MRC National Mouse Genetics Network
@mrcmousenetwork.bsky.social
Distributed challenge-led research clusters working with the Mary Lyon Centre at MRC Harwell to accelerate understanding of human disease using #MouseModels
Our Best Models Working Group can offer advice on the use of a range of model systems.
Next in our series highlighting the diverse expertise of our Working Group are Prof Matthew Guille and Dr Annie Godwin who work with Xenopus to recreate novel human gene variants thought to cause disease.
Next in our series highlighting the diverse expertise of our Working Group are Prof Matthew Guille and Dr Annie Godwin who work with Xenopus to recreate novel human gene variants thought to cause disease.
November 6, 2025 at 12:45 PM
Our Best Models Working Group can offer advice on the use of a range of model systems.
Next in our series highlighting the diverse expertise of our Working Group are Prof Matthew Guille and Dr Annie Godwin who work with Xenopus to recreate novel human gene variants thought to cause disease.
Next in our series highlighting the diverse expertise of our Working Group are Prof Matthew Guille and Dr Annie Godwin who work with Xenopus to recreate novel human gene variants thought to cause disease.
Our Best Models Working Group can offer advice on the use of a range of model systems.
Over the coming weeks, we will be highlighting the diverse expertise of our Working Group, starting with Julia Cordero, an expert in the use of Drosophila to study intestinal biology.
#MeetTheExpert
Over the coming weeks, we will be highlighting the diverse expertise of our Working Group, starting with Julia Cordero, an expert in the use of Drosophila to study intestinal biology.
#MeetTheExpert
November 4, 2025 at 8:20 AM
Our Best Models Working Group can offer advice on the use of a range of model systems.
Over the coming weeks, we will be highlighting the diverse expertise of our Working Group, starting with Julia Cordero, an expert in the use of Drosophila to study intestinal biology.
#MeetTheExpert
Over the coming weeks, we will be highlighting the diverse expertise of our Working Group, starting with Julia Cordero, an expert in the use of Drosophila to study intestinal biology.
#MeetTheExpert
Last session in full swing! #OrganoidsAreUs2025
September 25, 2025 at 2:11 PM
Last session in full swing! #OrganoidsAreUs2025
Our first session of today's #OrganoidsAreUs2025 is dedicated to organoid models in cancer research.
We go with
✨ Vincenzo Corbo
✨ Ben Dwyer
✨ Maximilian Reichert
✨ Chiara Braconi
Another packed session for a critical and fast-developing field!
We go with
✨ Vincenzo Corbo
✨ Ben Dwyer
✨ Maximilian Reichert
✨ Chiara Braconi
Another packed session for a critical and fast-developing field!
September 25, 2025 at 9:42 AM
Our first session of today's #OrganoidsAreUs2025 is dedicated to organoid models in cancer research.
We go with
✨ Vincenzo Corbo
✨ Ben Dwyer
✨ Maximilian Reichert
✨ Chiara Braconi
Another packed session for a critical and fast-developing field!
We go with
✨ Vincenzo Corbo
✨ Ben Dwyer
✨ Maximilian Reichert
✨ Chiara Braconi
Another packed session for a critical and fast-developing field!
Second session on #StemCells #regeneration and #cancer. We start with
🧪 Phil Jones from the @sangerinstitute.bsky.social
🧪 Followed by Suet Yu Leung from Hong Kong Uni and
🧪 Eleanor Earp from @edinburghuni.bsky.social ,
✨ First keynote lecture by Helmuth Gehart from @ethz.ch
#OrganoidsAreUs2025
🧪 Phil Jones from the @sangerinstitute.bsky.social
🧪 Followed by Suet Yu Leung from Hong Kong Uni and
🧪 Eleanor Earp from @edinburghuni.bsky.social ,
✨ First keynote lecture by Helmuth Gehart from @ethz.ch
#OrganoidsAreUs2025
September 24, 2025 at 12:28 PM
Second session on #StemCells #regeneration and #cancer. We start with
🧪 Phil Jones from the @sangerinstitute.bsky.social
🧪 Followed by Suet Yu Leung from Hong Kong Uni and
🧪 Eleanor Earp from @edinburghuni.bsky.social ,
✨ First keynote lecture by Helmuth Gehart from @ethz.ch
#OrganoidsAreUs2025
🧪 Phil Jones from the @sangerinstitute.bsky.social
🧪 Followed by Suet Yu Leung from Hong Kong Uni and
🧪 Eleanor Earp from @edinburghuni.bsky.social ,
✨ First keynote lecture by Helmuth Gehart from @ethz.ch
#OrganoidsAreUs2025
A day dedicated to #StemCells #regeneration and #cancer. 1st session sponsored by TECAN with Nick Barker from A*STAR, Amian Barai from @univ-amu.fr and our first Tony Burgess Orator, Vivian Li from @crick.ac.uk, providing a fascinating insight into this fast-developing area #OrganoidsAreUs2025
