Sreeparna Pradhan
@sreeparnap.bsky.social
K. Lisa Yang Brain-Body Center Postdoctoral Fellow at Steve Flavell's Lab @Picower Inst, MIT | PhD from Michael Hendricks' Lab @IPN, McGill Univ | Animal behavior | Neuroscience | Open science
Pinned
Thrilled to share this in its final, published form! Huge thanks to the reviewers for their insightful feedback—it truly opened up exciting new directions!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Sreeparna Pradhan
What a gem from @dudinlab.bsky.social @gautamdey.bsky.social @centriolelab.bsky.social in Cell! Expansion microscopy atlas of >200 eukaryotes comparing cytoskeletal architectures revealing structures not seen before. Stunning visualisation! Exactly the kind of transformative cell biology we need.
October 31, 2025 at 5:45 PM
What a gem from @dudinlab.bsky.social @gautamdey.bsky.social @centriolelab.bsky.social in Cell! Expansion microscopy atlas of >200 eukaryotes comparing cytoskeletal architectures revealing structures not seen before. Stunning visualisation! Exactly the kind of transformative cell biology we need.
Reposted by Sreeparna Pradhan
Excited to share our new #biorxivpreprint:
“Sexual dimorphism in the complete connectome of the Drosophila male central nervous system” www.biorxiv.org/content/10.1...
We describe the #connectomics reconstruction and analysis of an entire adult #maleCNS #drosophila central nervous system. 1/10
“Sexual dimorphism in the complete connectome of the Drosophila male central nervous system” www.biorxiv.org/content/10.1...
We describe the #connectomics reconstruction and analysis of an entire adult #maleCNS #drosophila central nervous system. 1/10
October 15, 2025 at 4:17 PM
Excited to share our new #biorxivpreprint:
“Sexual dimorphism in the complete connectome of the Drosophila male central nervous system” www.biorxiv.org/content/10.1...
We describe the #connectomics reconstruction and analysis of an entire adult #maleCNS #drosophila central nervous system. 1/10
“Sexual dimorphism in the complete connectome of the Drosophila male central nervous system” www.biorxiv.org/content/10.1...
We describe the #connectomics reconstruction and analysis of an entire adult #maleCNS #drosophila central nervous system. 1/10
Reposted by Sreeparna Pradhan
Our group at the Allen Institute is recruiting a technician and postdoc to work on light microscopy-based connectomics. Please DM me or share with anyone you think may be interested in this NIH BRAIN CONNECTS funded project.
October 8, 2025 at 12:28 AM
Our group at the Allen Institute is recruiting a technician and postdoc to work on light microscopy-based connectomics. Please DM me or share with anyone you think may be interested in this NIH BRAIN CONNECTS funded project.
Reposted by Sreeparna Pradhan
Roseate spoonbills will splash their wings through the water as part of their beauty routine. Here's one doing so mid-splash, facing straight ahead towards the camera. I really love this shot. #birds
October 4, 2025 at 6:14 PM
Roseate spoonbills will splash their wings through the water as part of their beauty routine. Here's one doing so mid-splash, facing straight ahead towards the camera. I really love this shot. #birds
Reposted by Sreeparna Pradhan
Truly impressive number of birds migrating tonight. More than 800 MILLION birds up in the air right now❗ #BirdMigration
September 25, 2025 at 2:59 AM
Truly impressive number of birds migrating tonight. More than 800 MILLION birds up in the air right now❗ #BirdMigration
Reposted by Sreeparna Pradhan
C. elegans is a real animal and we set out to understand how it comes to have its distinctive biogeography. Its ancestral center of diversity is in the higher elevation forests of Hawaii. Its closest relatives are spread across east Asia. Did they travel from Asia? [Preprint 🧵]
September 24, 2025 at 8:33 PM
C. elegans is a real animal and we set out to understand how it comes to have its distinctive biogeography. Its ancestral center of diversity is in the higher elevation forests of Hawaii. Its closest relatives are spread across east Asia. Did they travel from Asia? [Preprint 🧵]
Reposted by Sreeparna Pradhan
Very excited to share this finding from my postdoctoral work that is now published in #ScienceAdvances. We show how the gut’s epithelium modifies enteric behaviors during nutritional adversity via distinct peptidergic signaling axes.
www.science.org/doi/10.1126/...
