MRC National Mouse Genetics Network
@mrcmousenetwork.bsky.social
Distributed challenge-led research clusters working with the Mary Lyon Centre at MRC Harwell to accelerate understanding of human disease using #MouseModels
Our Best Models Working Group can offer advice on the use of a range of model systems.
The next in our series of #MeetTheExpert posts features Owen Sansom, whose group has created advanced mouse models matching a variety of human colorectal cancer subtypes.
nmgn.mrc.ukri.org/working-grou...
The next in our series of #MeetTheExpert posts features Owen Sansom, whose group has created advanced mouse models matching a variety of human colorectal cancer subtypes.
nmgn.mrc.ukri.org/working-grou...
February 12, 2026 at 12:51 PM
Our Best Models Working Group can offer advice on the use of a range of model systems.
The next in our series of #MeetTheExpert posts features Owen Sansom, whose group has created advanced mouse models matching a variety of human colorectal cancer subtypes.
nmgn.mrc.ukri.org/working-grou...
The next in our series of #MeetTheExpert posts features Owen Sansom, whose group has created advanced mouse models matching a variety of human colorectal cancer subtypes.
nmgn.mrc.ukri.org/working-grou...
Our Best Models Working Group can offer advice on the use of a range of model systems.
The next in our series of #MeetTheExpert posts features Laura Greaves, whose group investigates the role of age-related mitochondrial DNA mutations in cancer biology
nmgn.mrc.ukri.org/working-grou...
The next in our series of #MeetTheExpert posts features Laura Greaves, whose group investigates the role of age-related mitochondrial DNA mutations in cancer biology
nmgn.mrc.ukri.org/working-grou...
February 10, 2026 at 8:38 AM
Our Best Models Working Group can offer advice on the use of a range of model systems.
The next in our series of #MeetTheExpert posts features Laura Greaves, whose group investigates the role of age-related mitochondrial DNA mutations in cancer biology
nmgn.mrc.ukri.org/working-grou...
The next in our series of #MeetTheExpert posts features Laura Greaves, whose group investigates the role of age-related mitochondrial DNA mutations in cancer biology
nmgn.mrc.ukri.org/working-grou...
MAPK-driven epithelial cell plasticity underlies colorectal cancer therapeutic resistance:
Members of our Cancer Cluster contributed to a recent paper that provides insight into resistance to therapy and suggests strategies that may improve therapeutic efficacy
nmgn.mrc.ukri.org/news/mapk-dr...
Members of our Cancer Cluster contributed to a recent paper that provides insight into resistance to therapy and suggests strategies that may improve therapeutic efficacy
nmgn.mrc.ukri.org/news/mapk-dr...
MAPK-driven epithelial cell plasticity underlies CRC therapeutic resistance | National Mouse Genetics Network
(White et al., Cancer Research UK Scotland Institute and collaborators across the MRC National Mouse Genetics Network – Cancer Cluster) Colorectal cancer (CRC) is a genetically complex disease, yet re...
nmgn.mrc.ukri.org
February 4, 2026 at 3:25 PM
MAPK-driven epithelial cell plasticity underlies colorectal cancer therapeutic resistance:
Members of our Cancer Cluster contributed to a recent paper that provides insight into resistance to therapy and suggests strategies that may improve therapeutic efficacy
nmgn.mrc.ukri.org/news/mapk-dr...
Members of our Cancer Cluster contributed to a recent paper that provides insight into resistance to therapy and suggests strategies that may improve therapeutic efficacy
nmgn.mrc.ukri.org/news/mapk-dr...
Our Best Models Working Group can offer advice on the use of a range of model systems.
The next in our series of posts highlighting our diverse expertise features Prof Robin Williams, whose group uses Dictyostelium to identify the proteins targeted by drugs
nmgn.mrc.ukri.org/working-grou...
The next in our series of posts highlighting our diverse expertise features Prof Robin Williams, whose group uses Dictyostelium to identify the proteins targeted by drugs
nmgn.mrc.ukri.org/working-grou...
February 4, 2026 at 2:19 PM
Our Best Models Working Group can offer advice on the use of a range of model systems.
The next in our series of posts highlighting our diverse expertise features Prof Robin Williams, whose group uses Dictyostelium to identify the proteins targeted by drugs
nmgn.mrc.ukri.org/working-grou...
The next in our series of posts highlighting our diverse expertise features Prof Robin Williams, whose group uses Dictyostelium to identify the proteins targeted by drugs
nmgn.mrc.ukri.org/working-grou...
