Milan Gerovac
@gerovac.bsky.social
Pinned
Milan Gerovac
@gerovac.bsky.social
· Oct 31
Use antisense oligomers to silence phage genes and discover new biology.
@jorg-vogel-lab.bsky.social @helmholtz-hiri.bsky.social @helmholtzhzi.bsky.social @uni-wuerzburg.de
print: www.nature.com/articles/s41...
highlight: www.nature.com/articles/s41...
briefing: www.nature.com/articles/d41...
@jorg-vogel-lab.bsky.social @helmholtz-hiri.bsky.social @helmholtzhzi.bsky.social @uni-wuerzburg.de
print: www.nature.com/articles/s41...
highlight: www.nature.com/articles/s41...
briefing: www.nature.com/articles/d41...
Reposted by Milan Gerovac
My time in @martinsteinegger.bsky.social's group is ending, but I’m staying in Korea to build a lab at Sungkyunkwan University School of Medicine. If you or someone you know is interested in molecular machine learning and open-source bioinformatics, please reach out. I am hiring!
mirdita.org
mirdita.org
Mirdita Lab - Laboratory for Computational Biology & Molecular Machine Learning
Mirdita Lab builds scalable bioinformatics methods.
mirdita.org
January 20, 2026 at 11:07 AM
My time in @martinsteinegger.bsky.social's group is ending, but I’m staying in Korea to build a lab at Sungkyunkwan University School of Medicine. If you or someone you know is interested in molecular machine learning and open-source bioinformatics, please reach out. I am hiring!
mirdita.org
mirdita.org
Reposted by Milan Gerovac
Think outside the box and address the most pressing challenges in infection research with us!🧑🔬 We're offering 10 PhD positions at five HZI sites across Germany.
👉Don’t miss out—apply by February 28, 2026 and contribute to shaping the future of infection research
jobs.helmholtz-hzi.de/job/Braunsch...
👉Don’t miss out—apply by February 28, 2026 and contribute to shaping the future of infection research
jobs.helmholtz-hzi.de/job/Braunsch...
January 20, 2026 at 1:46 PM
Think outside the box and address the most pressing challenges in infection research with us!🧑🔬 We're offering 10 PhD positions at five HZI sites across Germany.
👉Don’t miss out—apply by February 28, 2026 and contribute to shaping the future of infection research
jobs.helmholtz-hzi.de/job/Braunsch...
👉Don’t miss out—apply by February 28, 2026 and contribute to shaping the future of infection research
jobs.helmholtz-hzi.de/job/Braunsch...
Reposted by Milan Gerovac
I’m thrilled to share our work on phage triggers of the bacterial immune system in its final form @natmicrobiol.nature.com www.nature.com/articles/s41...
A phage protein screen identifies triggers of the bacterial innate immune system - Nature Microbiology
A library of 400 phage protein-coding genes is used to find a trove of antiphage systems, revealing systems that target tail fibre and major capsid proteins.
www.nature.com
January 18, 2026 at 10:45 PM
I’m thrilled to share our work on phage triggers of the bacterial immune system in its final form @natmicrobiol.nature.com www.nature.com/articles/s41...
Reposted by Milan Gerovac
Happy to share our recent preprint:
"DNA-intercalating antiphage molecules trigger abortive infection through mutual destruction and synergize with bacterial immunity"
www.biorxiv.org/content/10.6...
@spp2330.bsky.social, @mibinet.bsky.social, @dfg.de @hhu.de @fzj.bsky.social
"DNA-intercalating antiphage molecules trigger abortive infection through mutual destruction and synergize with bacterial immunity"
www.biorxiv.org/content/10.6...
@spp2330.bsky.social, @mibinet.bsky.social, @dfg.de @hhu.de @fzj.bsky.social
January 14, 2026 at 8:57 AM
Happy to share our recent preprint:
"DNA-intercalating antiphage molecules trigger abortive infection through mutual destruction and synergize with bacterial immunity"
www.biorxiv.org/content/10.6...
@spp2330.bsky.social, @mibinet.bsky.social, @dfg.de @hhu.de @fzj.bsky.social
"DNA-intercalating antiphage molecules trigger abortive infection through mutual destruction and synergize with bacterial immunity"
www.biorxiv.org/content/10.6...
@spp2330.bsky.social, @mibinet.bsky.social, @dfg.de @hhu.de @fzj.bsky.social
Reposted by Milan Gerovac
Reposted by Milan Gerovac
3′UTR-derived small RNA couples acid resistance to metabolic reprogramming of Salmonella within macrophages url: academic.oup.com/nar/article/...
