Prof Anthony Isles
@profantisles.bsky.social
#Neuroscience 🧠 | #ImprintedGenes 🧬 | #preclinical models 🐭🧫| MURIDAE lead @mrcmousenetwork.bsky.social | Cardiff University | posting in a personal capacity, mostly about science
https://profiles.cardiff.ac.uk/staff/islesar1
https://profiles.cardiff.ac.uk/staff/islesar1
Pinned
The Preclinical Animal Network (PCAN): Integrative high-throughput phenotyping of standardized mouse models for Prader-Willi syndrome https://www.biorxiv.org/content/10.1101/2025.10.24.684371v1
This work, initiated and supported by #FPWR, represents an international collaboration involving @mrcharwell.bsky.social, #CardiffUniversity, #INMED and #IIT, to establish a standardised and open-access preclinical ‘Resource’ for Prader-Willi syndrome #PWS
🐭🧬
🐭🧬
Reposted by Prof Anthony Isles
Love being reminded to do this every year. It's a win/win all round
November 11, 2025 at 11:00 AM
Love being reminded to do this every year. It's a win/win all round
Reposted by Prof Anthony Isles
📢 I highly recommend this opportunity! 📢
My time as an Editorial Board member of @royalsocietypublishing.org #PhilTransB is drawing to a close, but please contact me if you would like to discuss any #neuroscience 🧠 or #genetics 🧬 ideas for theme issues
Find out more at bit.ly/PTBproposals
My time as an Editorial Board member of @royalsocietypublishing.org #PhilTransB is drawing to a close, but please contact me if you would like to discuss any #neuroscience 🧠 or #genetics 🧬 ideas for theme issues
Find out more at bit.ly/PTBproposals
November 10, 2025 at 9:55 AM
📢 I highly recommend this opportunity! 📢
My time as an Editorial Board member of @royalsocietypublishing.org #PhilTransB is drawing to a close, but please contact me if you would like to discuss any #neuroscience 🧠 or #genetics 🧬 ideas for theme issues
Find out more at bit.ly/PTBproposals
My time as an Editorial Board member of @royalsocietypublishing.org #PhilTransB is drawing to a close, but please contact me if you would like to discuss any #neuroscience 🧠 or #genetics 🧬 ideas for theme issues
Find out more at bit.ly/PTBproposals
📢 I highly recommend this opportunity! 📢
My time as an Editorial Board member of @royalsocietypublishing.org #PhilTransB is drawing to a close, but please contact me if you would like to discuss any #neuroscience 🧠 or #genetics 🧬 ideas for theme issues
Find out more at bit.ly/PTBproposals
My time as an Editorial Board member of @royalsocietypublishing.org #PhilTransB is drawing to a close, but please contact me if you would like to discuss any #neuroscience 🧠 or #genetics 🧬 ideas for theme issues
Find out more at bit.ly/PTBproposals
November 10, 2025 at 9:55 AM
📢 I highly recommend this opportunity! 📢
My time as an Editorial Board member of @royalsocietypublishing.org #PhilTransB is drawing to a close, but please contact me if you would like to discuss any #neuroscience 🧠 or #genetics 🧬 ideas for theme issues
Find out more at bit.ly/PTBproposals
My time as an Editorial Board member of @royalsocietypublishing.org #PhilTransB is drawing to a close, but please contact me if you would like to discuss any #neuroscience 🧠 or #genetics 🧬 ideas for theme issues
Find out more at bit.ly/PTBproposals
Reposted by Prof Anthony Isles
Other work by the Ladybird artists
Red Squirrel
Artist: CF Tunnicliffe
Red Squirrel
Artist: CF Tunnicliffe
November 7, 2025 at 8:16 AM
Other work by the Ladybird artists
Red Squirrel
Artist: CF Tunnicliffe
Red Squirrel
Artist: CF Tunnicliffe
Reposted by Prof Anthony Isles
Our Best Models Working Group can offer advice on the use of a range of model systems.
Next in our series highlighting the diverse expertise of our Working Group are Prof Matthew Guille and Dr Annie Godwin who work with Xenopus to recreate novel human gene variants thought to cause disease.
Next in our series highlighting the diverse expertise of our Working Group are Prof Matthew Guille and Dr Annie Godwin who work with Xenopus to recreate novel human gene variants thought to cause disease.
November 6, 2025 at 12:45 PM
Our Best Models Working Group can offer advice on the use of a range of model systems.
