Rory Hennell James
@rorydhj.bsky.social
Postdoc at the CSSB Hamburg, studying mycobacterial secretion with #CryoEM and #CryoET. Generally something of a nerd. He/him.
Reposted by Rory Hennell James
🔬 Experience Research Life at Cambridge!
Applications are now open for the 2026 Experience Postgrad Life Sciences Programme. Gain hands-on lab experience with an 8-week summer placement, in partnership with @corpuscambridge.bsky.social!
🔗 www.exppg.lifesci.cam.ac.uk
#SummerPlacement #Cambridge
Applications are now open for the 2026 Experience Postgrad Life Sciences Programme. Gain hands-on lab experience with an 8-week summer placement, in partnership with @corpuscambridge.bsky.social!
🔗 www.exppg.lifesci.cam.ac.uk
#SummerPlacement #Cambridge
November 13, 2025 at 10:52 AM
🔬 Experience Research Life at Cambridge!
Applications are now open for the 2026 Experience Postgrad Life Sciences Programme. Gain hands-on lab experience with an 8-week summer placement, in partnership with @corpuscambridge.bsky.social!
🔗 www.exppg.lifesci.cam.ac.uk
#SummerPlacement #Cambridge
Applications are now open for the 2026 Experience Postgrad Life Sciences Programme. Gain hands-on lab experience with an 8-week summer placement, in partnership with @corpuscambridge.bsky.social!
🔗 www.exppg.lifesci.cam.ac.uk
#SummerPlacement #Cambridge
Reposted by Rory Hennell James
An Asgard archaeon with internal membrane compartments
Brilliant study led by @fmacleod.bsky.social and Andriko von Kügelgen. Tight collaboration with @buzzbaum.bsky.social and lab. Congrats to all authors!
www.biorxiv.org/content/10.1...
Brilliant study led by @fmacleod.bsky.social and Andriko von Kügelgen. Tight collaboration with @buzzbaum.bsky.social and lab. Congrats to all authors!
www.biorxiv.org/content/10.1...
November 7, 2025 at 10:44 AM
An Asgard archaeon with internal membrane compartments
Brilliant study led by @fmacleod.bsky.social and Andriko von Kügelgen. Tight collaboration with @buzzbaum.bsky.social and lab. Congrats to all authors!
www.biorxiv.org/content/10.1...
Brilliant study led by @fmacleod.bsky.social and Andriko von Kügelgen. Tight collaboration with @buzzbaum.bsky.social and lab. Congrats to all authors!
www.biorxiv.org/content/10.1...
Reposted by Rory Hennell James
Our first lab paper is out! We identify and solve the first structure of the SND3 translocon involved in fungal membrane protein insertion. Congratulations @tzujingyang.bsky.social, and our colleagues @saumyakm.bsky.social, @hummerlab.bsky.social and Julian Langer. Read more ⬇️ and ➡️ rdcu.be/eNgIO
SNDing proteins into the membrane! Our new publication from @melaniemcdowell.bsky.social ’s group identifies the SND3 protein as a new route for membrane protein insertion! 🍄 📘 Read more here: www.mpg.de/25599408/102... Image: Louise Duever.
October 30, 2025 at 5:42 PM
Our first lab paper is out! We identify and solve the first structure of the SND3 translocon involved in fungal membrane protein insertion. Congratulations @tzujingyang.bsky.social, and our colleagues @saumyakm.bsky.social, @hummerlab.bsky.social and Julian Langer. Read more ⬇️ and ➡️ rdcu.be/eNgIO
Reposted by Rory Hennell James
Genuinely delighted to download a PhD thesis from a university repository where the author has neglected to remove the words "BITCH THIS IS YOUR THESIS" from the filename.
October 30, 2025 at 8:21 AM
Genuinely delighted to download a PhD thesis from a university repository where the author has neglected to remove the words "BITCH THIS IS YOUR THESIS" from the filename.
The latest work from the Marlovits group in collaboration with the Sartori group. Victor used Elastic Strain Analysis to complement Jiři's original Staring at the Structures for Ages Analysis and understand the chemo-mechanical coupling of the RuvAB AAA+ ATPase
Elastic analysis bridges structure and dynamics of an AAA+ molecular motor pubmed.ncbi.nlm.nih.gov/41134915/ #cryoem
October 26, 2025 at 10:25 AM
The latest work from the Marlovits group in collaboration with the Sartori group. Victor used Elastic Strain Analysis to complement Jiři's original Staring at the Structures for Ages Analysis and understand the chemo-mechanical coupling of the RuvAB AAA+ ATPase
Reposted by Rory Hennell James
The German company that makes the mechanical ladder used in the Louvre heist has used the image to advertise, with the text 'When you need to move fast'
10/10 response, no notes
10/10 response, no notes
October 24, 2025 at 8:27 AM
The German company that makes the mechanical ladder used in the Louvre heist has used the image to advertise, with the text 'When you need to move fast'
10/10 response, no notes
10/10 response, no notes
Reposted by Rory Hennell James
Looking for a PhD? 🚀 MIBTP projects are out lots to explore!