3′UTR-derived small RNA couples acid resistance to metabolic reprogramming of Salmonella within macrophages
Abstract. Acid resistance is crucial for enterobacteria to withstand host acidic environments during infection, including the gastrointestinal tract and ma
academic.oup.com
January 7, 2026 at 8:19 AM
3′UTR-derived small RNA couples acid resistance to metabolic reprogramming of Salmonella within macrophages url: academic.oup.com/nar/article/...
Phages go persistent, what does it mean for phage therapy and how can this special feature be leveraged? Take a look at the work of @emggroupucph.bsky.social, to which we contributed @helmholtzhzi.bsky.social:
www.nature.com/articles/s41...
N&V www.nature.com/articles/s41...
www.nature.com/articles/s41...
N&V www.nature.com/articles/s41...
January 5, 2026 at 7:18 PM
Phages go persistent, what does it mean for phage therapy and how can this special feature be leveraged? Take a look at the work of @emggroupucph.bsky.social, to which we contributed @helmholtzhzi.bsky.social:
www.nature.com/articles/s41...
N&V www.nature.com/articles/s41...
www.nature.com/articles/s41...
N&V www.nature.com/articles/s41...
Reposted by Milan Gerovac
Bakterielle Infektionen können uns krank machen oder sogar zum Tod führen. Zudem wirken Antibiotika durch zunehmende Resistenzen immer schlechter.
@quarkswdr.bsky.social zeigt, wie rasant sich Bakterien vermehren & welche Rolle #Antibiotikaresistenzen dabei spielen. www.quarks.de/gesundheit/m...
@quarkswdr.bsky.social zeigt, wie rasant sich Bakterien vermehren & welche Rolle #Antibiotikaresistenzen dabei spielen. www.quarks.de/gesundheit/m...
Bakterien gegen Mensch: Wer wird gewinnen?
www.quarks.de
December 15, 2025 at 2:08 PM
Bakterielle Infektionen können uns krank machen oder sogar zum Tod führen. Zudem wirken Antibiotika durch zunehmende Resistenzen immer schlechter.
@quarkswdr.bsky.social zeigt, wie rasant sich Bakterien vermehren & welche Rolle #Antibiotikaresistenzen dabei spielen. www.quarks.de/gesundheit/m...
@quarkswdr.bsky.social zeigt, wie rasant sich Bakterien vermehren & welche Rolle #Antibiotikaresistenzen dabei spielen. www.quarks.de/gesundheit/m...
Reposted by Milan Gerovac
Phages are full of genes of unknown function that are likely adaptive in specific conditions.
New preprint: Phage TnSeq identifies essential genes rapidly and knocks all non-essentials. We would like to send a pool of phiKZ mutants to anyone wanting it! Reach out
tinyurl.com/bdcfrejh
New preprint: Phage TnSeq identifies essential genes rapidly and knocks all non-essentials. We would like to send a pool of phiKZ mutants to anyone wanting it! Reach out
tinyurl.com/bdcfrejh
December 8, 2025 at 3:04 PM
Phages are full of genes of unknown function that are likely adaptive in specific conditions.
New preprint: Phage TnSeq identifies essential genes rapidly and knocks all non-essentials. We would like to send a pool of phiKZ mutants to anyone wanting it! Reach out
tinyurl.com/bdcfrejh
New preprint: Phage TnSeq identifies essential genes rapidly and knocks all non-essentials. We would like to send a pool of phiKZ mutants to anyone wanting it! Reach out
tinyurl.com/bdcfrejh
Reposted by Milan Gerovac
📢 We have multiple open PhD positions to study bacterial immune systems using cutting-edge cryo-EM, microbiology, and biochemistry in our group! Join us and uncover how bacterial defenses eliminate predators and engineer next-gen biotech tools.
🔥 Apply by Jan 8, 2026
Details: phd.pages.ista.ac.at
🔥 Apply by Jan 8, 2026
Details: phd.pages.ista.ac.at
phd.pages.ista.ac.at
December 2, 2025 at 8:44 AM
📢 We have multiple open PhD positions to study bacterial immune systems using cutting-edge cryo-EM, microbiology, and biochemistry in our group! Join us and uncover how bacterial defenses eliminate predators and engineer next-gen biotech tools.
🔥 Apply by Jan 8, 2026
Details: phd.pages.ista.ac.at
🔥 Apply by Jan 8, 2026
Details: phd.pages.ista.ac.at
Reposted by Milan Gerovac
Impact of Small RNA Sponges on Regulatory RNA Networks in Bacteria
#microsky
www.annualreviews.org/content/jour...
#microsky
www.annualreviews.org/content/jour...
