Dina Grohmann
@curiousdina.bsky.social
Curious scientist and fan of single molecules, RNA and Archaea
Amazing work showing how TDMD plays out on the molecular level! Congrats!!
When RNA Degradation 🤝 meets 🤝 Protein Degradation! tinyurl.com/E3TDMD In a collaboration of @bartellab.bsky.social and Schulman lab, we show that, in target-directed microRNA degradation (TDMD), 2-RNA-factors recruit an E3 ligase and induce the degradation of not only a protein but also RNA (1/5).
January 6, 2026 at 2:24 PM
Amazing work showing how TDMD plays out on the molecular level! Congrats!!
Reposted by Dina Grohmann
Slightly overdue article highlight!
In PNAS, we use smFRET to reveal how polypeptide release factor 2 (RF2) undergoes a cascade of structural changes to catalyze polypeptide release during translation termination and ArfA-mediated ribosome rescue.
🧵⬇️
doi.org/10.1073/pnas...
In PNAS, we use smFRET to reveal how polypeptide release factor 2 (RF2) undergoes a cascade of structural changes to catalyze polypeptide release during translation termination and ArfA-mediated ribosome rescue.
🧵⬇️
doi.org/10.1073/pnas...
January 5, 2026 at 4:27 PM
Slightly overdue article highlight!
In PNAS, we use smFRET to reveal how polypeptide release factor 2 (RF2) undergoes a cascade of structural changes to catalyze polypeptide release during translation termination and ArfA-mediated ribosome rescue.
🧵⬇️
doi.org/10.1073/pnas...
In PNAS, we use smFRET to reveal how polypeptide release factor 2 (RF2) undergoes a cascade of structural changes to catalyze polypeptide release during translation termination and ArfA-mediated ribosome rescue.
🧵⬇️
doi.org/10.1073/pnas...
A new year brings new opportunities: we are looking to fill a permanent professorship position with a Microbiologist preferably with expertise on archaeal biology, RNA biology or imaging techniques to unravel cell biology in prokaryotes! Please share and/or apply :)! www.nature.com/naturecareer...
Professurship (W2) in Microbiology - Regensburg (Stadt), Bayern (DE) job with Universität Regensburg | 12851113
UNIVERSITY OF REGENSBURG The Faculty of Biology and Pre-Clinical Medicine invites applications for a Professurship (W2) in Microbiology To be...
www.nature.com
January 5, 2026 at 9:46 AM
A new year brings new opportunities: we are looking to fill a permanent professorship position with a Microbiologist preferably with expertise on archaeal biology, RNA biology or imaging techniques to unravel cell biology in prokaryotes! Please share and/or apply :)! www.nature.com/naturecareer...
Reposted by Dina Grohmann
A (belated!) highlight from an excellent collaboration with
@dunhamlab.bsky.social and #HouLabTJU.
In this Nat Commun paper, we combine smFRET and cryo-EM to show how the tRNA modification m¹G37 stabilizes the reading frame—and what happens when it’s missing.
@dunhamlab.bsky.social and #HouLabTJU.
In this Nat Commun paper, we combine smFRET and cryo-EM to show how the tRNA modification m¹G37 stabilizes the reading frame—and what happens when it’s missing.
January 4, 2026 at 6:34 PM
A (belated!) highlight from an excellent collaboration with
@dunhamlab.bsky.social and #HouLabTJU.
In this Nat Commun paper, we combine smFRET and cryo-EM to show how the tRNA modification m¹G37 stabilizes the reading frame—and what happens when it’s missing.
@dunhamlab.bsky.social and #HouLabTJU.
In this Nat Commun paper, we combine smFRET and cryo-EM to show how the tRNA modification m¹G37 stabilizes the reading frame—and what happens when it’s missing.
Reposted by Dina Grohmann
The Human Archaeome: Commensals, Opportunists, or Emerging Pathogens?
#microbiology #archaea #GutMicrobiota #MicroSky #ArchaeaSky
www.mdpi.com/2076-0817/14...
#microbiology #archaea #GutMicrobiota #MicroSky #ArchaeaSky
www.mdpi.com/2076-0817/14...
