Frank Harrell
@f2harrell.bsky.social
Professor of Biostatistics
Vanderbilt University School of Medicine
Expert Biostatistics Advisor
FDA Center for Drug Evaluation and Research
https://hbiostat.org https://fharrell.com
Vanderbilt University School of Medicine
Expert Biostatistics Advisor
FDA Center for Drug Evaluation and Research
https://hbiostat.org https://fharrell.com
Reposted by Frank Harrell
we need to talk about that Ring Super Bowl ad
February 10, 2026 at 8:18 PM
we need to talk about that Ring Super Bowl ad
Reposted by Frank Harrell
Weekend reads: Largest leucovorin-autism trial retracted; a paper mill detector for cancer research articles; infant opioid poisoning report flagged
Weekend reads: Largest leucovorin-autism trial retracted; a paper mill detector for cancer research articles; infant opioid poisoning report flagged
If your week flew by — we know ours did — catch up here with what you might have missed. The week at Retraction Watch featured: Spanish court rules researcher plagiarized colleague, orders withdraw…
retractionwatch.com
February 7, 2026 at 1:22 PM
Weekend reads: Largest leucovorin-autism trial retracted; a paper mill detector for cancer research articles; infant opioid poisoning report flagged
Reposted by Frank Harrell
#statstab #479 Different ways of calculating OLS regression coefficients (in R)
Thoughts: The are many ways to skin a variable...
#rstats #regression #modelling #tutorial #r #glm #ols #coding
thomvolker.github.io/blog/2506_re...
Thoughts: The are many ways to skin a variable...
#rstats #regression #modelling #tutorial #r #glm #ols #coding
thomvolker.github.io/blog/2506_re...
Different ways of calculating OLS regression coefficients (in R) – Thom Volker
Many different ways of calculating OLS regression coefficients exist, but some ways are more efficient than others. In this post we discuss some of the most common ways of calculating OLS regression c...
thomvolker.github.io
February 5, 2026 at 8:16 PM
#statstab #479 Different ways of calculating OLS regression coefficients (in R)
Thoughts: The are many ways to skin a variable...
#rstats #regression #modelling #tutorial #r #glm #ols #coding
thomvolker.github.io/blog/2506_re...
Thoughts: The are many ways to skin a variable...
#rstats #regression #modelling #tutorial #r #glm #ols #coding
thomvolker.github.io/blog/2506_re...
Excellent article related to overselling of conformal prediction.
Ya im not buying into the hype either www.argmin.net/p/maybe-your...
Maybe You're Wrong
Quantiles, Prediction Intervals, and what theory can tell you about the future.
www.argmin.net
February 5, 2026 at 2:44 PM
Excellent article related to overselling of conformal prediction.
Reposted by Frank Harrell
Liam Ramos gets to meet the pilot and visit the cockpit on his flight home from the Texas ICE camp
This little boy has become an inadvertent symbol of resistance
A reminder of why we fight
What ICE did to this child was wrong.
May the kindness he receives today help heal the damage.
This little boy has become an inadvertent symbol of resistance
A reminder of why we fight
What ICE did to this child was wrong.
May the kindness he receives today help heal the damage.
February 1, 2026 at 8:32 PM
Liam Ramos gets to meet the pilot and visit the cockpit on his flight home from the Texas ICE camp
This little boy has become an inadvertent symbol of resistance
A reminder of why we fight
What ICE did to this child was wrong.
May the kindness he receives today help heal the damage.
This little boy has become an inadvertent symbol of resistance
A reminder of why we fight
What ICE did to this child was wrong.
May the kindness he receives today help heal the damage.
Reposted by Frank Harrell
Weekend reads: Did a researcher ‘Obscure a Baby’s Poisoning?’; ‘Critical social media posts linked to retractions’; arXiv ‘clamps down on AI slop’
Weekend reads: Did a researcher ‘Obscure a Baby’s Poisoning?’; ‘Critical social media posts linked to retractions’; arXiv ‘clamps down on AI slop’
If your week flew by — we know ours did — catch up here with what you might have missed. The week at Retraction Watch featured: Study is stolen, sold, published. Now the victim is accused of plagia…
retractionwatch.com
January 31, 2026 at 12:36 PM
Weekend reads: Did a researcher ‘Obscure a Baby’s Poisoning?’; ‘Critical social media posts linked to retractions’; arXiv ‘clamps down on AI slop’
Reposted by Frank Harrell
State-sponsored white supremacist terror.
MINNESOTA — Mom goes outside to warm up her car, ICE grabs her: "Please, my car kids are all alone in the house!”
