Rich Giadone
@rmgiadone.bsky.social
“Aging postdoc” using stem cells and organoids to study the aging brain with Lee Rubin in the Dept. of Stem Cell and Regenerative Biology @Harvard
CReM of BUSM and UMass Lowell alum, first gen college goer
CReM of BUSM and UMass Lowell alum, first gen college goer
Beyond grateful for the generous support of AFAR to continue my work on the aging brain in the Rubin lab at the Department of Stem Cell and Regenerative Biology @harvard.edu! Looking forward to meeting everyone involved with AFAR!
Introducing 2025 Glenn Foundation for Medical Research Postdoctoral Fellowships in Aging Research recipient Richard Giadone, PhD, of @harvard.edu, who will research “Pharmacologic Recapitulation of Parabiosis to Improve the Aging Central Nervous System.”
Learn more here: www.afar.org/grantee-prof...
Learn more here: www.afar.org/grantee-prof...
November 14, 2025 at 7:13 PM
Beyond grateful for the generous support of AFAR to continue my work on the aging brain in the Rubin lab at the Department of Stem Cell and Regenerative Biology @harvard.edu! Looking forward to meeting everyone involved with AFAR!
"Single cell RNA sequencing of juvenile bigfoot tissue reveals heterogeneity across juvenile bigfoot cell populations"
I'll wait for the single cell sequencing evidence before I believe it
August 16, 2025 at 8:45 PM
"Single cell RNA sequencing of juvenile bigfoot tissue reveals heterogeneity across juvenile bigfoot cell populations"
Thrilled to have co-led the @harvard.edu Stem Cell Institute Internship Program (HIP) this summer alongside David Scadden and Vicki Rosen! As a HIP alum, it was SO rewarding to see the next generation experience all that shaped my own journey. The future of stem cell biology is a bright one!!
August 8, 2025 at 5:03 PM
Thrilled to have co-led the @harvard.edu Stem Cell Institute Internship Program (HIP) this summer alongside David Scadden and Vicki Rosen! As a HIP alum, it was SO rewarding to see the next generation experience all that shaped my own journey. The future of stem cell biology is a bright one!!
Reposted by Rich Giadone
i make a smooth $37k a year dawg
So many researchers, myself included, work many more hours than what we are funded (i.e. it's not uncommon to work 10hrs/week on a project that we're only getting 10% salary support). Rest-assured--NIH grants are NOT lining ANYONE's pocketbooks. Dumbass. #academicsky
August 8, 2025 at 4:33 AM
i make a smooth $37k a year dawg
Absolutely gutted... RIP to the 🐐 of 🐐s www.youtube.com/watch?v=216Y...
I Just Wasn't Made For These Times
YouTube video by The Beach Boys - Topic
www.youtube.com
June 11, 2025 at 5:43 PM
Absolutely gutted... RIP to the 🐐 of 🐐s www.youtube.com/watch?v=216Y...
Congrats to the indefatigable Sean Simonini for successfully defending this undergrad thesis @kcs-umasslowell.bsky.social!!
Sean's a recent Goldwater Scholarship recipient (www.uml.edu/news/stories...) who, most impressively, commuted >2 hours via the @mbta.com to the lab in Cambridge everyday!!!
Sean's a recent Goldwater Scholarship recipient (www.uml.edu/news/stories...) who, most impressively, commuted >2 hours via the @mbta.com to the lab in Cambridge everyday!!!
May 5, 2025 at 12:40 PM
Congrats to the indefatigable Sean Simonini for successfully defending this undergrad thesis @kcs-umasslowell.bsky.social!!
Sean's a recent Goldwater Scholarship recipient (www.uml.edu/news/stories...) who, most impressively, commuted >2 hours via the @mbta.com to the lab in Cambridge everyday!!!
Sean's a recent Goldwater Scholarship recipient (www.uml.edu/news/stories...) who, most impressively, commuted >2 hours via the @mbta.com to the lab in Cambridge everyday!!!
Come check me out at #ISSCR2025, taking place in Hong Kong on 11-14 June 2025!!! Just a short flight from Boston invt.io/1bxbi53lnwm @isscr.org
I'm speaking at ISSCR 2025 Annual Meeting, join me
Register now
invt.io
April 29, 2025 at 2:48 PM
Come check me out at #ISSCR2025, taking place in Hong Kong on 11-14 June 2025!!! Just a short flight from Boston invt.io/1bxbi53lnwm @isscr.org
Diapause and age deceleration!!
