NC3Rs
@nc3rs.bsky.social
A UK-based scientific organisation dedicated to helping the research community worldwide to identify, develop and use 3Rs technologies and approaches. https://nc3rs.org.uk/
@gmrc.bsky.social has published its rearing manual online: nc3rs.org.uk/3rs-resource...
Reviewed by the NC3Rs and other external experts, this resource supports consistent, reliable and reproducible insect husbandry and empowers institutions to adopt wax moth larvae as a partial replacement model.
Reviewed by the NC3Rs and other external experts, this resource supports consistent, reliable and reproducible insect husbandry and empowers institutions to adopt wax moth larvae as a partial replacement model.
Galleria mellonella rearing manual
Developed by the Galleria Mellonella Research Centre at the University of Exeter, to support consistent, reliable and reproducible insect husbandry.
nc3rs.org.uk
January 16, 2026 at 11:40 AM
@gmrc.bsky.social has published its rearing manual online: nc3rs.org.uk/3rs-resource...
Reviewed by the NC3Rs and other external experts, this resource supports consistent, reliable and reproducible insect husbandry and empowers institutions to adopt wax moth larvae as a partial replacement model.
Reviewed by the NC3Rs and other external experts, this resource supports consistent, reliable and reproducible insect husbandry and empowers institutions to adopt wax moth larvae as a partial replacement model.
Are you involved in toxicology studies with dogs, minipigs or non-human primates? Register for our next welfare webinar to learn habituation techniques to refine their use in safety assessment: nc3rs.org.uk/events/welfa...
📅 29 January, 12.30 – 13.30 (GMT)
⏰ Registration closes: 28 January
📅 29 January, 12.30 – 13.30 (GMT)
⏰ Registration closes: 28 January
Welfare webinar: Habituation of minipigs, non-human primates and dogs for procedures in toxicology studies
Practical guidance to reduce stress during inhalation studies, blood sampling and ophthalmological exams.
nc3rs.org.uk
January 13, 2026 at 11:09 AM
Are you involved in toxicology studies with dogs, minipigs or non-human primates? Register for our next welfare webinar to learn habituation techniques to refine their use in safety assessment: nc3rs.org.uk/events/welfa...
📅 29 January, 12.30 – 13.30 (GMT)
⏰ Registration closes: 28 January
📅 29 January, 12.30 – 13.30 (GMT)
⏰ Registration closes: 28 January
Register for our online workshop ‘Rigorous experiments and clear communication with the Experimental Design Assistant’ as part of Love Methods Week this January: nc3rs.org.uk/events/love-...
📅 20 January, 9.00 – 11.00 (GMT)
⏰ Registration closes 19 January
📜 Certificates of attendance available
📅 20 January, 9.00 – 11.00 (GMT)
⏰ Registration closes 19 January
📜 Certificates of attendance available
January 9, 2026 at 1:11 PM
Register for our online workshop ‘Rigorous experiments and clear communication with the Experimental Design Assistant’ as part of Love Methods Week this January: nc3rs.org.uk/events/love-...
📅 20 January, 9.00 – 11.00 (GMT)
⏰ Registration closes 19 January
📜 Certificates of attendance available
📅 20 January, 9.00 – 11.00 (GMT)
⏰ Registration closes 19 January
📜 Certificates of attendance available
2026 is continuing where 2025 left off with a focus on alternatives to animal use in research and testing. Today the Parliamentary Office of Science and Technology published a POSTnote on this topic highlighting the opportunities and challenges: post.parliament.uk/research-bri...
Technology alternatives to animals in life sciences research
How is the UK replacing animal testing with technology alternatives? What are the opportunities, risks and barriers?
post.parliament.uk
January 5, 2026 at 12:25 PM
2026 is continuing where 2025 left off with a focus on alternatives to animal use in research and testing. Today the Parliamentary Office of Science and Technology published a POSTnote on this topic highlighting the opportunities and challenges: post.parliament.uk/research-bri...
Developed in direct response to NC3Rs recommendations, new guidance from the World Health Organisation (@who.int) encourages manufacturers and regulators to replace or remove animal-based quality control methods for vaccines and biologics: nc3rs.org.uk/news/new-who...
