That's certainly one option. Another (maybe simpler) is to use much more informative outcomes than dichotomised responses and time to first event.

Single arm trials all the way down!

Couple of quick responses - yes rate diseases are a BIG problem as it's really hard to do trials in a conventional way because of the lack of numbers. But that's not an excuse to allow sloppy thinking and inadequate research

"Seizing Brexit opportunities to deregulate" was mostly unspecified magic fairy pixie bullshit then, and it's not going to get any more realistic in the hands of a bunch of Reform clowns who don't know how anything works, don't care to learn and disdain anyone that might.

While I'm here... your desire to give patients your favourite treatment is not a research question

@beatrizgoulao.bsky.social
might be a good contact here.

And of course lots of hospitals are in locations that aren't easy to reach by public transport.
This sort of exploitation seems to have been completely normalised.

Absolutely! The whole idea of employers charging their "valued" staff to come to work is insane. Worst example in UK is hospitals, where doctors and nurses and everyone else are expected to pay through the nose for a parking permit.

IS THAT IT?
Pathetic.