So nothing has changed and Homan was just to put a new face on the cruelty, got it
(H/T longtimehistory)
So nothing has changed and Homan was just to put a new face on the cruelty, got it
(H/T longtimehistory)
January 30, 2026 at 3:25 AM
State-sponsored white supremacist terror.
Reposted by Frank Harrell
A Minnesota woman observing ICE agents in her car was cornered on one-way streets. An agent approached, called her by name—citing facial recognition. Days later, her Global Entry and TSA privileges were revoked, with no explanation.
How ICE Already Knows Who Minneapolis Protesters Are
www.nytimes.com
January 30, 2026 at 11:55 AM
A Minnesota woman observing ICE agents in her car was cornered on one-way streets. An agent approached, called her by name—citing facial recognition. Days later, her Global Entry and TSA privileges were revoked, with no explanation.
Reposted by Frank Harrell
So much of my work on overseas deployments can be boiled down to “people like you when you do nice things and aren’t a jerk.”
Non-masked MN National Guard are out handing out hot chocolate, coffee and donuts to protesters. One simple act has de-escalated the situation and helped gain the trust of people. See the difference between professional soldiers and the pretend tough guys in CBP and ICE?
January 26, 2026 at 2:14 AM
So much of my work on overseas deployments can be boiled down to “people like you when you do nice things and aren’t a jerk.”
Reposted by Frank Harrell
Judging by the poor quality of biomarker research I see reported in biomedical journals, my article "How to Do Bad Biomarker Research" must have been hugely influential: www.fharrell.com/post/badb/in... #Statistics #StatsSky #EpiSky
How to Do Bad Biomarker Research – Statistical Thinking
This article covers some of the bad statistical practices that have crept into biomarker research, including setting the bar too low for demonstrating that biomarker information is new, believing that...
www.fharrell.com
January 23, 2026 at 12:41 PM
Judging by the poor quality of biomarker research I see reported in biomedical journals, my article "How to Do Bad Biomarker Research" must have been hugely influential: www.fharrell.com/post/badb/in... #Statistics #StatsSky #EpiSky
Reposted by Frank Harrell
Dr. Gladys West, the pioneering mathematician whose work laid the foundation for modern GPS technology, has died. She was 95.
Dr. Gladys West, Mathematician Whose Work Made GPS Possible, Dies at 95
ALEXANDRIA, VA — Dr. Gladys West, the pioneering mathematician whose work laid the foundation for modern GPS technology, has died. She passed away
thezebra.org
January 19, 2026 at 6:00 PM
Dr. Gladys West, the pioneering mathematician whose work laid the foundation for modern GPS technology, has died. She was 95.
#Statistics thought of the day: Multiplicities have caused massive confusion. Rather than making arbitrary multiplicity adjustments, it is far more productive and interpretable to set the bar higher regarding actual assertions being made. hbiostat.org/bayes/bet/mu... #StatsSky #clinicaltrials #rct
4 Multiplicity – Introduction to Bayes for Evaluating Treatments
hbiostat.org
January 19, 2026 at 4:52 PM
#Statistics thought of the day: Multiplicities have caused massive confusion. Rather than making arbitrary multiplicity adjustments, it is far more productive and interpretable to set the bar higher regarding actual assertions being made. hbiostat.org/bayes/bet/mu... #StatsSky #clinicaltrials #rct
Reposted by Frank Harrell
DHS’ annual reports have also shown this for years. Minnesota isn’t even in the top 10. Not by a long shot.
ohss.dhs.gov/sites/defaul...
ohss.dhs.gov/sites/defaul...
January 18, 2026 at 10:49 PM
DHS’ annual reports have also shown this for years. Minnesota isn’t even in the top 10. Not by a long shot.
ohss.dhs.gov/sites/defaul...
ohss.dhs.gov/sites/defaul...
Reposted by Frank Harrell
Now more than ever, we're a two timing, back stabbing, and disloyal nation without integrity.
January 18, 2026 at 2:36 PM
Now more than ever, we're a two timing, back stabbing, and disloyal nation without integrity.
The FDA Commissioner advocating for Bayesian design and analysis is a thrill to see. www.fda.gov/news-events/... #StatsSky #Statistics #bayes #clinicaltrial #pharma #rct @fda.gov
January 15, 2026 at 1:58 PM
The FDA Commissioner advocating for Bayesian design and analysis is a thrill to see. www.fda.gov/news-events/... #StatsSky #Statistics #bayes #clinicaltrial #pharma #rct @fda.gov
FDA drugs and biologics guidance for Bayesian clinical trials is something I've been dreaming of for decades. I am thrilled that this draft has been released!! #Statistics #StatsSky #fda #clinicaltrial #bayes
This is a big deal for speeding up clinical trials, and for pediatric use after adult trials have proved successful. The @USFDA goes Bayesian.
