Ruth Montgomery
@rrmsky.bsky.social
Immunologist at Yale School of Medicine
Associate Dean for Scientific Affairs @YaleMed
Innate immunity ❤️
Associate Dean for Scientific Affairs @YaleMed
Innate immunity ❤️
Reposted by Ruth Montgomery
The Trump admin has been targeting whistleblowers, from the #FEMA36 to the countless other patriotic public servants and scientists across NIH, CDC, NASA, and more who spoke out about the danger posed by the chaos in our federal agencies. This is an concerted, autocratic effort to silence dissent.
RFK Jr fires top NIH scientist weeks after she files whistleblower complaint
Jeanne Marrazzo’s complaint reportedly involved the Trump administration’s hostility toward vaccines
www.theguardian.com
October 3, 2025 at 3:16 PM
The Trump admin has been targeting whistleblowers, from the #FEMA36 to the countless other patriotic public servants and scientists across NIH, CDC, NASA, and more who spoke out about the danger posed by the chaos in our federal agencies. This is an concerted, autocratic effort to silence dissent.
New research from Dixit lab @yalemed.bsky.social showing nerve-associated macrophages (NAMs) decline in aging which impairs the breakdown of fat and increases inflammaging. Dixit addresses the biology of aging and intercommunication between nerves and macrophages. www.nature.com/articles/s43...
Nerve-associated macrophages control adipose homeostasis across lifespan and restrain age-related inflammation - Nature Aging
Gonzalez-Hurtado, Leveau and colleagues characterize adipose resident tissue macrophages across lifespan in mice, finding that nerve-associated macrophages, which mitigate inflammation and control lipolysis and catecholamine resistance, are lost during aging.
www.nature.com
October 3, 2025 at 1:26 PM
New research from Dixit lab @yalemed.bsky.social showing nerve-associated macrophages (NAMs) decline in aging which impairs the breakdown of fat and increases inflammaging. Dixit addresses the biology of aging and intercommunication between nerves and macrophages. www.nature.com/articles/s43...
Reposted by Ruth Montgomery
Taliban Bans Books by Women in Afghanistan’s Universities www.nytimes.com/2025/09/19/w...
Taliban Bans Books by Women in Afghanistan’s Universities
www.nytimes.com
September 19, 2025 at 6:14 PM
Taliban Bans Books by Women in Afghanistan’s Universities www.nytimes.com/2025/09/19/w...
Congratulations to our outstanding @yalemed.bsky.social colleague @virusesimmunity.bsky.social
🎉 Congratulations to HHMI Investigators Clifford Brangwynne and Akiko Iwasaki, the two winners of the 30th annual Keio Medical Science Prize. This international prize, awarded by Keio University in Tokyo, honors scientists who have made major contributions to the fields of medical or life sciences.
September 20, 2025 at 3:26 PM
Congratulations to our outstanding @yalemed.bsky.social colleague @virusesimmunity.bsky.social
Count on #macrophages to promote health! Congratulations to my @yalemed.bsky.social colleagues for this very novel paper.
Discovery of a new type of immune cell in fat tissue that promotes infllammaging (chronic inflammation with aging)
www.nature.com/articles/d41...
www.nature.com/articles/s43...
www.nature.com/articles/d41...
www.nature.com/articles/s43...
Nerve-associated macrophages control adipose homeostasis across lifespan and restrain age-related inflammation - Nature Aging
Gonzalez-Hurtado, Leveau and colleagues characterize adipose resident tissue macrophages across lifespan in mice, finding that nerve-associated macrophages, which mitigate inflammation and control lip...
www.nature.com
September 4, 2025 at 6:07 PM
Count on #macrophages to promote health! Congratulations to my @yalemed.bsky.social colleagues for this very novel paper.
Reposted by Ruth Montgomery
mRNA technologies: Unlimited potential to improve human health. I spoke with the fantastic Erin Shumaker at POLITICO to discuss this topic and its applications to cancer, autoimmunity and beyond.