New WHO guidelines on non-animal tests for quality control of biologics
Developed in direct response to NC3Rs recommendations, new guidance supports manufacturers and regulators to transition to non-animal testing strategies.
nc3rs.org.uk
December 18, 2025 at 10:00 AM
Developed in direct response to NC3Rs recommendations, new guidance from the World Health Organisation (@who.int) encourages manufacturers and regulators to replace or remove animal-based quality control methods for vaccines and biologics: nc3rs.org.uk/news/new-who...
Eight teams kick-started the commercialisation of their 3Rs tools and technologies this year through the BBSRC-NC3Rs ICURe Explore programme.
Learn more about their success and next steps to translate new approaches into real-world applications that minimise animal use: nc3rs.org.uk/news/driving...
Learn more about their success and next steps to translate new approaches into real-world applications that minimise animal use: nc3rs.org.uk/news/driving...
December 17, 2025 at 2:05 PM
Eight teams kick-started the commercialisation of their 3Rs tools and technologies this year through the BBSRC-NC3Rs ICURe Explore programme.
Learn more about their success and next steps to translate new approaches into real-world applications that minimise animal use: nc3rs.org.uk/news/driving...
Learn more about their success and next steps to translate new approaches into real-world applications that minimise animal use: nc3rs.org.uk/news/driving...
Our next welfare webinar will focus on practical guidance to habituate dogs, minipigs and non-human primates to procedures in toxicology studies, minimising stress and refining their use in safety assessment.
📅 Thursday 29 January, 12.30 – 13.30 (GMT)
👉 Register: nc3rs.org.uk/events/welfa...
📅 Thursday 29 January, 12.30 – 13.30 (GMT)
👉 Register: nc3rs.org.uk/events/welfa...
Welfare webinar: Habituation of minipigs, non-human primates and dogs for procedures in toxicology studies
Practical guidance to reduce stress during inhalation studies, blood sampling and ophthalmological exams.
nc3rs.org.uk
December 10, 2025 at 3:47 PM
Our next welfare webinar will focus on practical guidance to habituate dogs, minipigs and non-human primates to procedures in toxicology studies, minimising stress and refining their use in safety assessment.
📅 Thursday 29 January, 12.30 – 13.30 (GMT)
👉 Register: nc3rs.org.uk/events/welfa...
📅 Thursday 29 January, 12.30 – 13.30 (GMT)
👉 Register: nc3rs.org.uk/events/welfa...
The OECD has agreed to develop new guidance that will reduce the number of fish used in some environmental toxicology studies. This is a result of work led by the NC3Rs and collaborators to understand and solve challenges in vitellogenin assessment.
Find out more: nc3rs.org.uk/news/new-int...
Find out more: nc3rs.org.uk/news/new-int...
December 5, 2025 at 11:14 AM
The OECD has agreed to develop new guidance that will reduce the number of fish used in some environmental toxicology studies. This is a result of work led by the NC3Rs and collaborators to understand and solve challenges in vitellogenin assessment.
Find out more: nc3rs.org.uk/news/new-int...
Find out more: nc3rs.org.uk/news/new-int...
Join @drejpearl.bsky.social at @unistrathclyde.bsky.social 3Rs day next week for an interactive workshop on using the Experimental Design Assistant to design rigorous in vivo experiments, with live support and guidance on hand.
📅 Friday 5 December
👉 Find out more: nc3rs.org.uk/events/unive...
📅 Friday 5 December
👉 Find out more: nc3rs.org.uk/events/unive...
November 27, 2025 at 3:57 PM
Join @drejpearl.bsky.social at @unistrathclyde.bsky.social 3Rs day next week for an interactive workshop on using the Experimental Design Assistant to design rigorous in vivo experiments, with live support and guidance on hand.
📅 Friday 5 December
👉 Find out more: nc3rs.org.uk/events/unive...
📅 Friday 5 December
👉 Find out more: nc3rs.org.uk/events/unive...
Our Chief Executive Vicky Robinson appears in @resprofnews.bsky.social today, in an opinion piece focusing on the UK government's ambitious strategy to replace the use of animals in research and testing: www.researchprofessionalnews.com/rr-news-uk-v....