Next in our series highlighting the diverse expertise of our Working Group are Prof Matthew Guille and Dr Annie Godwin who work with Xenopus to recreate novel human gene variants thought to cause disease.
Next in our series highlighting the diverse expertise of our Working Group are Prof Matthew Guille and Dr Annie Godwin who work with Xenopus to recreate novel human gene variants thought to cause disease.
Reposted by Prof Anthony Isles
This work, initiated and supported by #FPWR, represents an international collaboration involving @mrcharwell.bsky.social, #CardiffUniversity, #INMED and #IIT, to establish a standardised and open-access preclinical ‘Resource’ for Prader-Willi syndrome #PWS
🐭🧬
🐭🧬
The Preclinical Animal Network (PCAN): Integrative high-throughput phenotyping of standardized mouse models for Prader-Willi syndrome https://www.biorxiv.org/content/10.1101/2025.10.24.684371v1
October 29, 2025 at 1:33 PM
This work, initiated and supported by #FPWR, represents an international collaboration involving @mrcharwell.bsky.social, #CardiffUniversity, #INMED and #IIT, to establish a standardised and open-access preclinical ‘Resource’ for Prader-Willi syndrome #PWS
🐭🧬
🐭🧬
Reposted by Prof Anthony Isles
This was a worthwhile use of my morning 🔉
October 25, 2025 at 12:07 PM
This was a worthwhile use of my morning 🔉
Just catching up on the Life Scientific on #BBCR4 with @jimalkhalili.bsky.social - this episode featuring AP De Silva is wonderful 😊
I think all scientific careers require a dose of serendipity, and now I know where the word comes from!
www.bbc.co.uk/sounds/play/...
I think all scientific careers require a dose of serendipity, and now I know where the word comes from!
www.bbc.co.uk/sounds/play/...
The Life Scientific - AP De Silva on building molecular fluorescence sensors for healthcare - BBC Sounds
Photochemist AP De Silva on engineering molecular sensors to help revolutionise healthcare
www.bbc.co.uk
October 31, 2025 at 5:32 PM
Just catching up on the Life Scientific on #BBCR4 with @jimalkhalili.bsky.social - this episode featuring AP De Silva is wonderful 😊
I think all scientific careers require a dose of serendipity, and now I know where the word comes from!
www.bbc.co.uk/sounds/play/...
I think all scientific careers require a dose of serendipity, and now I know where the word comes from!
www.bbc.co.uk/sounds/play/...
This work, initiated and supported by #FPWR, represents an international collaboration involving @mrcharwell.bsky.social, #CardiffUniversity, #INMED and #IIT, to establish a standardised and open-access preclinical ‘Resource’ for Prader-Willi syndrome #PWS
🐭🧬
🐭🧬
The Preclinical Animal Network (PCAN): Integrative high-throughput phenotyping of standardized mouse models for Prader-Willi syndrome https://www.biorxiv.org/content/10.1101/2025.10.24.684371v1
October 29, 2025 at 1:33 PM
This work, initiated and supported by #FPWR, represents an international collaboration involving @mrcharwell.bsky.social, #CardiffUniversity, #INMED and #IIT, to establish a standardised and open-access preclinical ‘Resource’ for Prader-Willi syndrome #PWS
🐭🧬
🐭🧬
Reposted by Prof Anthony Isles
Minority representation on TV causes outrage
From the new Private Eye, in shops now.
From the new Private Eye, in shops now.
October 29, 2025 at 12:01 PM
Minority representation on TV causes outrage
From the new Private Eye, in shops now.
From the new Private Eye, in shops now.
Reposted by Prof Anthony Isles
The Preclinical Animal Network (PCAN): Integrative high-throughput phenotyping of standardized mouse models for Prader-Willi syndrome https://www.biorxiv.org/content/10.1101/2025.10.24.684371v1
October 26, 2025 at 10:32 AM
The Preclinical Animal Network (PCAN): Integrative high-throughput phenotyping of standardized mouse models for Prader-Willi syndrome https://www.biorxiv.org/content/10.1101/2025.10.24.684371v1
Reposted by Prof Anthony Isles
Reposted by Prof Anthony Isles
Early (and therefore less expensive!) registration for this fantastic meeting in beautiful city closes this Friday 31st!(#Halloween - 👻🎃)
We are delighted to announce that the First Genomic Imprinting Valencian Meeting will take place from 17 to 19 November 2025 in the beautiful city of Valencia (Spain).
