’s first paper is out!! We show the first structures of #Asgard #chromatin by #cryo-EM 🧬❄️
Asgard histones form closed and open hypernucleosomes. Closed are conserved across #Archaea, while open resemble eukaryotic H3–H4 octasomes and are Asgard-specific. More here: www.cell.com/molecular-ce...
Asgard histones form closed and open hypernucleosomes. Closed are conserved across #Archaea, while open resemble eukaryotic H3–H4 octasomes and are Asgard-specific. More here: www.cell.com/molecular-ce...
October 28, 2025 at 3:07 PM
Lab’s first paper is out!! We show the first structures of #Asgard #chromatin by #cryo-EM 🧬❄️
Asgard histones form closed and open hypernucleosomes. Closed are conserved across #Archaea, while open resemble eukaryotic H3–H4 octasomes and are Asgard-specific. More here: www.cell.com/molecular-ce...
Asgard histones form closed and open hypernucleosomes. Closed are conserved across #Archaea, while open resemble eukaryotic H3–H4 octasomes and are Asgard-specific. More here: www.cell.com/molecular-ce...
Reposted by RNA & Ribosome Homeostasis Lab @École Polytechnique / @CNRS
How to become a "hot RNA" 🌡️? The answers were kindly provided by hyperthermophilic archaea: rRNA modifications are key! Check out this new publication presenting pan-modification profiling of the epitranscriptome. www.cell.com/cell/fulltex.... (1/3)
Pan-modification profiling facilitates a cross-evolutionary dissection of the thermoregulated ribosomal epitranscriptome
Pan-Mod-seq enables systematic, multi-modification mapping of rRNA across life. Applying
it to diverse organisms reveals that hyperthermophiles dynamically install stabilizing
modifications to support...
www.cell.com
October 27, 2025 at 1:19 PM
How to become a "hot RNA" 🌡️? The answers were kindly provided by hyperthermophilic archaea: rRNA modifications are key! Check out this new publication presenting pan-modification profiling of the epitranscriptome. www.cell.com/cell/fulltex.... (1/3)
Reposted by RNA & Ribosome Homeostasis Lab @École Polytechnique / @CNRS
Pan-modification profiling facilitates a cross-evolutionary dissection of the thermoregulated ribosomal epitranscriptome #rnasky #microsky www.cell.com/cell/abstrac...
Pan-modification profiling facilitates a cross-evolutionary dissection of the thermoregulated ribosomal epitranscriptome
Pan-Mod-seq enables systematic, multi-modification mapping of rRNA across life. Applying
it to diverse organisms reveals that hyperthermophiles dynamically install stabilizing
modifications to support...
www.cell.com
October 25, 2025 at 7:52 AM
Pan-modification profiling facilitates a cross-evolutionary dissection of the thermoregulated ribosomal epitranscriptome #rnasky #microsky www.cell.com/cell/abstrac...
Reposted by RNA & Ribosome Homeostasis Lab @École Polytechnique / @CNRS
Amazing paper from collaborators Schraga Schwartz and Moran Shalev-Benami at Weizmann. Nucleotide resolution sequencing of 16 RNA modifications from diverse organisms cultured under basal and 'extreme' conditions + enzymology, structure, synthesis, and biophysics.
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
Pan-modification profiling facilitates a cross-evolutionary dissection of the thermoregulated ribosomal epitranscriptome
Pan-Mod-seq enables systematic, multi-modification mapping of rRNA across life. Applying
it to diverse organisms reveals that hyperthermophiles dynamically install stabilizing
modifications to support...
www.cell.com
October 24, 2025 at 5:20 PM
Amazing paper from collaborators Schraga Schwartz and Moran Shalev-Benami at Weizmann. Nucleotide resolution sequencing of 16 RNA modifications from diverse organisms cultured under basal and 'extreme' conditions + enzymology, structure, synthesis, and biophysics.