@erinlschumaker.bsky.social
@politico.com
@cornertx
#mRNA #Cancer
politi.co/3VjfRvu
@erinlschumaker.bsky.social
@politico.com
@cornertx
#mRNA #Cancer
politi.co/3VjfRvu
Losing the mRNA arms race
politi.co
August 23, 2025 at 1:46 PM
mRNA technologies: Unlimited potential to improve human health. I spoke with the fantastic Erin Shumaker at POLITICO to discuss this topic and its applications to cancer, autoimmunity and beyond.
@erinlschumaker.bsky.social
@politico.com
@cornertx
#mRNA #Cancer
politi.co/3VjfRvu
@erinlschumaker.bsky.social
@politico.com
@cornertx
#mRNA #Cancer
politi.co/3VjfRvu
Reposted by Ruth Montgomery
#Resource
Proteomic characterization of varicella-zoster virus–host protein interactions and infection-induced changes in a neuronal cell line identifies potential targets for drug discovery and molecular insights into severe disease.
#MicroSky
www.nature.com/articles/s41...
Proteomic characterization of varicella-zoster virus–host protein interactions and infection-induced changes in a neuronal cell line identifies potential targets for drug discovery and molecular insights into severe disease.
#MicroSky
www.nature.com/articles/s41...
Multi-proteomic profiling of the varicella-zoster virus–host interface reveals host susceptibilities to severe infection - Nature Microbiology
Proteomic characterization of varicella-zoster virus–host protein interactions and infection-induced changes in a neuronal cell line identifies potential targets for drug discovery and molecular insig...
www.nature.com
August 1, 2025 at 2:09 PM
#Resource
Proteomic characterization of varicella-zoster virus–host protein interactions and infection-induced changes in a neuronal cell line identifies potential targets for drug discovery and molecular insights into severe disease.
#MicroSky
www.nature.com/articles/s41...
Proteomic characterization of varicella-zoster virus–host protein interactions and infection-induced changes in a neuronal cell line identifies potential targets for drug discovery and molecular insights into severe disease.
#MicroSky
www.nature.com/articles/s41...
Reposted by Ruth Montgomery
Come get your curated #immune #assays from 1,000s of human subjects at our website
immunespace.org
🧪 #immunology #IDSky #ImmuneSky
immunespace.org/query/filters
giphy.com/gifs/Giflyti...
immunespace.org
🧪 #immunology #IDSky #ImmuneSky
immunespace.org/query/filters
giphy.com/gifs/Giflyti...
Analyze Lucky Charms GIF by Giflytics - Find & Share on GIPHY
Discover & share this Analyze Lucky Charms GIF by Giflytics with everyone you know. GIPHY is how you search, share, discover, and create GIFs.
giphy.com
August 6, 2025 at 10:32 PM
Come get your curated #immune #assays from 1,000s of human subjects at our website
immunespace.org
🧪 #immunology #IDSky #ImmuneSky
immunespace.org/query/filters
giphy.com/gifs/Giflyti...
immunespace.org
🧪 #immunology #IDSky #ImmuneSky
immunespace.org/query/filters
giphy.com/gifs/Giflyti...
Reposted by Ruth Montgomery
On Aug. 1, ASM & partner societies filed an expanded amicus brief with SCOTUS to defend scientific integrity & protect early-career researchers. The brief highlights the harm caused by NIH grant terminations, including canceling the MOSAIC program. asm.org/press-releas...
Scientific Societies File Supreme Court Amicus Brief in Support of NIH Grantees
ASM and fellow societies filed an amicus brief with the Supreme Court, calling for the swift restoration of NIH grant funding supporting early-career scientists, such as the MOSAIC program.
asm.org
August 4, 2025 at 9:23 PM
On Aug. 1, ASM & partner societies filed an expanded amicus brief with SCOTUS to defend scientific integrity & protect early-career researchers. The brief highlights the harm caused by NIH grant terminations, including canceling the MOSAIC program. asm.org/press-releas...
Reposted by Ruth Montgomery
The NIH budget will INCREASE by $400 million — not slashed by 40%, as Trump proposed — according to a proposal by Senate appropriators, says Sen Murray.