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www.science.org/doi/10.1126/...
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Gut epithelium modifies enteric behaviors during nutritional adversity via distinct peptidergic signaling axes
Gut epithelium modulates output from distinct enteric circuits by altering secretion of insulin and noninsulin peptides.
www.science.org
September 24, 2025 at 8:17 PM
Very excited to share this finding from my postdoctoral work that is now published in #ScienceAdvances. We show how the gut’s epithelium modifies enteric behaviors during nutritional adversity via distinct peptidergic signaling axes.
www.science.org/doi/10.1126/...
Thread ⬇️
(1/n)
www.science.org/doi/10.1126/...
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Such a "cheesy" story!
Such a delight to share our work on the evolution of a cheese rind fungus in @currentbiology.bsky.social.
This is the fantastic PhD work of @nicolasleonlouw.bsky.social and resulted from amazing collaborations, a wedding proposal(!), an undergrad course, & more!
🧵
www.cell.com/current-biol...
This is the fantastic PhD work of @nicolasleonlouw.bsky.social and resulted from amazing collaborations, a wedding proposal(!), an undergrad course, & more!
🧵
www.cell.com/current-biol...
Long-term monitoring of a North American cheese cave reveals mechanisms and consequences of fungal adaptation
Using a unique longitudinal sampling approach, Louw et al. demonstrate how a cheese-associated
Penicillium population has adapted in an artisan cheese production facility in Vermont,
USA. Adaptation i...
www.cell.com
September 16, 2025 at 6:21 PM
Such a "cheesy" story!
Reposted by Sreeparna Pradhan
Please help me to celebrate Mei Zhen, an innovator and tremendous collaborator, named to the Royal Society of Canada Academy of Science on September 4, 2025
September 6, 2025 at 5:56 PM
Please help me to celebrate Mei Zhen, an innovator and tremendous collaborator, named to the Royal Society of Canada Academy of Science on September 4, 2025
Reposted by Sreeparna Pradhan
Can't wait to read this preprint from Misha Ahrens and team. Calcium imaging in larval zebrafish, in every cell in the body! Amazing.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
August 22, 2025 at 10:21 PM
Can't wait to read this preprint from Misha Ahrens and team. Calcium imaging in larval zebrafish, in every cell in the body! Amazing.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Sreeparna Pradhan
Neuronal diversity is written in transcriptional codes 🧬. But what is the logic of these codes that define cell types and wiring patterns?
To find out we built a #scRNAseq developmental atlas of the Drosophila nerve cord and linked it to the #connectome 🪰🧠
#preprint thread ⬇️1/8
To find out we built a #scRNAseq developmental atlas of the Drosophila nerve cord and linked it to the #connectome 🪰🧠
#preprint thread ⬇️1/8
August 21, 2025 at 4:04 PM
Neuronal diversity is written in transcriptional codes 🧬. But what is the logic of these codes that define cell types and wiring patterns?
To find out we built a #scRNAseq developmental atlas of the Drosophila nerve cord and linked it to the #connectome 🪰🧠
#preprint thread ⬇️1/8
To find out we built a #scRNAseq developmental atlas of the Drosophila nerve cord and linked it to the #connectome 🪰🧠
#preprint thread ⬇️1/8
Reposted by Sreeparna Pradhan
Exciting new Ruta lab preprint by @annaryba.bsky.social et al. on the neural underpinnings of intraspecific behavioral variation: Strain variation identifies a neural substrate for behavioral evolution Drosophila
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Strain variation identifies a neural substrate for behavioral evolution in Drosophila
Sexual selection acts on heritable differences within species, driving the parallel diversification of signal production in one sex and behavioral responses in the other. This coevolution implies that...
www.biorxiv.org
August 21, 2025 at 9:43 AM
Exciting new Ruta lab preprint by @annaryba.bsky.social et al. on the neural underpinnings of intraspecific behavioral variation: Strain variation identifies a neural substrate for behavioral evolution Drosophila
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Sreeparna Pradhan
New preprint: Scientists, how many times has this happened to you? You collect all kinds of data from a camera or microscope. But then you are faced with an analysis pipeline that threatens to take 100x longer than collecting the data did!