🔥🔥🔥 OUR NEW PREPRINT: Slowing and reversing aging? Nature does it, here we show how! Age deceleration and reversal gene patterns in dauer diapause. @cecad.bsky.social @unicologne.bsky.social @uniklinikkoeln.bsky.social www.biorxiv.org/content/10.1...
Age deceleration and reversal gene patterns in dauer diapause
The aging process is characterized by a general decrease in physical functionality and poses the biggest risk factor for a variety of diseases such as cancer, cardiovascular diseases, and neurodegener...
www.biorxiv.org
April 20, 2025 at 12:59 PM
Diapause and age deceleration!!
Reposted by Rich Giadone
Academia is cool because if you're doing it right, every paper you published in the last 3 years feels inadequate now that you understand the topic better, but it'll take 3 years to get out the version where you get it more right, and you get to do that until one day you die! Isn't that cool
April 19, 2025 at 7:11 PM
Academia is cool because if you're doing it right, every paper you published in the last 3 years feels inadequate now that you understand the topic better, but it'll take 3 years to get out the version where you get it more right, and you get to do that until one day you die! Isn't that cool
Reposted by Rich Giadone
☕Have you read this study from our journal (@naturecellbiology.bsky.social) yet?
Studies of endolysosomes and #proteostasis suggest a role for lysosomal quality control in #Alzheimers disease pathology.
bit.ly/4lSORPV
Studies of endolysosomes and #proteostasis suggest a role for lysosomal quality control in #Alzheimers disease pathology.
bit.ly/4lSORPV
Proteostasis and lysosomal repair deficits in transdifferentiated neurons of Alzheimer’s disease - Nature Cell Biology
Chou et al. generate transdifferentiated human neurons from fibroblasts from young or aged individuals and patients with Alzheimer’s disease. Studies of endolysosomes and proteostasis suggest a role f...
bit.ly
April 17, 2025 at 6:34 PM
☕Have you read this study from our journal (@naturecellbiology.bsky.social) yet?
Studies of endolysosomes and #proteostasis suggest a role for lysosomal quality control in #Alzheimers disease pathology.
bit.ly/4lSORPV
Studies of endolysosomes and #proteostasis suggest a role for lysosomal quality control in #Alzheimers disease pathology.
bit.ly/4lSORPV
Reposted by Rich Giadone
Most people haven’t heard of this test, which is available in the US. It accurately predicts Alzheimer’s (not just if there’s a risk, but when). It is modulated by exercise and likely other lifestyle factors.
Here’s (almost) everything we know about it
erictopol.substack.com/p/the-breakt...
Here’s (almost) everything we know about it
erictopol.substack.com/p/the-breakt...
April 14, 2025 at 1:48 PM
Most people haven’t heard of this test, which is available in the US. It accurately predicts Alzheimer’s (not just if there’s a risk, but when). It is modulated by exercise and likely other lifestyle factors.
Here’s (almost) everything we know about it
erictopol.substack.com/p/the-breakt...
Here’s (almost) everything we know about it
erictopol.substack.com/p/the-breakt...
Reposted by Rich Giadone
Two clinical trials reported in Nature demonstrate the safety of stem cell therapies for Parkinson’s disease. The papers investigate the use of cells derived from human induced pluripotent stem cells and human embryonic stem cells. go.nature.com/4ikcJc2
go.nature.com/4jfSRYX 🧪
go.nature.com/4jfSRYX 🧪
April 16, 2025 at 10:18 PM
Two clinical trials reported in Nature demonstrate the safety of stem cell therapies for Parkinson’s disease. The papers investigate the use of cells derived from human induced pluripotent stem cells and human embryonic stem cells. go.nature.com/4ikcJc2
go.nature.com/4jfSRYX 🧪
go.nature.com/4jfSRYX 🧪
Reposted by Rich Giadone
It has taken decades to get to this point, but stem cells for Parkinson's disease showing promise in 2 clinical trials
nature.com/articles/d41...
nature.com/articles/s41...
nature.com/articles/s41...
nature.com/articles/d41...
nature.com/articles/s41...
nature.com/articles/s41...