January 4, 2026 at 10:23 AM
The Human Archaeome: Commensals, Opportunists, or Emerging Pathogens?
#microbiology #archaea #GutMicrobiota #MicroSky #ArchaeaSky
www.mdpi.com/2076-0817/14...
#microbiology #archaea #GutMicrobiota #MicroSky #ArchaeaSky
www.mdpi.com/2076-0817/14...
Reposted by Dina Grohmann
jede*r kann etwas tun
January 3, 2026 at 4:54 PM
jede*r kann etwas tun
Reposted by Dina Grohmann
Wie recht @meta-bene.bsky.social doch hatte:
January 3, 2026 at 6:49 PM
Wie recht @meta-bene.bsky.social doch hatte:
Reposted by Dina Grohmann
Troubleshooting common errors in assemblies of long-read metagenomes www.nature.com/articles/s41... #jcampubs
Troubleshooting common errors in assemblies of long-read metagenomes - Nature Biotechnology
Long-read sequence assemblies from metagenomes contain frequent errors.
www.nature.com
January 2, 2026 at 8:30 PM
Troubleshooting common errors in assemblies of long-read metagenomes www.nature.com/articles/s41... #jcampubs
Reposted by Dina Grohmann
Marine archaea and their functional networks in oceanic biogeochemical cycling link.springer.com/article/10.1...
Marine archaea and their functional networks in oceanic biogeochemical cycling - Discover Oceans
Marine archaea are nowadays recognized as central elements in ocean food webs, playing key roles in global nitrogen cycling and other biogeochemical processes. Metabolic diversity enables marine archa...
link.springer.com
December 29, 2025 at 4:43 PM
Marine archaea and their functional networks in oceanic biogeochemical cycling link.springer.com/article/10.1...
Reposted by Dina Grohmann
The final edition of our “New Microbes Discovered in 2025” series is here. After exploring new viruses, bacteria, and fungi, this last #FEMSmicroBlog highlights the archaea identified in 2025: buff.ly/pJpA0Ax #NewMicrobes
December 30, 2025 at 11:28 AM
The final edition of our “New Microbes Discovered in 2025” series is here. After exploring new viruses, bacteria, and fungi, this last #FEMSmicroBlog highlights the archaea identified in 2025: buff.ly/pJpA0Ax #NewMicrobes
Thanks to all who provide these illustrations for free - it helps so much for teaching etc! It’s like a Christmas present again and again ☺️
A free, open-access library of high-quality organism illustrations for science communication
A free, open-access library of high-quality organism illustrations for science communication
We create vector graphics of model organisms and emerging biological research organisms to enhance our publications. We’re sharing these editable graphics under a CC0 license for other scientists to...
doi.org
December 30, 2025 at 7:20 AM
Thanks to all who provide these illustrations for free - it helps so much for teaching etc! It’s like a Christmas present again and again ☺️
Reposted by Dina Grohmann
A free, open-access library of high-quality organism illustrations for science communication
A free, open-access library of high-quality organism illustrations for science communication
We create vector graphics of model organisms and emerging biological research organisms to enhance our publications. We’re sharing these editable graphics under a CC0 license for other scientists to...
doi.org
December 29, 2025 at 6:03 PM
A free, open-access library of high-quality organism illustrations for science communication
Reposted by Dina Grohmann
Wie digitaler Hass und Ressentiment geschürt und geschützt werden, lässt sich hier exemplarisch sehen....wer noch nicht weiß, wohin zum Jahresende spenden: einfach an @hateaid.org www.sueddeutsche.de/politik/usa-...
USA sanktionieren Führung der deutschen Organisation Hate Aid
Die beiden Geschäftsführerinnen Anna-Lena von Hodenberg und Josephine Ballon dürfen nicht mehr in die USA einreisen.
www.sueddeutsche.de
December 24, 2025 at 11:50 AM
Wie digitaler Hass und Ressentiment geschürt und geschützt werden, lässt sich hier exemplarisch sehen....wer noch nicht weiß, wohin zum Jahresende spenden: einfach an @hateaid.org www.sueddeutsche.de/politik/usa-...