UK’s plan to reduce animal experiments is strong - Research Professional News
Government strategy reflects recent progress and sets a path to the future, says Vicky Robinson
www.researchprofessionalnews.com
November 26, 2025 at 12:07 PM
Our Chief Executive Vicky Robinson appears in @resprofnews.bsky.social today, in an opinion piece focusing on the UK government's ambitious strategy to replace the use of animals in research and testing: www.researchprofessionalnews.com/rr-news-uk-v....
📢 Webinar: Data-driven design of fish cell line-based reproductive toxicity assays
📅 Tuesday 9 December, 14.00 – 15.00 (GMT)
👉 nc3rs.org.uk/events/data-...
Learn about in vitro assays to replace some in vivo fish tests in environmental risk assessment, developed through our SAFE CRACK IT Challenge.
📅 Tuesday 9 December, 14.00 – 15.00 (GMT)
👉 nc3rs.org.uk/events/data-...
Learn about in vitro assays to replace some in vivo fish tests in environmental risk assessment, developed through our SAFE CRACK IT Challenge.
November 24, 2025 at 4:29 PM
📢 Webinar: Data-driven design of fish cell line-based reproductive toxicity assays
📅 Tuesday 9 December, 14.00 – 15.00 (GMT)
👉 nc3rs.org.uk/events/data-...
Learn about in vitro assays to replace some in vivo fish tests in environmental risk assessment, developed through our SAFE CRACK IT Challenge.
📅 Tuesday 9 December, 14.00 – 15.00 (GMT)
👉 nc3rs.org.uk/events/data-...
Learn about in vitro assays to replace some in vivo fish tests in environmental risk assessment, developed through our SAFE CRACK IT Challenge.
At the @lasa-uk.bsky.social conference this week Jess Eddy shared NC3Rs resources on evaluating environmental enrichment: nc3rs.org.uk/3rs-resource...
Other talks in a great 3Rs session covered best practice in oncology, positive welfare science, zebrafish enrichment and rodent housing refinements.
Other talks in a great 3Rs session covered best practice in oncology, positive welfare science, zebrafish enrichment and rodent housing refinements.
November 20, 2025 at 3:30 PM
At the @lasa-uk.bsky.social conference this week Jess Eddy shared NC3Rs resources on evaluating environmental enrichment: nc3rs.org.uk/3rs-resource...
Other talks in a great 3Rs session covered best practice in oncology, positive welfare science, zebrafish enrichment and rodent housing refinements.
Other talks in a great 3Rs session covered best practice in oncology, positive welfare science, zebrafish enrichment and rodent housing refinements.
Congratulations to @alessiovagnoni.bsky.social who has been announced as a recipient of this year’s AAALAC International Global 3Rs Award recognising his ongoing work in advancing the 3Rs: www.aaalac.org/awards/globa...
Global 3Rs Winners
LEARN MORE / APPLY 2025 Award Winners ASIA-PACIFIC Bing Zhou, Ph.D., M.D. “Amelioration of nonalcoholic fatty liver disease by inhibiting the deubiquitylating enzyme RPN11” Cell Metabolism Sha
www.aaalac.org
November 14, 2025 at 12:40 PM
Congratulations to @alessiovagnoni.bsky.social who has been announced as a recipient of this year’s AAALAC International Global 3Rs Award recognising his ongoing work in advancing the 3Rs: www.aaalac.org/awards/globa...
The latest issue of Tech3Rs, our newsletter for animal technicians, has been published: nc3rs.org.uk/3rs-resource...
November 12, 2025 at 3:21 PM
The latest issue of Tech3Rs, our newsletter for animal technicians, has been published: nc3rs.org.uk/3rs-resource...
The NC3Rs has a strong track record in investing in in vitro models of human disease that replace the use of animals. We have recently partnered with the MRC, Wellcome and Innovate UK on a £15.9M funding call to develop human in vitro models of complex disease.
nc3rs.org.uk/news/nc3rs-g...
nc3rs.org.uk/news/nc3rs-g...
NC3Rs grant holders receive funding in MRC call
£15.9M awarded to develop human in vitro models of complex disease.
nc3rs.org.uk
November 12, 2025 at 10:37 AM
The NC3Rs has a strong track record in investing in in vitro models of human disease that replace the use of animals. We have recently partnered with the MRC, Wellcome and Innovate UK on a £15.9M funding call to develop human in vitro models of complex disease.
nc3rs.org.uk/news/nc3rs-g...
nc3rs.org.uk/news/nc3rs-g...