"Some have asked if there will even be an NIH by [2029]. The commmittee's resounding message is yes—Congress has your back", she says.
"Some have asked if there will even be an NIH by [2029]. The commmittee's resounding message is yes—Congress has your back", she says.
July 31, 2025 at 1:53 PM
The NIH budget will INCREASE by $400 million — not slashed by 40%, as Trump proposed — according to a proposal by Senate appropriators, says Sen Murray.
"Some have asked if there will even be an NIH by [2029]. The commmittee's resounding message is yes—Congress has your back", she says.
"Some have asked if there will even be an NIH by [2029]. The commmittee's resounding message is yes—Congress has your back", she says.
Reposted by Ruth Montgomery
More insights from #IMPACC studies, including polymorphism that might protect in #covid19 in online publication.
Authors include: @skleinstein.bsky.social @bjoernpeters.bsky.social @sesmalab.bsky.social @vivianasimonlab.bsky.social @joanndarce.bsky.social ++ others
insight.jci.org/articles/vie...
Authors include: @skleinstein.bsky.social @bjoernpeters.bsky.social @sesmalab.bsky.social @vivianasimonlab.bsky.social @joanndarce.bsky.social ++ others
insight.jci.org/articles/vie...
July 31, 2025 at 4:00 PM
More insights from #IMPACC studies, including polymorphism that might protect in #covid19 in online publication.
Authors include: @skleinstein.bsky.social @bjoernpeters.bsky.social @sesmalab.bsky.social @vivianasimonlab.bsky.social @joanndarce.bsky.social ++ others
insight.jci.org/articles/vie...
Authors include: @skleinstein.bsky.social @bjoernpeters.bsky.social @sesmalab.bsky.social @vivianasimonlab.bsky.social @joanndarce.bsky.social ++ others
insight.jci.org/articles/vie...
Reposted by Ruth Montgomery
Our collaborators identify chief predictor of #covid19 severity + death. Many authors include members of #IMPACC network: @rrmsky.bsky.social @bjoernpeters.bsky.social @skleinstein.bsky.social @sesmalab.bsky.social
@joanndarce.bsky.social @droferlevy.bsky.social
www.frontiersin.org/journals/med...
@joanndarce.bsky.social @droferlevy.bsky.social
www.frontiersin.org/journals/med...
Frontiers | Baseline predictors for 28-day COVID-19 severity and mortality among hospitalized patients: results from the IMPACC study
IntroductionThe coronavirus disease 2019 (COVID-19) pandemic threatened public health and placed a significant burden on medical resources. The Immunophenoty...
www.frontiersin.org
July 29, 2025 at 2:52 PM
Our collaborators identify chief predictor of #covid19 severity + death. Many authors include members of #IMPACC network: @rrmsky.bsky.social @bjoernpeters.bsky.social @skleinstein.bsky.social @sesmalab.bsky.social
@joanndarce.bsky.social @droferlevy.bsky.social
www.frontiersin.org/journals/med...
@joanndarce.bsky.social @droferlevy.bsky.social
www.frontiersin.org/journals/med...
Reposted by Ruth Montgomery
Reposted by Ruth Montgomery
Three members of the NIH council of councils publish a letter to the editor, coming out against proposed budget cuts and recent grant terminations
“The NIH is not just a national treasure — it is a global beacon of biomedical excellence. … We must not weaken it.”
www.nature.com/articles/d41...
“The NIH is not just a national treasure — it is a global beacon of biomedical excellence. … We must not weaken it.”
www.nature.com/articles/d41...
Protect the integrity of the US National Institutes of Health
Letter to the Editor
www.nature.com
July 23, 2025 at 12:57 PM
Three members of the NIH council of councils publish a letter to the editor, coming out against proposed budget cuts and recent grant terminations
“The NIH is not just a national treasure — it is a global beacon of biomedical excellence. … We must not weaken it.”
www.nature.com/articles/d41...
“The NIH is not just a national treasure — it is a global beacon of biomedical excellence. … We must not weaken it.”
www.nature.com/articles/d41...
