Simon Gates
@sim0ngates.bsky.social
I have no need of that hypothesis.
Reposted by Simon Gates
So @jamesheathers.bsky.social & I answer the burning question: does Cake cause Herpes? No, but one can torture the data to give that impression, and that's a problem. Promiscuous dichotomisation in biomedical science hugely increases spurious findings, best avoided
link.springer.com/article/10.1...
link.springer.com/article/10.1...
November 13, 2025 at 12:42 PM
So @jamesheathers.bsky.social & I answer the burning question: does Cake cause Herpes? No, but one can torture the data to give that impression, and that's a problem. Promiscuous dichotomisation in biomedical science hugely increases spurious findings, best avoided
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Reposted by Simon Gates
"Seizing Brexit opportunities to deregulate" was mostly unspecified magic fairy pixie bullshit then, and it's not going to get any more realistic in the hands of a bunch of Reform clowns who don't know how anything works, don't care to learn and disdain anyone that might.
November 8, 2025 at 9:18 AM
"Seizing Brexit opportunities to deregulate" was mostly unspecified magic fairy pixie bullshit then, and it's not going to get any more realistic in the hands of a bunch of Reform clowns who don't know how anything works, don't care to learn and disdain anyone that might.
Not sure about the "acting like"
Trump is acting like a dictator, who has no meaningful constraints "If he decides if it is appropriate" to attack the people he was elected to serve. www.nytimes.com/2025/10/28/u...
Trump Says He Is Prepared to Send ‘More Than the National Guard’ Into U.S. Cities
www.nytimes.com
October 28, 2025 at 10:50 PM
Not sure about the "acting like"
Reposted by Simon Gates
📝 New Research Methods & Reporting article: Covariate adjustment in cluster randomised trials 📝
A practical guide for when and how to adjust for covariates. Read more ⬇️
www.bmj.com/content/391/...
A practical guide for when and how to adjust for covariates. Read more ⬇️
www.bmj.com/content/391/...
October 27, 2025 at 9:25 AM
📝 New Research Methods & Reporting article: Covariate adjustment in cluster randomised trials 📝
A practical guide for when and how to adjust for covariates. Read more ⬇️
www.bmj.com/content/391/...
A practical guide for when and how to adjust for covariates. Read more ⬇️
www.bmj.com/content/391/...
Reposted by Simon Gates
On Wed, Dec 10 I am offering a comprehensive introduction to Bayesian regression modeling, with exercises in both RStan and PyStan, at a steep discount in an effort to raise funds for World Central Kitchen and United Farm Workers. For registration details see betanalpha.github.io/courses/.
Courses
betanalpha.github.io
October 27, 2025 at 12:33 PM
On Wed, Dec 10 I am offering a comprehensive introduction to Bayesian regression modeling, with exercises in both RStan and PyStan, at a steep discount in an effort to raise funds for World Central Kitchen and United Farm Workers. For registration details see betanalpha.github.io/courses/.
Reposted by Simon Gates
Five-year survival rates might be the most misleading statistics in medicine.
Even smart people can make incorrect inferences. Here are the top four:
1. If a patient is diagnosed early, it is tempting to think the probability is 91% that they will survive five years after diagnosis.
Even smart people can make incorrect inferences. Here are the top four:
1. If a patient is diagnosed early, it is tempting to think the probability is 91% that they will survive five years after diagnosis.
October 27, 2025 at 1:58 PM
Five-year survival rates might be the most misleading statistics in medicine.
Even smart people can make incorrect inferences. Here are the top four:
1. If a patient is diagnosed early, it is tempting to think the probability is 91% that they will survive five years after diagnosis.
Even smart people can make incorrect inferences. Here are the top four:
1. If a patient is diagnosed early, it is tempting to think the probability is 91% that they will survive five years after diagnosis.
Reposted by Simon Gates
🚨 Recruitment to the TMRP's Doctoral Training Partnership PhD Studentship programme 2026 is now open
This is great scheme - don't miss out on your chance to apply.
See mrctmrpdtp.com/current-oppo... for all opportunities.
#TMRP #ClinicalTrials #PhDStudentship #TrialMethodology #UKCTUNetwork
This is great scheme - don't miss out on your chance to apply.
See mrctmrpdtp.com/current-oppo... for all opportunities.
#TMRP #ClinicalTrials #PhDStudentship #TrialMethodology #UKCTUNetwork
Current Opportunities
We have an iCASE studentship available to start for the 2025/2026 academic year, and applications to our fifth round of recruitment to our DTP to start in October 2026 are now also open. Please see…
mrctmrpdtp.com
October 24, 2025 at 11:31 AM
🚨 Recruitment to the TMRP's Doctoral Training Partnership PhD Studentship programme 2026 is now open
This is great scheme - don't miss out on your chance to apply.
See mrctmrpdtp.com/current-oppo... for all opportunities.
#TMRP #ClinicalTrials #PhDStudentship #TrialMethodology #UKCTUNetwork
This is great scheme - don't miss out on your chance to apply.