A win for #IBD patients, and especially for kids with #IBD. @crohnsandcolitisau.bsky.social @f2harrell.bsky.social
www.fda.gov/news-events/...
A win for #IBD patients, and especially for kids with #IBD. @crohnsandcolitisau.bsky.social @f2harrell.bsky.social
www.fda.gov/news-events/...
FDA Issues Guidance on Modernizing Statistical Methods for Clinical Trials
The U.S. Food and Drug Administration today published draft guidance designed to facilitate the use of Bayesian methodologies in clinical trials of drugs and biologics, helping drug developers make be...
www.fda.gov
January 13, 2026 at 4:07 PM
FDA drugs and biologics guidance for Bayesian clinical trials is something I've been dreaming of for decades. I am thrilled that this draft has been released!! #Statistics #StatsSky #fda #clinicaltrial #bayes
I can hear Noem saying "These look like domestic terrorists."
11 January 1939 | Czech Jewish girl Věra Vohryzková was born (right).
She was deported to #Auschwitz from #Theresienstadt ghetto on 18 December 1943 with her mother Štěpánka and brother Jiří. None of them survived.
She was deported to #Auschwitz from #Theresienstadt ghetto on 18 December 1943 with her mother Štěpánka and brother Jiří. None of them survived.
January 11, 2026 at 1:49 PM
I can hear Noem saying "These look like domestic terrorists."
Reposted by Frank Harrell
A stunning, and damning, video analysis by @nytimes.com
After rewatching the video a few more times and seeing the NYT breakdown there are a few things that stand out.
First, it looks like there’s an onlooker standing *very* close to, if not directly in, the line of fire behind the vehicle. This seems exceptionally reckless.
First, it looks like there’s an onlooker standing *very* close to, if not directly in, the line of fire behind the vehicle. This seems exceptionally reckless.
Video: Videos Contradict Trump Administration Account of ICE Shooting in Minneapolis
An analysis of footage from three camera angles show that the vehicle appears to be turning away from a federal officer as he opened fire.
www.nytimes.com
January 8, 2026 at 6:11 PM
A stunning, and damning, video analysis by @nytimes.com
WTF?
"I’m going to pause here just to review: an institution that purports to be a university has told a philosophy professor he is forbidden from teaching Plato."
surreal times
dailynous.com/2026/01/06/t...
surreal times
dailynous.com/2026/01/06/t...
Texas A&M Bans Plato - Daily Nous
Drop the race and gender material from your course and the Plato readings, or teach a different course. You have a day to decide. That's a paraphrase of what Martin Peterson, professor of philosophy a...
dailynous.com
January 7, 2026 at 12:43 PM
WTF?
Highly, highly recommended for persons interested in Bayesian methods and for persons not interested in Bayesian methods who should be.
And we're live, Lecture A1 is online. Introduction to Bayesian workflow, generative models, estimands, estimators, estimates, error checking, beginnings of probability theory and Bayesian updating. www.youtube.com/watch?v=ztbY...
January 6, 2026 at 12:21 PM
Highly, highly recommended for persons interested in Bayesian methods and for persons not interested in Bayesian methods who should be.
Reposted by Frank Harrell
The website of the foundation Jalil founded, which publishes several journals, hosts conferences and offers editorial services, also referred to him as Al-Attabi until recently. But after we contacted him, the name of the foundation’s CEO and owner changed to “Mustafa Tareq Shanshool" on the site.
Dogged by retractions, Iraqi researcher and publisher uses a different name
Abduladheem Turki Jalil Researchers change the name they publish under for many reasons, most of which aren’t fodder for a Retraction Watch story. Trying to skirt a publishing ban is one that is. A…
retractionwatch.com
January 6, 2026 at 11:58 AM
The website of the foundation Jalil founded, which publishes several journals, hosts conferences and offers editorial services, also referred to him as Al-Attabi until recently. But after we contacted him, the name of the foundation’s CEO and owner changed to “Mustafa Tareq Shanshool" on the site.
Reposted by Frank Harrell
Timezones are so weird. Australia is in 2026, Canada is in 2025, and the United States is in 1939.
December 31, 2025 at 6:12 PM
Timezones are so weird. Australia is in 2026, Canada is in 2025, and the United States is in 1939.