Reposted by Ruth Montgomery
Really cool stuff! @dremilygoldberg.bsky.social @astratman.bsky.social @bbparis1984.bsky.social @balynzaro.bsky.social
Neutrophil TLR2 signaling promotes lipid accumulation and vascular plaque growth https://www.biorxiv.org/content/10.1101/2025.07.09.663961v1
July 15, 2025 at 6:17 AM
Reposted by Ruth Montgomery
Excited to be involved with this work driven by @dremilygoldberg.bsky.social and her team! Read the preprint now!
"Neutrophil TLR2 signaling promotes lipid accumulation and vascular plaque growth"
"Neutrophil TLR2 signaling promotes lipid accumulation and vascular plaque growth"
Neutrophil TLR2 signaling promotes lipid accumulation and vascular plaque growth https://www.biorxiv.org/content/10.1101/2025.07.09.663961v1
July 15, 2025 at 3:47 PM
Excited to be involved with this work driven by @dremilygoldberg.bsky.social and her team! Read the preprint now!
"Neutrophil TLR2 signaling promotes lipid accumulation and vascular plaque growth"
"Neutrophil TLR2 signaling promotes lipid accumulation and vascular plaque growth"
Reposted by Ruth Montgomery
NEW: In an unprecedented move, the NIH will soon disinvite dozens of scientists about to take positions on advisory councils that make final decisions on grant funding.
NIH staff were told to select others aligned with the Trump administration and told to expect placements by political appointees.
NIH staff were told to select others aligned with the Trump administration and told to expect placements by political appointees.
Exclusive: NIH to dismiss dozens of grant reviewers to align with Trump priorities
The move would undo years of work, leaving advisory councils understaffed, and without the full expertise needed for reviews.
www.nature.com
July 14, 2025 at 11:25 PM
NEW: In an unprecedented move, the NIH will soon disinvite dozens of scientists about to take positions on advisory councils that make final decisions on grant funding.
NIH staff were told to select others aligned with the Trump administration and told to expect placements by political appointees.
NIH staff were told to select others aligned with the Trump administration and told to expect placements by political appointees.
Reposted by Ruth Montgomery
Excited to see this new review piece that we wrote together with Jennifer Garrison and Alison Kochersberger on the modern tools and approaches to study #ovarian #aging out this week at @genesdev.bsky.social!
genesdev.cshlp.org/content/earl... #GeroSky #WomensHealth 🧪🧬
A 🧵1/3
genesdev.cshlp.org/content/earl... #GeroSky #WomensHealth 🧪🧬
A 🧵1/3
July 14, 2025 at 4:16 PM
Excited to see this new review piece that we wrote together with Jennifer Garrison and Alison Kochersberger on the modern tools and approaches to study #ovarian #aging out this week at @genesdev.bsky.social!
genesdev.cshlp.org/content/earl... #GeroSky #WomensHealth 🧪🧬
A 🧵1/3
genesdev.cshlp.org/content/earl... #GeroSky #WomensHealth 🧪🧬
A 🧵1/3
Reposted by Ruth Montgomery
Our collaborator Purvesh Katri, and others, discover a #signature of #immune health.
med.stanford.edu/news/all-new...
@stanfordimmunology.bsky.social
med.stanford.edu/news/all-new...
@stanfordimmunology.bsky.social
Immune ‘dysregulation’ present prior to infection predicts severe responses
Stanford Medicine-led research finds that a gene signature capturing immune health or dysfunction can forecast patient outcomes following subsequent viral or bacterial infections.
med.stanford.edu
July 9, 2025 at 7:50 PM
Our collaborator Purvesh Katri, and others, discover a #signature of #immune health.
med.stanford.edu/news/all-new...
@stanfordimmunology.bsky.social
med.stanford.edu/news/all-new...
@stanfordimmunology.bsky.social
Well annotated, curated, multiparameter FREE #immunology data, folks!
Our project spans 8+ institutions, with human cohorts studied with multiplex transcriptional, #cytokine, and #proteomic assays; multiparameter #phenotyping of leukocyte subsets + many computational methods.
Get our #data for your own investigations.