Impact of Small RNA Sponges on Regulatory RNA Networks in Bacteria
Decades of research into the noncoding transcriptome have unveiled a complex, multilayered web of molecular interactions that govern gene expression, protein synthesis, and cellular function, challeng...
www.annualreviews.org
November 29, 2025 at 4:12 AM
Impact of Small RNA Sponges on Regulatory RNA Networks in Bacteria
#microsky
www.annualreviews.org/content/jour...
#microsky
www.annualreviews.org/content/jour...
Reposted by Milan Gerovac
Von Biotechnologie bis Pandemiebewältigung: Heute feierten wir mit Partnern, Alumni & Gästen aus Wissenschaft, Politik & Wirtschaft #HZI60. Zu den Gratulant:innen zählten u.a. Nds. Ministerpräsident Olaf Lies, Martin Keller @helmholtz.de & Otmar D. Wiestler.
www.helmholtz-hzi.de/media-center...
www.helmholtz-hzi.de/media-center...
November 27, 2025 at 8:05 PM
Von Biotechnologie bis Pandemiebewältigung: Heute feierten wir mit Partnern, Alumni & Gästen aus Wissenschaft, Politik & Wirtschaft #HZI60. Zu den Gratulant:innen zählten u.a. Nds. Ministerpräsident Olaf Lies, Martin Keller @helmholtz.de & Otmar D. Wiestler.
www.helmholtz-hzi.de/media-center...
www.helmholtz-hzi.de/media-center...
Reposted by Milan Gerovac
Angesichts zunehmender #Antibiotikaresistenzen können #Phagen ein vielversprechender Therapieansatz sein, so @jorg-vogel-lab.bsky.social @helmholtz-hiri.bsky.social. Mehr über das Potenzial von #Bakteriophagen erfahrt ihr hier: www.helmholtz-hzi.de/media-center... #WAAW2025 #Weltantibiotikawoche
November 24, 2025 at 9:36 AM
Angesichts zunehmender #Antibiotikaresistenzen können #Phagen ein vielversprechender Therapieansatz sein, so @jorg-vogel-lab.bsky.social @helmholtz-hiri.bsky.social. Mehr über das Potenzial von #Bakteriophagen erfahrt ihr hier: www.helmholtz-hzi.de/media-center... #WAAW2025 #Weltantibiotikawoche
Reposted by Milan Gerovac
The HZI is seeking new junior group leaders for its HUMAN program: If you’re passionate about infection biology, data science, or #AI driven health research, this is your chance to lead your own team.
🧬 Deadline: November 26
www.helmholtz-hzi.de/en/career/jo...
www.helmholtz-hzi.de/en/career/jo...
🧬 Deadline: November 26
www.helmholtz-hzi.de/en/career/jo...
www.helmholtz-hzi.de/en/career/jo...
November 21, 2025 at 8:20 AM
The HZI is seeking new junior group leaders for its HUMAN program: If you’re passionate about infection biology, data science, or #AI driven health research, this is your chance to lead your own team.
🧬 Deadline: November 26
www.helmholtz-hzi.de/en/career/jo...
www.helmholtz-hzi.de/en/career/jo...
🧬 Deadline: November 26
www.helmholtz-hzi.de/en/career/jo...
www.helmholtz-hzi.de/en/career/jo...
Reposted by Milan Gerovac
🚨Preprint alert - this is a big one! We transfer the revolutionary power of TnSeq to bacteriophages.
Our HIDEN-SEQ links the "dark matter" genes of your favorite phage to any selectable phenotype, guiding the path from fun observations to molecular mechanisms.
A thread 1/8
Our HIDEN-SEQ links the "dark matter" genes of your favorite phage to any selectable phenotype, guiding the path from fun observations to molecular mechanisms.
A thread 1/8
November 20, 2025 at 8:40 PM
🚨Preprint alert - this is a big one! We transfer the revolutionary power of TnSeq to bacteriophages.
Our HIDEN-SEQ links the "dark matter" genes of your favorite phage to any selectable phenotype, guiding the path from fun observations to molecular mechanisms.
A thread 1/8
Our HIDEN-SEQ links the "dark matter" genes of your favorite phage to any selectable phenotype, guiding the path from fun observations to molecular mechanisms.
A thread 1/8
Reposted by Milan Gerovac
Große Phagen, kleine Phagen, Phagen aus Primatenkot... 💩Die Forschenden am @helmholtz-hiri.bsky.social, @helmholtz-hioh.bsky.social & HZI gehen in ihrer Bakteriophagen-Forschung an die Grenzen!