Today the UK government has released a strategy to support the development, validation and uptake of alternative methods.
Read more: www.gov.uk/government/n...
Read more: www.gov.uk/government/n...
Animal testing to be phased out faster as UK unveils roadmap for alternative methods
New plan backs researchers to seize on new and developing opportunities to phase out animal tests with specific commitments for the coming years.
www.gov.uk
November 11, 2025 at 9:26 AM
Today the UK government has released a strategy to support the development, validation and uptake of alternative methods.
Read more: www.gov.uk/government/n...
Read more: www.gov.uk/government/n...
❗Survey deadline extended: Friday 12 December❗
If you have experience of the monocyte activation test as a replacement for the rabbit pyrogen test, please take 30 minutes to share your insights: nc3rs.org.uk/our-portfoli...
If you have experience of the monocyte activation test as a replacement for the rabbit pyrogen test, please take 30 minutes to share your insights: nc3rs.org.uk/our-portfoli...
NEW SURVEY. Do you manufacture, regulate or produce biological therapeutics? Help the NC3Rs shape the future of non-animal pyrogenicity testing of biologics: nc3rs.org.uk/our-portfoli...
Supporting 3Rs approaches in biologicals testing
nc3rs.org.uk
November 10, 2025 at 12:54 PM
❗Survey deadline extended: Friday 12 December❗
If you have experience of the monocyte activation test as a replacement for the rabbit pyrogen test, please take 30 minutes to share your insights: nc3rs.org.uk/our-portfoli...
If you have experience of the monocyte activation test as a replacement for the rabbit pyrogen test, please take 30 minutes to share your insights: nc3rs.org.uk/our-portfoli...
Our next welfare webinar will focus on using positive reinforcement techniques to improve the welfare of pigs and dogs in research by encouraging voluntary cooperation with procedures and reducing stress.
📅 Thursday 27 November, 12.30 – 13.30 (GMT)
👉 Register: nc3rs.org.uk/events/welfa...
📅 Thursday 27 November, 12.30 – 13.30 (GMT)
👉 Register: nc3rs.org.uk/events/welfa...
November 6, 2025 at 3:02 PM
Our next welfare webinar will focus on using positive reinforcement techniques to improve the welfare of pigs and dogs in research by encouraging voluntary cooperation with procedures and reducing stress.
📅 Thursday 27 November, 12.30 – 13.30 (GMT)
👉 Register: nc3rs.org.uk/events/welfa...
📅 Thursday 27 November, 12.30 – 13.30 (GMT)
👉 Register: nc3rs.org.uk/events/welfa...
New publication: Home-cage monitoring to refine and reduce animal use in drug safety testing
A cross-sector collaboration demonstrates that non-invasive, continuous monitoring of rodent behaviour improves detection of central nervous system side effects for new drugs.
👉 nc3rs.org.uk/news/home-ca...
A cross-sector collaboration demonstrates that non-invasive, continuous monitoring of rodent behaviour improves detection of central nervous system side effects for new drugs.
👉 nc3rs.org.uk/news/home-ca...
November 5, 2025 at 9:33 AM
New publication: Home-cage monitoring to refine and reduce animal use in drug safety testing
A cross-sector collaboration demonstrates that non-invasive, continuous monitoring of rodent behaviour improves detection of central nervous system side effects for new drugs.
👉 nc3rs.org.uk/news/home-ca...
A cross-sector collaboration demonstrates that non-invasive, continuous monitoring of rodent behaviour improves detection of central nervous system side effects for new drugs.
👉 nc3rs.org.uk/news/home-ca...
⏳ Pyrogenicity testing survey closing on Thursday 7 November.
Please take 30 minutes to share your insights into the monocyte activation test and support our work to drive wider adoption of non-animal approaches in biologics quality control testing.
Take the survey: nc3rs.org.uk/our-portfoli...
Please take 30 minutes to share your insights into the monocyte activation test and support our work to drive wider adoption of non-animal approaches in biologics quality control testing.
Take the survey: nc3rs.org.uk/our-portfoli...
NEW SURVEY. Do you manufacture, regulate or produce biological therapeutics? Help the NC3Rs shape the future of non-animal pyrogenicity testing of biologics: nc3rs.org.uk/our-portfoli...