Reposted by Dina Grohmann
Reposted by Dina Grohmann
Calling all archaeal enthusiasts! 🔬🔥 From molecular machines to microbial communities, Archaea never fail to surprise us!
We are excited to announce the 2026 EMBO Workshop on the Molecular Biology of Archaea, 6–10 July in Cambridge, UK!
Sign up here: meetings.embo.org/event/26-arc...
#ArchaeaSky
We are excited to announce the 2026 EMBO Workshop on the Molecular Biology of Archaea, 6–10 July in Cambridge, UK!
Sign up here: meetings.embo.org/event/26-arc...
#ArchaeaSky
December 16, 2025 at 2:18 PM
Calling all archaeal enthusiasts! 🔬🔥 From molecular machines to microbial communities, Archaea never fail to surprise us!
We are excited to announce the 2026 EMBO Workshop on the Molecular Biology of Archaea, 6–10 July in Cambridge, UK!
Sign up here: meetings.embo.org/event/26-arc...
#ArchaeaSky
We are excited to announce the 2026 EMBO Workshop on the Molecular Biology of Archaea, 6–10 July in Cambridge, UK!
Sign up here: meetings.embo.org/event/26-arc...
#ArchaeaSky
Reposted by Dina Grohmann
Bacterial genomes encode a rich repertoire of antiphage systems, but we still know surprisingly little about when these systems are actually expressed.
In this preprint, Lucas Paoli et al, ask what shapes antiphage systems expression in native contexts.
www.biorxiv.org/content/10.6...
In this preprint, Lucas Paoli et al, ask what shapes antiphage systems expression in native contexts.
www.biorxiv.org/content/10.6...
Environment and physiology shape antiphage system expression
Bacteria and archaea encode on average ten antiphage systems. Quorum sensing, cellular, or transcription factors can regulate specific systems (CRISPR-Cas, CBASS). Yet, a systematic assessment of anti...
www.biorxiv.org
December 15, 2025 at 9:49 PM
Bacterial genomes encode a rich repertoire of antiphage systems, but we still know surprisingly little about when these systems are actually expressed.
In this preprint, Lucas Paoli et al, ask what shapes antiphage systems expression in native contexts.
www.biorxiv.org/content/10.6...
In this preprint, Lucas Paoli et al, ask what shapes antiphage systems expression in native contexts.
www.biorxiv.org/content/10.6...
So true 🙈! And some of those changes are just not acceptable … changing the name of the ASGARD archaea superphylum? Not a good idea 😠!
You spend your life learning the natural history of the prokaryotes with all this complex taxonomy and then right when you are so proud of your well earned wisdom all the names change just in time for your brain to be too old to handle it
My current relationship with bacterial taxonomy...
December 13, 2025 at 4:45 PM
So true 🙈! And some of those changes are just not acceptable … changing the name of the ASGARD archaea superphylum? Not a good idea 😠!
Reposted by Dina Grohmann
Who invented non-reflective glass?
American physicist & chemist Katharine Burr Blodgett in 1938.
It revolutionized optics--& led to the coatings used today in everything from eyeglasses to phone screens. She was the first woman to earn a PhD in #physics from Cambridge, 1926. #WomenInSTEM #inventor
American physicist & chemist Katharine Burr Blodgett in 1938.
It revolutionized optics--& led to the coatings used today in everything from eyeglasses to phone screens. She was the first woman to earn a PhD in #physics from Cambridge, 1926. #WomenInSTEM #inventor
December 12, 2025 at 11:46 PM
Who invented non-reflective glass?
American physicist & chemist Katharine Burr Blodgett in 1938.
It revolutionized optics--& led to the coatings used today in everything from eyeglasses to phone screens. She was the first woman to earn a PhD in #physics from Cambridge, 1926. #WomenInSTEM #inventor
American physicist & chemist Katharine Burr Blodgett in 1938.
