Dan Tyrrell
@danis1337.bsky.social
Asst. Professor at UAB Pathology | T cells, aging, mitos, 🧠,🫀, ☕️, 🐭, 🔬, data vis | He/him | Views mine
Watching the CFP with my 8-yo son and #67 gets a penalty. Brah went wild
January 20, 2026 at 1:49 AM
Watching the CFP with my 8-yo son and #67 gets a penalty. Brah went wild
I took my baby to get vaccinated yesterday. Is the gov’t gonna get me??
January 13, 2026 at 2:23 PM
I took my baby to get vaccinated yesterday. Is the gov’t gonna get me??
ChoreDash, where you pay someone to do stuff you don’t want to do
January 6, 2026 at 3:16 PM
ChoreDash, where you pay someone to do stuff you don’t want to do
Christmas is over. now approaching the gauntlet - Valentines day, anniversary, birthday, mother's day
December 30, 2025 at 2:44 PM
Christmas is over. now approaching the gauntlet - Valentines day, anniversary, birthday, mother's day
Reposted by Dan Tyrrell
Review @jem.org
T cell engagers emerge as a compelling therapeutic modality
rupress.org/jem/article/...
T cell engagers emerge as a compelling therapeutic modality
rupress.org/jem/article/...
December 28, 2025 at 4:37 AM
Review @jem.org
T cell engagers emerge as a compelling therapeutic modality
rupress.org/jem/article/...
T cell engagers emerge as a compelling therapeutic modality
rupress.org/jem/article/...
Got my own Christmas story thing going on. Kid shot himself point blank in the eye with a nerf gun so we’re here at the eye ER. you’ll shoot your eye out kid
December 28, 2025 at 3:29 AM
Got my own Christmas story thing going on. Kid shot himself point blank in the eye with a nerf gun so we’re here at the eye ER. you’ll shoot your eye out kid
Reposted by Dan Tyrrell
TGFβ Angiogenesis
Endothelial Cell TGFBR1/2 KO🐭
Retina
👉⏬Angiogenesis into intermediate/deeper vascular plexus
👉Widespread vascular tufts
👉Ectopic αSMA+/NG2+ mural cell
👉Spontaneous choroid neovascularization
👉EC inflamm
👉Extensive immune cell infiltr
#eLife 2025
elifesciences.org/articles/107...
Endothelial Cell TGFBR1/2 KO🐭
Retina
👉⏬Angiogenesis into intermediate/deeper vascular plexus
👉Widespread vascular tufts
👉Ectopic αSMA+/NG2+ mural cell
👉Spontaneous choroid neovascularization
👉EC inflamm
👉Extensive immune cell infiltr
#eLife 2025
elifesciences.org/articles/107...
December 27, 2025 at 1:32 PM
TGFβ Angiogenesis
Endothelial Cell TGFBR1/2 KO🐭
Retina
👉⏬Angiogenesis into intermediate/deeper vascular plexus
👉Widespread vascular tufts
👉Ectopic αSMA+/NG2+ mural cell
👉Spontaneous choroid neovascularization
👉EC inflamm
👉Extensive immune cell infiltr
#eLife 2025
elifesciences.org/articles/107...
Endothelial Cell TGFBR1/2 KO🐭
Retina
👉⏬Angiogenesis into intermediate/deeper vascular plexus
👉Widespread vascular tufts
👉Ectopic αSMA+/NG2+ mural cell
👉Spontaneous choroid neovascularization
👉EC inflamm
👉Extensive immune cell infiltr
#eLife 2025
elifesciences.org/articles/107...
My kid just said the thumb is not a finger. 🧐
December 24, 2025 at 6:51 PM
My kid just said the thumb is not a finger. 🧐
apparently the summer semester is just called "Summer". Missed opportunity IMO
Sewanee university calls their semesters "Advent Semester" and "Easter Semester"
December 9, 2025 at 7:08 PM
apparently the summer semester is just called "Summer". Missed opportunity IMO
Sewanee university calls their semesters "Advent Semester" and "Easter Semester"
December 9, 2025 at 7:02 PM
Sewanee university calls their semesters "Advent Semester" and "Easter Semester"
Henry VIII had a gold chain that said “I prefer to die rather than change my mind” and I love that!! Loool
December 7, 2025 at 4:44 PM
Henry VIII had a gold chain that said “I prefer to die rather than change my mind” and I love that!! Loool
Nothing like your kid bringing a ziplock bag full of water home in their backpack from school
December 3, 2025 at 1:06 PM
Nothing like your kid bringing a ziplock bag full of water home in their backpack from school
Really looking forward to the Thanksgiving NYT crossword
November 27, 2025 at 1:48 AM
Really looking forward to the Thanksgiving NYT crossword
Reposted by Dan Tyrrell
#MicrovascularAging 🐴Tendon
Young 2~5 y/o
Aged 18~22 y/o
Superficial digital flexor tendon
⏬μCT microvascular (φ>=37 μm) density, φ
⏫VWF+ microvessels
⏫PDGFRβ+ pericytes
⏬Des+/Myh11+ mural cells
5 mm cubes for 3D immunostaining
#AgingCell 2025
onlinelibrary.wiley.com/doi/10.1111/...
