Ruth Montgomery
@rrmsky.bsky.social
Immunologist at Yale School of Medicine
Associate Dean for Scientific Affairs @YaleMed
Innate immunity ❤️
Associate Dean for Scientific Affairs @YaleMed
Innate immunity ❤️
Solo markers were interesting but combining gene SNPs and plasma metabolite data showed predictions for severe #COVID. That's why we study the whole #SystemsImmunology #BigScience #Teamwork
Our #IMPACC research in @pnas.org helps explain why people experience #Covid_19 so differently. @joanndarce.bsky.social @naama-kanarek.bsky.social @bostonchildrens.bsky.social @harvardmed.bsky.social @meduniwien.ac.at @yalemed.bsky.social @broadinstitute.org #NIAID
pubmed.ncbi.nlm.nih.gov/41410771/
pubmed.ncbi.nlm.nih.gov/41410771/
MTHFR allele and one-carbon metabolic profile predict severity of COVID-19 - PubMed
While the public health burden of SARS-CoV-2 infection has lessened due to natural and vaccine-acquired immunity, emergence of less virulent variants, and antiviral medications, COVID-19 continues to take a significant toll. There are thousands of new hospitalizations and hundreds of deaths per week …
pubmed.ncbi.nlm.nih.gov
December 18, 2025 at 7:52 PM
Solo markers were interesting but combining gene SNPs and plasma metabolite data showed predictions for severe #COVID. That's why we study the whole #SystemsImmunology #BigScience #Teamwork
Reposted by Ruth Montgomery
Dr. Leila Denmark co-developed the pertussis (whooping cough) vaccine.
World's oldest practicing pediatrician until she retired at age 103 (after 73 yrs). At the time of her death at age 114 & 60 days, she was the 5th-oldest validated living person in the world & 3rd-oldest in the US. #WomenInSTEM
World's oldest practicing pediatrician until she retired at age 103 (after 73 yrs). At the time of her death at age 114 & 60 days, she was the 5th-oldest validated living person in the world & 3rd-oldest in the US. #WomenInSTEM
December 15, 2025 at 3:35 PM
Dr. Leila Denmark co-developed the pertussis (whooping cough) vaccine.
World's oldest practicing pediatrician until she retired at age 103 (after 73 yrs). At the time of her death at age 114 & 60 days, she was the 5th-oldest validated living person in the world & 3rd-oldest in the US. #WomenInSTEM
World's oldest practicing pediatrician until she retired at age 103 (after 73 yrs). At the time of her death at age 114 & 60 days, she was the 5th-oldest validated living person in the world & 3rd-oldest in the US. #WomenInSTEM
Reposted by Ruth Montgomery
I am excited to share our new paper @JExpMed led by our one and only #Alejandra_Aroca
December 12, 2025 at 4:40 PM
I am excited to share our new paper @JExpMed led by our one and only #Alejandra_Aroca
Reposted by Ruth Montgomery
Representative Betty McCollum (D-MN, 4th) met with AAI Councilors Gwendalyn Randolph, Steve Jameson, and CPA Chair Lauren Ehrlich! They had a great conversation about how crucial robust funding is for NIH. Thank you for the support! #AAIadvocacy
December 10, 2025 at 6:45 PM
Representative Betty McCollum (D-MN, 4th) met with AAI Councilors Gwendalyn Randolph, Steve Jameson, and CPA Chair Lauren Ehrlich! They had a great conversation about how crucial robust funding is for NIH. Thank you for the support! #AAIadvocacy
Reposted by Ruth Montgomery
AAI Councilors Donna Farber, Avery August, and Laurie Harrington had a wonderful meeting with staff from Rep. Josh Riley’s (D-NY, 19th) office, discussing the importance of NIH funding and science-based policy. #AAIadvocacy
December 10, 2025 at 5:58 PM
AAI Councilors Donna Farber, Avery August, and Laurie Harrington had a wonderful meeting with staff from Rep. Josh Riley’s (D-NY, 19th) office, discussing the importance of NIH funding and science-based policy. #AAIadvocacy
Reposted by Ruth Montgomery
The NIH grant cuts in 2025
www.nytimes.com/interactive/...
www.nytimes.com/interactive/...
December 2, 2025 at 3:16 PM
The NIH grant cuts in 2025
www.nytimes.com/interactive/...
www.nytimes.com/interactive/...
Reposted by Ruth Montgomery
Super excited for the upcoming #cellbio2025 @ascbiology.bsky.social @embo.org meeting in Philadelphia! Check out the Special President's session on "The Rising Tide of Science Denial" on Saturday at 1pm!
December 2, 2025 at 12:01 AM
Super excited for the upcoming #cellbio2025 @ascbiology.bsky.social @embo.org meeting in Philadelphia! Check out the Special President's session on "The Rising Tide of Science Denial" on Saturday at 1pm!