#ImmuneSky #IDsky
immunespace.org
Get our #data for your own investigations.
#ImmuneSky #IDsky
immunespace.org
July 1, 2025 at 3:23 PM
Well annotated, curated, multiparameter FREE #immunology data, folks!
Reposted by Ruth Montgomery
Wow, when lower IFN in aging is a good thing! Congratulations Chaz L and team. #ImmuneProfiling
#Aging Epigenetic attenuation of interferon signaling is associated with aging-related improvements in systemic lupus erythematosus | Science Translational Medicine www.science.org/doi/10.1126/...
#Aging Epigenetic attenuation of interferon signaling is associated with aging-related improvements in systemic lupus erythematosus | Science Translational Medicine www.science.org/doi/10.1126/...
Epigenetic attenuation of interferon signaling is associated with aging-related improvements in systemic lupus erythematosus
Patients with systemic lupus erythematosus exhibit aging-related decreases in interferon signaling that correlate with improved disease activity.
www.science.org
June 27, 2025 at 3:19 PM
Wow, when lower IFN in aging is a good thing! Congratulations Chaz L and team. #ImmuneProfiling
#Aging Epigenetic attenuation of interferon signaling is associated with aging-related improvements in systemic lupus erythematosus | Science Translational Medicine www.science.org/doi/10.1126/...
#Aging Epigenetic attenuation of interferon signaling is associated with aging-related improvements in systemic lupus erythematosus | Science Translational Medicine www.science.org/doi/10.1126/...
Reposted by Ruth Montgomery
“In a study that enrolled 5000 healthy adults before the flu season started and followed them until after it ended, the highest dose of the drug provided 76.1% protection from disease, compared with a placebo shot, its developer, Cidara Therapeutics, reported in a press release& on an investor call”
A single shot of a flu drug could outperform vaccines—and protect for an entire season
One injection of a long-lasting drug showed up to 76% efficacy in a large trial
www.science.org
June 24, 2025 at 9:27 PM
“In a study that enrolled 5000 healthy adults before the flu season started and followed them until after it ended, the highest dose of the drug provided 76.1% protection from disease, compared with a placebo shot, its developer, Cidara Therapeutics, reported in a press release& on an investor call”
Reposted by Ruth Montgomery
News: The American Academy of Pediatrics says it will no longer take part in the process of ACIP meetings.
“We won’t lend our name or our expertise to a system that is being politicized at the expense of children’s health,” the group's president says.
www.statnews.com/2025/06/25/c...
“We won’t lend our name or our expertise to a system that is being politicized at the expense of children’s health,” the group's president says.
www.statnews.com/2025/06/25/c...
CDC vaccine advisory committee to review long-approved immunizations
A leader of the CDC's reconstituted vaccine advisory committee said the panel would start a review of long-approved shots.
www.statnews.com
June 25, 2025 at 6:06 PM
News: The American Academy of Pediatrics says it will no longer take part in the process of ACIP meetings.
“We won’t lend our name or our expertise to a system that is being politicized at the expense of children’s health,” the group's president says.
www.statnews.com/2025/06/25/c...
“We won’t lend our name or our expertise to a system that is being politicized at the expense of children’s health,” the group's president says.
www.statnews.com/2025/06/25/c...
Reposted by Ruth Montgomery
“Cassidy’s comments — including that the panel’s upcoming meeting be canceled until it is “fully staffed with more robust and balanced representation” — represent the harshest condemnation of Kennedy’s actions by the senator, who ultimately cast the key vote that secured Kennedy’s confirmation.”
Cassidy calls to delay meeting of CDC's vaccine panel in challenge to RFK Jr.
A key GOP senator is calling for the CDC's vaccine meeting to be postponed after RFK Jr. shook up the panel.
www.statnews.com
June 24, 2025 at 12:43 AM
“Cassidy’s comments — including that the panel’s upcoming meeting be canceled until it is “fully staffed with more robust and balanced representation” — represent the harshest condemnation of Kennedy’s actions by the senator, who ultimately cast the key vote that secured Kennedy’s confirmation.”