September 24, 2025 at 8:46 AM
A day dedicated to #StemCells #regeneration and #cancer. 1st session sponsored by TECAN with Nick Barker from A*STAR, Amian Barai from @univ-amu.fr and our first Tony Burgess Orator, Vivian Li from @crick.ac.uk, providing a fascinating insight into this fast-developing area #OrganoidsAreUs2025
Opening session sponsored by @stemcell.com and OLS with a welcome from Director Owen Sansom @cruk-si.bsky.social and Elizabeth Vincan @unimelb.bsky.social . Our plenary speaker Prof Hans Clevers from @utrechtuniversity.bsky.social talks about human epithelial organoids. #OrganoidsAreUs2025
September 23, 2025 at 5:01 PM
Opening session sponsored by @stemcell.com and OLS with a welcome from Director Owen Sansom @cruk-si.bsky.social and Elizabeth Vincan @unimelb.bsky.social . Our plenary speaker Prof Hans Clevers from @utrechtuniversity.bsky.social talks about human epithelial organoids. #OrganoidsAreUs2025
We are ready to go at the CRUK Scotland Institute, @cruk-si.bsky.social, for this exciting meeting, bringing together a huge wealth of new technologies and scientific advances. First session this afternoon. Watch this space! #OrganoidsAreUs2025
September 23, 2025 at 11:18 AM
We are ready to go at the CRUK Scotland Institute, @cruk-si.bsky.social, for this exciting meeting, bringing together a huge wealth of new technologies and scientific advances. First session this afternoon. Watch this space! #OrganoidsAreUs2025
On 14th November, we are once again holding our Network Science Day in York, which is an exciting opportunity for Network members and non-members to engage and develop new collaborations!
The meeting is free to attend. Find out more and register by emailing us at Genetics_Network@har.mrc.ac.uk.
The meeting is free to attend. Find out more and register by emailing us at Genetics_Network@har.mrc.ac.uk.
September 16, 2025 at 12:15 PM
On 14th November, we are once again holding our Network Science Day in York, which is an exciting opportunity for Network members and non-members to engage and develop new collaborations!
The meeting is free to attend. Find out more and register by emailing us at Genetics_Network@har.mrc.ac.uk.
The meeting is free to attend. Find out more and register by emailing us at Genetics_Network@har.mrc.ac.uk.
Sid took his work forward and independently drove the development of a computational tool (dualGSEA) that enables statistical and biological analysis of gene expression data to facilitate a more nuanced interpretation of transcriptomic info and contribute to the identification of therapeutic targets
June 10, 2025 at 3:56 PM
Sid took his work forward and independently drove the development of a computational tool (dualGSEA) that enables statistical and biological analysis of gene expression data to facilitate a more nuanced interpretation of transcriptomic info and contribute to the identification of therapeutic targets
In early 2024, Sid’s work resulted in a new way to classify tumours based on biological pathways rather than individual gene expression. This allowed the identification of a slow cycling phenotype (PSD3) that spanned two of the CMSs and resulted in poor outcomes despite a less aggressive appearance.
June 10, 2025 at 3:56 PM
In early 2024, Sid’s work resulted in a new way to classify tumours based on biological pathways rather than individual gene expression. This allowed the identification of a slow cycling phenotype (PSD3) that spanned two of the CMSs and resulted in poor outcomes despite a less aggressive appearance.
In 2023, Sid was involved with the challenge of aligning genetically engineered mouse models with the consensus molecular subtypes (CMS1-4) of human colorectal cancers, developing the MmCMS classifier to more accurately match mouse models with human cancers and improve translatability.
June 10, 2025 at 3:56 PM
In 2023, Sid was involved with the challenge of aligning genetically engineered mouse models with the consensus molecular subtypes (CMS1-4) of human colorectal cancers, developing the MmCMS classifier to more accurately match mouse models with human cancers and improve translatability.
And India and Avery talking about #microbiome and #inflammation. The Gut Florist on great form!
May 19, 2025 at 8:23 PM
And India and Avery talking about #microbiome and #inflammation. The Gut Florist on great form!