Supporting 3Rs approaches in biologicals testing
nc3rs.org.uk
November 3, 2025 at 3:13 PM
⏳ Pyrogenicity testing survey closing on Thursday 7 November.
Please take 30 minutes to share your insights into the monocyte activation test and support our work to drive wider adoption of non-animal approaches in biologics quality control testing.
Take the survey: nc3rs.org.uk/our-portfoli...
Please take 30 minutes to share your insights into the monocyte activation test and support our work to drive wider adoption of non-animal approaches in biologics quality control testing.
Take the survey: nc3rs.org.uk/our-portfoli...
@inserm.fr have reached approaching 1,000 researchers with a training course that uses the NC3Rs Experimental Design Assistant (EDA) to teach best practice for experimental design of in vivo studies.
Learn more in our interview with the organiser behind Parcours-EDA: nc3rs.org.uk/news/experim...
Learn more in our interview with the organiser behind Parcours-EDA: nc3rs.org.uk/news/experim...
The Experimental Design Assistant: From research planning to training tool
A national training initiative in France is using the EDA to embed robust experimental design into real-world research practice.
nc3rs.org.uk
October 31, 2025 at 10:51 AM
@inserm.fr have reached approaching 1,000 researchers with a training course that uses the NC3Rs Experimental Design Assistant (EDA) to teach best practice for experimental design of in vivo studies.
Learn more in our interview with the organiser behind Parcours-EDA: nc3rs.org.uk/news/experim...
Learn more in our interview with the organiser behind Parcours-EDA: nc3rs.org.uk/news/experim...
Our Chief Executive Vicky Robinson provided comment on the statistics of scientific procedures on animals carried out in Great Britain in 2024, released today.
Read the report from the Home Office: www.gov.uk/government/s...
Read the report from the Home Office: www.gov.uk/government/s...
October 23, 2025 at 11:34 AM
Our Chief Executive Vicky Robinson provided comment on the statistics of scientific procedures on animals carried out in Great Britain in 2024, released today.
Read the report from the Home Office: www.gov.uk/government/s...
Read the report from the Home Office: www.gov.uk/government/s...
NC3Rs staff have co-authored a new chapter in the fourth edition of the IACUC Handbook to support ethical review bodies assess the reliability of animal research. It includes practical support to avoid animals being wasted in studies that produce unreliable results: nc3rs.org.uk/news/conside...
October 22, 2025 at 12:58 PM
NC3Rs staff have co-authored a new chapter in the fourth edition of the IACUC Handbook to support ethical review bodies assess the reliability of animal research. It includes practical support to avoid animals being wasted in studies that produce unreliable results: nc3rs.org.uk/news/conside...
⏳ NC3Rs-BBSRC Business Interaction Vouchers application deadline approaching: 16.00, Tuesday 4 November.
Apply for up to £25k to support industry-academic collaborations that advance 3Rs approaches in oncology, cardiovascular science and new approach methodologies: nc3rs.org.uk/our-funding-...
Apply for up to £25k to support industry-academic collaborations that advance 3Rs approaches in oncology, cardiovascular science and new approach methodologies: nc3rs.org.uk/our-funding-...
October 22, 2025 at 9:04 AM
⏳ NC3Rs-BBSRC Business Interaction Vouchers application deadline approaching: 16.00, Tuesday 4 November.
Apply for up to £25k to support industry-academic collaborations that advance 3Rs approaches in oncology, cardiovascular science and new approach methodologies: nc3rs.org.uk/our-funding-...
Apply for up to £25k to support industry-academic collaborations that advance 3Rs approaches in oncology, cardiovascular science and new approach methodologies: nc3rs.org.uk/our-funding-...
A new imaging system developed through our Transgene Track CRACK IT Challenge enables real-time, non-invasive monitoring of gene and cell therapies in rodents – reducing animal use and improving data quality in preclinical studies.
Learn more: nc3rs.org.uk/crackit/news...
Learn more: nc3rs.org.uk/crackit/news...
October 17, 2025 at 1:24 PM
A new imaging system developed through our Transgene Track CRACK IT Challenge enables real-time, non-invasive monitoring of gene and cell therapies in rodents – reducing animal use and improving data quality in preclinical studies.
Learn more: nc3rs.org.uk/crackit/news...
Learn more: nc3rs.org.uk/crackit/news...