Clinical trials test the safety of stem-cell therapy for Parkinson’s disease
Transplanting dopamine-releasing neurons into the brain is a promising regenerative therapy for Parkinson’s disease. Two clinical trials show that it is safe, but more evidence is needed to prove its ...
nature.com
April 16, 2025 at 3:35 PM
It has taken decades to get to this point, but stem cells for Parkinson's disease showing promise in 2 clinical trials
nature.com/articles/d41...
nature.com/articles/s41...
nature.com/articles/s41...
nature.com/articles/d41...
nature.com/articles/s41...
nature.com/articles/s41...
Reposted by Rich Giadone
ISSCR reaffirms support for U.S. federally funded human embryonic stem cell research—supported by bipartisan leadership for over two decades. Read our statement.
www.isscr.org/isscr-news/i...
www.isscr.org/isscr-news/i...
ISSCR Statement on the Scientific and Therapeutic Value of Human Embryonic Stem Cell Research — International Society for Stem Cell Research
Human embryonic stem (hES) cells represent a foundational platform in stem cell science. Their capacity for sustained self-renewal and pluripotency—the ability to differentiate into all cell types in ...
www.isscr.org
April 15, 2025 at 3:45 PM
ISSCR reaffirms support for U.S. federally funded human embryonic stem cell research—supported by bipartisan leadership for over two decades. Read our statement.
www.isscr.org/isscr-news/i...
www.isscr.org/isscr-news/i...
This story is crazy!
Detection of neural stem cells outside the brain: international study in mice could be a breakthrough for regenerative medicine. International study published in @naturecellbiology.bsky.social by Dong Han, Hans R. Schöler and many others.
🔗📢Press release: www.mpi-muenster.mpg.de/press-releas...
🔗📢Press release: www.mpi-muenster.mpg.de/press-releas...
Detection of neural stem cells outside the brain
Detection of neural stem cells outside the brain: The discovery of peripheral neural stem cells in mice could open up enormous possibilities for the development of treatments for neurological diseases...
www.mpi-muenster.mpg.de
April 12, 2025 at 12:10 AM
This story is crazy!
Let’s go boss!!!!!! #LeeRubin2028
The ISSCR is pleased to announce the results of its 2025 election and to welcome new leaders to the ISSCR Executive Committee and Board of Directors! Congratulations to Fiona Doetsch, Lee Rubin, Megan Munsie, Lijian Hui, Wei Xie, and Peter Zandstra.
www.isscr.org/isscr-news/t...
www.isscr.org/isscr-news/t...
April 8, 2025 at 11:33 PM
Let’s go boss!!!!!! #LeeRubin2028
Reposted by Rich Giadone
NIA Caenorhabditis Intervention Testing Program: identification of robust and reproducible pharmacological interventions that promote longevity across experimentally accessible, genetically diverse populations
link.springer.com/article/10.1...
link.springer.com/article/10.1...
NIA Caenorhabditis Intervention Testing Program: identification of robust and reproducible pharmacological interventions that promote longevity across experimentally accessible, genetically diverse po...
A core facet of the National Institute on Aging’s mission is to identify pharmacological interventions that can promote human healthy aging and long life. As part of the comprehensive effort toward th...
link.springer.com
April 6, 2025 at 4:54 AM
NIA Caenorhabditis Intervention Testing Program: identification of robust and reproducible pharmacological interventions that promote longevity across experimentally accessible, genetically diverse populations
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Reposted by Rich Giadone
CRISPRai simultaneously activates and represses two genes in single cells go.nature.com/4apFU9q
rdcu.be/efe0E
rdcu.be/efe0E
Bidirectional epigenetic editing reveals hierarchies in gene regulation - Nature Biotechnology
CRISPRai simultaneously activates and represses two genes in single cells.
go.nature.com
April 2, 2025 at 2:06 AM
CRISPRai simultaneously activates and represses two genes in single cells go.nature.com/4apFU9q
rdcu.be/efe0E
rdcu.be/efe0E
Reposted by Rich Giadone
2/2 Lifetime risk is higher for Women 48%, Black adults 44%, APOE ε4 carriers 59%.
📈 Annual U.S. dementia cases are projected to nearly double—from 514K to 1 million US citizens by 2060. Prevention & research are urgent priorities. Please repost & follow for more! doi.org/10.1038/s415...
📈 Annual U.S. dementia cases are projected to nearly double—from 514K to 1 million US citizens by 2060. Prevention & research are urgent priorities. Please repost & follow for more! doi.org/10.1038/s415...