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
Reposted by RNA & Ribosome Homeostasis Lab @École Polytechnique / @CNRS
WE ARE BACK!!! Archaea Power Hour will return this coming WEDNESDAY, Oct. 22nd at 10AM EST/4PM CET. Check your email for the Zoom link (coming soon) or register here: forms.gle/6QvCjHH2H4pxro…. Take a look at the exciting talks we have planned to kick off our fall seminar series:
October 17, 2025 at 3:50 PM
WE ARE BACK!!! Archaea Power Hour will return this coming WEDNESDAY, Oct. 22nd at 10AM EST/4PM CET. Check your email for the Zoom link (coming soon) or register here: forms.gle/6QvCjHH2H4pxro…. Take a look at the exciting talks we have planned to kick off our fall seminar series:
Reposted by RNA & Ribosome Homeostasis Lab @École Polytechnique / @CNRS
BIG ANNOUNCEMENT📣: I haven’t been this excited to be part of something new in 15 years… Thrilled to reveal the passion project I’ve been working on for the past year and a half!🙀🥳 (thread 👇)
October 15, 2025 at 12:22 PM
BIG ANNOUNCEMENT📣: I haven’t been this excited to be part of something new in 15 years… Thrilled to reveal the passion project I’ve been working on for the past year and a half!🙀🥳 (thread 👇)
Reposted by RNA & Ribosome Homeostasis Lab @École Polytechnique / @CNRS
Our work on ribosome hibernation in archaea is out!
We identified Hib, a new hibernation factor broadly distributed across archaea.
Check out the preprint 👉 biorxiv.org/content/10.1101/2025.10.11.676729v1
(1/🧵)
We identified Hib, a new hibernation factor broadly distributed across archaea.
Check out the preprint 👉 biorxiv.org/content/10.1101/2025.10.11.676729v1
(1/🧵)
October 13, 2025 at 4:26 PM
Our work on ribosome hibernation in archaea is out!
We identified Hib, a new hibernation factor broadly distributed across archaea.
Check out the preprint 👉 biorxiv.org/content/10.1101/2025.10.11.676729v1
(1/🧵)
We identified Hib, a new hibernation factor broadly distributed across archaea.
Check out the preprint 👉 biorxiv.org/content/10.1101/2025.10.11.676729v1
(1/🧵)
Reposted by RNA & Ribosome Homeostasis Lab @École Polytechnique / @CNRS
No Genetics? Try ASOs – A non-genetic approach to silence genes at the phage-host interface. We use it to study jumbo phage biology and anti-phage defence.
@jorg-vogel-lab.bsky.social @helmholtz-hiri.bsky.social
@uni-wuerzburg.de @helmholtzhzi.bsky.social
published now in @nature.com
@jorg-vogel-lab.bsky.social @helmholtz-hiri.bsky.social
@uni-wuerzburg.de @helmholtzhzi.bsky.social
published now in @nature.com
Programmable antisense oligomers for phage functional genomics - Nature
Establishing antisense oligomers as versatile, non-genetic tools to silence phage mRNAs opens applications in basic research and biotechnology, as shown by identifying essential factors for propagatio...
www.nature.com
September 11, 2025 at 9:10 AM
No Genetics? Try ASOs – A non-genetic approach to silence genes at the phage-host interface. We use it to study jumbo phage biology and anti-phage defence.
@jorg-vogel-lab.bsky.social @helmholtz-hiri.bsky.social
@uni-wuerzburg.de @helmholtzhzi.bsky.social
published now in @nature.com
@jorg-vogel-lab.bsky.social @helmholtz-hiri.bsky.social
@uni-wuerzburg.de @helmholtzhzi.bsky.social
published now in @nature.com
Reposted by RNA & Ribosome Homeostasis Lab @École Polytechnique / @CNRS
New article on equitable reuse of public sequencing data, published in @natmicrobiol.nature.com!
Led by the Data reuse core team @lhug.bsky.social @environmicrobio.bsky.social Cristina Moraru, @geomicrosoares.bsky.social, @folker.bsky.social and with Anke Heyer and The Data Reuse Consotrium!
Led by the Data reuse core team @lhug.bsky.social @environmicrobio.bsky.social Cristina Moraru, @geomicrosoares.bsky.social, @folker.bsky.social and with Anke Heyer and The Data Reuse Consotrium!