Fresh insights reveal how cancer gene mutations drive tumour growth:
Andrew Wood (lead of our Degron Cluster) has co-led a team that created a comprehensive map that shows how hundreds of possible mutations in a key cancer gene influence tumour growth
nmgn.mrc.ukri.org/news/fresh-i...
Andrew Wood (lead of our Degron Cluster) has co-led a team that created a comprehensive map that shows how hundreds of possible mutations in a key cancer gene influence tumour growth
nmgn.mrc.ukri.org/news/fresh-i...
Fresh insights reveal how cancer gene mutations drive tumour growth | National Mouse Genetics Network
Scientists have created a comprehensive map showing how hundreds of possible mutations in a key cancer gene influence tumour growth, offering a new insight that could guide the development of […]
nmgn.mrc.ukri.org
February 2, 2026 at 10:18 AM
Fresh insights reveal how cancer gene mutations drive tumour growth:
Andrew Wood (lead of our Degron Cluster) has co-led a team that created a comprehensive map that shows how hundreds of possible mutations in a key cancer gene influence tumour growth
nmgn.mrc.ukri.org/news/fresh-i...
Andrew Wood (lead of our Degron Cluster) has co-led a team that created a comprehensive map that shows how hundreds of possible mutations in a key cancer gene influence tumour growth
nmgn.mrc.ukri.org/news/fresh-i...
Our Best Models Working Group can offer advice on the use of a range of model systems.
The next in our series highlighting our diverse expertise features Dr Andrew Wood, whose lab uses genome editing and targeted protein degradation to study genetic disease using cell lines, organoids, and mice.
The next in our series highlighting our diverse expertise features Dr Andrew Wood, whose lab uses genome editing and targeted protein degradation to study genetic disease using cell lines, organoids, and mice.
January 30, 2026 at 10:28 AM
Our Best Models Working Group can offer advice on the use of a range of model systems.
The next in our series highlighting our diverse expertise features Dr Andrew Wood, whose lab uses genome editing and targeted protein degradation to study genetic disease using cell lines, organoids, and mice.
The next in our series highlighting our diverse expertise features Dr Andrew Wood, whose lab uses genome editing and targeted protein degradation to study genetic disease using cell lines, organoids, and mice.
Our Best Models Working Group can offer advice on the use of a range of model systems.
The next in our series of posts highlighting our diverse expertise features Dr Alex Whitworth, whose group uses Drosophila models of neurodegenerative diseases.
nmgn.mrc.ukri.org/working-grou...
The next in our series of posts highlighting our diverse expertise features Dr Alex Whitworth, whose group uses Drosophila models of neurodegenerative diseases.
nmgn.mrc.ukri.org/working-grou...
January 27, 2026 at 12:16 PM
Our Best Models Working Group can offer advice on the use of a range of model systems.
The next in our series of posts highlighting our diverse expertise features Dr Alex Whitworth, whose group uses Drosophila models of neurodegenerative diseases.
nmgn.mrc.ukri.org/working-grou...
The next in our series of posts highlighting our diverse expertise features Dr Alex Whitworth, whose group uses Drosophila models of neurodegenerative diseases.
nmgn.mrc.ukri.org/working-grou...
The MRC National Mouse Genetics Network’s Best Models Working Group connects researchers with the right expertise in biological models and computational tools as part of our commitment to the #3Rs.
nmgn.mrc.ukri.org/working-grou...
#MeetTheExpert
nmgn.mrc.ukri.org/working-grou...
#MeetTheExpert
January 21, 2026 at 11:36 AM
The MRC National Mouse Genetics Network’s Best Models Working Group connects researchers with the right expertise in biological models and computational tools as part of our commitment to the #3Rs.
nmgn.mrc.ukri.org/working-grou...
#MeetTheExpert
nmgn.mrc.ukri.org/working-grou...
#MeetTheExpert
A study led by Owen Sansom, Director of the National Mouse Genetics Network, has identified the protein NPM1 as a potential therapeutic target in liver and bowel cancers:
www.bbc.co.uk/news/article...
www.bbc.co.uk/news/article...
Scientists discover potential new treatment to tackle cancer
The research focused on the genetic faults that allow the disease to hijack a signalling system in the body.
www.bbc.co.uk
January 20, 2026 at 12:44 PM
A study led by Owen Sansom, Director of the National Mouse Genetics Network, has identified the protein NPM1 as a potential therapeutic target in liver and bowel cancers:
www.bbc.co.uk/news/article...
www.bbc.co.uk/news/article...