See mrctmrpdtp.com/current-oppo... for all opportunities.
#TMRP #ClinicalTrials #PhDStudentship #TrialMethodology #UKCTUNetwork
Reposted by Simon Gates
Join us for Professor Paula Williamson's webinar: 'Decarbonising the healthcare, social care and research systems' on Thursday 11 December 2025 13:00 - 14:00. Register free here www.hrb-tmrn.ie/training-edu... @hrb-tmrn.bsky.social
October 22, 2025 at 10:03 AM
Join us for Professor Paula Williamson's webinar: 'Decarbonising the healthcare, social care and research systems' on Thursday 11 December 2025 13:00 - 14:00. Register free here www.hrb-tmrn.ie/training-edu... @hrb-tmrn.bsky.social
This is excellent.
Wellcome seem to have lost their minds a bit here.
Wellcome seem to have lost their minds a bit here.
New blogpost on my concerns about Wellcome LEAP new $50m program on autism/microbiome links. deevybee.blogspot.com/2025/10/a-le...
#autism #microbiome #biomarkers #diagnostic
#autism #microbiome #biomarkers #diagnostic
A LEAP into the future, or off a cliff: Wellcome LEAP's new $50M program
A few days ago, I saw this post on LinkedIn: How does the gut microbiome shape early brain development? That’s what FORM, a new $50 million...
deevybee.blogspot.com
October 21, 2025 at 8:49 AM
This is excellent.
Wellcome seem to have lost their minds a bit here.
Wellcome seem to have lost their minds a bit here.
Reposted by Simon Gates
Which reminds me, it's that time of year again for National Trust members to vote. The easiest way is to use the 'quick vote' to keep out the traditionalist 'Restore Trust' candidates. secure.cesvotes.com/V3-3-0/nt25/...
1/2
1/2
September 8, 2025 at 2:42 PM
Which reminds me, it's that time of year again for National Trust members to vote. The easiest way is to use the 'quick vote' to keep out the traditionalist 'Restore Trust' candidates. secure.cesvotes.com/V3-3-0/nt25/...
1/2
1/2
It's happening
👉Also Sorbonne bsky.app/profile/sorb... pulled out of 'THE' University Ranking 👇
Important step in times of massive, systematic gaming by Universities, being a main incentive for Hyperprolific Publishing, Citation Cartels, Paper Mills & Junk Science!
#researchintegrity, #Chemsky, #CompChemSky
Important step in times of massive, systematic gaming by Universities, being a main incentive for Hyperprolific Publishing, Citation Cartels, Paper Mills & Junk Science!
#researchintegrity, #Chemsky, #CompChemSky
Why Sorbonne pulled out of university ranking
France’s Sorbonne University plans to leave the Times Higher Education (THE) Rankings, adding its name to a growing number of universities rejecting lists that play one institution off against another...
sciencebusiness.net
October 19, 2025 at 7:58 AM
It's happening
Reposted by Simon Gates
Since I'm about to head out to DC's No Kings protest, here's a quick look at America's ORIGINAL No Kings movement, and a review of how many of George III's crimes outlined in the Declaration have been repeated by Trump. juliansanchez.substack.com/p/trump-vs-g...
Trump vs. George III: A No Kings Comparison
Our own mad king is repeating many of his predecessors' greatest hits
juliansanchez.substack.com
October 18, 2025 at 3:21 PM
Since I'm about to head out to DC's No Kings protest, here's a quick look at America's ORIGINAL No Kings movement, and a review of how many of George III's crimes outlined in the Declaration have been repeated by Trump. juliansanchez.substack.com/p/trump-vs-g...
Reposted by Simon Gates
I will bet my bike that close to zero of the British racists that this law is pandering to could pass A-level English.
Migrants will be required to pass A Level standard of English
Migrants will be required to pass tough new English language requirements under a law introduced in Parliament today.
www.gov.uk
October 14, 2025 at 6:03 PM
I will bet my bike that close to zero of the British racists that this law is pandering to could pass A-level English.
But the media love it as it saves them doing any actual work.
Private Eye offers up an excellently scornful commentary on the relentless polling. It’s become ridiculous and has oversimplified our politics to dangerous levels of stupid and irresponsible.
October 10, 2025 at 7:34 AM
But the media love it as it saves them doing any actual work.
Reposted by Simon Gates
Free stickers suitable for flag-bearing lampposts. Send a large A4 envelope with a 1st class large stamp to me at Bragg Office, PO Box 6830 Bridport DT6 9BH and I’ll send you a sheet. #ReclaimtheFlag 🏴🏴🏴🇬🇧
October 5, 2025 at 3:57 PM
Free stickers suitable for flag-bearing lampposts. Send a large A4 envelope with a 1st class large stamp to me at Bragg Office, PO Box 6830 Bridport DT6 9BH and I’ll send you a sheet. #ReclaimtheFlag 🏴🏴🏴🇬🇧
Reposted by Simon Gates
Reform’s Russia connections are a danger to our national security.