August 20, 2025 at 4:58 PM
New preprint: Scientists, how many times has this happened to you? You collect all kinds of data from a camera or microscope. But then you are faced with an analysis pipeline that threatens to take 100x longer than collecting the data did!
Reposted by Sreeparna Pradhan
The pipeline is hardware-agnostic, scales to system capabilities, and will improve along with the underlying foundation models. Very little fine tuning is required to tailor it to a large range of use cases.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Large vision model framework for automated C. elegans analysis: From static morphometry to dynamic neural activity
Quantitative phenotyping of Caenorhabditis elegans is essential across numerous fields, yet data extraction remains a significant analytical bottleneck. Traditional segmentation methods, typically rel...
www.biorxiv.org
August 20, 2025 at 4:58 PM
The pipeline is hardware-agnostic, scales to system capabilities, and will improve along with the underlying foundation models. Very little fine tuning is required to tailor it to a large range of use cases.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Sreeparna Pradhan
The funds are approved! We're hiring a postdoc to build a CRISPRa toolkit to identify new aging mechanisms in C. elegans.
Email or DM me to find out more. Please share & repost!
Email or DM me to find out more. Please share & repost!
a man in a suit has a name tag on his jacket that says dennis
Alt: a man in a suit has a name tag on his jacket that says dennis
media.tenor.com
August 13, 2025 at 6:36 PM
The funds are approved! We're hiring a postdoc to build a CRISPRa toolkit to identify new aging mechanisms in C. elegans.
Email or DM me to find out more. Please share & repost!
Email or DM me to find out more. Please share & repost!
Reposted by Sreeparna Pradhan
Happy to share our publication - Comparative connectomics of two distantly related nematode species reveals patterns of nervous system evolution www.science.org/doi/10.1126/...
Comparative connectomics of two distantly related nematode species reveals patterns of nervous system evolution
Understanding the evolution of the bilaterian brain requires a detailed exploration of the precise nature of cellular and subcellular differences between related species. We undertook an electron micr...
www.science.org
July 31, 2025 at 6:42 PM
Happy to share our publication - Comparative connectomics of two distantly related nematode species reveals patterns of nervous system evolution www.science.org/doi/10.1126/...
Reposted by Sreeparna Pradhan
Happy 107th Birthday, Brenda Milner! Her contributions to neuropsychology shaped the way we understand the human brain. From surviving two world wars and two pandemics, to paving the way for future generations of researchers, Milner’s legacy continues. @mcgill.ca @cusm-muhc.bsky.social
July 15, 2025 at 2:05 PM
Happy 107th Birthday, Brenda Milner! Her contributions to neuropsychology shaped the way we understand the human brain. From surviving two world wars and two pandemics, to paving the way for future generations of researchers, Milner’s legacy continues. @mcgill.ca @cusm-muhc.bsky.social
Reposted by Sreeparna Pradhan
Hard to remember that just 12 years ago there was no @biorxivpreprint.bsky.social and almost no one in the biology community preprinted their work. What a long way we’ve come. @reinierprosee.bsky.social and I wrote a thing about how @biologists.bsky.social embraced the preprint world
Staying ahead of the curve: a decade of preprints in biology
When Cold Spring Harbor Laboratory announced the launch of bioRxiv in November 2013, only the braver or more radical amongst us would have predicted that it heralded a lasting change within the scienc...
journals.biologists.com
July 1, 2025 at 6:41 PM
Hard to remember that just 12 years ago there was no @biorxivpreprint.bsky.social and almost no one in the biology community preprinted their work. What a long way we’ve come. @reinierprosee.bsky.social and I wrote a thing about how @biologists.bsky.social embraced the preprint world
Reposted by Sreeparna Pradhan
C. elegans enthusiasts - join me and @stern-lab.bsky.social for a pre #worm25 meeting online workshop on *Monitoring inter-individual diversity across multiple levels and timescales* - Jun 26, 2025 12:30 PM Eastern Time
us06web.zoom.us/j/8544967372...
please share!
us06web.zoom.us/j/8544967372...
please share!