Please join us and spread the word!
esdeveniments.uv.es/134020/detai...
Please join us and spread the word!
esdeveniments.uv.es/134020/detai...
Genomic Imprinting Valencian Meeting
Genomic Imprinting Meeting will take place in Valencia, a dazzling city that beautifully blends history, art, and modernity, creating a captivating atmosphere for everyone who visits. Its historic cen...
esdeveniments.uv.es
October 27, 2025 at 11:31 AM
Early (and therefore less expensive!) registration for this fantastic meeting in beautiful city closes this Friday 31st!(#Halloween - 👻🎃)
Reposted by Prof Anthony Isles
Really pleased to see this huge project out in the wild... fantastic collaborative effort with @valtertucci.bsky.social Francoise Muscatelli & @mrcharwell.bsky.social, with strong support and funding from the Foundation for Prader-Willi Research #FPWR
🐭🧬🐭🧬
🐭🧬🐭🧬
The Preclinical Animal Network (PCAN): Integrative high-throughput phenotyping of standardized mouse models for Prader-Willi syndrome https://www.biorxiv.org/content/10.1101/2025.10.24.684371v1
October 27, 2025 at 10:43 AM
Really pleased to see this huge project out in the wild... fantastic collaborative effort with @valtertucci.bsky.social Francoise Muscatelli & @mrcharwell.bsky.social, with strong support and funding from the Foundation for Prader-Willi Research #FPWR
🐭🧬🐭🧬
🐭🧬🐭🧬
Early (and therefore less expensive!) registration for this fantastic meeting in beautiful city closes this Friday 31st!(#Halloween - 👻🎃)
We are delighted to announce that the First Genomic Imprinting Valencian Meeting will take place from 17 to 19 November 2025 in the beautiful city of Valencia (Spain).
Please join us and spread the word!
esdeveniments.uv.es/134020/detai...
Please join us and spread the word!
esdeveniments.uv.es/134020/detai...
Genomic Imprinting Valencian Meeting
Genomic Imprinting Meeting will take place in Valencia, a dazzling city that beautifully blends history, art, and modernity, creating a captivating atmosphere for everyone who visits. Its historic cen...
esdeveniments.uv.es
October 27, 2025 at 11:31 AM
Early (and therefore less expensive!) registration for this fantastic meeting in beautiful city closes this Friday 31st!(#Halloween - 👻🎃)
Really pleased to see this huge project out in the wild... fantastic collaborative effort with @valtertucci.bsky.social Francoise Muscatelli & @mrcharwell.bsky.social, with strong support and funding from the Foundation for Prader-Willi Research #FPWR
🐭🧬🐭🧬
🐭🧬🐭🧬
The Preclinical Animal Network (PCAN): Integrative high-throughput phenotyping of standardized mouse models for Prader-Willi syndrome https://www.biorxiv.org/content/10.1101/2025.10.24.684371v1
October 27, 2025 at 10:43 AM
Really pleased to see this huge project out in the wild... fantastic collaborative effort with @valtertucci.bsky.social Francoise Muscatelli & @mrcharwell.bsky.social, with strong support and funding from the Foundation for Prader-Willi Research #FPWR
🐭🧬🐭🧬
🐭🧬🐭🧬
Reposted by Prof Anthony Isles
“An Autumn gale is stripping off the leaves and sweeping them along in the slanting squall of rain”
Artist: CF Tunnicliffe
Writer: EL Grant Watson
(What to Look for in Autumn, 1960)
Artist: CF Tunnicliffe
Writer: EL Grant Watson
(What to Look for in Autumn, 1960)
October 26, 2025 at 7:46 AM
“An Autumn gale is stripping off the leaves and sweeping them along in the slanting squall of rain”
Artist: CF Tunnicliffe
Writer: EL Grant Watson
(What to Look for in Autumn, 1960)
Artist: CF Tunnicliffe
Writer: EL Grant Watson
(What to Look for in Autumn, 1960)
Reposted by Prof Anthony Isles
Out today in Nature: We uncover a neural mechanism for the integration of two internal states - hunger and estrous state - and how this integration shapes pup-directed behaviors in mice.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Integration of hunger and hormonal state gates infant-directed aggression - Nature
Combined behavioural, circuit-level and cellular approaches are used to demonstrate how hypothalamic neurons integrate hunger and oestrous state to drive a switch in how female mice interact with pups...
www.nature.com
October 22, 2025 at 3:30 PM
Out today in Nature: We uncover a neural mechanism for the integration of two internal states - hunger and estrous state - and how this integration shapes pup-directed behaviors in mice.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Prof Anthony Isles
🧠🌟🐭 Excited to share some of my postdoc work on the evolution of dexterity!