It revolutionized optics--& led to the coatings used today in everything from eyeglasses to phone screens. She was the first woman to earn a PhD in #physics from Cambridge, 1926. #WomenInSTEM #inventor
Uh, nice 🤩! One of our favourite archaea in stylish colours ☺️!
DAY 189
SPECIES 189 - Pyrococcus furiosus
STAGE: Archaea
MEDIUM: Arches Paper. Chromatek and QoR Watercolor. Sakura pen
P. furiosus known as the "furious fireball" archaeon, due to its high mobility, rapid growth and ability to thrive in deep-sea volcanic vents
#sciart #watercolor #archaea #art
SPECIES 189 - Pyrococcus furiosus
STAGE: Archaea
MEDIUM: Arches Paper. Chromatek and QoR Watercolor. Sakura pen
P. furiosus known as the "furious fireball" archaeon, due to its high mobility, rapid growth and ability to thrive in deep-sea volcanic vents
#sciart #watercolor #archaea #art
December 11, 2025 at 9:10 PM
Uh, nice 🤩! One of our favourite archaea in stylish colours ☺️!
Reposted by Dina Grohmann
Delighted to share our latest preprint on reverse gyrase, a unique topoisomerase found exclusively in thermophiles!
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
Reverse gyrase and 3D genome architecture suppress hyperthermophile genome instability arising from horizontal gene transfer
Reverse gyrase (Rgy), a distinctive topoisomerase conserved in all hyperthermophiles, has the unique ability to introduce positive DNA supercoils. It has long been hypothesized that Rgy overwinds geno...
www.biorxiv.org
December 11, 2025 at 6:40 AM
Delighted to share our latest preprint on reverse gyrase, a unique topoisomerase found exclusively in thermophiles!
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
A day of celebration @ the Grohmann Lab: since 10 years we are a fantastic team with lots of passion for science & teaching & #Archaea, #single-molecules and the many facets of #RNAbiology. I am endlessly grateful to all who are and were part of the lab and built a strong team - truly special 🫶!
December 8, 2025 at 8:10 PM
A day of celebration @ the Grohmann Lab: since 10 years we are a fantastic team with lots of passion for science & teaching & #Archaea, #single-molecules and the many facets of #RNAbiology. I am endlessly grateful to all who are and were part of the lab and built a strong team - truly special 🫶!
Reposted by Dina Grohmann
Nice! Full attention to RNA polymerase - one of the most exciting molecular machineries (ok, ribosomes are cool too 😉)!
Cellular and viral RNA polymerases: evolutionary insights into eukaryotic origins www.cell.com/trends/micro... #jcampubs
Cellular and viral RNA polymerases: evolutionary insights into eukaryotic origins
Nucleocytoplasmic large DNA viruses (NCLDVs) encode multi-subunit RNA polymerases
(msRNAPs) that challenge conventional views of viral evolution. Phylogenetic and structural
studies reveal that NCLDV ...
www.cell.com
December 6, 2025 at 10:48 AM
Nice! Full attention to RNA polymerase - one of the most exciting molecular machineries (ok, ribosomes are cool too 😉)!
Reposted by Dina Grohmann
Dynamic protrusions mediate unique crawling motility in Asgard Archaea (Promethearchaeota) www.biorxiv.org/content/10.1... #jcampubs
December 2, 2025 at 1:54 PM
Dynamic protrusions mediate unique crawling motility in Asgard Archaea (Promethearchaeota) www.biorxiv.org/content/10.1... #jcampubs
Reposted by Dina Grohmann
The epitranscriptome formed by the growing number of modifications occurring within mRNA transcripts.
We have been mapping mRNA modifications for over a decade.
=> Characterizing their functions -- especially on translation -- is a research frontier.
We have been mapping mRNA modifications for over a decade.
=> Characterizing their functions -- especially on translation -- is a research frontier.
November 30, 2025 at 2:36 PM
The epitranscriptome formed by the growing number of modifications occurring within mRNA transcripts.
We have been mapping mRNA modifications for over a decade.
=> Characterizing their functions -- especially on translation -- is a research frontier.
We have been mapping mRNA modifications for over a decade.
=> Characterizing their functions -- especially on translation -- is a research frontier.