The National Mouse Genetics Network has contributed to a new briefing from the UK Parliamentary Office of Science and Technology (POST) that examines the development and use of emerging technologies as alternatives to animals in life sciences research.
nmgn.mrc.ukri.org/news/mary-ly...
nmgn.mrc.ukri.org/news/mary-ly...
Mary Lyon Centre and National Mouse Genetics Network contribute to Parliamentary report on research models | National Mouse Genetics Network
The UK Parliamentary Office of Science and Technology (POST) has published a new briefing examining the development and use of emerging technologies as alternatives to animals in life sciences researc...
nmgn.mrc.ukri.org
January 13, 2026 at 10:08 AM
The National Mouse Genetics Network has contributed to a new briefing from the UK Parliamentary Office of Science and Technology (POST) that examines the development and use of emerging technologies as alternatives to animals in life sciences research.
nmgn.mrc.ukri.org/news/mary-ly...
nmgn.mrc.ukri.org/news/mary-ly...
Reposted by MRC National Mouse Genetics Network
10 days left to apply for this position at #LancasterUniversity working on the #MURIDAE project @mrcmousenetwork.bsky.social
🧠🧬🐭
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📢 Job Alert 📢
Post-doc position at #LancasterUniversity working on the #MURIDAE project @mrcmousenetwork.bsky.social
Working with #genetic #preclinical models for #schizophrenia 🧠🧬🐭
Please repost!
www.jobs.ac.uk/job/DPW471/s...
Post-doc position at #LancasterUniversity working on the #MURIDAE project @mrcmousenetwork.bsky.social
Working with #genetic #preclinical models for #schizophrenia 🧠🧬🐭
Please repost!
www.jobs.ac.uk/job/DPW471/s...
Senior Research Associate at Lancaster University
An opportunity for an academic position as a Senior Research Associate is available, as advertised on jobs.ac.uk. Apply now and explore other academic job openings.
www.jobs.ac.uk
January 8, 2026 at 8:13 AM
10 days left to apply for this position at #LancasterUniversity working on the #MURIDAE project @mrcmousenetwork.bsky.social
🧠🧬🐭
🧠🧬🐭
Still time to apply to join this incredible team and contribute to our understanding of neurodevelopmental disorders. #PreclinicalResearch #Genetics
10 days left to apply for this position at #LancasterUniversity working on the #MURIDAE project @mrcmousenetwork.bsky.social
🧠🧬🐭
🧠🧬🐭
📢 Job Alert 📢
Post-doc position at #LancasterUniversity working on the #MURIDAE project @mrcmousenetwork.bsky.social
Working with #genetic #preclinical models for #schizophrenia 🧠🧬🐭
Please repost!
www.jobs.ac.uk/job/DPW471/s...
Post-doc position at #LancasterUniversity working on the #MURIDAE project @mrcmousenetwork.bsky.social
Working with #genetic #preclinical models for #schizophrenia 🧠🧬🐭
Please repost!
www.jobs.ac.uk/job/DPW471/s...
January 10, 2026 at 8:05 AM
Still time to apply to join this incredible team and contribute to our understanding of neurodevelopmental disorders. #PreclinicalResearch #Genetics
Reposted by MRC National Mouse Genetics Network
📢 Job Alert 📢
Post-doc position at #LancasterUniversity working on the #MURIDAE project @mrcmousenetwork.bsky.social
Working with #genetic #preclinical models for #schizophrenia 🧠🧬🐭
Please repost!
www.jobs.ac.uk/job/DPW471/s...
Post-doc position at #LancasterUniversity working on the #MURIDAE project @mrcmousenetwork.bsky.social
Working with #genetic #preclinical models for #schizophrenia 🧠🧬🐭
Please repost!
www.jobs.ac.uk/job/DPW471/s...
Senior Research Associate at Lancaster University
An opportunity for an academic position as a Senior Research Associate is available, as advertised on jobs.ac.uk. Apply now and explore other academic job openings.
www.jobs.ac.uk
December 19, 2025 at 10:23 AM
📢 Job Alert 📢
Post-doc position at #LancasterUniversity working on the #MURIDAE project @mrcmousenetwork.bsky.social
Working with #genetic #preclinical models for #schizophrenia 🧠🧬🐭
Please repost!
www.jobs.ac.uk/job/DPW471/s...