We compared deer mice evolved in forest vs prairie habitats. We found that forest mice have:
(1) more corticospinal neurons (CSNs)
(2) better hand dexterity
(3) more dexterous climbing, which is linked to CSN number🧵
We compared deer mice evolved in forest vs prairie habitats. We found that forest mice have:
(1) more corticospinal neurons (CSNs)
(2) better hand dexterity
(3) more dexterous climbing, which is linked to CSN number🧵
October 22, 2025 at 8:41 PM
🧠🌟🐭 Excited to share some of my postdoc work on the evolution of dexterity!
We compared deer mice evolved in forest vs prairie habitats. We found that forest mice have:
(1) more corticospinal neurons (CSNs)
(2) better hand dexterity
(3) more dexterous climbing, which is linked to CSN number🧵
We compared deer mice evolved in forest vs prairie habitats. We found that forest mice have:
(1) more corticospinal neurons (CSNs)
(2) better hand dexterity
(3) more dexterous climbing, which is linked to CSN number🧵
Looking forward to catching up on this 🧬
Loved doing this, with clever people, and Brian, talking ancestry, ancient DNA coalescence theory: these are some of my favourite things.
NEW EPISODE: Who are our ancestors and why does it matter?
Join our expert panellists as they answer audience questions about ancient DNA.
Listen on your favourite podcast platform: lnk.to/AQOSAncientD...
Join our expert panellists as they answer audience questions about ancient DNA.
Listen on your favourite podcast platform: lnk.to/AQOSAncientD...
October 22, 2025 at 1:46 PM
Looking forward to catching up on this 🧬
Reposted by Prof Anthony Isles
Well done @sorayam.bsky.social, and good luck in the final! 🤞
🌟 WiNUK Recognition Awards 2025 Finalists! 🌟
We’re celebrating excellence across neuroscience at the #WiNUKAwards2025 🧠✨
We’re celebrating excellence across neuroscience at the #WiNUKAwards2025 🧠✨
October 21, 2025 at 1:43 PM
Well done @sorayam.bsky.social, and good luck in the final! 🤞
Reposted by Prof Anthony Isles
I am thrilled to share our latest work: we identified a population of central amygdala neurons that promote the earliest and perhaps most important social behavior: pup suckling!... We also developed new tools for pup neuroscience
Work by @Jeff Moore now at USC, a collaboration with @Sam Pfaff lab
Work by @Jeff Moore now at USC, a collaboration with @Sam Pfaff lab
October 21, 2025 at 10:18 AM
I am thrilled to share our latest work: we identified a population of central amygdala neurons that promote the earliest and perhaps most important social behavior: pup suckling!... We also developed new tools for pup neuroscience
Work by @Jeff Moore now at USC, a collaboration with @Sam Pfaff lab
Work by @Jeff Moore now at USC, a collaboration with @Sam Pfaff lab
Reposted by Prof Anthony Isles
The modern world in old Ladybird books.
“A small digital computer designed for the businessman” (1971)
Artist: BH Robinson
“A small digital computer designed for the businessman” (1971)
Artist: BH Robinson
October 19, 2025 at 7:02 PM
The modern world in old Ladybird books.
“A small digital computer designed for the businessman” (1971)
Artist: BH Robinson
“A small digital computer designed for the businessman” (1971)
Artist: BH Robinson
Reposted by Prof Anthony Isles
Teasing apart #Parent-of-origin effects on #complex #traits 😎
#GenomicImprinting #ImprintedGenes 🧬
www.nature.com/articles/s41...
#GenomicImprinting #ImprintedGenes 🧬
www.nature.com/articles/s41...
Parent-of-origin effects on complex traits in up to 236,781 individuals - Nature
A novel multistep strategy reveals how parent-of-origin effects shape complex traits in large-scale biobanks.
www.nature.com
October 16, 2025 at 7:38 PM
Teasing apart #Parent-of-origin effects on #complex #traits 😎
#GenomicImprinting #ImprintedGenes 🧬
www.nature.com/articles/s41...
#GenomicImprinting #ImprintedGenes 🧬
www.nature.com/articles/s41...