🔬 #Bacteria • #AMR • #Interdisciplinary • FUN!
My projects explore how Gram-negative bacteria build and maintain their three-layered cell envelope, using cryo-EM, fluorescence microscopy and biochemistry.
warwick.ac.uk/fac/cross_fa...
🔬 #Bacteria • #AMR • #Interdisciplinary • FUN!
My projects explore how Gram-negative bacteria build and maintain their three-layered cell envelope, using cryo-EM, fluorescence microscopy and biochemistry.
warwick.ac.uk/fac/cross_fa...
Dr Melissa Webby
Dr Melissa Webby
warwick.ac.uk
October 23, 2025 at 5:56 PM
Looking for a PhD? 🚀 MIBTP projects are out lots to explore!
🔬 #Bacteria • #AMR • #Interdisciplinary • FUN!
My projects explore how Gram-negative bacteria build and maintain their three-layered cell envelope, using cryo-EM, fluorescence microscopy and biochemistry.
warwick.ac.uk/fac/cross_fa...
🔬 #Bacteria • #AMR • #Interdisciplinary • FUN!
My projects explore how Gram-negative bacteria build and maintain their three-layered cell envelope, using cryo-EM, fluorescence microscopy and biochemistry.
warwick.ac.uk/fac/cross_fa...
Reposted by Rory Hennell James
Finally, just about 2 years after finishing the postdoc the last part of my work is finally online! We determined the structure of HSV-1 Origin Binding Protein, the viral initiator of DNA replication, by cryo-EM 🧪🧬🧶🧵 #cryoEM #structuralbiology
October 23, 2025 at 6:37 AM
Finally, just about 2 years after finishing the postdoc the last part of my work is finally online! We determined the structure of HSV-1 Origin Binding Protein, the viral initiator of DNA replication, by cryo-EM 🧪🧬🧶🧵 #cryoEM #structuralbiology
Reposted by Rory Hennell James
Our colleagues Vinith Kishore and Valentin Debarnot from the @ivandokmanic.bsky.social lab have come up with an amazing deep learning tool for denoising and filling the missing wedge in #cryoET data. I'm pleased to introduce Icecream🍧
Icecream: High-Fidelity Equivariant Cryo-Electron Tomography
Cryo-electron tomography (cryo-ET) visualizes 3D cellular architecture in near-native states. Recent deep-learning methods (CryoCARE, IsoNet, DeepDeWedge, CryoLithe) improve denoising and artifact cor...
www.biorxiv.org
October 23, 2025 at 11:13 AM
Our colleagues Vinith Kishore and Valentin Debarnot from the @ivandokmanic.bsky.social lab have come up with an amazing deep learning tool for denoising and filling the missing wedge in #cryoET data. I'm pleased to introduce Icecream🍧
Reposted by Rory Hennell James
As it is International Wombat Day, I must share this by Dante Gabriel Rossetti (ostensibly) concerning his pet wombat:
OH how the family affections combat
Within this heart, and each hour flings a bomb at
My burning soul! Neither from owl nor from bat
Can peace be gained until I clasp my wombat.
OH how the family affections combat
Within this heart, and each hour flings a bomb at
My burning soul! Neither from owl nor from bat
Can peace be gained until I clasp my wombat.
October 22, 2025 at 7:04 AM
As it is International Wombat Day, I must share this by Dante Gabriel Rossetti (ostensibly) concerning his pet wombat:
OH how the family affections combat
Within this heart, and each hour flings a bomb at
My burning soul! Neither from owl nor from bat
Can peace be gained until I clasp my wombat.
OH how the family affections combat
Within this heart, and each hour flings a bomb at
My burning soul! Neither from owl nor from bat
Can peace be gained until I clasp my wombat.
Reposted by Rory Hennell James
🚨Our paper is out! 🥳
Hijacking a bacterial ABC transporter for efficient genetic code expansion.
Many congrats to everyone involved - a multi-year effort led by @taruniype.bsky.social @maxfottner.bsky.social
www.nature.com/articles/s41...
it all started years ago with a failed experiment
🧵👇 1/9
Hijacking a bacterial ABC transporter for efficient genetic code expansion.