@jorg-vogel-lab.bsky.social @jenshoer.bsky.social @gerovac.bsky.social @jangogarten.bsky.social #WAAW2025
@jorg-vogel-lab.bsky.social @jenshoer.bsky.social @gerovac.bsky.social @jangogarten.bsky.social #WAAW2025
November 17, 2025 at 10:44 AM
Große Phagen, kleine Phagen, Phagen aus Primatenkot... 💩Die Forschenden am @helmholtz-hiri.bsky.social, @helmholtz-hioh.bsky.social & HZI gehen in ihrer Bakteriophagen-Forschung an die Grenzen!
@jorg-vogel-lab.bsky.social @jenshoer.bsky.social @gerovac.bsky.social @jangogarten.bsky.social #WAAW2025
@jorg-vogel-lab.bsky.social @jenshoer.bsky.social @gerovac.bsky.social @jangogarten.bsky.social #WAAW2025
Reposted by Milan Gerovac
Immer mehr Bakterien werden resistent & #Antibiotika stoßen an Grenzen.
Zur #Weltantibiotikawoche zeigen unsere Forschenden, dass Hoffnung in einem uralten biologischen Prinzip liegen könnte: #Bakteriophagen - #Viren, die gezielt Bakterien angreifen. #WAAW2025 www.helmholtz-hzi.de/media-center...
Zur #Weltantibiotikawoche zeigen unsere Forschenden, dass Hoffnung in einem uralten biologischen Prinzip liegen könnte: #Bakteriophagen - #Viren, die gezielt Bakterien angreifen. #WAAW2025 www.helmholtz-hzi.de/media-center...
November 17, 2025 at 10:44 AM
Immer mehr Bakterien werden resistent & #Antibiotika stoßen an Grenzen.
Zur #Weltantibiotikawoche zeigen unsere Forschenden, dass Hoffnung in einem uralten biologischen Prinzip liegen könnte: #Bakteriophagen - #Viren, die gezielt Bakterien angreifen. #WAAW2025 www.helmholtz-hzi.de/media-center...
Zur #Weltantibiotikawoche zeigen unsere Forschenden, dass Hoffnung in einem uralten biologischen Prinzip liegen könnte: #Bakteriophagen - #Viren, die gezielt Bakterien angreifen. #WAAW2025 www.helmholtz-hzi.de/media-center...
Reposted by Milan Gerovac
Can we leverage bacterial competition for targeted replacement of harmful strains? Maybe! Our recent piece in @natmicrobiol.nature.com provides a theoretical framework and a set of experiments to show what it might take: www.nature.com/articles/s41...
Strain displacement in microbiomes via ecological competition - Nature Microbiology
Mathematical modelling and experimental tests reveal principles that govern displacement of a resident strain by an invader in microbial communities.
www.nature.com
November 7, 2025 at 10:34 PM
Can we leverage bacterial competition for targeted replacement of harmful strains? Maybe! Our recent piece in @natmicrobiol.nature.com provides a theoretical framework and a set of experiments to show what it might take: www.nature.com/articles/s41...
Reposted by Milan Gerovac
After 5 years of waiting, the new #CRISPR classification by Makarova et al. is out @natmicrobiol.nature.com www.nature.com/articles/s41...
An updated evolutionary classification of CRISPR–Cas systems including rare variants - Nature Microbiology
An exploration of previously undescribed variants from the long tail of the CRISPR–Cas distribution.
www.nature.com
November 6, 2025 at 1:49 PM
After 5 years of waiting, the new #CRISPR classification by Makarova et al. is out @natmicrobiol.nature.com www.nature.com/articles/s41...
Reposted by Milan Gerovac
Growth-coupled microbial biosynthesis of the animal pigment xanthommatin — Led by Leah Bushin, featuring M. Gracia Alvan, @danielvolke.bsky.social @oscarpuiggene.bsky.social in a fantastic collaboration w/Brad Moore @labnikel.bsky.social @natbiotech.nature.com 🦑
www.nature.com/articles/s41...
www.nature.com/articles/s41...
November 3, 2025 at 12:49 PM
Growth-coupled microbial biosynthesis of the animal pigment xanthommatin — Led by Leah Bushin, featuring M. Gracia Alvan, @danielvolke.bsky.social @oscarpuiggene.bsky.social in a fantastic collaboration w/Brad Moore @labnikel.bsky.social @natbiotech.nature.com 🦑
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Use antisense oligomers to silence phage genes and discover new biology.
@jorg-vogel-lab.bsky.social @helmholtz-hiri.bsky.social @helmholtzhzi.bsky.social @uni-wuerzburg.de
print: www.nature.com/articles/s41...
highlight: www.nature.com/articles/s41...
briefing: www.nature.com/articles/d41...