Post-doc position at #LancasterUniversity working on the #MURIDAE project @mrcmousenetwork.bsky.social
Working with #genetic #preclinical models for #schizophrenia 🧠🧬🐭
Please repost!
www.jobs.ac.uk/job/DPW471/s...
Our Best Models Working Group can offer advice on the use of a range of model systems.
The next in our series of posts highlighting our diverse expertise features Dr Alex Benedetto, a Senior Lecturer in Integrative Physiology, who works with C. elegans.
nmgn.mrc.ukri.org/working-grou...
The next in our series of posts highlighting our diverse expertise features Dr Alex Benedetto, a Senior Lecturer in Integrative Physiology, who works with C. elegans.
nmgn.mrc.ukri.org/working-grou...
November 20, 2025 at 11:41 AM
Our Best Models Working Group can offer advice on the use of a range of model systems.
The next in our series of posts highlighting our diverse expertise features Dr Alex Benedetto, a Senior Lecturer in Integrative Physiology, who works with C. elegans.
nmgn.mrc.ukri.org/working-grou...
The next in our series of posts highlighting our diverse expertise features Dr Alex Benedetto, a Senior Lecturer in Integrative Physiology, who works with C. elegans.
nmgn.mrc.ukri.org/working-grou...
Our Best Models Working Group can offer advice on the use of a range of model systems.
The next in our series of posts highlighting our diverse expertise features Prof Karen Liu, who works on congenital anomalies arising during embryonic development.
nmgn.mrc.ukri.org/working-grou...
The next in our series of posts highlighting our diverse expertise features Prof Karen Liu, who works on congenital anomalies arising during embryonic development.
nmgn.mrc.ukri.org/working-grou...
November 18, 2025 at 9:00 AM
Our Best Models Working Group can offer advice on the use of a range of model systems.
The next in our series of posts highlighting our diverse expertise features Prof Karen Liu, who works on congenital anomalies arising during embryonic development.
nmgn.mrc.ukri.org/working-grou...
The next in our series of posts highlighting our diverse expertise features Prof Karen Liu, who works on congenital anomalies arising during embryonic development.
nmgn.mrc.ukri.org/working-grou...
Reposted by MRC National Mouse Genetics Network
Great talk by Claire and Rosie this afternoon @mrcmousenetwork.bsky.social meeting!
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November 14, 2025 at 3:25 PM
Great talk by Claire and Rosie this afternoon @mrcmousenetwork.bsky.social meeting!
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Reposted by MRC National Mouse Genetics Network
Great two days in York with the MRC National Mouse Genetics Network. Always a pleasure to be invited to share MitoCluster's work, thank you!
@mrcmousenetwork.bsky.social @jellevda.bsky.social @lauragreaves.bsky.social @robpitceathly.bsky.social
@mrcmousenetwork.bsky.social @jellevda.bsky.social @lauragreaves.bsky.social @robpitceathly.bsky.social
November 14, 2025 at 5:22 PM
Great two days in York with the MRC National Mouse Genetics Network. Always a pleasure to be invited to share MitoCluster's work, thank you!
@mrcmousenetwork.bsky.social @jellevda.bsky.social @lauragreaves.bsky.social @robpitceathly.bsky.social
@mrcmousenetwork.bsky.social @jellevda.bsky.social @lauragreaves.bsky.social @robpitceathly.bsky.social
Reposted by MRC National Mouse Genetics Network
Just heading home from our @mrcmousenetwork.bsky.social MRC NMGN Science Meeting 2025 in York where our Congenital Anomalies Cluster shared updates on our clinical VUS & phenotyping pipelines at the podium! Great discussions! #FunctionalGenomics #RareDisease #CongenitalAnomalies
November 14, 2025 at 6:40 PM
Just heading home from our @mrcmousenetwork.bsky.social MRC NMGN Science Meeting 2025 in York where our Congenital Anomalies Cluster shared updates on our clinical VUS & phenotyping pipelines at the podium! Great discussions! #FunctionalGenomics #RareDisease #CongenitalAnomalies
Our Best Models Working Group can offer advice on the use of a range of model systems.
The next in our series of posts highlighting our diverse expertise features Dr Xiao Fu, who uses integrative data science and computational modelling approaches to study cancer.
The next in our series of posts highlighting our diverse expertise features Dr Xiao Fu, who uses integrative data science and computational modelling approaches to study cancer.