Sponsoring #Pint25 at a packed @oxfordblue.bsky.social and our own @rsbains.bsky.social going through the journey to passive behaviour monitoring powered by #AI @mrcharwell.bsky.social
May 19, 2025 at 6:47 PM
Sponsoring #Pint25 at a packed @oxfordblue.bsky.social and our own @rsbains.bsky.social going through the journey to passive behaviour monitoring powered by #AI @mrcharwell.bsky.social
#Glasgow gave us the most amazing welcome for #IMGCGlasgow! The sun shone for the whole time and we felt hugely welcome. The science was exciting, new and old friends were met, possibilities opened up and we look forward to meeting again soon! Thanks everyone! #MouseGenetics #PreclinicalResearch
April 10, 2025 at 8:37 AM
#Glasgow gave us the most amazing welcome for #IMGCGlasgow! The sun shone for the whole time and we felt hugely welcome. The science was exciting, new and old friends were met, possibilities opened up and we look forward to meeting again soon! Thanks everyone! #MouseGenetics #PreclinicalResearch
Martin Hrabě de Angelis is giving this year’s Snell lecture. His work with @impc-phenotypes.bsky.social and Infrafrontier and long standing collaboration with the @mrcharwell.bsky.social makes him a great friend! Congratulations! #IMGCGlasgow
April 9, 2025 at 2:20 PM
Martin Hrabě de Angelis is giving this year’s Snell lecture. His work with @impc-phenotypes.bsky.social and Infrafrontier and long standing collaboration with the @mrcharwell.bsky.social makes him a great friend! Congratulations! #IMGCGlasgow
Paula Clark from the @mrclmb.bsky.social and the Haem Cluster talking about generating a good mouse model to study immune cell function
#IMGCGlasgow
#IMGCGlasgow
April 9, 2025 at 10:13 AM
Paula Clark from the @mrclmb.bsky.social and the Haem Cluster talking about generating a good mouse model to study immune cell function
#IMGCGlasgow
#IMGCGlasgow
There was some Network fun as well as we gathered for a lovely dinner and relaxation evening. Nothing beats a chat with some good food and a drink! #WorkIsFun
April 9, 2025 at 9:55 AM
There was some Network fun as well as we gathered for a lovely dinner and relaxation evening. Nothing beats a chat with some good food and a drink! #WorkIsFun
Not a network talk but we really enjoyed this one by @davidashbrook.bsky.social on transgenic models of Alzheimer’s Disease on different genetic backgrounds. Loads of data and incredible imaging!
April 9, 2025 at 8:13 AM
Not a network talk but we really enjoyed this one by @davidashbrook.bsky.social on transgenic models of Alzheimer’s Disease on different genetic backgrounds. Loads of data and incredible imaging!
And finally Claus Nerlow form the Haem Cluster describing models of acute leukaemia regulated by GATA2 mutations #IMGCGlasgow
April 8, 2025 at 8:25 AM
And finally Claus Nerlow form the Haem Cluster describing models of acute leukaemia regulated by GATA2 mutations #IMGCGlasgow
Our Director Owen Sansom describing decades long work that is now involving the Cancer Cluster to generate and characterise mouse models of colorectal cancer that more faithfully recapitulate human disease #IMGCGlasgow
April 8, 2025 at 8:13 AM
Our Director Owen Sansom describing decades long work that is now involving the Cancer Cluster to generate and characterise mouse models of colorectal cancer that more faithfully recapitulate human disease #IMGCGlasgow
This morning session is Network loaded, starting with Sevda Boyanova from the @ukdri.ac.uk talking about the standardised phenotyping pipelines established for Alzheimer’s and frontotemporal dementia mouse models at the @mrcharwell.bsky.social Great attendance despite the early start! #IMGCGlasgow
April 8, 2025 at 7:47 AM
This morning session is Network loaded, starting with Sevda Boyanova from the @ukdri.ac.uk talking about the standardised phenotyping pipelines established for Alzheimer’s and frontotemporal dementia mouse models at the @mrcharwell.bsky.social Great attendance despite the early start! #IMGCGlasgow
What a welcome by #Glasgow City Chambers! One of the highlights of this #IMGCGlasgow!
@yannherault.bsky.social
@yannherault.bsky.social
April 7, 2025 at 5:57 PM
What a welcome by #Glasgow City Chambers! One of the highlights of this #IMGCGlasgow!
@yannherault.bsky.social
@yannherault.bsky.social
The Mary Lyon Award lecture given by Rachel Lynch of the University of North Carolina at Chapel Hill talking to us about the Systems Genetics Core Facility she heads and the challenges of maintenance and distribution of the Collaborative Cross strains #IMGCGlasgow @mmrrc.bsky.social
April 7, 2025 at 12:47 PM
The Mary Lyon Award lecture given by Rachel Lynch of the University of North Carolina at Chapel Hill talking to us about the Systems Genetics Core Facility she heads and the challenges of maintenance and distribution of the Collaborative Cross strains #IMGCGlasgow @mmrrc.bsky.social
Ageing Cluster member Nicholas Schaum presenting the cluster and the work he’s doing to advance our understanding of the ageing process and the possible intervention points for a healthier life using #mouse cohorts at different age points #IMGCGlasgow #AgeingResearch @mrcharwell.bsky.social
April 7, 2025 at 9:32 AM
Ageing Cluster member Nicholas Schaum presenting the cluster and the work he’s doing to advance our understanding of the ageing process and the possible intervention points for a healthier life using #mouse cohorts at different age points #IMGCGlasgow #AgeingResearch @mrcharwell.bsky.social