Many congrats to everyone involved - a multi-year effort led by @taruniype.bsky.social @maxfottner.bsky.social
www.nature.com/articles/s41...
it all started years ago with a failed experiment
🧵👇 1/9
Hijacking a bacterial ABC transporter for genetic code expansion - Nature
Bacterial ATP-binding cassette (ABC) transporters can be utilized and engineered to transport non-canonical amino acids into Escherichia coli for highly efficient synthesis of proteins with novel func...
www.nature.com
October 16, 2025 at 2:06 PM
🚨Our paper is out! 🥳
Hijacking a bacterial ABC transporter for efficient genetic code expansion.
Many congrats to everyone involved - a multi-year effort led by @taruniype.bsky.social @maxfottner.bsky.social
www.nature.com/articles/s41...
it all started years ago with a failed experiment
🧵👇 1/9
Hijacking a bacterial ABC transporter for efficient genetic code expansion.
Many congrats to everyone involved - a multi-year effort led by @taruniype.bsky.social @maxfottner.bsky.social
www.nature.com/articles/s41...
it all started years ago with a failed experiment
🧵👇 1/9
Reposted by Rory Hennell James
Been playing down at the beach
October 17, 2025 at 8:56 AM
Been playing down at the beach
Reposted by Rory Hennell James
Open position to work on Type IX secretion (#T9SS) in our lab, in collaboration withe the group of Eric Reynolds at the Dental School of the University of Melbourne. Please spread the word, and forward to anyone potentially interested ! Apply here:
emploi.cnrs.fr/Offres/Docto...
emploi.cnrs.fr/Offres/Docto...
Portail Emploi CNRS - Offre d'emploi - Thèse en Microbiologie-Biochimie (H/F)
emploi.cnrs.fr
October 9, 2025 at 12:18 PM
Open position to work on Type IX secretion (#T9SS) in our lab, in collaboration withe the group of Eric Reynolds at the Dental School of the University of Melbourne. Please spread the word, and forward to anyone potentially interested ! Apply here:
emploi.cnrs.fr/Offres/Docto...
emploi.cnrs.fr/Offres/Docto...
Reposted by Rory Hennell James
🧐Checkout our preprint revealing the stepwise firing💥 mechanism of a Contractile Injection System @xujwet.bsky.social&@chipericson.bsky.social trapped the complex by structure-guided engineering🧪 in multiple intermediate states and imaged them by multimodal #cryoEM❄️🔬
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
October 8, 2025 at 9:18 PM
🧐Checkout our preprint revealing the stepwise firing💥 mechanism of a Contractile Injection System @xujwet.bsky.social&@chipericson.bsky.social trapped the complex by structure-guided engineering🧪 in multiple intermediate states and imaged them by multimodal #cryoEM❄️🔬
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Rory Hennell James
Explaining to my wife that I cannot simply “read the books I’ve already bought and haven’t read” like some kind of peasant.
October 5, 2025 at 3:14 PM
Explaining to my wife that I cannot simply “read the books I’ve already bought and haven’t read” like some kind of peasant.
Reposted by Rory Hennell James
Become my colleague @oxfordbiochemistry.bsky.social !
2 Associate Professorships in the areas of
- prokaryotic/eukaryotic microbiology
- metabolism
my.corehr.com/pls/uoxrecru...
2 Associate Professorships in the areas of
- prokaryotic/eukaryotic microbiology
- metabolism
my.corehr.com/pls/uoxrecru...
Job Details
my.corehr.com
September 29, 2025 at 9:25 AM
Become my colleague @oxfordbiochemistry.bsky.social !
2 Associate Professorships in the areas of
- prokaryotic/eukaryotic microbiology
- metabolism
my.corehr.com/pls/uoxrecru...
2 Associate Professorships in the areas of
- prokaryotic/eukaryotic microbiology
- metabolism
my.corehr.com/pls/uoxrecru...
Reposted by Rory Hennell James
Assistant/Associate Professor in Structural Biology, Biophysics or Biological Imaging
www.biozentrum.unibas.ch/open-positio...
#biozentrum #University #Basel #Professor #Structural #Biology #Biophysics #Biological #Imaging
www.biozentrum.unibas.ch/open-positio...
#biozentrum #University #Basel #Professor #Structural #Biology #Biophysics #Biological #Imaging
September 29, 2025 at 2:58 PM
Assistant/Associate Professor in Structural Biology, Biophysics or Biological Imaging
www.biozentrum.unibas.ch/open-positio...
#biozentrum #University #Basel #Professor #Structural #Biology #Biophysics #Biological #Imaging
www.biozentrum.unibas.ch/open-positio...