Meet the Experts | National Mouse Genetics Network
We connect researchers with specialists in diverse model systems to support innovation and refinement.
nmgn.mrc.ukri.org
November 12, 2025 at 1:31 PM
Our Best Models Working Group can offer advice on the use of a range of model systems.
The next in our series of posts highlighting our diverse expertise features Dr Xiao Fu, who uses integrative data science and computational modelling approaches to study cancer.
The next in our series of posts highlighting our diverse expertise features Dr Xiao Fu, who uses integrative data science and computational modelling approaches to study cancer.
We welcome the government’s effort to provide a clear roadmap for the phasing out of the use of animals in research, while maintaining scientific rigour and safety standards.
Today the UK government has released a strategy to support the development, validation and uptake of alternative methods.
Read more: www.gov.uk/government/n...
Read more: www.gov.uk/government/n...
Animal testing to be phased out faster as UK unveils roadmap for alternative methods
New plan backs researchers to seize on new and developing opportunities to phase out animal tests with specific commitments for the coming years.
www.gov.uk
November 12, 2025 at 11:33 AM
We welcome the government’s effort to provide a clear roadmap for the phasing out of the use of animals in research, while maintaining scientific rigour and safety standards.
Our Best Models Working Group can offer advice on the use of a range of model systems.
Next in our series highlighting the diverse expertise of our Working Group are Prof Matthew Guille and Dr Annie Godwin who work with Xenopus to recreate novel human gene variants thought to cause disease.
Next in our series highlighting the diverse expertise of our Working Group are Prof Matthew Guille and Dr Annie Godwin who work with Xenopus to recreate novel human gene variants thought to cause disease.
November 6, 2025 at 12:45 PM
Our Best Models Working Group can offer advice on the use of a range of model systems.
Next in our series highlighting the diverse expertise of our Working Group are Prof Matthew Guille and Dr Annie Godwin who work with Xenopus to recreate novel human gene variants thought to cause disease.
Next in our series highlighting the diverse expertise of our Working Group are Prof Matthew Guille and Dr Annie Godwin who work with Xenopus to recreate novel human gene variants thought to cause disease.
Our Best Models Working Group can offer advice on the use of a range of model systems.
Over the coming weeks, we will be highlighting the diverse expertise of our Working Group, starting with Julia Cordero, an expert in the use of Drosophila to study intestinal biology.
#MeetTheExpert
Over the coming weeks, we will be highlighting the diverse expertise of our Working Group, starting with Julia Cordero, an expert in the use of Drosophila to study intestinal biology.
#MeetTheExpert
November 4, 2025 at 8:20 AM
Our Best Models Working Group can offer advice on the use of a range of model systems.
Over the coming weeks, we will be highlighting the diverse expertise of our Working Group, starting with Julia Cordero, an expert in the use of Drosophila to study intestinal biology.
#MeetTheExpert
Over the coming weeks, we will be highlighting the diverse expertise of our Working Group, starting with Julia Cordero, an expert in the use of Drosophila to study intestinal biology.
#MeetTheExpert
If you want advice on selecting the most appropriate model for your research, contact the NMGN Best Models Working Group to be connected with researchers with expertise in diverse biological models and computational tools:
nmgn.mrc.ukri.org/working-grou...
#MeetTheExpert #3Rs
nmgn.mrc.ukri.org/working-grou...
#MeetTheExpert #3Rs
Meet the Experts | National Mouse Genetics Network
We connect researchers with specialists in diverse model systems to support innovation and refinement.
nmgn.mrc.ukri.org
October 31, 2025 at 12:20 PM
If you want advice on selecting the most appropriate model for your research, contact the NMGN Best Models Working Group to be connected with researchers with expertise in diverse biological models and computational tools:
nmgn.mrc.ukri.org/working-grou...
#MeetTheExpert #3Rs
nmgn.mrc.ukri.org/working-grou...
#MeetTheExpert #3Rs
Nice place for a bit of work and hopefully some fun!
We recently welcomed Prof. Fiona Powrie and her team to the MRC CMM for the yearly Microbiome Cluster @mrcmousenetwork.bsky.social meeting. The Microbiome Cluster studies the impact of the microbiome on genetic diseases involving barrier surface malfunction.
🔗 Find out more buff.ly/zuLgJ1J
🔗 Find out more buff.ly/zuLgJ1J
October 9, 2025 at 5:15 PM
Nice place for a bit of work and hopefully some fun!
Last session in full swing! #OrganoidsAreUs2025
September 25, 2025 at 2:11 PM
Last session in full swing! #OrganoidsAreUs2025