@jorg-vogel-lab.bsky.social @helmholtz-hiri.bsky.social @helmholtzhzi.bsky.social @uni-wuerzburg.de
print: www.nature.com/articles/s41...
highlight: www.nature.com/articles/s41...
briefing: www.nature.com/articles/d41...
October 31, 2025 at 8:08 AM
Use antisense oligomers to silence phage genes and discover new biology.
@jorg-vogel-lab.bsky.social @helmholtz-hiri.bsky.social @helmholtzhzi.bsky.social @uni-wuerzburg.de
print: www.nature.com/articles/s41...
highlight: www.nature.com/articles/s41...
briefing: www.nature.com/articles/d41...
@jorg-vogel-lab.bsky.social @helmholtz-hiri.bsky.social @helmholtzhzi.bsky.social @uni-wuerzburg.de
print: www.nature.com/articles/s41...
highlight: www.nature.com/articles/s41...
briefing: www.nature.com/articles/d41...
Reposted by Milan Gerovac
Proud to be part of this incredible multidisciplinary team uncovering why some people are NOT infected by Salmonella. This new Wellcome Trust @wellcometrust.bsky.social funding will allow us to uncover why some people naturally resist infection and colonisation by Salmonella Typhimurium.
NEWS | Professor @jayhinton.bsky.social and an international team have been awarded £4.56M Wellcome Discovery Award to investigate natural human resistance to Salmonella
🔗 bit.ly/4hujsRG
@livuninews.bsky.social | #TeamLivUni
🔗 bit.ly/4hujsRG
@livuninews.bsky.social | #TeamLivUni
October 30, 2025 at 3:50 PM
Proud to be part of this incredible multidisciplinary team uncovering why some people are NOT infected by Salmonella. This new Wellcome Trust @wellcometrust.bsky.social funding will allow us to uncover why some people naturally resist infection and colonisation by Salmonella Typhimurium.
Reposted by Milan Gerovac
Cool work by @microberna.bsky.social & Kai Papenfort, presenting the first RNA-RNA map in C. crescentus using RIL-seq, revealing an RNA sponge that controls the transition from nutrient abundance to starvation; new insights into RNA networks and stress responses!
#RNA
www.nature.com/articles/s41...
#RNA
www.nature.com/articles/s41...
An RNA sponge directs the transition from feast to famine in Caulobacter crescentus - Nature Communications
In bacteria, many small regulatory RNAs (sRNAs) associate with the RNA chaperone Hfq to modulate gene expression at the post-transcriptional level. Here, the authors identify global Hfq-mediated RNA-R...
www.nature.com
October 30, 2025 at 1:43 PM
Cool work by @microberna.bsky.social & Kai Papenfort, presenting the first RNA-RNA map in C. crescentus using RIL-seq, revealing an RNA sponge that controls the transition from nutrient abundance to starvation; new insights into RNA networks and stress responses!
#RNA
www.nature.com/articles/s41...
#RNA
www.nature.com/articles/s41...
Reposted by Milan Gerovac
@prczhaoyansong.bsky.social’s deep dive into the dark matter of compost communities is now out 🎉 Genomic islands hijack jumbo phages—whose capsids enable transfer of large tracts of DNA—shedding new light on the scale & scope of phage-mediated gene flow 😎
www.pnas.org/doi/10.1073/...
www.pnas.org/doi/10.1073/...
Jumbo phage–mediated transduction of genomic islands | PNAS
Bacteria acquire new genes by horizontal gene transfer, typically mediated by mobile
genetic elements (MGEs). While plasmids, bacteriophages, and c...
www.pnas.org
October 29, 2025 at 7:19 AM
Reposted by Milan Gerovac
One transcript, two functions: the emerging roles of dual-function RNAs
microLIFE review by @lizmarialuke.bsky.social and Kai Papenfort at @uni-jena.de
academic.oup.com/microlife/ad...
microLIFE review by @lizmarialuke.bsky.social and Kai Papenfort at @uni-jena.de
academic.oup.com/microlife/ad...
One transcript, two functions: the emerging roles of dual-function RNAs
Abstract. Bacteria use small regulatory RNAs (sRNAs) and small proteins to change gene expression and modulate cellular processes in response to changing e
academic.oup.com
October 27, 2025 at 6:15 PM
One transcript, two functions: the emerging roles of dual-function RNAs
microLIFE review by @lizmarialuke.bsky.social and Kai Papenfort at @uni-jena.de
academic.oup.com/microlife/ad...
microLIFE review by @lizmarialuke.bsky.social and Kai Papenfort at @uni-jena.de
academic.oup.com/microlife/ad...