#biozentrum #University #Basel #Professor #Structural #Biology #Biophysics #Biological #Imaging
Reposted by Rory Hennell James
Phenomenal. In my 10 year update of A Brief History, I make the point that in the first edition, not one disease had been successfully treated using gene therapy. Today that number is at least 7.
September 24, 2025 at 12:23 PM
Phenomenal. In my 10 year update of A Brief History, I make the point that in the first edition, not one disease had been successfully treated using gene therapy. Today that number is at least 7.
Reposted by Rory Hennell James
PPE51 is one of the best candidates to form a MOM transport channel. However, our data indicate that it is not that simple. PPE51 mutations in Mmarinum (4 close homologs) indeed reduce the growth on glycerol & glucose, but also highly increase permeability.. and no, we do not fully understand this
PPE51 modulates membrane integrity in Mycobacterium marinum | mBio
The impermeable outer membrane of pathogenic mycobacteria presents a major obstacle
to nutrient acquisition and antibiotic penetration. PPE51, a substrate of the ESX-5
secretion system, has previously...
journals.asm.org
September 23, 2025 at 7:48 AM
PPE51 is one of the best candidates to form a MOM transport channel. However, our data indicate that it is not that simple. PPE51 mutations in Mmarinum (4 close homologs) indeed reduce the growth on glycerol & glucose, but also highly increase permeability.. and no, we do not fully understand this
Reposted by Rory Hennell James
Structure and substrate recognition by the Twin-arginine translocation (Tat) pathway core complex https://www.biorxiv.org/content/10.1101/2025.09.18.677151v1
September 19, 2025 at 3:46 AM
Structure and substrate recognition by the Twin-arginine translocation (Tat) pathway core complex https://www.biorxiv.org/content/10.1101/2025.09.18.677151v1
Reposted by Rory Hennell James
Reposted by Rory Hennell James
Many of the most complex and useful functions in biology emerge at the scale of whole genomes.
Today, we share our preprint “Generative design of novel bacteriophages with genome language models”, where we validate the first, functional AI-generated genomes 🧵
Today, we share our preprint “Generative design of novel bacteriophages with genome language models”, where we validate the first, functional AI-generated genomes 🧵
September 17, 2025 at 3:03 PM
Many of the most complex and useful functions in biology emerge at the scale of whole genomes.
Today, we share our preprint “Generative design of novel bacteriophages with genome language models”, where we validate the first, functional AI-generated genomes 🧵
Today, we share our preprint “Generative design of novel bacteriophages with genome language models”, where we validate the first, functional AI-generated genomes 🧵
Is anyone in #MicroSky aware of the rapamycin dimerisation working in (myco)bacteria? Or some other inducible dimerisation?
I'd like to give this a go but I'm wary of fusing a 24-mer to my protein of interest
I'd like to give this a go but I'm wary of fusing a 24-mer to my protein of interest
Paper alert🚨
Label your protein of interest and localize it in cryoET 👁️❄️
Genetically encoded FerriTag as a specific label for cryo-electron tomography: Structure www.cell.com/structure/fu...
Label your protein of interest and localize it in cryoET 👁️❄️
Genetically encoded FerriTag as a specific label for cryo-electron tomography: Structure www.cell.com/structure/fu...
Genetically encoded FerriTag as a specific label for cryo-electron tomography
Wang et al. present an optimized labeling strategy for cryo-electron tomography based
on genetically encoded FerriTag. This system uses rapamycin to recruit iron-loaded
ferritin to target proteins, en...
www.cell.com
September 12, 2025 at 8:29 AM
Is anyone in #MicroSky aware of the rapamycin dimerisation working in (myco)bacteria? Or some other inducible dimerisation?
I'd like to give this a go but I'm wary of fusing a 24-mer to my protein of interest
I'd like to give this a go but I'm wary of fusing a 24-mer to my protein of interest
This looks super cool, and could be the solution to a problem I've been having for a while.
Congrats all!
Congrats all!
Sub-cellular chemical mapping in bacteria using correlated cryogenic electron and mass spectrometry imaging
Congrats Hannah Ochner and authors on this important paper! Strong collaboration with @kiranrpatil.bsky.social
www.biorxiv.org/cgi/content/...
@mrclmb.bsky.social @wellcometrust.bsky.social
Congrats Hannah Ochner and authors on this important paper! Strong collaboration with @kiranrpatil.bsky.social
www.biorxiv.org/cgi/content/...
@mrclmb.bsky.social @wellcometrust.bsky.social
August 31, 2025 at 9:02 PM
This looks super cool, and could be the solution to a problem I've been having for a while.
Congrats all!
Congrats all!