Join our Cloud HD Video Meeting
Zoom is the leader in modern enterprise cloud communications.
us06web.zoom.us
June 25, 2025 at 8:19 AM
C. elegans enthusiasts - join me and @stern-lab.bsky.social for a pre #worm25 meeting online workshop on *Monitoring inter-individual diversity across multiple levels and timescales* - Jun 26, 2025 12:30 PM Eastern Time
us06web.zoom.us/j/8544967372...
please share!
us06web.zoom.us/j/8544967372...
please share!
Reposted by Sreeparna Pradhan
I will be opening my new lab in September at UBC! if you’re coming to #Worm25 and are looking for graduate studies or a postdoc position, let’s meet! Vancouver + worms = perfect vibes. www.zoology.ubc.ca/~yeecs/labsi... Please share! 🙌
June 25, 2025 at 1:48 PM
I will be opening my new lab in September at UBC! if you’re coming to #Worm25 and are looking for graduate studies or a postdoc position, let’s meet! Vancouver + worms = perfect vibes. www.zoology.ubc.ca/~yeecs/labsi... Please share! 🙌
Reposted by Sreeparna Pradhan
This is so cool - octopus can sense microbiomes: sending a gift link www.nytimes.com/2025/06/17/s...
Eight Arms to Taste Your Microbiome
www.nytimes.com
June 19, 2025 at 5:45 PM
This is so cool - octopus can sense microbiomes: sending a gift link www.nytimes.com/2025/06/17/s...
Reposted by Sreeparna Pradhan
Happy to present a single cell atlas of ALL glia, in BOTH sexes of an animal (in vivo validated!)! Fab work by postdoc @glia-maria.bsky.social, team, & collaboration with @manusetty.bsky.social . Find insights into glia, new analytics and ML models, and browse our companion website (wormglia.org)
React App
Web site created using create-react-app
wormglia.org
June 16, 2025 at 9:16 PM
Happy to present a single cell atlas of ALL glia, in BOTH sexes of an animal (in vivo validated!)! Fab work by postdoc @glia-maria.bsky.social, team, & collaboration with @manusetty.bsky.social . Find insights into glia, new analytics and ML models, and browse our companion website (wormglia.org)
Reposted by Sreeparna Pradhan
Reposted by Sreeparna Pradhan
In 1975 "Bohemian Rhapsody" and "Space Oddity" were on the UK top 100, and Ward, Thomson, White, and Brenner published the first reconstruction of the C. elegans sensory anatomy.
A short 50 years later, we reconstructed the same neurons and glia in the embryo:
doi.org/10.1101/2025...
A short 50 years later, we reconstructed the same neurons and glia in the embryo:
doi.org/10.1101/2025...
June 9, 2025 at 11:11 AM
In 1975 "Bohemian Rhapsody" and "Space Oddity" were on the UK top 100, and Ward, Thomson, White, and Brenner published the first reconstruction of the C. elegans sensory anatomy.
A short 50 years later, we reconstructed the same neurons and glia in the embryo:
doi.org/10.1101/2025...
A short 50 years later, we reconstructed the same neurons and glia in the embryo:
doi.org/10.1101/2025...
Reposted by Sreeparna Pradhan
Move over, starling murmurations. There’s a slimier, squirmier collective behavior in town. It's a living, twisting tower of worms.
Everybody, meet the wormuration 🪱🪱
Latest paper by Daniela Perez, Serena Ding and team @uni-konstanz.de
Paper: doi.org/10.1016/j.cu...
youtube.com/shorts/F8QVc...
Everybody, meet the wormuration 🪱🪱
Latest paper by Daniela Perez, Serena Ding and team @uni-konstanz.de
Paper: doi.org/10.1016/j.cu...
youtube.com/shorts/F8QVc...
Have you ever seen a worm tower?
YouTube video by Max Planck Institute of Animal Behavior
youtube.com
June 5, 2025 at 3:22 PM
Move over, starling murmurations. There’s a slimier, squirmier collective behavior in town. It's a living, twisting tower of worms.
Everybody, meet the wormuration 🪱🪱
Latest paper by Daniela Perez, Serena Ding and team @uni-konstanz.de
Paper: doi.org/10.1016/j.cu...
youtube.com/shorts/F8QVc...
Everybody, meet the wormuration 🪱🪱
Latest paper by Daniela Perez, Serena Ding and team @uni-konstanz.de
Paper: doi.org/10.1016/j.cu...
youtube.com/shorts/F8QVc...