Reposted by Ruth Montgomery
We are proud to feature 2025 RCCN Pilot Awardees Lauren Ferrante and Kathryn Callahan in this Pilot Awardee Spotlight! Learn more about their Inter-NIA Center pilot project here: bit.ly/4izqwNF #Frailty #AgingResearch
December 1, 2025 at 6:50 PM
We are proud to feature 2025 RCCN Pilot Awardees Lauren Ferrante and Kathryn Callahan in this Pilot Awardee Spotlight! Learn more about their Inter-NIA Center pilot project here: bit.ly/4izqwNF #Frailty #AgingResearch
Reposted by Ruth Montgomery
Honored to be recognized as one of 25 Best Leaders by @usnews.com including 5 in the Health category. I look forward to meeting some extraordinary colleagues at an upcoming event in Wash DC www.usnews.com/news/leaders...
November 17, 2025 at 4:54 PM
Honored to be recognized as one of 25 Best Leaders by @usnews.com including 5 in the Health category. I look forward to meeting some extraordinary colleagues at an upcoming event in Wash DC www.usnews.com/news/leaders...
Reposted by Ruth Montgomery
The Trump admin has been targeting whistleblowers, from the #FEMA36 to the countless other patriotic public servants and scientists across NIH, CDC, NASA, and more who spoke out about the danger posed by the chaos in our federal agencies. This is an concerted, autocratic effort to silence dissent.
RFK Jr fires top NIH scientist weeks after she files whistleblower complaint
Jeanne Marrazzo’s complaint reportedly involved the Trump administration’s hostility toward vaccines
www.theguardian.com
October 3, 2025 at 3:16 PM
The Trump admin has been targeting whistleblowers, from the #FEMA36 to the countless other patriotic public servants and scientists across NIH, CDC, NASA, and more who spoke out about the danger posed by the chaos in our federal agencies. This is an concerted, autocratic effort to silence dissent.
New research from Dixit lab @yalemed.bsky.social showing nerve-associated macrophages (NAMs) decline in aging which impairs the breakdown of fat and increases inflammaging. Dixit addresses the biology of aging and intercommunication between nerves and macrophages. www.nature.com/articles/s43...
Nerve-associated macrophages control adipose homeostasis across lifespan and restrain age-related inflammation - Nature Aging
Gonzalez-Hurtado, Leveau and colleagues characterize adipose resident tissue macrophages across lifespan in mice, finding that nerve-associated macrophages, which mitigate inflammation and control lipolysis and catecholamine resistance, are lost during aging.
www.nature.com
October 3, 2025 at 1:26 PM
New research from Dixit lab @yalemed.bsky.social showing nerve-associated macrophages (NAMs) decline in aging which impairs the breakdown of fat and increases inflammaging. Dixit addresses the biology of aging and intercommunication between nerves and macrophages. www.nature.com/articles/s43...
Reposted by Ruth Montgomery
Taliban Bans Books by Women in Afghanistan’s Universities www.nytimes.com/2025/09/19/w...
Taliban Bans Books by Women in Afghanistan’s Universities
www.nytimes.com
September 19, 2025 at 6:14 PM
Taliban Bans Books by Women in Afghanistan’s Universities www.nytimes.com/2025/09/19/w...
Congratulations to our outstanding @yalemed.bsky.social colleague @virusesimmunity.bsky.social
🎉 Congratulations to HHMI Investigators Clifford Brangwynne and Akiko Iwasaki, the two winners of the 30th annual Keio Medical Science Prize. This international prize, awarded by Keio University in Tokyo, honors scientists who have made major contributions to the fields of medical or life sciences.
September 20, 2025 at 3:26 PM
Congratulations to our outstanding @yalemed.bsky.social colleague @virusesimmunity.bsky.social
Count on #macrophages to promote health! Congratulations to my @yalemed.bsky.social colleagues for this very novel paper.
Discovery of a new type of immune cell in fat tissue that promotes infllammaging (chronic inflammation with aging)
www.nature.com/articles/d41...
www.nature.com/articles/s43...
www.nature.com/articles/d41...
www.nature.com/articles/s43...
Nerve-associated macrophages control adipose homeostasis across lifespan and restrain age-related inflammation - Nature Aging
Gonzalez-Hurtado, Leveau and colleagues characterize adipose resident tissue macrophages across lifespan in mice, finding that nerve-associated macrophages, which mitigate inflammation and control lip...
www.nature.com
September 4, 2025 at 6:07 PM
Count on #macrophages to promote health! Congratulations to my @yalemed.bsky.social colleagues for this very novel paper.