September 26, 2025 at 7:34 PM
New article on equitable reuse of public sequencing data, published in @natmicrobiol.nature.com!
Led by the Data reuse core team @lhug.bsky.social @environmicrobio.bsky.social Cristina Moraru, @geomicrosoares.bsky.social, @folker.bsky.social and with Anke Heyer and The Data Reuse Consotrium!
Led by the Data reuse core team @lhug.bsky.social @environmicrobio.bsky.social Cristina Moraru, @geomicrosoares.bsky.social, @folker.bsky.social and with Anke Heyer and The Data Reuse Consotrium!
Reposted by RNA & Ribosome Homeostasis Lab @École Polytechnique / @CNRS
Biogenesis and function of archaeal lipoproteins.
This takes me back. The first papers I published from my new group were on lipoprotein biogenesis in Streptomyces with @proftracypalmer.bsky.social about 15y ago.
www.nature.com/articles/s41...
This takes me back. The first papers I published from my new group were on lipoprotein biogenesis in Streptomyces with @proftracypalmer.bsky.social about 15y ago.
www.nature.com/articles/s41...
Uncovering the prevalence, key biogenesis enzymes, and biological significance of archaeal lipoproteins - Nature Communications
Lipoproteins are major cell-surface components in archaea, but their functions and the lipidation mechanisms are unclear. Here, Hong et al. identify two proteins required for attachment of proteins to unique archaeal membrane lipids via thioether bonds, and demonstrate their importance in archaeal physiology.
www.nature.com
September 28, 2025 at 10:54 AM
Biogenesis and function of archaeal lipoproteins.
This takes me back. The first papers I published from my new group were on lipoprotein biogenesis in Streptomyces with @proftracypalmer.bsky.social about 15y ago.
www.nature.com/articles/s41...
This takes me back. The first papers I published from my new group were on lipoprotein biogenesis in Streptomyces with @proftracypalmer.bsky.social about 15y ago.
www.nature.com/articles/s41...
Reposted by RNA & Ribosome Homeostasis Lab @École Polytechnique / @CNRS
Please re-post:
Interested in chromatin and its evolution? Good news! There's still time to join us in beautiful Catalonia (9-12 Dec) to discuss eukaryotic, bacterial, archaeal, and viral chromatin and how it all hangs together meetings.embo.org/event/24-evo...
Abstract deadline: 30 September
Interested in chromatin and its evolution? Good news! There's still time to join us in beautiful Catalonia (9-12 Dec) to discuss eukaryotic, bacterial, archaeal, and viral chromatin and how it all hangs together meetings.embo.org/event/24-evo...
Abstract deadline: 30 September
EvoChromo: Evolutionary approaches to research in chromatin
Chromatin is the complex of DNA, RNA and protein that is found making up the chromosomes in eukaryotic cells. Chromatin is essential for proper genome function and is involved in chromosome segregati…
meetings.embo.org
September 8, 2025 at 11:14 AM
Please re-post:
Interested in chromatin and its evolution? Good news! There's still time to join us in beautiful Catalonia (9-12 Dec) to discuss eukaryotic, bacterial, archaeal, and viral chromatin and how it all hangs together meetings.embo.org/event/24-evo...
Abstract deadline: 30 September
Interested in chromatin and its evolution? Good news! There's still time to join us in beautiful Catalonia (9-12 Dec) to discuss eukaryotic, bacterial, archaeal, and viral chromatin and how it all hangs together meetings.embo.org/event/24-evo...
Abstract deadline: 30 September
Happy to share our contribution for this book on circular RNAs....With my colleague Hubert Becker, we provide a short survey on circular RNA in Archaea...
#RNAsky #Archaea
link.springer.com/chapter/10.1...
#RNAsky #Archaea
link.springer.com/chapter/10.1...