It’s time for a public inquiry.
It’s time for a public inquiry.
Nathan Gill’s treachery puts him in same league as the “Cambridge Five”
Reform’s Russia connections may endanger our security – time for a public inquiry
bylines.scot
October 1, 2025 at 5:20 AM
Reform’s Russia connections are a danger to our national security.
It’s time for a public inquiry.
It’s time for a public inquiry.
Reposted by Simon Gates
Flexible Goal-Drive Bayesian Design - video of presentation is now available at www.fharrell.com/talk/gdesign/ #Statistics #StatsSky #bayes #rct
Goal-Driven Flexible Bayesian Design – Statistical Thinking
The majority of clinicals trials that are successfully launched end with equivocal results, with confidence intervals that are too wide to allow drawing a conclusion other than “the money was spent”. ...
www.fharrell.com
September 30, 2025 at 2:12 PM
Flexible Goal-Drive Bayesian Design - video of presentation is now available at www.fharrell.com/talk/gdesign/ #Statistics #StatsSky #bayes #rct
Reposted by Simon Gates
Read more about RCTs and why they’re so important: ourworldindata.org/randomized-c...
Why randomized controlled trials matter and the procedures that strengthen them
Randomized controlled trials are a key tool to study cause and effect. Why do they matter and how do they work?
ourworldindata.org
September 24, 2025 at 2:15 PM
Read more about RCTs and why they’re so important: ourworldindata.org/randomized-c...
Reposted by Simon Gates
This is from @bmj.com from 24 years ago, for goodness sake (it was countering Wakefield’s anti-vaxx nonsense)
RFK Jr, Trump and the MDs at the press conference today who are their anti-vaxx lackeys—Drs Oz, Bhattacharya, & Makary—are playing such a dangerous game 😢
RFK Jr, Trump and the MDs at the press conference today who are their anti-vaxx lackeys—Drs Oz, Bhattacharya, & Makary—are playing such a dangerous game 😢
September 23, 2025 at 1:01 AM
This is from @bmj.com from 24 years ago, for goodness sake (it was countering Wakefield’s anti-vaxx nonsense)
RFK Jr, Trump and the MDs at the press conference today who are their anti-vaxx lackeys—Drs Oz, Bhattacharya, & Makary—are playing such a dangerous game 😢
RFK Jr, Trump and the MDs at the press conference today who are their anti-vaxx lackeys—Drs Oz, Bhattacharya, & Makary—are playing such a dangerous game 😢
Trump channelling Andrew Wakefield.
Trump: "The MMR I think should be taken separately. This is based on what I feel."
September 23, 2025 at 6:23 AM
Trump channelling Andrew Wakefield.
Reposted by Simon Gates
Reposted by Simon Gates
The use of Bayesian methods in the design of trials and the analysis of the findings provides several potential benefits, which may be particularly applicable in Trauma & Orthopaedic surgery.
#ClinicalTrials #BayesianStatistics #RCTs #OrthoSky
@docfarrow.bsky.social
ow.ly/xeXm50WRwZN
#ClinicalTrials #BayesianStatistics #RCTs #OrthoSky
@docfarrow.bsky.social
ow.ly/xeXm50WRwZN
September 10, 2025 at 4:24 PM
The use of Bayesian methods in the design of trials and the analysis of the findings provides several potential benefits, which may be particularly applicable in Trauma & Orthopaedic surgery.
#ClinicalTrials #BayesianStatistics #RCTs #OrthoSky
@docfarrow.bsky.social
ow.ly/xeXm50WRwZN
#ClinicalTrials #BayesianStatistics #RCTs #OrthoSky
@docfarrow.bsky.social
ow.ly/xeXm50WRwZN
Reposted by Simon Gates
Join us at #atmc25 as we explore "Better Trials Through Better Methods"
Invited speakers and program details now available - more at www.atmc25.com
Secure your ticket today! Early🐦 must end 26/9
Invited speakers and program details now available - more at www.atmc25.com
Secure your ticket today! Early🐦 must end 26/9
September 10, 2025 at 3:58 AM
Join us at #atmc25 as we explore "Better Trials Through Better Methods"
Invited speakers and program details now available - more at www.atmc25.com
Secure your ticket today! Early🐦 must end 26/9
Invited speakers and program details now available - more at www.atmc25.com
Secure your ticket today! Early🐦 must end 26/9
Reposted by Simon Gates
I confused some people recently when I talked about executive function, so I wrote an entire post on the topic.
blog.genesmindsmachines.com/p/what-is-ex...
blog.genesmindsmachines.com/p/what-is-ex...
What is executive function?
In a recent post about the abilities and personality traits required to complete a PhD program, I mentioned the concept of executive function. From some of the responses I received, I gather that it’s...
blog.genesmindsmachines.com
September 8, 2025 at 6:58 PM
I confused some people recently when I talked about executive function, so I wrote an entire post on the topic.
blog.genesmindsmachines.com/p/what-is-ex...
blog.genesmindsmachines.com/p/what-is-ex...