Reposted by Ruth Montgomery
mRNA technologies: Unlimited potential to improve human health. I spoke with the fantastic Erin Shumaker at POLITICO to discuss this topic and its applications to cancer, autoimmunity and beyond.
@erinlschumaker.bsky.social
@politico.com
@cornertx
#mRNA #Cancer
politi.co/3VjfRvu
@erinlschumaker.bsky.social
@politico.com
@cornertx
#mRNA #Cancer
politi.co/3VjfRvu
Losing the mRNA arms race
politi.co
August 23, 2025 at 1:46 PM
mRNA technologies: Unlimited potential to improve human health. I spoke with the fantastic Erin Shumaker at POLITICO to discuss this topic and its applications to cancer, autoimmunity and beyond.
@erinlschumaker.bsky.social
@politico.com
@cornertx
#mRNA #Cancer
politi.co/3VjfRvu
@erinlschumaker.bsky.social
@politico.com
@cornertx
#mRNA #Cancer
politi.co/3VjfRvu
Reposted by Ruth Montgomery
#Resource
Proteomic characterization of varicella-zoster virus–host protein interactions and infection-induced changes in a neuronal cell line identifies potential targets for drug discovery and molecular insights into severe disease.
#MicroSky
www.nature.com/articles/s41...
Proteomic characterization of varicella-zoster virus–host protein interactions and infection-induced changes in a neuronal cell line identifies potential targets for drug discovery and molecular insights into severe disease.
#MicroSky
www.nature.com/articles/s41...
Multi-proteomic profiling of the varicella-zoster virus–host interface reveals host susceptibilities to severe infection - Nature Microbiology
Proteomic characterization of varicella-zoster virus–host protein interactions and infection-induced changes in a neuronal cell line identifies potential targets for drug discovery and molecular insig...
www.nature.com
August 1, 2025 at 2:09 PM
#Resource
Proteomic characterization of varicella-zoster virus–host protein interactions and infection-induced changes in a neuronal cell line identifies potential targets for drug discovery and molecular insights into severe disease.
#MicroSky
www.nature.com/articles/s41...
Proteomic characterization of varicella-zoster virus–host protein interactions and infection-induced changes in a neuronal cell line identifies potential targets for drug discovery and molecular insights into severe disease.
#MicroSky
www.nature.com/articles/s41...
Reposted by Ruth Montgomery
Come get your curated #immune #assays from 1,000s of human subjects at our website
immunespace.org
🧪 #immunology #IDSky #ImmuneSky
immunespace.org/query/filters
giphy.com/gifs/Giflyti...
immunespace.org
🧪 #immunology #IDSky #ImmuneSky
immunespace.org/query/filters
giphy.com/gifs/Giflyti...
Analyze Lucky Charms GIF by Giflytics - Find & Share on GIPHY
Discover & share this Analyze Lucky Charms GIF by Giflytics with everyone you know. GIPHY is how you search, share, discover, and create GIFs.
giphy.com
August 6, 2025 at 10:32 PM
Come get your curated #immune #assays from 1,000s of human subjects at our website
immunespace.org
🧪 #immunology #IDSky #ImmuneSky
immunespace.org/query/filters
giphy.com/gifs/Giflyti...
immunespace.org
🧪 #immunology #IDSky #ImmuneSky
immunespace.org/query/filters
giphy.com/gifs/Giflyti...
Reposted by Ruth Montgomery
On Aug. 1, ASM & partner societies filed an expanded amicus brief with SCOTUS to defend scientific integrity & protect early-career researchers. The brief highlights the harm caused by NIH grant terminations, including canceling the MOSAIC program. asm.org/press-releas...
Scientific Societies File Supreme Court Amicus Brief in Support of NIH Grantees
ASM and fellow societies filed an amicus brief with the Supreme Court, calling for the swift restoration of NIH grant funding supporting early-career scientists, such as the MOSAIC program.
asm.org
August 4, 2025 at 9:23 PM
On Aug. 1, ASM & partner societies filed an expanded amicus brief with SCOTUS to defend scientific integrity & protect early-career researchers. The brief highlights the harm caused by NIH grant terminations, including canceling the MOSAIC program. asm.org/press-releas...
Reposted by Ruth Montgomery
The NIH budget will INCREASE by $400 million — not slashed by 40%, as Trump proposed — according to a proposal by Senate appropriators, says Sen Murray.
"Some have asked if there will even be an NIH by [2029]. The commmittee's resounding message is yes—Congress has your back", she says.
"Some have asked if there will even be an NIH by [2029]. The commmittee's resounding message is yes—Congress has your back", she says.
July 31, 2025 at 1:53 PM
The NIH budget will INCREASE by $400 million — not slashed by 40%, as Trump proposed — according to a proposal by Senate appropriators, says Sen Murray.