Circular RNAs in Archaea
Circular RNA molecules were first described more than 40 years ago. However, it is only recently that the broadness of their phylogenetic distribution has been revealed. Since their discoveries, ...
link.springer.com
September 1, 2025 at 1:57 PM
Happy to share our contribution for this book on circular RNAs....With my colleague Hubert Becker, we provide a short survey on circular RNA in Archaea...
#RNAsky #Archaea
link.springer.com/chapter/10.1...
#RNAsky #Archaea
link.springer.com/chapter/10.1...
Reposted by RNA & Ribosome Homeostasis Lab @École Polytechnique / @CNRS
Our RAPPL purification of ribosomes and associated material is out. I am really proud of this study in collaboration primary with Pavlovic-Djuranovic lab, as well as Jovanovic and Hashem Labs. This method aims to replace 60 years old purification of ribosomes by sucrose cushions
rdcu.be/ezlhg
rdcu.be/ezlhg
A rapid, simple, and economical method for the isolation of ribosomes and translational machinery for structural and functional studies
Nature Communications - Here, the authors present a method to rapidly isolate actively translating ribosomes in a time- and cost-effective manner using poly-lysine. The method is compatible with a...
rdcu.be
August 5, 2025 at 1:19 PM
Our RAPPL purification of ribosomes and associated material is out. I am really proud of this study in collaboration primary with Pavlovic-Djuranovic lab, as well as Jovanovic and Hashem Labs. This method aims to replace 60 years old purification of ribosomes by sucrose cushions
rdcu.be/ezlhg
rdcu.be/ezlhg
Reposted by RNA & Ribosome Homeostasis Lab @École Polytechnique / @CNRS
Fresh preprint from the
@novoalab.bsky.social !😀📌 Do you want to barcode up to 96 #RNA samples in your #nanopore flowcells? How well do RNA #modification-aware models perform? What if there is #noBasecallingModel for your modification-of-interest? Find it out here!😊 www.biorxiv.org/content/10.1...
@novoalab.bsky.social !😀📌 Do you want to barcode up to 96 #RNA samples in your #nanopore flowcells? How well do RNA #modification-aware models perform? What if there is #noBasecallingModel for your modification-of-interest? Find it out here!😊 www.biorxiv.org/content/10.1...
Systematic benchmarking of basecalling models for RNA modification detection with highly-multiplexed nanopore sequencing
Nanopore direct RNA sequencing (DRS) holds promise for advancing our understanding of the epitranscriptome by detecting RNA modifications in native RNA molecules. Recently, Oxford Nanopore Technologie...
www.biorxiv.org
August 3, 2025 at 2:23 PM
Fresh preprint from the
@novoalab.bsky.social !😀📌 Do you want to barcode up to 96 #RNA samples in your #nanopore flowcells? How well do RNA #modification-aware models perform? What if there is #noBasecallingModel for your modification-of-interest? Find it out here!😊 www.biorxiv.org/content/10.1...
@novoalab.bsky.social !😀📌 Do you want to barcode up to 96 #RNA samples in your #nanopore flowcells? How well do RNA #modification-aware models perform? What if there is #noBasecallingModel for your modification-of-interest? Find it out here!😊 www.biorxiv.org/content/10.1...
Reposted by RNA & Ribosome Homeostasis Lab @École Polytechnique / @CNRS
Dear all,
We are starting an exciting new project in close collaboration with Clément Carré in Paris, France.
A fully funded PhD position is available in my group at the vetmeduni Vienna!
Please help us spreading the word - please forward it to interested students.
We are starting an exciting new project in close collaboration with Clément Carré in Paris, France.
A fully funded PhD position is available in my group at the vetmeduni Vienna!
Please help us spreading the word - please forward it to interested students.
www.vetmeduni.ac.at
July 30, 2025 at 12:03 PM
Dear all,
We are starting an exciting new project in close collaboration with Clément Carré in Paris, France.
A fully funded PhD position is available in my group at the vetmeduni Vienna!
Please help us spreading the word - please forward it to interested students.
We are starting an exciting new project in close collaboration with Clément Carré in Paris, France.
A fully funded PhD position is available in my group at the vetmeduni Vienna!
Please help us spreading the word - please forward it to interested students.