Young 2~5 y/o
Aged 18~22 y/o
Superficial digital flexor tendon
⏬μCT microvascular (φ>=37 μm) density, φ
⏫VWF+ microvessels
⏫PDGFRβ+ pericytes
⏬Des+/Myh11+ mural cells
5 mm cubes for 3D immunostaining
#AgingCell 2025
onlinelibrary.wiley.com/doi/10.1111/...
November 26, 2025 at 12:34 PM
#MicrovascularAging 🐴Tendon
Young 2~5 y/o
Aged 18~22 y/o
Superficial digital flexor tendon
⏬μCT microvascular (φ>=37 μm) density, φ
⏫VWF+ microvessels
⏫PDGFRβ+ pericytes
⏬Des+/Myh11+ mural cells
5 mm cubes for 3D immunostaining
#AgingCell 2025
onlinelibrary.wiley.com/doi/10.1111/...
Young 2~5 y/o
Aged 18~22 y/o
Superficial digital flexor tendon
⏬μCT microvascular (φ>=37 μm) density, φ
⏫VWF+ microvessels
⏫PDGFRβ+ pericytes
⏬Des+/Myh11+ mural cells
5 mm cubes for 3D immunostaining
#AgingCell 2025
onlinelibrary.wiley.com/doi/10.1111/...
Reposted by Dan Tyrrell
“Time is brain” for cell therapies?🧠
Our #AdvSci perspective😆
@rrust.bsky.social
@dominikusbrian.com
@lydenlab.bsky.social
#StemCellTherapy for #Stroke should be timed to a biomarker-defined “window of receptivity”, not just the thrombolysis clock
advanced.onlinelibrary.wiley.com/doi/10.1002/...
Our #AdvSci perspective😆
@rrust.bsky.social
@dominikusbrian.com
@lydenlab.bsky.social
#StemCellTherapy for #Stroke should be timed to a biomarker-defined “window of receptivity”, not just the thrombolysis clock
advanced.onlinelibrary.wiley.com/doi/10.1002/...
November 18, 2025 at 8:07 PM
“Time is brain” for cell therapies?🧠
Our #AdvSci perspective😆
@rrust.bsky.social
@dominikusbrian.com
@lydenlab.bsky.social
#StemCellTherapy for #Stroke should be timed to a biomarker-defined “window of receptivity”, not just the thrombolysis clock
advanced.onlinelibrary.wiley.com/doi/10.1002/...
Our #AdvSci perspective😆
@rrust.bsky.social
@dominikusbrian.com
@lydenlab.bsky.social
#StemCellTherapy for #Stroke should be timed to a biomarker-defined “window of receptivity”, not just the thrombolysis clock
advanced.onlinelibrary.wiley.com/doi/10.1002/...
Columbus was interesting. There was so much superstition and unknown in the 1400’s. The main motivation for finding new lands was basically to bring gold back to the Spanish King and Queen. By that metric, Columbus was a failure
November 16, 2025 at 3:29 PM
Columbus was interesting. There was so much superstition and unknown in the 1400’s. The main motivation for finding new lands was basically to bring gold back to the Spanish King and Queen. By that metric, Columbus was a failure
When did football announcers decide to start saying ‘2-minute timeout’ and ‘red area’ instead of 2-minute warning and red zone
November 15, 2025 at 6:27 PM
When did football announcers decide to start saying ‘2-minute timeout’ and ‘red area’ instead of 2-minute warning and red zone
Hannibal was very cool in an ancient type of way. The whole elephant over the alps thing is pretty overblown though. They all died almost right away
November 13, 2025 at 11:25 PM
Hannibal was very cool in an ancient type of way. The whole elephant over the alps thing is pretty overblown though. They all died almost right away
I need to settle a family debate. Is The Nightmare Before Christmas a Halloween movie or Christmas movie?
November 6, 2025 at 12:32 AM
I need to settle a family debate. Is The Nightmare Before Christmas a Halloween movie or Christmas movie?
Submitting a 2nd R01 application to a gov’t bureaucracy that isn’t there. Do we have to meet deadlines to fulfill our obligation? Yes. Does the gov’t? No, apparently
November 3, 2025 at 6:10 PM
Submitting a 2nd R01 application to a gov’t bureaucracy that isn’t there. Do we have to meet deadlines to fulfill our obligation? Yes. Does the gov’t? No, apparently
This was super interesting. That trip would have sucked but they survived mostly intact
November 3, 2025 at 4:21 PM
This was super interesting. That trip would have sucked but they survived mostly intact
This was a cool book. The underground resistance in the Netherlands during WWII. So cool how women were so overlooked in some cases that they could do really covert espionage for the allies
October 30, 2025 at 12:58 PM
This was a cool book. The underground resistance in the Netherlands during WWII. So cool how women were so overlooked in some cases that they could do really covert espionage for the allies