"Some have asked if there will even be an NIH by [2029]. The commmittee's resounding message is yes—Congress has your back", she says.
"Some have asked if there will even be an NIH by [2029]. The commmittee's resounding message is yes—Congress has your back", she says.
Reposted by Ruth Montgomery
More insights from #IMPACC studies, including polymorphism that might protect in #covid19 in online publication.
Authors include: @skleinstein.bsky.social @bjoernpeters.bsky.social @sesmalab.bsky.social @vivianasimonlab.bsky.social @joanndarce.bsky.social ++ others
insight.jci.org/articles/vie...
Authors include: @skleinstein.bsky.social @bjoernpeters.bsky.social @sesmalab.bsky.social @vivianasimonlab.bsky.social @joanndarce.bsky.social ++ others
insight.jci.org/articles/vie...
July 31, 2025 at 4:00 PM
More insights from #IMPACC studies, including polymorphism that might protect in #covid19 in online publication.
Authors include: @skleinstein.bsky.social @bjoernpeters.bsky.social @sesmalab.bsky.social @vivianasimonlab.bsky.social @joanndarce.bsky.social ++ others
insight.jci.org/articles/vie...
Authors include: @skleinstein.bsky.social @bjoernpeters.bsky.social @sesmalab.bsky.social @vivianasimonlab.bsky.social @joanndarce.bsky.social ++ others
insight.jci.org/articles/vie...
Reposted by Ruth Montgomery
Our collaborators identify chief predictor of #covid19 severity + death. Many authors include members of #IMPACC network: @rrmsky.bsky.social @bjoernpeters.bsky.social @skleinstein.bsky.social @sesmalab.bsky.social
@joanndarce.bsky.social @droferlevy.bsky.social
www.frontiersin.org/journals/med...
@joanndarce.bsky.social @droferlevy.bsky.social
www.frontiersin.org/journals/med...
Frontiers | Baseline predictors for 28-day COVID-19 severity and mortality among hospitalized patients: results from the IMPACC study
IntroductionThe coronavirus disease 2019 (COVID-19) pandemic threatened public health and placed a significant burden on medical resources. The Immunophenoty...
www.frontiersin.org
July 29, 2025 at 2:52 PM
Our collaborators identify chief predictor of #covid19 severity + death. Many authors include members of #IMPACC network: @rrmsky.bsky.social @bjoernpeters.bsky.social @skleinstein.bsky.social @sesmalab.bsky.social
@joanndarce.bsky.social @droferlevy.bsky.social
www.frontiersin.org/journals/med...
@joanndarce.bsky.social @droferlevy.bsky.social
www.frontiersin.org/journals/med...
Reposted by Ruth Montgomery
Reposted by Ruth Montgomery
Three members of the NIH council of councils publish a letter to the editor, coming out against proposed budget cuts and recent grant terminations
“The NIH is not just a national treasure — it is a global beacon of biomedical excellence. … We must not weaken it.”
www.nature.com/articles/d41...
“The NIH is not just a national treasure — it is a global beacon of biomedical excellence. … We must not weaken it.”
www.nature.com/articles/d41...
Protect the integrity of the US National Institutes of Health
Letter to the Editor
www.nature.com
July 23, 2025 at 12:57 PM
Three members of the NIH council of councils publish a letter to the editor, coming out against proposed budget cuts and recent grant terminations
“The NIH is not just a national treasure — it is a global beacon of biomedical excellence. … We must not weaken it.”
www.nature.com/articles/d41...
“The NIH is not just a national treasure — it is a global beacon of biomedical excellence. … We must not weaken it.”
www.nature.com/articles/d41...
Reposted by Ruth Montgomery
Really cool stuff! @dremilygoldberg.bsky.social @astratman.bsky.social @bbparis1984.bsky.social @balynzaro.bsky.social
Neutrophil TLR2 signaling promotes lipid accumulation and vascular plaque growth https://www.biorxiv.org/content/10.1101/2025.07.09.663961v1
July 15, 2025 at 6:17 AM
Reposted by Ruth Montgomery
Excited to be involved with this work driven by @dremilygoldberg.bsky.social and her team! Read the preprint now!
"Neutrophil TLR2 signaling promotes lipid accumulation and vascular plaque growth"
"Neutrophil TLR2 signaling promotes lipid accumulation and vascular plaque growth"
Neutrophil TLR2 signaling promotes lipid accumulation and vascular plaque growth https://www.biorxiv.org/content/10.1101/2025.07.09.663961v1
July 15, 2025 at 3:47 PM
Excited to be involved with this work driven by @dremilygoldberg.bsky.social and her team! Read the preprint now!
"Neutrophil TLR2 signaling promotes lipid accumulation and vascular plaque growth"
"Neutrophil TLR2 signaling promotes lipid accumulation and vascular plaque growth"