Lifetime risk and projected burden of dementia - Nature Medicine
A cohort study of over 15,000 US adults found that the lifetime risk of developing dementia from ages 55 to 95 is 42%, with the highest risk in APOE ε4 carriers, women and Black adults, and projected…
doi.org
March 29, 2025 at 12:30 PM
2/2 Lifetime risk is higher for Women 48%, Black adults 44%, APOE ε4 carriers 59%.
📈 Annual U.S. dementia cases are projected to nearly double—from 514K to 1 million US citizens by 2060. Prevention & research are urgent priorities. Please repost & follow for more! doi.org/10.1038/s415...
📈 Annual U.S. dementia cases are projected to nearly double—from 514K to 1 million US citizens by 2060. Prevention & research are urgent priorities. Please repost & follow for more! doi.org/10.1038/s415...
Reposted by Rich Giadone
#Turnover atlas of #proteome and #phosphoproteome across #mouse #tissues and #brain regions: Cell www.cell.com/cell/fulltex...
Turnover atlas of proteome and phosphoproteome across mouse tissues and brain regions
This study presents a comprehensive atlas of protein and phosphoprotein turnover across
16 mouse tissues and brain regions using advanced proteomics and isotope labeling.
It reveals tissue-specific pr...
www.cell.com
March 20, 2025 at 10:50 PM
#Turnover atlas of #proteome and #phosphoproteome across #mouse #tissues and #brain regions: Cell www.cell.com/cell/fulltex...
John Gurdon on early "encouragement" from his science teacher @nobelprize.bsky.social
March 13, 2025 at 9:28 PM
John Gurdon on early "encouragement" from his science teacher @nobelprize.bsky.social
Reposted by Rich Giadone
“Today Google is launching an AI co-scientist, a new AI system built on Gemini 2.0 designed to aid scientists in creating novel hypotheses and research plans.
AI co-scientist is a collaborative tool to help experts gather research and refine their work”
blog.google/feed/google-...
AI co-scientist is a collaborative tool to help experts gather research and refine their work”
blog.google/feed/google-...
We’re launching a new AI system for scientists.
Today Google is launching an AI co-scientist, a new AI system built on Gemini 2.0 designed to aid scientists in creating novel hypotheses and research plans. Researchers…
blog.google
February 20, 2025 at 1:05 AM
“Today Google is launching an AI co-scientist, a new AI system built on Gemini 2.0 designed to aid scientists in creating novel hypotheses and research plans.
AI co-scientist is a collaborative tool to help experts gather research and refine their work”
blog.google/feed/google-...
AI co-scientist is a collaborative tool to help experts gather research and refine their work”
blog.google/feed/google-...
Reposted by Rich Giadone
A protein language model trained to predict subcellular localization for human proteins can generate de novo sequences with the desired localization and identify pathological mutations.
@itamarchinn.bsky.social @pgmikhael.bsky.social
www.science.org/doi/10.1126/...
@itamarchinn.bsky.social @pgmikhael.bsky.social
www.science.org/doi/10.1126/...
February 10, 2025 at 10:28 PM
A protein language model trained to predict subcellular localization for human proteins can generate de novo sequences with the desired localization and identify pathological mutations.
@itamarchinn.bsky.social @pgmikhael.bsky.social
www.science.org/doi/10.1126/...
@itamarchinn.bsky.social @pgmikhael.bsky.social
www.science.org/doi/10.1126/...
wHy WoUlD aNyOnE nOt WaNt To WoRk In AcAdEmIa???//
“If the freeze is not stopped, I might lose my house."
Some NSF-funded postdocs are having trouble paying rent and credit card bills because their salaries were paused this week, even though the federal funding freeze memo was rescinded.
www.statnews.com/2025/01/30/t...
Some NSF-funded postdocs are having trouble paying rent and credit card bills because their salaries were paused this week, even though the federal funding freeze memo was rescinded.
www.statnews.com/2025/01/30/t...
National Science Foundation suspends salary payments, leaving researchers unable to pay their bills
An NSF online payment system remained down after the federal funding freeze was lifted, leaving early-career scientists scrambling to pay bills
www.statnews.com
January 31, 2025 at 5:25 PM
wHy WoUlD aNyOnE nOt WaNt To WoRk In AcAdEmIa???//
Reposted by Rich Giadone
